Publications

2024

Abel AC, Mühlethaler T, Dessin C, Schachtsiek T, Sammet B, Sharpe T, et al.
Bridging the maytansine and vinca sites: Cryptophycins target β-tubulin's T5-loop
Journal of Biological Chemistry. 2024; 300(6): 107363 (10 pp.). https://doi.org/10.1016/j.jbc.2024.107363
DORA PSI
Cellini A, Shankar MK, Nimmrich A, Hunt LA, Monrroy L, Mutisya J, et al.
Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography
Nature Chemistry. 2024; 16: 624-632. https://doi.org/10.1038/s41557-023-01413-9
DORA PSI
Christen P, Jaussi R, Benoit R
Biochemie und Molekularbiologie. Eine Einführung in 40 Lerneinheiten
2nd ed. Berlin: Springer Nature; 2024. https://doi.org/10.1007/978-3-662-65477-4
DORA PSI
Dessin C, Schachtsiek T, Voss J, Abel AC, Neumann B, Stammler HG, et al.
Highly cytotoxic cryptophycin derivatives with modification in unit D for conjugation
Angewandte Chemie International Edition. 2024: e202416210 (13 pp.). https://doi.org/10.1002/anie.202416210
DORA PSI
Ding X, Aureli S, Vaithia A, Lavriha P, Schuster D, Khanppnavar B, et al.
Structural basis of connexin-36 gap junction channel inhibition
Cell Discovery. 2024; 10(1): 68 (4 pp.). https://doi.org/10.1038/s41421-024-00691-y
DORA PSI
Gotthard G, Mous S, Weinert T, Maia RNA, James D, Dworkowski F, et al.
Capturing the blue-light activated state of the Phot-LOV1 domain from Chlamydomonas reinhardtii using time-resolved serial synchrotron crystallography
IUCrJ. 2024; 11(5): (17 pp.). https://doi.org/10.1107/S2052252524005608
DORA PSI
Gotthard G, Flores-Ibarra A, Carrillo M, Kepa MW, Mason TJ, Stegmann DP, et al.
Fixed-target pump–probe SFX: eliminating the scourge of light contamination
IUCrJ. 2024; 11(5): 1-13. https://doi.org/10.1107/S2052252524005591
DORA PSI
Holfeld A, Schuster D, Sesterhenn F, Gillingham AK, Stalder P, Haenseler W, et al.
Systematic identification of structure-specific protein–protein interactions
Molecular Systems Biology. 2024; 20: 651-675. https://doi.org/10.1038/s44320-024-00037-6
DORA PSI
Homer JA, Koelln RA, Barrow AS, Gialelis TL, Boiarska Z, Steinohrt NS, et al.
Modular synthesis of functional libraries by accelerated SuFEx click chemistry
Chemical Science. 2024; 15: 3879-3892. https://doi.org/10.1039/d3sc05729a
DORA PSI
Jiang Y, Rex DAB, Schuster D, Neely BA, Rosano GL, Volkmar N, et al.
Comprehensive overview of bottom-up proteomics using mass spectrometry
ACS Measurement Science Au. 2024; 4(4): 338-417. https://doi.org/10.1021/acsmeasuresciau.3c00068
DORA PSI
Khanppnavar B, North RA, Ventura S, Xu Y
Advances, challenges, and opportunities in structural biology
Trends in Biochemical Sciences. 2024; 49(2): 93-96. https://doi.org/10.1016/j.tibs.2023.12.006
DORA PSI
Khanppnavar B, Schuster D, Lavriha P, Uliana F, Özel M, Mehta V, et al.
Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics
EMBO Reports. 2024; 25: 1513-1540. https://doi.org/10.1038/s44319-024-00076-y
DORA PSI
Khanppnavar B, Choo JPS, Hagedoorn PL, Smolentsev G, Štefanić S, Kumaran S, et al.
Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase
Nature Chemistry. 2024; 16: 1496-1504. https://doi.org/10.1038/s41557-024-01523-y
DORA PSI
Khusainov G, Standfuss J, Weinert T
The time revolution in macromolecular crystallography
Structural Dynamics. 2024; 11(2): 020901 (17 pp.). https://doi.org/10.1063/4.0000247
DORA PSI
Lavriha P, Qi C, Korkhov VM
Expression, purification, and nanodisc reconstitution of connexin-43 hemichannels for structural characterization by cryo-electron microscopyp
In: Mammano F, Retamal M, eds. Connexin hemichannels. Methods and protocols. Methods in molecular biology. New York, NY: Springer Nature; 2024:29-43. https://doi.org/10.1007/978-1-0716-3842-2_3
DORA PSI
Meier SM, Steinmetz MO, Barral Y
Microtubule specialization by +TIP networks: from mechanisms to functional implications
Trends in Biochemical Sciences. 2024; 49(4): 318-332. https://doi.org/10.1016/j.tibs.2024.01.005
DORA PSI
Mortelmans T, Marty B, Kazazis D, Padeste C, Li X, Ekinci Y
Three-dimensional microfluidic capillary device for rapid and multiplexed immunoassays in whole blood
ACS Sensors. 2024; 9(5): 2455-2464. https://doi.org/10.1021/acssensors.4c00153
DORA PSI
Reynders M, Garścia M, Müller-Deku A, Wranik M, Krauskopf K, de la Osa de la Rosa L, et al.
A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol
Chemical Science. 2024; 15(31): 12301-12309. https://doi.org/10.1039/d4sc03072a
DORA PSI
Rodrigues MJ, Tejero O, Mühle J, Pamula F, Das I, Tsai CJ, et al.
Activating an invertebrate bistable opsin with the all-trans 6.11 retinal analog
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2024; 121(31): e2406814121 (3 pp.). https://doi.org/10.1073/pnas.2406814121
DORA PSI
Saha S, Khanppnavar B, Maharana J, Kim H, Carino CMC, Daly C, et al.
Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor
Cell. 2024; 187(17): 4751-4769.e25. https://doi.org/10.1016/j.cell.2024.07.005
DORA PSI
Schuster D, Khanppnavar B, Kantarci I, Mehta V, Korkhov VM
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling
Trends in Biochemical Sciences. 2024; 49(2): 156-168. https://doi.org/10.1016/j.tibs.2023.12.002
DORA PSI
Steinmetz MO, Prota AE
Structure-based discovery and rational design of microtubule-targeting agents
Current Opinion in Structural Biology. 2024; 87: 102845 (15 pp.). https://doi.org/10.1016/j.sbi.2024.102845
DORA PSI
Tsujino S, Sato Y, Jia S, Kepa MW, Trampari S, Tomizaki T
Inertial mixing of acoustically levitated droplets for time-lapse protein crystallography
Droplet. 2024; 3(3): e132 (11 PP.). https://doi.org/10.1002/dro2.132
DORA PSI

2023

Amer M, Leka O, Jasko P, Frey D, Li X, Kammerer RA
A coiled-coil-based design strategy for the thermostabilization of G-protein-coupled receptors
Scientific Reports. 2023; 13(1): 10159 (11 pp.). https://doi.org/10.1038/s41598-023-36855-1
DORA PSI
Barret DCA, Schuster D, Rodrigues MJ, Leitner A, Picotti P, Schertler GFX, et al.
Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2023; 120(15): e2300309120 (10 pp.). https://doi.org/10.1073/pnas.2300309120
DORA PSI
Bertrand Q, Coquille S, Iorio A, Sterpone F, Madern D
Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases
Journal of Structural Biology. 2023; 215(4): 108039 (13 pp.). https://doi.org/10.1016/j.jsb.2023.108039
DORA PSI
Boiarska Z, Pérez-Peña H, Abel A-C, Marzullo P, Álvarez-Bernad B, Bonato F, et al.
Maytansinol functionalization: towards useful probes for studying microtubule dynamics
Chemistry: A European Journal. 2023; 29(5): e202203431 (12 pp.). https://doi.org/10.1002/chem.202203431
DORA PSI
Carrillo M, Mason TJ, Karpik A, Martiel I, Kepa MW, McAuley KE, et al.
Micro-structured polymer fixed targets for serial crystallography at synchrotrons and XFELs
IUCrJ. 2023; 10(6): 678-693. https://doi.org/10.1107/S2052252523007595
DORA PSI
Casadei CM, Hosseinizadeh A, Bliven S, Weinert T, Standfuss J, Fung R, et al.
Low-pass spectral analysis of time-resolved serial femtosecond crystallography data
Structural Dynamics. 2023; 10(3): 034101 (18 pp.). https://doi.org/10.1063/4.0000178
DORA PSI
Chen X, Portran D, Widmer LA, Stangier MM, Czub MP, Liakopoulos D, et al.
The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips
Journal of Cell Biology. 2023; 222(7): e202110126 (18 pp.). https://doi.org/10.1083/jcb.202110126
DORA PSI
Christou N-E, Apostolopoulou V, Melo DVM, Ruppert M, Fadini A, Henkel A, et al.
Time-resolved crystallography captures light-driven DNA repair
Science. 2023; 382(6674): 1015-1020. https://doi.org/10.1126/science.adj4270
DORA PSI
Estévez-Gallego J, Álvarez-Bernad B, Pera B, Wullschleger C, Raes O, Menche D, et al.
Chemical modulation of microtubule structure through the laulimalide/peloruside site
Structure. 2023; 31(1): 88-99.e5. https://doi.org/10.1016/j.str.2022.11.006
DORA PSI
Giese C, Puorger C, Ignatov O, Bečárová Z, Weber ME, Schärer MA, et al.
Stochastic chain termination in bacterial pilus assembly
Nature Communications. 2023; 14(1): 7718 (21 pp.). https://doi.org/10.1038/s41467-023-43449-y
DORA PSI
Gill R, Hora R, Alam MM, Bansal A, Bhatt TK, Sharma A
Editorial: Frontiers in malaria research
Frontiers in Microbiology. 2023; 14: 1191773 (4 pp.). https://doi.org/10.3389/fmicb.2023.1191773
DORA PSI
Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, et al.
Ultrafast structural changes direct the first molecular events of vision
Nature. 2023; 615: 939-944. https://doi.org/10.1038/s41586-023-05863-6
DORA PSI
Han Y, Zhuang Q, Ren R
Approaches for evolutionary, biochemical, and structural analysis of bacterial steroid 5a-reductases
In: Methods in enzymology. sine loco: Elsevier; 2023:237-261. https://doi.org/10.1016/bs.mie.2023.04.006
DORA PSI
Leka O, Wu Y, Zanetti G, Furler S, Reinberg T, Marinho J, et al.
A DARPin promotes faster onset of botulinum neurotoxin A1 action
Nature Communications. 2023; 14(1): 8317 (12 pp.). https://doi.org/10.1038/s41467-023-44102-4
DORA PSI
Leonarski F, Nan J, Matej Z, Bertrand Q, Furrer A, Gorgisyan I, et al.
Kilohertz serial crystallography with the JUNGFRAU detector at a fourth-generation synchrotron source
IUCrJ. 2023; 10(6): 729-737. https://doi.org/10.1107/S2052252523008618
DORA PSI
Maestre-Reyna M, Wang P-H, Nango E, Hosokawa Y, Saft M, Furrer A, et al.
Visualizing the DNA repair process by a photolyase at atomic resolution
Science. 2023; 382(6674): eadd7795 (14 pp.). https://doi.org/10.1126/science.add7795
DORA PSI
Meier SM, Farcas A-M, Kumar A, Ijavi M, Bill RT, Stelling J, et al.
Multivalency ensures persistence of a +TIP body at specialized microtubule ends
Nature Cell Biology. 2023; 25: 56-67. https://doi.org/10.1038/s41556-022-01035-2
DORA PSI
Prota AE, Lucena-Agell D, Ma Y, Estevez-Gallego J, Li S, Bargsten K, et al.
Structural insight into the stabilization of microtubules by taxanes
eLife. 2023; 12: e84791 (35 pp.). https://doi.org/10.7554/elife.84791
DORA PSI
Pérez-Peña H, Abel AC, Shevelev M, Prota AE, Pieraccini S, Horvath D
Computational approaches to the rational design of tubulin-targeting agents
Biomolecules. 2023; 13(2): 285 (35 pp.). https://doi.org/10.3390/biom13020285
DORA PSI
Qi C, Gutierrez SA, Lavriha P, Othman A, Lopez-Pigozzi D, Bayraktar E, et al.
Structure of the connexin-43 gap junction channel in a putative closed state
eLife. 2023; 12: RP87616 (27 pp.). https://doi.org/10.7554/eLife.87616
DORA PSI
Qi C, Lavriha P, Bayraktar E, Vaithia A, Schuster D, Pannella M, et al.
Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels
Science Advances. 2023; 9(35): eadh4890 (14 pp.). https://doi.org/10.1126/sciadv.adh4890
DORA PSI
Ramirez-Rios S, Choi SR, Sanyal C, Blum TB, Bosc C, Krichen F, et al.
VASH1–SVBP and VASH2–SVBP generate different detyrosination profiles on microtubules
Journal of Cell Biology. 2023; 222(2): e202205096 (30 pp.). https://doi.org/10.1083/jcb.202205096
DORA PSI
Robin AY, Brochier-Armanet C, Bertrand Q, Barette C, Girard E, Madern D
Deciphering evolutionary trajectories of lactate dehydrogenases provides new insights into allostery
Molecular Biology and Evolution. 2023; 40(10): msad223 (22 pp.). https://doi.org/10.1093/molbev/msad223
DORA PSI
Rodrigues MJ, Casadei CM, Weinert T, Panneels V, Schertler GFX
Correction of rhodopsin serial crystallography diffraction intensities for a lattice-translocation defect
Acta Crystallographica Section D: Structural Biology. 2023; 79(3): D79 (10 pp.). https://doi.org/10.1107/S2059798323000931
DORA PSI
Seo D, Kammerer RA, Alexandrescu AT
Solution NMR assignments and structure for the dimeric kinesin neck domain
Biomolecular NMR Assignments. 2023; 17: 301-307. https://doi.org/10.1007/s12104-023-10159-x
DORA PSI
Wranik M, Kepa MW, Beale EV, James D, Bertrand Q, Weinert T, et al.
