Publications

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Amrhein JA, Berger LM, Balourdas DI, Joerger AC, Menge A, Krämer A, et al.
    Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3
    Journal of Medicinal Chemistry. 2024; 67(1): 674-690. https://doi.org/10.1021/acs.jmedchem.3c01980
    DORA PSI
  • Balourdas DI, Markl AM, Krämer A, Settanni G, Joerger AC
    Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators
    Cell Death & Disease. 2024; 15(6): 408. https://doi.org/10.1038/s41419-024-06739-x
    DORA PSI
  • Berlin M, Cantley J, Bookbinder M, Bortolon E, Broccatelli F, Cadelina G, et al.
    PROTACs targeting BRM (SMARCA2) afford selective In vivo degradation over BRG1 (SMARCA4) and are active in BRG1 mutant xenograft tumor models
    Journal of Medicinal Chemistry. 2024; 67: 1262-1313. https://doi.org/10.1021/acs.jmedchem.3c01781
    DORA PSI
  • Bozhüyük KAJ, Präve L, Kegler C, Schenk L, Kaiser S, Schelhas C, et al.
    Evolution-inspired engineering of nonribosomal peptide synthetases
    Science. 2024; 383(6689): eadg4320 (11 pp.). https://doi.org/10.1126/science.adg4320
    DORA PSI
  • Brescia FF, Korf L, Essen L-O, Zorn H, Ruehl M
    A novel O- and S-methyltransferase from Pleurotus sapidus is involved in flavor formation
    Journal of Agricultural and Food Chemistry. 2024; 72(12): 6471-6480. https://doi.org/10.1021/acs.jafc.3c08849
    DORA PSI
  • Böttcher J, Fuchs JE, Mayer M, Kahmann J, Zak KM, Wunberg T, et al.
    Ligandability assessment of the C-terminal Rel-homology domain of NFAT1
    Archiv der Pharmazie. 2024; 357(6): 2300649 (7 pp.). https://doi.org/10.1002/ardp.202300649
    DORA PSI
  • Chikunova A, Manley MP, Heijjer CN, Drenth CS, Cramer‐Blok AJ, Ahmad MUD, et al.
    Conserved proline residues prevent dimerization and aggregation in the β‐lactamase BlaC
    Protein Science. 2024; 33(4). https://doi.org/10.1002/pro.4972
    DORA PSI
  • Dötsch L, Davies C, Hennes E, Schönfeld J, Kumar A, Guita CDCL, et al.
    Discovery of the sEH inhibitor epoxykynin as a potent kynurenine pathway modulator
    Journal of Medicinal Chemistry. 2024; 67(6): 4691-4706. https://doi.org/10.1021/acs.jmedchem.3c02245
    DORA PSI
  • Feuillard J, Couston J, Benito Y, Hodille E, Dumitrescu O, Blaise M
    Biochemical and structural characterization of a class A β-lactamase from Nocardia cyriacigeorgica
    Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2024; 80: 13-21. https://doi.org/10.1107/S2053230X23010671
    DORA PSI
  • Götz MG, Godwin K, Price R, Dorn R, Merrill-Steskal G, Klemmer W, et al.
    Macrocyclic oxindole peptide epoxyketones - a comparative study of macrocyclic inhibitors of the 20S proteasome
    ACS Medicinal Chemistry Letters. 2024; 15(4): 533-539. https://doi.org/10.1021/acsmedchemlett.4c00017
    DORA PSI
  • Heyndrickx I, Deswarte K, Verstraete K, Verschueren KHG, Smole U, Aegerter H, et al.
    Ym1 protein crystals promote type 2 immunity
    eLife. 2024; 12: RP90676 (17 pp.). https://doi.org/10.7554/eLife.90676
    DORA PSI
  • Huang CY, Metz A, Lange R, Artico N, Potot C, Hazemann J, et al.
    Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket
    Acta Crystallographica Section D: Structural Biology. 2024; 80: 123-136. https://doi.org/10.1107/S2059798324000329
    DORA PSI
  • Höing L, Sowa ST, Toplak M, Reinhardt JK, Jakob R, Maier T, et al.
    Biosynthesis of the bacterial antibiotic 3,7-dihydroxytropolone through enzymatic salvaging of catabolic shunt products
    Chemical Science. 2024; 15(20): 7749-7756. https://doi.org/10.1039/d4sc01715c
    DORA PSI
  • Illigmann A, Vielberg MT, Lakemeyer M, Wolf F, Dema T, Stange P, et al.
