Publications

PDB structures measured at X06SA

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Schulte T, Magdaong NCM, Di Valentin M, Agostini A, Tait CE, Niedzwiedzki DM, et al.
    Structural and spectroscopic characterization of the peridinin-chlorophyll a-protein (PCP) complex from Heterocapsa pygmaea (HPPCP)
    Biochimica et Biophysica Acta: Bioenergetics. 2025; 1866(1): 149510 (17 pp.). https://doi.org/10.1016/j.bbabio.2024.149510
    DORA PSI
  • Amrhein JA, Berger LM, Balourdas DI, Joerger AC, Menge A, Krämer A, et al.
    Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3
    Journal of Medicinal Chemistry. 2024; 67(1): 674-690. https://doi.org/10.1021/acs.jmedchem.3c01980
    DORA PSI
  • Balourdas DI, Markl AM, Krämer A, Settanni G, Joerger AC
    Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators
    Cell Death & Disease. 2024; 15(6): 408. https://doi.org/10.1038/s41419-024-06739-x
    DORA PSI
  • Bauer N, Balourdas DI, Schneider JR, Zhang X, Berger LM, Berger BT, et al.
    Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization
    ACS Chemical Biology. 2024; 19(2): 266-279. https://doi.org/10.1021/acschembio.3c00427
    DORA PSI
  • Beier A, Platzer G, Höfurthner T, Ptaszek AL, Lichtenecker RJ, Geist L, et al.
    Probing protein-ligand methyl−π interaction geometries through chemical shift measurements of selectively labeled methyl groups
    Journal of Medicinal Chemistry. 2024; 67(15): 13187-13196. https://doi.org/10.1021/acs.jmedchem.4c01128
    DORA PSI
  • Berlin M, Cantley J, Bookbinder M, Bortolon E, Broccatelli F, Cadelina G, et al.
    PROTACs targeting BRM (SMARCA2) afford selective In vivo degradation over BRG1 (SMARCA4) and are active in BRG1 mutant xenograft tumor models
    Journal of Medicinal Chemistry. 2024; 67: 1262-1313. https://doi.org/10.1021/acs.jmedchem.3c01781
    DORA PSI
  • Bolduc PN, Pfaffenbach M, Evans R, Xin Z, Henry KL, Gao F, et al.
    A tiny pocket packs a punch: leveraging pyridones for the discovery of CNS-penetrant aza-indazole IRAK4 inhibitors
    ACS Medicinal Chemistry Letters. 2024; 15(5): 714-721. https://doi.org/10.1021/acsmedchemlett.4c00102
    DORA PSI
  • Bozhüyük KAJ, Präve L, Kegler C, Schenk L, Kaiser S, Schelhas C, et al.
    Evolution-inspired engineering of nonribosomal peptide synthetases
    Science. 2024; 383(6689): eadg4320 (11 pp.). https://doi.org/10.1126/science.adg4320
    DORA PSI
  • Brescia FF, Korf L, Essen L-O, Zorn H, Ruehl M
    A novel O- and S-methyltransferase from Pleurotus sapidus is involved in flavor formation
    Journal of Agricultural and Food Chemistry. 2024; 72(12): 6471-6480. https://doi.org/10.1021/acs.jafc.3c08849
    DORA PSI
  • Bruno P, Micoli A, Corsi M, Pala D, Guariento S, Fiorelli C, et al.
    Discovery and optimization of pyridazinones as PI3Kδ selective inhibitors for administration by inhalation
    Journal of Medicinal Chemistry. 2024; 67: 11103-11124. https://doi.org/10.1021/acs.jmedchem.4c00610
    DORA PSI
  • Buffa V, Meyners C, Sugiarto WO, Bauder M, Gaali S, Hausch F
    1,4-pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile
    ChemMedChem. 2024; 19(17): e202400264 (23 pp.). https://doi.org/10.1002/cmdc.202400264
    DORA PSI
  • Böttcher J, Fuchs JE, Mayer M, Kahmann J, Zak KM, Wunberg T, et al.
    Ligandability assessment of the C-terminal Rel-homology domain of NFAT1
    Archiv der Pharmazie. 2024; 357(6): 2300649 (7 pp.). https://doi.org/10.1002/ardp.202300649
    DORA PSI
  • Carswell E, Heinrich T, Petersson C, Gunera J, Garg S, Schwarz D, et al.
    Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold
    Bioorganic and Medicinal Chemistry Letters. 2024; 114: 129981 (8 pp.). https://doi.org/10.1016/j.bmcl.2024.129981
    DORA PSI
  • Champiré A, Berabez R, Braka A, Cosson A, Corret J, Girardin C, et al.
    Tetrahydropyridine LIMK inhibitors: structure activity studies and biological characterization
    European Journal of Medicinal Chemistry. 2024; 271: 116391 (27 pp.). https://doi.org/10.1016/j.ejmech.2024.116391
    DORA PSI
  • Chen D, Zhang X, Vorobieva AA, Tachibana R, Stein A, Jakob RP, et al.
    An evolved artificial radical cyclase enables the construction of bicyclic terpenoid scaffolds via an H-atom transfer pathway
    Nature Chemistry. 2024. https://doi.org/10.1038/s41557-024-01562-5
    DORA PSI
  • Chikunova A, Manley MP, Heijjer CN, Drenth CS, Cramer‐Blok AJ, Ahmad MUD, et al.
    Conserved proline residues prevent dimerization and aggregation in the β‐lactamase BlaC
    Protein Science. 2024; 33(4). https://doi.org/10.1002/pro.4972
    DORA PSI
  • DeRatt LG, Zhang Z, Pietsch C, Cisar JS, Zhang X, Wang W, et al.
    Discovery of JNJ-74856665: a novel isoquinolinone DHODH inhibitor for the treatment of AML
    Journal of Medicinal Chemistry. 2024; 67: 11254-11272. https://doi.org/10.1021/acs.jmedchem.4c00809
    DORA PSI
  • DeRatt LG, Zhang Z, Pietsch EC, Cisar J, Wang A, Wang C yuan, et al.
    Identification of isoquinolinone DHODH inhibitor isosteres
    Bioorganic and Medicinal Chemistry Letters. 2024; 113: 129965 (7 pp.). https://doi.org/10.1016/j.bmcl.2024.129965
    DORA PSI
  • Dötsch L, Davies C, Hennes E, Schönfeld J, Kumar A, Guita CDCL, et al.
    Discovery of the sEH inhibitor epoxykynin as a potent kynurenine pathway modulator
    Journal of Medicinal Chemistry. 2024; 67(6): 4691-4706. https://doi.org/10.1021/acs.jmedchem.3c02245
    DORA PSI
  • Evans R, Bolduc PN, Pfaffenbach M, Gao F, May-Dracka T, Fang T, et al.
    The discovery of 7-isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a potent, selective, and CNS-penetrant IRAK4 inhibitor for the treatment of ischemic stroke
    Journal of Medicinal Chemistry. 2024; 67(6): 4676-4690. https://doi.org/10.1021/acs.jmedchem.3c02226
    DORA PSI
  • Feuillard J, Couston J, Benito Y, Hodille E, Dumitrescu O, Blaise M
    Biochemical and structural characterization of a class A β-lactamase from Nocardia cyriacigeorgica
    Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2024; 80: 13-21. https://doi.org/10.1107/S2053230X23010671
    DORA PSI
  • Gerninghaus J, Zhubi R, Krämer A, Karim M, Tran DHN, Joerger AC, et al.
    Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent EPHA2/GAK kinase inhibitors
    Journal of Medicinal Chemistry. 2024; 67(1): 12534-12552. https://doi.org/10.1021/acs.jmedchem.4c00411
    DORA PSI
  • Gotthard G, Mous S, Weinert T, Maia RNA, James D, Dworkowski F, et al.
    Capturing the blue-light activated state of the Phot-LOV1 domain from Chlamydomonas reinhardtii using time-resolved serial synchrotron crystallography
    IUCrJ. 2024; 11(5): (17 pp.). https://doi.org/10.1107/S2052252524005608
    DORA PSI
  • Goverde CA, Pacesa M, Goldbach N, Dornfeld LJ, Balbi PEM, Georgeon S, et al.
    Computational design of soluble and functional membrane protein analogues
    Nature. 2024; 631(8020): 449-458. https://doi.org/10.1038/s41586-024-07601-y
    DORA PSI
  • Greco FA, Krämer A, Wahl L, Elson L, Ehret TAL, Gerninghaus J, et al.
    Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting
    European Journal of Medicinal Chemistry. 2024; 276: 116672 (22 pp.). https://doi.org/10.1016/j.ejmech.2024.116672
    DORA PSI
  • Götz MG, Godwin K, Price R, Dorn R, Merrill-Steskal G, Klemmer W, et al.