A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers
Nature Communications. 2023; 14(1): 7956 (12 pp.). https://doi.org/10.1038/s41467-023-43523-5
DORA PSI
Wranik M, Weinert T, Slavov C, Masini T, Furrer A, Gaillard N, et al.
Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
Nature Communications. 2023; 14(1): 903 (12 pp.). https://doi.org/10.1038/s41467-023-36481-5
DORA PSI
Wu D, Gucwa M, Czub MP, Cooper DR, Shabalin IG, Fritzen R, et al.
Structural and biochemical characterisation of Co²⁺-binding sites on serum albumins and their interplay with fatty acids
Chemical Science. 2023; 14(23): 6244-6258. https://doi.org/10.1039/d3sc01723k
DORA PSI

2022

Barreca M, Spanò V, Rocca R, Bivacqua R, Abel AC, Maruca A, et al.
Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: further chemical modifications and potential therapeutic effects against lymphomas
European Journal of Medicinal Chemistry. 2022; 243: 114744 (25 pp.). https://doi.org/10.1016/j.ejmech.2022.114744
DORA PSI
Bleuler-Martinez S, Varrot A, Olieric V, Schubert M, Vogt E, Fetz C, et al.
Structure–function relationship of a novel fucoside-binding fruiting body lectin from Coprinopsis cinerea exhibiting nematotoxic activity
Glycobiology. 2022; 32(7): 600-615. https://doi.org/10.1093/glycob/cwac020
DORA PSI
Botte M, Ni D, Schenck S, Zimmermann I, Chami M, Bocquet N, et al.
Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation
Nature Communications. 2022; 13(1): 1826 (10 pp.). https://doi.org/10.1038/s41467-022-29459-2
DORA PSI
Båth P, Banacore A, Börjesson P, Bosman R, Wickstrand C, Safari C, et al.
Lipidic cubic phase serial femtosecond crystallography structure of a photosynthetic reaction centre
Acta Crystallographica Section D: Structural Biology. 2022; 78(6): 698-708. https://doi.org/10.1107/S2059798322004144
DORA PSI
Cellini A, Shankar MK, Wahlgren WY, Nimmrich A, Furrer A, James D, et al.
Structural basis of the radical pair state in photolyases and cryptochromes
Chemical Communications. 2022; 58(31): 4889-4892. https://doi.org/10.1039/D2CC00376G
DORA PSI
Czub MP, Stewart AJ, Shabalin IG, Minor W
Organism-specific differences in the binding of ketoprofen to serum albumin
IUCrJ. 2022; 9(5): 551-561. https://doi.org/10.1107/S2052252522006820
DORA PSI
Fatton M, Filippidou S, Junier T, Cailleau G, Berge M, Poppleton D, et al.
Cryptosporulation in Kurthia spp. forces a rethinking of asporogenesis in Firmicutes
Environmental Microbiology. 2022; 24(12): 6320-6335. https://doi.org/10.1111/1462-2920.16145
DORA PSI
Gao L, Meiring JCM, Varady A, Ruider IE, Heise C, Wranik M, et al.
In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M
Journal of the American Chemical Society. 2022; 144(12): 5614-5628. https://doi.org/10.1021/jacs.2c01020
DORA PSI
Guyomar C, Bousquet C, Ku S, Heumann JM, Guilloux G, Gaillard N, et al.
Changes in seam number and location induce holes within microtubules assembled from porcine brain tubulin and in Xenopus egg cytoplasmic extracts
eLife. 2022; 11: e83021 (26 pp.). https://doi.org/10.7554/eLife.83021
DORA PSI
Heydenreich FM, Plouffe B, Rizk A, Milić D, Zhou J, Breton B, et al.
Michaelis-Menten quantification of ligand signaling bias applied to the promiscuous vasopressin V2 receptor
Molecular Pharmacology. 2022; 102(3): 139-149. https://doi.org/10.1124/molpharm.122.000497
DORA PSI
Hogrel G, Guild A, Graham S, Rickman H, Grüschow S, Bertrand Q, et al.
Cyclic nucleotide-induced helical structure activates a TIR immune effector
Nature. 2022; 608: 808-812. https://doi.org/10.1038/s41586-022-05070-9
DORA PSI
Kepa MW, Tomizaki T, Sato Y, Ozerov D, Sekiguchi H, Yasuda N, et al.
Acoustic levitation and rotation of thin films and their application for room temperature protein crystallography
Scientific Reports. 2022; 12: 5349 (14 pp.). https://doi.org/10.1038/s41598-022-09167-z
DORA PSI
Khanppnavar B, Maier J, Herborg F, Gradisch R, Lazzarin E, Luethi D, et al.
Structural basis of organic cation transporter-3 inhibition
Nature Communications. 2022; 13: 6714 (13 pp.). https://doi.org/10.1038/s41467-022-34284-8
DORA PSI
Lyapina E, Marin E, Gusach A, Orekhov P, Gerasimov A, Luginina A, et al.
Structural basis for receptor selectivity and inverse agonism in S1P₅ receptors
Nature Communications. 2022; 13(1): 4736 (14 pp.). https://doi.org/10.1038/s41467-022-32447-1
DORA PSI
Marzullo P, Boiarska Z, Pérez-Peña H, Abel AC, Álvarez-Bernad B, Lucena-Agell D, et al.
Maytansinol derivatives: side reactions as a chance for new tubulin binders
Chemistry: A European Journal. 2022; 28(2): e202103520 (10 pp.). https://doi.org/10.1002/chem.202103520
DORA PSI
Mehta V, Khanppnavar B, Schuster D, Kantarci I, Vercellino I, Kosturanova A, et al.
Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases
eLife. 2022; 11: e77032 (21 pp.). https://doi.org/10.7554/ELIFE.77032
DORA PSI
Mitola S, Ravelli C, Corsini M, Gianoncelli A, Galvagni F, Ballmer-Hofer K, et al.
Production and biochemical characterization of dimeric recombinant gremlin-1
International Journal of Molecular Sciences. 2022; 23(3): 1151 (10 pp.). https://doi.org/10.3390/ijms23031151
DORA PSI
Mortelmans T, Kazazis D, Padeste C, Berger P, Li X, Ekinci Y
Poly(methyl methacrylate)-based nanofluidic device for rapid and multiplexed serological antibody detection of SARS-CoV-2
ACS Applied Nano Materials. 2022; 5(1): 517-526. https://doi.org/10.1021/acsanm.1c03309
DORA PSI
Mous S, Gotthard G, Ehrenberg D, Sen S, Weinert T, Johnson PJM, et al.
Dynamics and mechanism of a light-driven chloride pump
Science. 2022; 375(6583): 845-851. https://doi.org/10.1126/science.abj6663
DORA PSI
Mühlethaler T, Olieric N, Ehrhard VA, Wranik M, Standfuss J, Sharma A, et al.
Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes
In: Inaba H, ed. Microtubules. Methods and protocols. Methods in molecular biology. New York: Humana Press; 2022:349-374. https://doi.org/10.1007/978-1-0716-1983-4_23
DORA PSI
Mühlethaler T, Milanos L, Ortega JA, Blum TB, Gioia D, Roy B, et al.