    Structure of Staphylococcus aureus ClpP bound to the covalent active-site inhibitor cystargolide A
    Angewandte Chemie International Edition. 2024; 63(3): e202314028 (10 pp.). https://doi.org/10.1002/anie.202314028
    DORA PSI
  • Jungfer K, Sigg A, Jinek M
    Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2
    Nucleic Acids Research. 2024; 52(1): 462-473. https://doi.org/10.1093/nar/gkad1102
    DORA PSI
  • Kjeldsen T, Andersen AS, Hubálek F, Johansson E, Kreiner FF, Schluckebier G, et al.
    Molecular engineering of insulin for recombinant expression in yeast
    Trends in Biotechnology. 2024; 42(4): 464-478. https://doi.org/10.1016/j.tibtech.2023.09.012
    DORA PSI
  • Krawinski P, Smithers L, van Dalsen L, Boland C, Ostrovitsa N, Pérez J, et al.
    7.10 MAG. A novel host monoacylglyceride for in meso (lipid cubic phase) crystallization of membrane proteins
    Crystal Growth and Design. 2024; 24(7): 2985-3001. https://doi.org/10.1021/acs.cgd.4c00087
    DORA PSI
  • Li F, Zhu WF, Empel C, Datsenko O, Kumar A, Xu Y, et al.
    Photosensitization enables Pauson-Khand-type reactions with nitrenes
    Science. 2024; 383(6682): 498-503. https://doi.org/10.1126/science.adm8095
    DORA PSI
  • Metz A, Stegmann DP, Panepucci EH, Buehlmann S, Huang CY, McAuley KE, et al.
    HEIDI: an experiment-management platform enabling high-throughput fragment and compound screening
    Acta Crystallographica Section D: Structural Biology. 2024; 80: 328-335. https://doi.org/10.1107/S2059798324002833
    DORA PSI
  • Morstein J, Amatuni A, Shuster A, Kuttenlochner W, Ko T, Abegg D, et al.
    Optical control of proteasomal protein degradation with a photoswitchable lipopeptide
    Angewandte Chemie International Edition. 2024; 63(8): e202314791 (7 pp.). https://doi.org/10.1002/anie.202314791
    DORA PSI
  • Nievergelt P, Berliat F, McAuley KE, Dorgan CR, van Well RM, Thorn A, et al.
    RNA oligomers at atomic resolution containing 1-methylpseudouridine, an essential building block of mRNA vaccines
    ChemMedChem. 2024; 19(7): e202300600 (5 pp.). https://doi.org/10.1002/cmdc.202300600
    DORA PSI
  • Pflüger T, Gschell M, Zhang L, Shnitsar V, Zabadné AJ, Zierep P, et al.
    How sensor Amt-like proteins integrate ammonium signals
    Science Advances. 2024; 10(23): eadm9441 (16 pp.). https://doi.org/10.1126/sciadv.adm9441
    DORA PSI
  • Rak M, Menge A, Tesch R, Berger LM, Balourdas DI, Shevchenko E, et al.
    Development of selective pyrido[2,3-d]pyrimidin-7(8H)-one-based Mammalian STE20-like (MST3/4) kinase inhibitors
    Journal of Medicinal Chemistry. 2024; 67(5): 3813-3842. https://doi.org/10.1021/acs.jmedchem.3c02217
    DORA PSI
  • Sagmeister T, Gubensäk N, Buhlheller C, Grininger C, Eder M, Ðordić A, et al.
    The molecular architecture of Lactobacillus S-layer: assembly and attachment to teichoic acids
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2024; 121(24): e2401686121 (12 pp.). https://doi.org/10.1073/pnas.2401686121
    DORA PSI
  • Santema LL, Rotilio L, Xiang R, Tjallinks G, Guallar V, Mattevi A, et al.
    Discovery and biochemical characterization of thermostable glycerol oxidases
    Applied Microbiology and Biotechnology. 2024; 108: 61 (14 pp.). https://doi.org/10.1007/s00253-023-12883-9
    DORA PSI
  • Schmalhofer M, Vagstad AL, Zhou Q, Bode HB, Groll M
    Polyketide trimming shapes dihydroxynaphthalene-melanin and anthraquinone pigments
    Advanced Science. 2024; 11(22): 2400184 (10 pp.). https://doi.org/10.1002/advs.202400184
    DORA PSI
  • Schweke H, Pacesa M, Levin T, Goverde CA, Kumar P, Duhoo Y, et al.