    Macrocyclic oxindole peptide epoxyketones - a comparative study of macrocyclic inhibitors of the 20S proteasome
    ACS Medicinal Chemistry Letters. 2024; 15(4): 533-539. https://doi.org/10.1021/acsmedchemlett.4c00017
    DORA PSI
  • Hazemann J, Kimmerlin T, Lange R, Sweeney AM, Bourquin G, Ritz D, et al.
    Identification of SARS-CoV-2 Mpro inhibitors through deep reinforcement learning for de novo drug design and computational chemistry approaches
    RSC Medicinal Chemistry. 2024; 15(6): 2146-2159. https://doi.org/10.1039/d4md00106k
    DORA PSI
  • Heyndrickx I, Deswarte K, Verstraete K, Verschueren KHG, Smole U, Aegerter H, et al.
    Ym1 protein crystals promote type 2 immunity
    eLife. 2024; 12: RP90676 (17 pp.). https://doi.org/10.7554/eLife.90676
    DORA PSI
  • Himmelbauer MK, Bajrami B, Basile R, Capacci A, Chen TY, Choi CK, et al.
    Discovery and preclinical characterization of BIIB129, a covalent, selective, and brain-penetrant BTK inhibitor for the treatment of multiple sclerosis
    Journal of Medicinal Chemistry. 2024; 67(10): 8122-8140. https://doi.org/10.1021/acs.jmedchem.4c00220
    DORA PSI
  • Huang CY, Metz A, Lange R, Artico N, Potot C, Hazemann J, et al.
    Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket
    Acta Crystallographica Section D: Structural Biology. 2024; 80: 123-136. https://doi.org/10.1107/S2059798324000329
    DORA PSI
  • Höing L, Sowa ST, Toplak M, Reinhardt JK, Jakob R, Maier T, et al.
    Biosynthesis of the bacterial antibiotic 3,7-dihydroxytropolone through enzymatic salvaging of catabolic shunt products
    Chemical Science. 2024; 15(20): 7749-7756. https://doi.org/10.1039/d4sc01715c
    DORA PSI
  • Illigmann A, Vielberg MT, Lakemeyer M, Wolf F, Dema T, Stange P, et al.
    Structure of Staphylococcus aureus ClpP bound to the covalent active-site inhibitor cystargolide A
    Angewandte Chemie International Edition. 2024; 63(3): e202314028 (10 pp.). https://doi.org/10.1002/anie.202314028
    DORA PSI
  • Inobe T, Sakaguchi R, Obita T, Mukaiyama A, Koike S, Yokoyama T, et al.
    Structural insights into rapamycin-induced oligomerization of a FRB–FKBP fusion protein
    FEBS Letters. 2024; 598: 2292-2305. https://doi.org/10.1002/1873-3468.14986
    DORA PSI
  • Jungfer K, Sigg A, Jinek M
    Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2
    Nucleic Acids Research. 2024; 52(1): 462-473. https://doi.org/10.1093/nar/gkad1102
    DORA PSI
  • Kesteleyn B, Herschke F, Darville N, Stoops B, Jacobs T, Jacoby E, et al.
    Spiro-azetidine oxindoles as long-acting injectables for pre-exposure prophylaxis against respiratory syncytial virus infections
    Journal of Medicinal Chemistry. 2024; 67: 10986-11002. https://doi.org/10.1021/acs.jmedchem.4c00514
    DORA PSI
  • Kjeldsen T, Andersen AS, Hubálek F, Johansson E, Kreiner FF, Schluckebier G, et al.
    Molecular engineering of insulin for recombinant expression in yeast
    Trends in Biotechnology. 2024; 42(4): 464-478. https://doi.org/10.1016/j.tibtech.2023.09.012
    DORA PSI
  • Koeppl LH, Popadić D, Saleem-Batcha R, Germer P, Andexer JN
    Structure, function and substrate preferences of archaeal S-adenosyl-l-homocysteine hydrolases
    Communications Biology. 2024; 7(1): 380 (15 pp.). https://doi.org/10.1038/s42003-024-06078-9
    DORA PSI
  • Krawinski P, Smithers L, van Dalsen L, Boland C, Ostrovitsa N, Pérez J, et al.