Rational design of a novel tubulin inhibitor with a unique mechanism of action
Angewandte Chemie International Edition. 2022; 61(25): e202204052 (11 pp.). https://doi.org/10.1002/anie.202204052
DORA PSI
Nass KJ, Ilie IM, Saller MJ, Driessen AJM, Caflisch A, Kammerer RA, et al.
The role of the N-terminal amphipathic helix in bacterial YidC: insights from functional studies, the crystal structure and molecular dynamics simulations
Biochimica et Biophysica Acta: Biomembranes. 2022; 1864(3): 183825 (9 pp.). https://doi.org/10.1016/j.bbamem.2021.183825
DORA PSI
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, et al.
Structural basis of adenylyl cyclase 9 activation
Nature Communications. 2022; 13(1): 1045 (11 pp.). https://doi.org/10.1038/s41467-022-28685-y
DORA PSI
Quast JP, Schuster D, Picotti P
protti: an R package for comprehensive data analysis of peptide- and protein-centric bottom-up proteomics data
Bioinformatics Advances. 2022; 2(1): vbab041 (3 pp.). https://doi.org/10.1093/bioadv/vbab041
DORA PSI
Trebosc V, Lucchini V, Narwal M, Wicki B, Gartenmann S, Schellhorn B, et al.
Targeting virulence regulation to disarm Acinetobacter baumannii pathogenesis
Virulence. 2022; 13(1): 1868-1883. https://doi.org/10.1080/21505594.2022.2135273
DORA PSI
Wang H, Mörman C, Sternke-Hoffmann R, Huang CY, Prota A, Ma P, et al.
Cu²⁺ ions modulate the interaction between α-synuclein and lipid membranes
Journal of Inorganic Biochemistry. 2022; 236: 111945 (10 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111945
DORA PSI
de la Roche NM, Mühlethaler T, Di Martino RMC, Ortega JA, Gioia D, Roy B, et al.
Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents
European Journal of Medicinal Chemistry. 2022; 241: 114614 (12 pp.). https://doi.org/10.1016/j.ejmech.2022.114614
DORA PSI

2021

Blum TB, Housset D, Clabbers MTB, van Genderen E, Bacia-Verloop M, Zander U, et al.
Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals
Acta Crystallographica Section D: Structural Biology. 2021; 77: 75-85. https://doi.org/10.1107/S2059798320014540
DORA PSI
Choo JPS, Kammerer RA, Li X, Li Z
High-Level Production of Phenylacetaldehyde using Fusion-Tagged Styrene Oxide Isomerase
Advanced Synthesis and Catalysis. 2021; 363(6): 1714-1721. https://doi.org/10.1002/adsc.202001500
DORA PSI
Gaillard N, Sharma A, Abbaali I, Liu T, Shilliday F, Cook AD, et al.
Inhibiting parasite proliferation using a rationally designed anti-tubulin agent
EMBO Molecular Medicine. 2021; 13(11): e13818 (12 pp.). https://doi.org/10.15252/emmm.202013818
DORA PSI
Gao L, Meiring JCM, Kraus Y, Wranik M, Weinert T, Pritzl SD, et al.
A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton
Cell Chemical Biology. 2021; 28(2): 228-241. https://doi.org/10.1016/j.chembiol.2020.11.007
DORA PSI
Harwood CR, Sykes DA, Hoare BL, Heydenreich FM, Uddin R, Poyner DR, et al.
Functional solubilization of the β₂-adrenoceptor using diisobutylene maleic acid
iScience. 2021; 24(12): 103362 (13 pp.). https://doi.org/10.1016/j.isci.2021.103362
DORA PSI
Ijavi M, Style RW, Emmanouilidis L, Kumar A, Meier SM, Torzynski AL, et al.
Surface tensiometry of phase separated protein and polymer droplets by the sessile drop method
Soft Matter. 2021; 17(6): 1655-1662. https://doi.org/10.1039/d0sm01319f
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Jernigan F, Branstrom A, Baird JD, Cao L, Dali M, Furia B, et al.
Preclinical and early clinical development of PTC596, a novel small-molecule tubulin-binding agent
Molecular Cancer Therapeutics. 2021; 20(10): 1846-1857. https://doi.org/10.1158/1535-7163.MCT-20-0774
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Kepa MW, Tomizaki T, Tsujino S
Development of on-demand sample loading of ultrasound acoustic levitators by focused acoustic radiation
In: IEEE international ultrasonics symposium (IUS 2021). Danvers, MA: IEEE; 2021:(3 pp.). https://doi.org/10.1109/IUS52206.2021.9593735
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Kumar A, Meier SM, Farcas A-M, Manatschal C, Barral Y, Steinmetz MO
Structure and regulation of the microtubule plus-end tracking protein Kar9
Structure. 2021; 29(11): 1266-1278.e4. https://doi.org/10.1016/j.str.2021.06.012
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Kutomi O, Yamamoto R, Hirose K, Mizuno K, Nakagiri Y, Imai H, et al.
A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light
Science Advances. 2021; 7(9): eabf3621 (12 pp.). https://doi.org/10.1126/sciadv.abf3621
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Leka O, Wu Y, Li X, Kammerer RA
Crystal structure of the catalytic domain of botulinum neurotoxin subtype A3
Journal of Biological Chemistry. 2021; 296: 100684 (8 pp.). https://doi.org/10.1016/j.jbc.2021.100684
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Lentini G, Ben Chaabene R, Vadas O, Ramakrishnan C, Mukherjee B, Mehta V, et al.
Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion
Nature Communications. 2021; 12(1): 3788 (17 pp.). https://doi.org/10.1038/s41467-021-24083-y
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Martiel I, Beale JH, Karpik A, Huang C-Y, Vera L, Olieric N, et al.
Versatile microporous polymer-based supports for serial macromolecular crystallography
Acta Crystallographica Section D: Structural Biology. 2021; 77(9): 1153-1167. https://doi.org/10.1107/S2059798321007324
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Matthew S, Chen Q-Y, Ratnayake R, Fermaintt CS, Lucena-Agell D, Bonato F, et al.
Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2021; 118(9): e2021847118 (11 pp.). https://doi.org/10.1073/pnas.2021847118
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Mühlethaler T, Gioia D, Prota AE, Sharpe ME, Cavalli A, Steinmetz MO
Comprehensive analysis of binding sites in tubulin
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Nass K, Bacellar C, Cirelli C, Dworkowski F, Gevorkov Y, James D, et al.
Pink-beam serial femtosecond crystallography for accurate structure-factor determination at an X-ray free-electron laser
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Panneels V, Diaz A, Imsand C, Guizar-Sicairos M, Müller E, Bittermann AG, et al.