    An atlas of protein homo-oligomerization across domains of life
    Cell. 2024; 187(4): 999-1010.e15. https://doi.org/10.1016/j.cell.2024.01.022
    DORA PSI
  • Tsujino S, Sato Y, Jia S, Kepa MW, Trampari S, Tomizaki T
    Inertial mixing of acoustically levitated droplets for time-lapse protein crystallography
    Droplet. 2024; e132. https://doi.org/10.1002/dro2.132
    DORA PSI
  • Vulpetti A, Rondeau JM, Bellance MH, Blank J, Boesch R, Boettcher A, et al.
    Ligandability assessment of IL-1β by integrated hit identification approaches
    Journal of Medicinal Chemistry. 2024; 67: 8141-8160. https://doi.org/10.1021/acs.jmedchem.4c00240
    DORA PSI
  • Wang W, Atherton P, Kreft M, te Molder L, van der Poel S, Hoekman L, et al.
    Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility
    Journal of Cell Science. 2024; 137(9): jcs262116 (13 pp.). https://doi.org/10.1242/jcs.262116
    DORA PSI
  • Wohlwend D, Mérono L, Bucka S, Ritter K, Jessen HJ, Friedrich T
    Structures of 3-acetylpyridine adenine dinucleotide and ADP-ribose bound to the electron input module of respiratory complex I
    Structure. 2024; 32(6): 715-724.e3. https://doi.org/10.1016/j.str.2024.02.013
    DORA PSI
  • Yu K, Zhang K, Jakob RP, Maier T, Ward TR
    An artificial nickel chlorinase based on the biotin-streptavidin technology
    Chemical Communications. 2024; 60(14): 1944-1947. https://doi.org/10.1039/d3cc05847f
    DORA PSI
  • Amaral B, Capacci A, Anderson T, Tezer C, Bajrami B, Lulla M, et al.
    Elucidation of the GSK3α structure informs the design of novel, paralog-selective inhibitors
    ACS Chemical Neuroscience. 2023; 14(6): 1080-1094. https://doi.org/10.1021/acschemneuro.2c00476
    DORA PSI
  • Arifi S, Marschner JA, Pollinger J, Isigkeit L, Heitel P, Kaiser A, et al.
    Targeting the alternative vitamin E metabolite binding site enables noncanonical PPARγ modulation
    Journal of the American Chemical Society. 2023; 145(27): 14802-14810. https://doi.org/10.1021/jacs.3c03417
    DORA PSI
  • Asano W, Yamanaka K, Ohara Y, Uhara T, Doi S, Orita T, et al.
    Fragment-based discovery of novel VE-PTP inhibitors using orthogonal biophysical techniques
    Biochemistry. 2023; 62(14): 2161-2169. https://doi.org/10.1021/acs.biochem.3c00079
    DORA PSI
  • Balboa JR, Essig DJ, Ma S, Karer N, Clemmensen LS, Pedersen SW, et al.
    Development of a potent cyclic peptide inhibitor of the nNOS/PSD-95 interaction
    Journal of Medicinal Chemistry. 2023; 66(1): 976-990. https://doi.org/10.1021/acs.jmedchem.2c01803
    DORA PSI
  • Balo T, Sapi A, Kiss A, Raimbaud E, Paysant J, Cattin M-E, et al.
    Synthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors
    Monatshefte für Chemie. 2023; 154: 1339-1357. https://doi.org/10.1007/s00706-021-02889-2
    DORA PSI
  • Boland C, Huang C-Y, Shanker Kaki S, Wang M, Olieric V, Caffrey M
    Se-MAG is a convenient additive for experimental phasing and structure determination of membrane proteins crystallised by the lipid cubic phase (in meso) method
    Crystals. 2023; 13(9): 1402 (20 pp.). https://doi.org/10.3390/cryst13091402
    DORA PSI
  • Brkic A, Leibundgut M, Jablonska J, Zanki V, Car Z, Petrovic Perokovic V, et al.
    Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
    Nature Communications. 2023; 14(1): 5498 (12 pp.). https://doi.org/10.1038/s41467-023-41244-3
    DORA PSI
  • Buchstaller H-P, Sala-Hojman A, Leiendecker M, Albers J, Anlauf U, Berges N, et al.
    Discovery of cycloalkyl[c]thiophenes as novel scaffolds for hypoxia-inducible factor-2α inhibitors
    Journal of Medicinal Chemistry. 2023; 66(13): 8666-8686. https://doi.org/10.1021/acs.jmedchem.3c00332
    DORA PSI
  • Busch MR, Rajendran C, Sterner R
    Structural and functional characterization of the ureidoacrylate amidohydrolase RutB from Escherichia coli
    Biochemistry. 2023; 62(3): 863-872. https://doi.org/10.1021/acs.biochem.2c00640
    DORA PSI
  • Cao Y, Kümmel F, Logemann E, Gebauer JM, Lawson AW, Yu D, et al.
    Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2023; 120(32): e2307604120 (11 pp.). https://doi.org/10.1073/pnas.2307604120
    DORA PSI
  • Cucuzza S, Michel E, Mittl PRE, Zerbe O, Plückthun A
    Improved repeat protein stability by combined consensus and computational protein design
    Biochemistry. 2023; 62(2): 318-329. https://doi.org/10.1021/acs.biochem.2c00083
    DORA PSI
  • Davis-Gilbert ZW, Krämer A, Dunford JE, Howell S, Senbabaoglu F, Wells CI, et al.
    Discovery of a potent and selective naphthyridine-based chemical probe for casein kinase 2
    ACS Medicinal Chemistry Letters. 2023; 14(4): 432-441. https://doi.org/10.1021/acsmedchemlett.2c00530
    DORA PSI
  • Deau E, Lindberg MF, Miege F, Roche D, George N, George P, et al.
    Leucettinibs, a class of DYRK/CLK kinase inhibitors Inspired by the marine sponge natural product leucettamine B
    Journal of Medicinal Chemistry. 2023; 66(15): 10694-10714. https://doi.org/10.1021/acs.jmedchem.3c00884
    DORA PSI
  • Dienemann J-N, Chen S-Y, Hitzenberger M, Sievert ML, Hacker SM, Prigge ST, et al.
    A chemical proteomic strategy reveals inhibitors of lipoate salvage in bacteria and parasites
    Angewandte Chemie International Edition. 2023; 62(31): e202304533 (9 pp.). https://doi.org/10.1002/anie.202304533
    DORA PSI
  • Doyle K, Roberts M, Harvey J, Hewer R, Zebisch M, Rangel V, et al.
    A covalent binding mode of a pyrazole-based CD38 inhibitor
    Helvetica Chimica Acta. 2023; 106(9): e202300080 (10 pp.). https://doi.org/10.1002/hlca.202300080
    DORA PSI
  • Ebenhoch R, Bauer M, Romig H, Gottschling D, Kley JT, Heine N, et al.
    Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design
    Acta Crystallographica Section D: Structural Biology. 2023; 79(10): 871-880. https://doi.org/10.1107/S2059798323006137
    DORA PSI
  • Ecker F, Vattekkatte A, Boland W, Groll M
    Metal-dependent enzyme symmetry guides the biosynthetic flux of terpene precursors
    Nature Chemistry. 2023; 15: 1188-1195. https://doi.org/10.1038/s41557-023-01235-9
    DORA PSI
  • Eltschkner S, Mellinger S, Buus S, Nielsen M, Paulsson KM, Lindkvist-Petersson K, et al.
    The structure of songbird MHC class I reveals antigen binding that is flexible at the N-terminus and static at the C-terminus
    Frontiers in Immunology. 2023; 14: 1209059 (14 pp.). https://doi.org/10.3389/fimmu.2023.1209059
    DORA PSI
  • Emmerich H-J, Schneider L, Essen L-O
    Structural and functional analysis of a prokaryotic (6-4) photolyase from the aquatic pathogen Vibrio cholerae
    Photochemistry and Photobiology. 2023; 99(5): 1248-1257. https://doi.org/10.1111/php.13783
    DORA PSI
  • Fleming JR, Hauth F, Hartig JS, Mayans O
    Crystal structure of a GCN5-related N-acetyltransferase from Lactobacillus curiae
    Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2023; 79: 217-223. https://doi.org/10.1107/S2053230X2300571X
    DORA PSI
  • Fonseca Lopez F, Miao J, Damjanovic J, Bischof L, Braun MB, Ling Y, et al.