    7.10 MAG. A novel host monoacylglyceride for in meso (lipid cubic phase) crystallization of membrane proteins
    Crystal Growth and Design. 2024; 24(7): 2985-3001. https://doi.org/10.1021/acs.cgd.4c00087
    DORA PSI
  • Kuttenlochner W, Beller P, Kaysser L, Groll M
    Deciphering the SAM- and metal-dependent mechanism of O-methyltransferases in cystargolide and belactosin biosynthesis: a structure–activity relationship study
    Journal of Biological Chemistry. 2024; 300(9): 107646 (8 pp.). https://doi.org/10.1016/j.jbc.2024.107646
    DORA PSI
  • Li F, Zhu WF, Empel C, Datsenko O, Kumar A, Xu Y, et al.
    Photosensitization enables Pauson-Khand-type reactions with nitrenes
    Science. 2024; 383(6682): 498-503. https://doi.org/10.1126/science.adm8095
    DORA PSI
  • Maslać N, Cadoux C, Bolte P, Murken F, Gu W, Milton RD, et al.
    Structural comparison of (hyper-)thermophilic nitrogenase reductases from three marine Methanococcales
    FEBS Journal. 2024; 291(15): 3454-3480. https://doi.org/10.1111/febs.17148
    DORA PSI
  • Metz A, Stegmann DP, Panepucci EH, Buehlmann S, Huang CY, McAuley KE, et al.
    HEIDI: an experiment-management platform enabling high-throughput fragment and compound screening
    Acta Crystallographica Section D: Structural Biology. 2024; 80: 328-335. https://doi.org/10.1107/S2059798324002833
    DORA PSI
  • Morstein J, Amatuni A, Shuster A, Kuttenlochner W, Ko T, Abegg D, et al.
    Optical control of proteasomal protein degradation with a photoswitchable lipopeptide
    Angewandte Chemie International Edition. 2024; 63(8): e202314791 (7 pp.). https://doi.org/10.1002/anie.202314791
    DORA PSI
  • Muñoz Sosa CJ, Lenz C, Hamann A, Farges F, Dopfer J, Krämer A, et al.
    A C-degron structure-based approach for the development of ligands targeting the E3 ligase TRIM7
    ACS Chemical Biology. 2024; 19(7): 1638-1647. https://doi.org/10.1021/acschembio.4c00301
    DORA PSI
  • Nakane T, Nakagawa R, Ishiguro S, Okazaki S, Mori H, Shuto Y, et al.
    Structure and engineering of Brevibacillus laterosporus Cas9
    Communications Biology. 2024; 7(1): 803 (10 pp.). https://doi.org/10.1038/s42003-024-06422-z
    DORA PSI
  • Nievergelt P, Berliat F, McAuley KE, Dorgan CR, van Well RM, Thorn A, et al.
    RNA oligomers at atomic resolution containing 1-methylpseudouridine, an essential building block of mRNA vaccines
    ChemMedChem. 2024; 19(7): e202300600 (5 pp.). https://doi.org/10.1002/cmdc.202300600
    DORA PSI
  • Ong HW, Yang X, Smith JL, Dickmander RJ, Brown JW, Havener TM, et al.
    More than an amide bioisostere: discovery of 1,2,4-triazole-containing pyrazolo[1,5-a]pyrimidine host CSNK2 inhibitors for combatting β-coronavirus replication
    Journal of Medicinal Chemistry. 2024; 67(14): 12261-12313. https://doi.org/10.1021/acs.jmedchem.4c00962
    DORA PSI
  • Pfaffenbach M, Bolduc PN, Xin Z, Gao F, Evans R, Fang T, et al.
    Discovery of BIO-8169-a highly potent, selective, and brain-penetrant IRAK4 inhibitor for the treatment of neuroinflammation
    Journal of Medicinal Chemistry. 2024; 67(10): 8383-8395. https://doi.org/10.1021/acs.jmedchem.4c00560
    DORA PSI
  • Pflüger T, Gschell M, Zhang L, Shnitsar V, Zabadné AJ, Zierep P, et al.
    How sensor Amt-like proteins integrate ammonium signals
    Science Advances. 2024; 10(23): eadm9441 (16 pp.). https://doi.org/10.1126/sciadv.adm9441
    DORA PSI
  • Rak M, Menge A, Tesch R, Berger LM, Balourdas DI, Shevchenko E, et al.