Imaging of retina cellular and subcellular structures using ptychographic hard X-ray tomography
Journal of Cell Science. 2021; 134(19): jcs258561 (8 pp.). https://doi.org/10.1242/jcs.258561
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Sharma A, Olieric N, Steinmetz MO
Centriole length control
Current Opinion in Structural Biology. 2021; 66: 89-95. https://doi.org/10.1016/j.sbi.2020.10.011
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Wu J, Blum TB, Farrell DP, DiMaio F, Abrahams JP, Luo J
Cryo-electron microscopy imaging of Alzheimer's amyloid-beta 42 oligomer displayed on a functionally and structurally relevant scaffold
Angewandte Chemie International Edition. 2021; 60(34): 18680-18687. https://doi.org/10.1002/anie.202104497
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Xiao X, Willemse J, Voskamp P, Li X, Prota AE, Lamers M, et al.
Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in Streptomyces
Open Biology. 2021; 11(2): 200409 (14 pp.). https://doi.org/10.1098/rsob.200409
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Yong C, Devine SM, Abel A-C, Tomlins SD, Muthiah D, Gao X, et al.
1,3-benzodioxole-modified noscapine analogues: synthesis, antiproliferative activity, and tubulin-bound structure
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Zhang X, Pizzoni A, Hong K, Naim N, Qi C, Korkhov V, et al.
CAP1 binds and activates adenylyl cyclase in mammalian cells
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2021; 118(24): e2024576118 (10 pp.). https://doi.org/10.1073/pnas.2024576118
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2020

Atherton J, Hummel JJA, Olieric N, Locke J, Peña A, Rosenfeld SS, et al.
The mechanism of kinesin inhibition by kinesin binding protein
eLife. 2020; 9: e61481 (30 pp.). https://doi.org/10.7554/eLife.61481
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Brunner JD, Schenck S
Production and application of nanobodies for membrane protein structural biology
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Brunner JD, Jakob RP, Schulze T, Neldner Y, Moroni A, Thiel G, et al.
Structural basis for ion selectivity in TMEM175 K⁺ channels
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Cannac F, Qi C, Falschlunger J, Hausmann G, Basler K, Korkhov VM
Cryo-EM structure of the Hedgehog release protein Dispatched
Science Advances. 2020; 6(16): eaay7928 (8 pp.). https://doi.org/10.1126/sciadv.aay7928
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Estévez-Gallego J, Josa-Prado F, Ku S, Buey RM, Balaguer FA, Prota AE, et al.
Structural model for differential cap maturation at growing microtubule ends
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Fiedler T, Fabrice TN, Studer V, Vinet A, Faltova L, Kammerer RA, et al.
Homodimerization of coronin A through the C-terminal coiled-coil domain is essential for multicellular differentiation of Dictyostelium discoideum
FEBS Letters. 2020; 594(13): 2116-2127. https://doi.org/10.1002/1873-3468.13787
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Graeber E, Korkhov VM
Affinity purification of membrane proteins
In: Perez C, Maier T, eds. Expression, purification, and structural biology of membrane proteins. Methods in molecular biology. New York: Humana; 2020:129-137. https://doi.org/10.1007/978-1-0716-0373-4_9
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Guo B, Rodriguez-Gabin A, Prota AE, Mühlethaler T, Zhang N, Ye K, et al.
Structural refinement of the tubulin ligand (+)-discodermolide to attenuate chemotherapy-mediated senescence
Molecular Pharmacology. 2020; 98(2): 156-167. https://doi.org/10.1124/mol.119.117457
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Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, et al.
Pharmaceutical-grade rigosertib is a microtubule-destabilizing agent
Molecular Cell. 2020; 79(1): 191-198.e3. https://doi.org/10.1016/j.molcel.2020.06.008
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Khannpnavar B, Mehta V, Qi C, Korkhov V
Structure and function of adenylyl cyclases, key enzymes in cellular signaling
Current Opinion in Structural Biology. 2020; 63: 34-41. https://doi.org/10.1016/j.sbi.2020.03.003
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Krammer W, Missimer JH, Habegger S, Pastore-Wapp M, Wiest R, Weder BJ
Sensing form - finger gaiting as key to tactile object exploration - a data glove analysis of a prototypical daily task
Journal of NeuroEngineering and Rehabilitation. 2020; 17(133): 1-17. https://doi.org/10.1186/s12984-020-00755-6
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Li X, Brunner C, Wu Y, Leka O, Schneider G, Kammerer RA
Structural insights into the interaction of botulinum neurotoxin a with its neuronal receptor SV2C
Toxicon. 2020; 175: 36-43. https://doi.org/10.1016/j.toxicon.2019.11.010
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Makarov S, Pikuz S, Ryazantsev S, Pikuz T, Buzmakov A, Rose M, et al.
Soft X-ray diffraction patterns measured by a LiF detector with sub-micrometre resolution and an ultimate dynamic range
Journal of Synchrotron Radiation. 2020; 27: 625-632. https://doi.org/10.1107/S1600577520002192
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Menzi S, Knopp G, Al Haddad A, Augustin S, Borca C, Gashi D, et al.
Generation and simple characterization of flat, liquid jets
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Miljus T, Sykes DA, Harwood CR, Vuckovic Z, Veprintsev DB
GPCR solubilization and quality control
In: Perez C, Maier T, eds. Expression, purification, and structural biology of membrane proteins. Methods in molecular biology. New York: Humana; 2020:105-127. https://doi.org/10.1007/978-1-0716-0373-4_8
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Mortelmans T, Kazazis D, Guzenko VA, Padeste C, Braun T, Li X, et al.
Grayscale e-beam lithography: effects of a delayed development for well-controlled 3D patterning
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Nass K, Cheng R, Vera L, Mozzanica A, Redford S, Ozerov D, et al.
Advances in long-wavelength native phasing at X-ray free-electron lasers
IUCrJ. 2020; 7: 965-975. https://doi.org/10.1107/S2052252520011379
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Oliva MA, Prota AE, Rodríguez-Salarichs J, Bennani YL, Jiménez-Barbero J, Bargsten K, et al.
Structural basis of noscapine activation for tubulin binding
Journal of Medicinal Chemistry. 2020; 63(15): 8495-8501. https://doi.org/10.1021/acs.jmedchem.0c00855
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Poghosyan E, Iacovache I, Faltova L, Leitner A, Yang P, Diener DR, et al.
The structure and symmetry of the radial spoke protein complex in Chlamydomonas flagella
Journal of Cell Science. 2020; 133(16): jcs245233 (9 pp.). https://doi.org/10.1242/jcs.245233
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Rodríguez-García R, Volkov VA, Chen C-Y, Katrukha EA, Olieric N, Aher A, et al.
Mechanisms of motor-independent membrane remodeling driven by dynamic microtubules
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Rößler P, Mayer D, Tsai C-J, Veprintsev DB, Schertler GFX, Gossert AD
GPCR activation states induced by nanobodies and mini-G proteins compared by NMR spectroscopy
Molecules. 2020; 25(24): 5984 (17 pp.). https://doi.org/10.3390/molecules25245984
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Skopintsev P, Ehrenberg D, Weinert T, James D, Kar RK, Johnson PJM, et al.
Femtosecond-to-millisecond structural changes in a light-driven sodium pump
Nature. 2020; 583: 314-318. https://doi.org/10.1038/s41586-020-2307-8
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Smolentsev G, Milne CJ, Guda A, Haldrup K, Szlachetko J, Azzaroli N, et al.