    Computational prediction of cyclic peptide structural ensembles and application to the design of keap1 binders
    Journal of Chemical Information and Modeling. 2023; 63(21): 6925-6937. https://doi.org/10.1021/acs.jcim.3c01337
    DORA PSI
  • Fraley AE, Dell M, Schmalhofer M, Meoded RA, Bergande C, Groll M, et al.
    Heterocomplex structure of a polyketide synthase component involved in modular backbone halogenation
    Structure. 2023; 31(5): 565-572.e4. https://doi.org/10.1016/j.str.2023.02.010
    DORA PSI
  • Furukawa Y, Shintani A, Narikiyo S, Sue K, Akutsu M, Muraki N
    Characterization of a novel cysteine-less Cu/Zn-superoxide dismutase in Paenibacillus lautus missing a conserved disulfide bond
    Journal of Biological Chemistry. 2023; 299(8): 105040 (13 pp.). https://doi.org/10.1016/j.jbc.2023.105040
    DORA PSI
  • Glögl M, Friedrich N, Cerutti G, Lemmin T, Kwon YD, Gorman J, et al.
    Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization
    Nature Structural and Molecular Biology. 2023; 30: 1323-1336. https://doi.org/10.1038/s41594-023-01062-z
    DORA PSI
  • Grädler U, Schwarz D, Wegener A, Eichhorn T, Bandeiras TM, Freitas MC, et al.
    Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding
    Journal of Biological Chemistry. 2023; 299(11): 105328 (14 pp.). https://doi.org/10.1016/j.jbc.2023.105328
    DORA PSI
  • Guler S, DiPoto MC, Crespo A, Caldwell R, Doerfel B, Grossmann N, et al.
    Selective Wee1 inhibitors led to antitumor activity in vitro and correlated with myelosuppression
    ACS Medicinal Chemistry Letters. 2023; 14(5): 566-576. https://doi.org/10.1021/acsmedchemlett.2c00481
    DORA PSI
  • Hashimoto K, Watanabe S, Akutsu M, Muraki N, Kamishina H, Furukawa Y, et al.
    Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy–linked E40K mutation
    Journal of Biological Chemistry. 2023; 299(6): 104798 (12 pp.). https://doi.org/10.1016/j.jbc.2023.104798
    DORA PSI
  • Hau JL, Kaltwasser S, Muras V, Casutt MS, Vohl G, Claußen B, et al.
    Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase
    Nature Structural and Molecular Biology. 2023; 30(11): 1686-1694. https://doi.org/10.1038/s41594-023-01099-0
    DORA PSI
  • Hermanns T, Uthoff M, Baumann U, Hofmann K
    The structural basis for deubiquitination by the fingerless USP-type effector TssM
    Life Science Alliance. 2023; 7(2): e202302422 (13 pp.). https://doi.org/10.26508/lsa.202302422
    DORA PSI
  • Hoegenauer K, An S, Axford J, Benander C, Bergsdorf C, Botsch J, et al.
    Discovery of ligands for TRIM58, a novel tissue-selective E3 ligase
    ACS Medicinal Chemistry Letters. 2023; 14(12): 1631-1639. https://doi.org/10.1021/acsmedchemlett.3c00259
    DORA PSI
  • Hu Z, Sitkoff D, Glunz PW, Zou Y, Wang C, Muckelbauer JK, et al.
    Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors
    Bioorganic and Medicinal Chemistry Letters. 2023; 88: 129304 (5 pp.). https://doi.org/10.1016/j.bmcl.2023.129304
    DORA PSI
  • Huber EM, Kreling L, Heinrich AK, Dünnebacke M, Pöthig A, Bode HB, et al.
    A set of closely related methyltransferases for site-specific tailoring of anthraquinone pigments
    Structure. 2023; 31(5): 573-583.e5. https://doi.org/10.1016/j.str.2023.03.001
    DORA PSI
  • Imai Y, Wakasugi D, Suzuki R, Kato S, Sugisaki M, Mima M, et al.
    Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor
    Bioorganic and Medicinal Chemistry Letters. 2023; 79: 129050 (6 pp.). https://doi.org/10.1016/j.bmcl.2022.129050
    DORA PSI
  • Isaikina P, Petrovic I, Jakob RP, Sarma P, Ranjan A, Baruah M, et al.