    Development of selective pyrido[2,3-d]pyrimidin-7(8H)-one-based Mammalian STE20-like (MST3/4) kinase inhibitors
    Journal of Medicinal Chemistry. 2024; 67(5): 3813-3842. https://doi.org/10.1021/acs.jmedchem.3c02217
    DORA PSI
  • Sabath K, Nabih A, Arnold C, Moussa R, Domjan D, Zaugg JB, et al.
    Basis of gene-specific transcription regulation by the Integrator complex
    Molecular Cell. 2024; 84(13): 2525-2541.e12. https://doi.org/10.1016/j.molcel.2024.05.027
    DORA PSI
  • Sagmeister T, Gubensäk N, Buhlheller C, Grininger C, Eder M, Ðordić A, et al.
    The molecular architecture of Lactobacillus S-layer: assembly and attachment to teichoic acids
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2024; 121(24): e2401686121 (12 pp.). https://doi.org/10.1073/pnas.2401686121
    DORA PSI
  • Santema LL, Rotilio L, Xiang R, Tjallinks G, Guallar V, Mattevi A, et al.
    Discovery and biochemical characterization of thermostable glycerol oxidases
    Applied Microbiology and Biotechnology. 2024; 108: 61 (14 pp.). https://doi.org/10.1007/s00253-023-12883-9
    DORA PSI
  • Schmalhofer M, Vagstad AL, Zhou Q, Bode HB, Groll M
    Polyketide trimming shapes dihydroxynaphthalene-melanin and anthraquinone pigments
    Advanced Science. 2024; 11(22): 2400184 (10 pp.). https://doi.org/10.1002/advs.202400184
    DORA PSI
  • Schweke H, Pacesa M, Levin T, Goverde CA, Kumar P, Duhoo Y, et al.
    An atlas of protein homo-oligomerization across domains of life
    Cell. 2024; 187(4): 999-1010.e15. https://doi.org/10.1016/j.cell.2024.01.022
    DORA PSI
  • Sommer-Kamann C, Breiltgens J, Zou Z, Gerhardt S, Saleem-Batcha R, Kemper F, et al.
    Structures and protein engineering of the α-keto acid C-methyltransferases SgvM and MrsA for rational substrate transfer
    ChemBioChem. 2024; 25(19): e202400258 (5 pp.). https://doi.org/10.1002/cbic.202400258
    DORA PSI
  • Stark Y, Menard F, Jeliazkov JR, Ernst P, Chembath A, Ashraf M, et al.
    Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2024; 121(27): e2318198121 (11 pp.). https://doi.org/10.1073/pnas.2318198121
    DORA PSI
  • Tsujino S, Sato Y, Jia S, Kepa MW, Trampari S, Tomizaki T
    Inertial mixing of acoustically levitated droplets for time-lapse protein crystallography
    Droplet. 2024; 3(3): e132 (11 PP.). https://doi.org/10.1002/dro2.132
    DORA PSI
  • Umezawa A, Matsumoto M, Handa H, Nakazawa K, Miyagawa M, Seifert GJ, et al.
    Cytosolic UDP-L-arabinose synthesis by bifunctional UDP-glucose 4-epimerases in Arabidopsis
    Plant Journal. 2024; 119(1): 508-524. https://doi.org/10.1111/tpj.16779
    DORA PSI
  • Vandyck K, McGowan DC, Luong XG, Stevens SK, Jekle A, Gupta K, et al.
    Discovery and preclinical profile of ALG-055009, a potent and selective thyroid hormone receptor beta (THR-β) agonist for the treatment of MASH
    Journal of Medicinal Chemistry. 2024; 67: 14840-14851. https://doi.org/10.1021/acs.jmedchem.4c01029
    DORA PSI
  • Vulpetti A, Rondeau JM, Bellance MH, Blank J, Boesch R, Boettcher A, et al.
    Ligandability assessment of IL-1β by integrated hit identification approaches
    Journal of Medicinal Chemistry. 2024; 67: 8141-8160. https://doi.org/10.1021/acs.jmedchem.4c00240
    DORA PSI
  • Wagner B, Smieško M, Jakob RP, Mühlethaler T, Cramer J, Maier T, et al.
    Analogues of the pan-selectin antagonist rivipansel (GMI-1070)
    European Journal of Medicinal Chemistry. 2024; 272: 116455 (12 pp.). https://doi.org/10.1016/j.ejmech.2024.116455
    DORA PSI
  • Wang W, Atherton P, Kreft M, te Molder L, van der Poel S, Hoekman L, et al.
    Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility
    Journal of Cell Science. 2024; 137(9): jcs262116 (13 pp.). https://doi.org/10.1242/jcs.262116
    DORA PSI
  • Wang D, Miyanaga A, Chisuga T, Kudo F, Eguchi T
    Engineering the substrate specificity of (S)-β-phenylalanine adenylation enzyme HitB
    ChemBioChem. 2024; 25(15): e202400383 (6 pp.). https://doi.org/10.1002/cbic.202400383
    DORA PSI
  • Werner A-D, Krapoth N, Norris MJ, Heine A, Klebe G, Saphire EO, et al.
    Development of a crystallographic screening to identify Sudan virus VP40 ligands
    ACS Omega. 2024; 9(30): 33193-33203. https://doi.org/10.1021/acsomega.4c04829
    DORA PSI
  • Wohlwend D, Mérono L, Bucka S, Ritter K, Jessen HJ, Friedrich T
    Structures of 3-acetylpyridine adenine dinucleotide and ADP-ribose bound to the electron input module of respiratory complex I
    Structure. 2024; 32(6): 715-724.e3. https://doi.org/10.1016/j.str.2024.02.013
    DORA PSI
  • Yagi S, Tagami S
    An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins
    Nature Communications. 2024; 15(1): 5938 (10 pp.). https://doi.org/10.1038/s41467-024-50013-9
    DORA PSI
  • Yokoyama T, Takayama Y, Mizuguchi M, Nabeshima Y, Kusaka K
    SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD+-binding pocket
    FEBS Letters. 2024; 598(18): 2269-2280. https://doi.org/10.1002/1873-3468.14961
    DORA PSI
  • Yu K, Zhang K, Jakob RP, Maier T, Ward TR
    An artificial nickel chlorinase based on the biotin-streptavidin technology
    Chemical Communications. 2024; 60(14): 1944-1947. https://doi.org/10.1039/d3cc05847f
    DORA PSI
  • Amaral B, Capacci A, Anderson T, Tezer C, Bajrami B, Lulla M, et al.
    Elucidation of the GSK3α structure informs the design of novel, paralog-selective inhibitors
    ACS Chemical Neuroscience. 2023; 14(6): 1080-1094. https://doi.org/10.1021/acschemneuro.2c00476
    DORA PSI
  • Arifi S, Marschner JA, Pollinger J, Isigkeit L, Heitel P, Kaiser A, et al.
    Targeting the alternative vitamin E metabolite binding site enables noncanonical PPARγ modulation
    Journal of the American Chemical Society. 2023; 145(27): 14802-14810. https://doi.org/10.1021/jacs.3c03417
    DORA PSI
  • Asano W, Yamanaka K, Ohara Y, Uhara T, Doi S, Orita T, et al.
    Fragment-based discovery of novel VE-PTP inhibitors using orthogonal biophysical techniques
    Biochemistry. 2023; 62(14): 2161-2169. https://doi.org/10.1021/acs.biochem.3c00079
    DORA PSI
  • Balboa JR, Essig DJ, Ma S, Karer N, Clemmensen LS, Pedersen SW, et al.
    Development of a potent cyclic peptide inhibitor of the nNOS/PSD-95 interaction
    Journal of Medicinal Chemistry. 2023; 66(1): 976-990. https://doi.org/10.1021/acs.jmedchem.2c01803
    DORA PSI
  • Balo T, Sapi A, Kiss A, Raimbaud E, Paysant J, Cattin M-E, et al.
    Synthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors
    Monatshefte für Chemie. 2023; 154: 1339-1357. https://doi.org/10.1007/s00706-021-02889-2
    DORA PSI
  • Boland C, Huang C-Y, Shanker Kaki S, Wang M, Olieric V, Caffrey M
    Se-MAG is a convenient additive for experimental phasing and structure determination of membrane proteins crystallised by the lipid cubic phase (in meso) method
    Crystals. 2023; 13(9): 1402 (20 pp.). https://doi.org/10.3390/cryst13091402
    DORA PSI
  • Brkic A, Leibundgut M, Jablonska J, Zanki V, Car Z, Petrovic Perokovic V, et al.
    Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
    Nature Communications. 2023; 14(1): 5498 (12 pp.). https://doi.org/10.1038/s41467-023-41244-3
    DORA PSI
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