Taking a snapshot of the triplet excited state of an OLED organometallic luminophore using X-rays
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Steib E, Laporte MH, Gambarotto D, Olieric N, Zheng C, Borgers S, et al.
WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity
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Weinert T, Panneels V
Membrane protein preparation for serial crystallography using high-viscosity injectors: rhodopsin as an example
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A tool for visualizing protein motions in time-resolved crystallography
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Xiao X, Elsayed SS, Wu C, van der Heul HU, Metsä-Ketelä M, Du C, et al.
Functional and structural insights into a novel promiscuous ketoreductase of the lugdunomycin biosynthetic pathway
ACS Chemical Biology. 2020; 15(9): 2529-2538. https://doi.org/10.1021/acschembio.0c00564
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Zook J, Shekhar M, Hansen D, Conrad C, Grant T, Gupta C, et al.
XFEL and NMR structures of Francisella lipoprotein reveal conformational space of drug target against tularemia
Structure. 2020; 28(5): 540-547.e3. https://doi.org/10.1016/j.str.2020.02.005
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2019

Abela E, Missimer JH, Pastore-Wapp M, Krammer W, Wiest R, Weder BJ
Early prediction of long-term tactile object recognition performance after sensorimotor stroke
Cortex. 2019; 115: 264-279. https://doi.org/10.1016/j.cortex.2019.01.018
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Akhmanova A, Steinmetz MO
Microtubule minus-end regulation at a glance
Journal of Cell Science. 2019; 132(11): jcs227850 (7 pp.). https://doi.org/10.1242/jcs.227850
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Atherton J, Luo Y, Xiang S, Yang C, Rai A, Jiang K, et al.
Structural determinants of microtubule minus end preference in CAMSAP CKK domains
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Basu S, Olieric V, Leonarski F, Matsugaki N, Kawano Y, Takashi T, et al.
Long-wavelength native-SAD phasing: opportunities and challenges
IUCrJ. 2019; 6(3): 1-14. https://doi.org/10.1107/S2052252519002756
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Bliven SE, Lafita A, Rose PW, Capitani G, Prlić A, Bourne PE
Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm
PLoS Computational Biology. 2019; 15(4): e1006842 (18 pp.). https://doi.org/10.1371/journal.pcbi.1006842
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Blum TB, Hahn A, Meier T, Davies KM, Kühlbrandt W
Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(10): 4250-4255. https://doi.org/10.1073/pnas.1816556116
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Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asís Balaguer F, Khan T, et al.
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents
European Journal of Medicinal Chemistry. 2019; 162: 290-320. https://doi.org/10.1016/j.ejmech.2018.11.004
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Brunner JD, Schenck S
Preparation of proteoliposomes with purified TMEM16 protein for accurate measures of lipid scramblase activity
In: Drin G, ed. Intracellular lipid transport. Methods in molecular biology. New York, NY, USA: Humana Press; 2019:181-199. https://doi.org/10.1007/978-1-4939-9136-5_14
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Casadei CM, Nass K, Barty A, Hunter MS, Padeste C, Tsai C-J, et al.
Structure-factor amplitude reconstruction from serial femtosecond crystallography of two-dimensional membrane-protein crystals
IUCrJ. 2019; 6: 34-45. https://doi.org/10.1107/S2052252518014641
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Chalupska D, Różycki B, Humpolickova J, Faltova L, Klima M, Boura E
Phosphatidylinositol 4-kinase IIIβ (PI4KB) forms highly flexible heterocomplexes that include ACBD3, 14-3-3, and Rab11 proteins
Scientific Reports. 2019; 9(1): 567 (11 pp.). https://doi.org/10.1038/s41598-018-37158-6
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Chen X, Widmer LA, Stangier MM, Steinmetz MO, Stelling J, Barral Y
Remote control of microtubule plus-end dynamics and function from the minus-end
eLife. 2019; 8: e48627 (32 pp.). https://doi.org/10.7554/eLife.48627
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Cury NM, Mühlethaler T, Laranjeira ABA, Canevarolo RR, Zenatti PP, Lucena-Agell D, et al.
Structural basis of colchicine-site targeting acylhydrazones active against multidrug-resistant acute lymphoblastic leukemia
iScience. 2019; 21: 95-109. https://doi.org/10.1016/j.isci.2019.10.003
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Dohle W, Prota AE, Menchon G, Hamel E, Steinmetz MO, Potter BVL
Tetrahydroisoquinoline sulfamates as potent microtubule disruptors: synthesis, antiproliferative and antitubulin activity of dichlorobenzyl-based derivatives, and a Tubulin cocrystal structure.
ACS Omega. 2019; 4: 755-764. https://doi.org/10.1021/acsomega.8b02879
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Dolenc J, van Gunsteren WF, Prota AE, Steinmetz MO, Missimer JH
Conformational properties of the chemotherapeutic drug analogue Epothilone A: how to model a flexible protein ligand using scarcely available experimental data
Journal of Chemical Information and Modeling. 2019; 59(5): 2218-2230. https://doi.org/10.1021/acs.jcim.9b00171
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Ehrenberg D, Varma N, Deupi X, Koyanagi M, Terakita A, Schertler GFX, et al.
The two-photon reversible reaction of the bistable jumping spider rhodopsin-1
Biophysical Journal. 2019; 116(7): 1248-1258. https://doi.org/10.1016/j.bpj.2019.02.025
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Faltova L, Jiang K, Frey D, Wu Y, Capitani G, Prota AE, et al.
Crystal structure of a heterotetrameric katanin p60:p80 complex
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Gavriilidou AFM, Hunziker H, Mayer D, Vuckovic Z, Veprintsev DB, Zenobi R
Insights into the basal activity and activation mechanism of the β1 adrenergic receptor using native mass spectrometry
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Graeber E, Korkhov VM
Characterisation of the ligand binding sites in the translocator protein TSPO using the chimeric bacterial-mammalian constructs
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Guo W, Liu B, Yin Y, Kan X, Gong Q, Li Y, et al.
Licochalcone A protects the blood milk barrier integrity and relieves the inflammatory response in LPS-induced mastitis
Frontiers in Immunology. 2019; 10: 287 (14 pp.). https://doi.org/10.3389/fimmu.2019.00287
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Guo W, Liu B, Hu G, Kan X, Li Y, Gong Q, et al.
Vanillin protects the blood-milk barrier and inhibits the inflammatory response in LPS-induced mastitis in mice
Toxicology and Applied Pharmacology. 2019; 365: 9-18. https://doi.org/10.1016/j.taap.2018.12.022
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Górzny MŁ, Opara NL, Guzenko VA, Cadarso VJ, Schift H, Li XD, et al.
Microfabricated silicon chip as lipid membrane sample holder for serial protein crystallography
Micro and Nano Engineering. 2019; 3: 31-36. https://doi.org/10.1016/j.mne.2019.03.002
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Haider RS, Wilhelm F, Rizk A, Mutt E, Deupi X, Peterhans C, et al.
Arrestin-1 engineering facilitates complex stabilization with native rhodopsin
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Hooikaas PJ, Martin M, Mühlethaler T, Kuijntjes G-J, Peeters CAE, Katrukha EA, et al.