    A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes
    Molecular Cell. 2023; 83(12): 2108-2121.e7. https://doi.org/10.1016/j.molcel.2023.05.002
    DORA PSI
  • Kaenying W, Choengpanya K, Tagami T, Wattana-Amorn P, Lang W, Okuyama M, et al.
    Crystal structure and identification of amino acid residues for catalysis and binding of GH3 AnBX β-xylosidase from Aspergillus niger
    Applied Microbiology and Biotechnology. 2023; 107(7-8): 2335-2349. https://doi.org/10.1007/s00253-023-12445-z
    DORA PSI
  • Kaspers MS, Pogenberg V, Pett C, Ernst S, Ecker F, Ochtrop P, et al.
    Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b
    Nature Communications. 2023; 14(1): 2245 (15 pp.). https://doi.org/10.1038/s41467-023-37621-7
    DORA PSI
  • Kim D, Herdeis L, Rudolph D, Zhao Y, Böttcher J, Vides A, et al.
    Pan-KRAS inhibitor disables oncogenic signalling and tumour growth
    Nature. 2023; 619(7968): 160-166. https://doi.org/10.1038/s41586-023-06123-3
    DORA PSI
  • Korf L, Ye X, Vogt MS, Steinchen W, Watad M, van der Does C, et al.
    Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis
    mBio. 2023; 14(6): e00859-23 (22 pp.). https://doi.org/10.1128/mbio.00859-23
    DORA PSI
  • Kunka A, Marques SM, Havlasek M, Vasina M, Velatova N, Cengelova L, et al.
    Advancing enzyme’s stability and catalytic efficiency through synergy of force-field calculations, evolutionary analysis, and machine learning
    ACS Catalysis. 2023; 13(19): 12506-12518. https://doi.org/10.1021/acscatal.3c02575
    DORA PSI
  • Kuttruff CA, Fleck M, Carotta S, Arnhof H, Bretschneider T, Dahmann G, et al.
    Discovery of BI 7446: a potent cyclic dinucleotide STING agonist with broad-spectrum variant activity for the treatment of cancer
    Journal of Medicinal Chemistry. 2023; 66(14): 9376-9400. https://doi.org/10.1021/acs.jmedchem.3c00510
    DORA PSI
  • Le K, Soth MJ, Cross JB, Liu G, Ray WJ, Ma J, et al.
    Discovery of IACS-52825, a potent and selective DLK inhibitor for treatment of chemotherapy-induced peripheral neuropathy
    Journal of Medicinal Chemistry. 2023; 66(14): 9954-9971. https://doi.org/10.1021/acs.jmedchem.3c00788
    DORA PSI
  • Lebrette H, Srinivas V, John J, Aurelius O, Kumar R, Lundin D, et al.
    Structure of a ribonucleotide reductase R2 protein radical
    Science. 2023; 382(6666): 109-113. https://doi.org/10.1126/science.adh8160
    DORA PSI
  • Lemcoff T, Alus L, Haataja JS, Wagner A, Zhang G, Pavan MJ, et al.
    Brilliant whiteness in shrimp from ultra-thin layers of birefringent nanospheres
    Nature Photonics. 2023; 17(6): 485-493. https://doi.org/10.1038/s41566-023-01182-4
    DORA PSI
  • Lentink S, Salazar Marcano DE, Moussawi MA, Vandebroek L, Van Meervelt L, Parac-Vogt T N
    Fine-tuning non-covalent interactions between hybrid metal-oxo clusters and proteins
    Faraday Discussions. 2023; 244(21): 21-38. https://doi.org/10.1039/d2fd00161f
    DORA PSI
  • Leonarski F, Brückner M, Lopez-Cuenca C, Mozzanica A, Stadler H-C, Matěj Z, et al.
    Jungfraujoch: hardware-accelerated data-acquisition system for kilohertz pixel-array X-ray detectors
    Journal of Synchrotron Radiation. 2023; 30: 227-234. https://doi.org/10.1107/S1600577522010268
    DORA PSI
  • Leonarski F, Nan J, Matej Z, Bertrand Q, Furrer A, Gorgisyan I, et al.
    Kilohertz serial crystallography with the JUNGFRAU detector at a fourth-generation synchrotron source
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