MAP7 family proteins regulate kinesin-1 recruitment and activation
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Jaeger K, Bruenle S, Weinert T, Guba W, Muehle J, Miyazaki T, et al.
Structural basis for allosteric ligand recognition in the human CC chemokine receptor 7
Cell. 2019; 178(5): 1222-1230. https://doi.org/10.1016/j.cell.2019.07.028
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James D, Weinert T, Skopintsev P, Furrer A, Gashi D, Tanaka T, et al.
Improving high viscosity extrusion of microcrystals for time-resolved serial femtosecond crystallography at X-ray lasers
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Kan X, Liu B, Guo W, Wei L, Lin Y, Guo Y, et al.
Myricetin relieves LPS-induced mastitis by inhibiting inflammatory response and repairing the blood-milk barrier
Journal of Cellular Physiology. 2019; 234(9): 16252-16262. https://doi.org/10.1002/jcp.28288
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Kashyap AS, Fernandez-Rodriguez L, Zhao Y, Monaco G, Trefny MP, Yoshida N, et al.
GEF-H1 signaling upon microtubule destabilization is required for dendritic cell activation and specific anti-tumor responses
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La Sala G, Olieric N, Sharma A, Viti F, de Asis Balaguer Perez F, Huang L, et al.
Structure, thermodynamics, and kinetics of plinabulin binding to two tubulin isotypes
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Liu B, Huang B, Hu G, He D, Li Y, Ran X, et al.
Isovitexin-mediated regulation of microglial polarization in lipopolysaccharide-induced neuroinflammation via activation of the CaMKKβ/AMPK-PGC-1α signaling axis
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Mayer D, Damberger FF, Samarasimhareddy M, Feldmueller M, Vuckovic Z, Flock T, et al.
Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
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Montaldo NP, Bordin DL, Brambilla A, Rösinger M, Fordyce Martin SL, Bjørås KØ, et al.
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
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Munk C, Mutt E, Isberg V, Nikolajsen LF, Bibbe JM, Flock T, et al.
An online resource for GPCR structure determination and analysis
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Nagata T, Koyanagi M, Tsukamoto H, Mutt E, Schertler GFX, Deupi X, et al.
The counterion–retinylidene Schiff base interaction of an invertebrate rhodopsin rearranges upon light activation
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Patterson JC, Joughin BA, Prota AE, Mühlethaler T, Jonas OH, Whitman MA, et al.
VISAGE reveals a targetable mitotic spindle vulnerability in cancer cells
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Qi C, Minin GD, Vercellino I, Wutz A, Korkhov VM
Structural basis of sterol recognition by human hedgehog receptor PTCH1
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Qi C, Sorrentino S, Medalia O, Korkhov VM
The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein
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Rai A, Liu T, Glauser S, Katrukha EA, Estévez-Gallego J, Rodríguez-García R, et al.
Taxanes convert regions of perturbed microtubule growth into rescue sites
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Samarasimhareddy M, Mayer D, Metanis N, Veprintsev D, Hurevich M, Friedler A
A targeted approach for the synthesis of multi-phosphorylated peptides: a tool for studying the role of phosphorylation patterns in proteins
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Standfuss J
Membrane protein dynamics studied by X-ray lasers - or why only time will tell
Current Opinion in Structural Biology. 2019; 57: 63-71. https://doi.org/10.1016/j.sbi.2019.02.001
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Tsai C-J, Marino J, Adaixo R, Pamula F, Muehle J, Maeda S, et al.
Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit
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Varma N, Mutt E, Mühle J, Panneels V, Terakita A, Deupi X, et al.
Crystal structure of jumping spider rhodopsin-1 as a light sensitive GPCR
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(29): 14547-14556. https://doi.org/10.1073/pnas.1902192116
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Wang N, Bosc C, Ryul Choi S, Boulan B, Peris L, Olieric N, et al.
Structural basis of tubulin detyrosination by the vasohibin–SVBP enzyme complex
Nature Structural and Molecular Biology. 2019; 26(7): 571-582. https://doi.org/10.1038/s41594-019-0241-y
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Weinert T, Skopintsev P, James D, Dworkowski F, Panepucci E, Kekilli D, et al.
Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography
Science. 2019; 365(6448): 61-65. https://doi.org/10.1126/science.aaw8634
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Wickstrand C, Nogly P, Nango E, Iwata S, Standfuss J, Neutze R
Bacteriorhodopsin: structural insights revealed using X-ray lasers and synchrotron radiation
Annual Review of Biochemistry. 2019; 88: 59-83. https://doi.org/10.1146/annurev-biochem-013118-111327
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Xie Y, Mansouri M, Rizk A, Berger P
Regulation of VEGFR2 trafficking and signaling by Rab GTPase-activating proteins
Scientific Reports. 2019; 9(1): 13342 (12 pp.). https://doi.org/10.1038/s41598-019-49646-4
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Zhu X, Poghosyan E, Rezabkova L, Mehall B, Sakakibara H, Hirono M, et al.
The roles of a flagellar HSP40 ensuring rhythmic beating
Molecular Biology of the Cell. 2019; 30(2): 228-241. https://doi.org/10.1091/mbc.E18-01-0047
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de Asís Balaguer F, Mühlethaler T, Estévez-Gallego J, Calvo E, Giménez-Abián J, Risinger AL, et al.
Crystal structure of the cyclostreptin-tubulin adduct: implications for tubulin activation by taxane-site ligands
International Journal of Molecular Sciences. 2019; 20(6): 1392 (17 pp.). https://doi.org/10.3390/ijms20061392
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Żyła DS, Prota AE, Capitani G, Glockshuber R
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Journal of Biological Chemistry. 2019; 294(27): 10553-10563. https://doi.org/10.1074/jbc.RA119.008610
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2018

CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain. Aher A, Kok M, Sharma A, Rai A, Olieric N, Rodriguez-Garcia R, Katrukha EA, Weinert T, Olieric V, Kapitein LC, Steinmetz MO, Dogterom M, Akhmanova A
DEVELOPMENTAL CELL 46, 40 (2018).
Cep120 promotes microtubule formation through a unique tubulin binding C2 domain Sharma A, Gerard Samuel F, Olieric N, Steinmetz Michel O
JOURNAL OF STRUCTURAL BIOLOGY -, S1047847718300248 (2018).
DOI: 10.1016/j.jsb.2018.01.009
Combinatorial use of disulfide bridges and native sulfur-SAD phasing for rapid structure determination of coiled-coils Kraatz Sebastian HW, Bianchi S, Steinmetz Michel O
BIOSCIENCE REPORTS 38, BSR20181073 (2018).
DOI: 10.1042/BSR20181073
Crystal structure of rhodopsin in complex with a mini-G o sheds light on the principles of G protein selectivity Tsai C, Pamula F, Nehmé R, Mühle J, Weinert T, Flock T, Nogly P, Edwards Patricia C, Carpenter B, Gruhl T, Ma P, Deupi X, Standfuss J, Tate Christopher G, Schertler Gebhard FX
Science Advances 4, eaat7052 (2018).
DOI: 10.1126/sciadv.aat7052
Development of Smart Optical Gels with Highly Magnetically Responsive Bicelles Isabettini S, Stucki S, Massabni S, Baumgartner ME, Reckey PQ, Kohlbrecher J, Ishikawa T, Windhab Erich J, Fischer P, Kuster S
ACS APPLIED MATERIALS & INTERFACES 10, 8926 (2018).
DOI: 10.1021/acsami.7b17134
Electron crystallography with the EIGER detector Tinti G, Fröjdh E, van Genderen E, Gruene T, Schmitt B, de Winter MDA, Weckhuysen BM, Abrahams J
IUCRJ 5, 190 (2018).
DOI: 10.1107/S2052252518000945
Expression and purification of the mammalian translocator protein for structural studies Graeber E, Korkhov Volodymyr M
PLOS ONE 13, e0198832 (2018).
DOI: 10.1371/journal.pone.0198832
Frontispiece: Characterization at the Level of Individual Crystals: Single-Crystal MFI Type Zeolite Grains Gruene T, Li T, van Genderen E, Pinar Ana B, van Bokhoven JA
CHEMISTRY - A EUROPEAN JOURNAL 24, 2384 (2018).
DOI: 10.1002/chem.201881065
In situ serial crystallography for rapid de novo membrane protein structure determination. Huang CY, Olieric V, Howe N, Warshamanage R, Weinert T, Panepucci E, Vogeley L, Basu S, Diederichs K, Caffrey M, Wang M
Communications Biology 1, 124 (2018).
DOI: 10.1038/S42003-018-0123-6
Ligand channel in pharmacologically stabilized rhodopsin. Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115, 3640 (2018).
Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton Steinmetz Michel O, Prota Andrea E
TRENDS IN CELL BIOLOGY 28, 776 (2018).
DOI: 10.1016/j.tcb.2018.05.001
Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure Dohle W, Jourdan Fabrice L, Menchon G, Prota Andrea E, Foster Paul A, Mannion P, Hamel E, Thomas Mark P, Kasprzyk Philip G, Ferrandis E, Steinmetz Michel O, Leese Mathew P, Potter Barry VL
JOURNAL OF MEDICINAL CHEMISTRY , acs.jmedchem.7b01474 (2018).
DOI: 10.1021/acs.jmedchem.7b01474
Resolution extension by image summing in serial femtosecond crystallography of two-dimensional membrane-protein crystals Casadei Cecilia M, Tsai C, Barty A, Hunter Mark S, Zatsepin Nadia A, Padeste C, Capitani G, Benner WHenry, Boutet S, Hau-Riege Stefan P, Kupitz C, Messerschmidt M, Ogren John I, Pardini T, Rothschild Kenneth J, Sala L, Segelke B, Williams Garth J, Evans James E, Li X, Coleman M, Pedrini B, Frank M
IUCRJ 5, 103 (2018).
DOI: 10.1107/S2052252517017043
Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser Nogly P, Weinert T, James D, Carbajo S, Ozerov D, Furrer A, Gashi D, Borin V, Skopintsev P, Jaeger K, Nass K, Båth P, Bosman R, Koglin J, Seaberg M, Lane T, Kekilli D, Brünle S, Tanaka T, Wu W, Milne C, White T, Barty A, Weierstall U, Panneels V, Nango E, Iwata S, Hunter M, Schapiro I, Schertler G, Neutze R, Standfuss J
SCIENCE 361, 145 (2018).
DOI: 10.1126/science.aat0094
Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex Jiang K, Faltova L, Hua S, Capitani G, Prota Andrea E, Landgraf C, Volkmer R, Kammerer Richard A, Steinmetz Michel O, Akhmanova A
STRUCTURE -, S0969212617304422 (2018).
DOI: 10.1016/j.str.2017.12.017
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents. Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asis Balaguer F, Khan T, Grillo A, Chemi G, Menchon G, Prota AE, Olieric N, Lucena-Agell D, Barasoain I, Diaz JF, Nebbioso A, Conte M, Lopresti L, Magnano S, Amet R, Kinsella P, Zisterer DM, Ibrahim O, OSullivan J, Morbidelli L, Spaccapelo R, Baldari C, Butini S, Novellino E, Campiani G, Altucci L, Steinmetz MO, Brogi S
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 162, 290 (2018).
Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site Smedley Christopher J, Stanley Paul A, Qazzaz Mohannad E, Prota Andrea E, Olieric N, Collins H, Eastman H, Barrow Andrew S, Lim K, Kam T, Smith Brian J, Duivenvoorden Hendrika M, Parker Belinda S, Bradshaw Tracey D, Steinmetz Michel O, Moses John E
Scientific Reports 8, 10617 (2018).
DOI: 10.1038/s41598-018-28880-2

2017

A new inhibitor of the beta-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling Beautrait A, Paradis Justine S, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich Franziska M, Khoury E, Audet M, Roux Philippe P, Veprintsev Dmitry B, Laporte Stéphane A, Bouvier M
NATURE COMMUNICATIONS 8, 15054 (2017).
DOI: 10.1038/ncomms15054
A structural model for microtubule minus-end recognition and protection by CAMSAP proteins Atherton J, Jiang K, Stangier M, Luo Y, Hua S, Houben K, van Hooff J, Joseph A, Scarabelli G, Grant B, Roberts A, Topf M, Steinmetz M, Baldus M, Moores C, Akhmanova A
NATURE STRUCTURAL & MOLECULAR BIOLOGY 24, 931 (2017).
DOI: 10.1038/nsmb.3483
Antivascular and antitumor properties of the tubulin-binding chalcone TUB091 Canela M, Noppen S, Bueno O, Prota A, Bargsten K, Sáez-Calvo G, Jimeno M, Benkheil M, Ribatti D, Velázquez S, Camarasa M, Díaz JFernando, Steinmetz MO, Priego E, Pérez-Pérez M, Liekens S
ONCOTARGET 8, 14325 (2017).
DOI: 10.18632/oncotarget.9527
Baculovirus-based genome editing in primary cells Mansouri M, Ehsaei Z, Taylor V, Berger P
PLASMID 90, 5 (2017).
DOI: 10.1016/j.plasmid.2017.01.003
Characterization at the level of individual crystals: single crystal MFI type zeolite grains Gruene T, Li T, van Genderen E, Pinar AB, van Bokhoven JA
CHEMISTRY - A EUROPEAN JOURNAL 24, 2384 (2017).
DOI: 10.1002/chem.201704213
Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS
MOLECULAR CELL Oct 5;68(1), 210 (2017).
DOI: 10.1016/j.molcel.2017.09.012
Comprehensive Analysis of the Role of Arrestin Residues in Receptor Binding Haider Raphael S, Rizk A, Schertler G, Ostermaier M
Springer International Publishing -, 83 (2017).
DOI: 10.1007/978-3-319-57553-7_7
Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C Benoit RM, Schaerer MA, Wieser MM, Li X, Frey D, Kammerer RA
Scientific Reports 7, 43588 (2017).
DOI: 10.1038/srep43588
Deconvolution of Buparlisib?s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention Bohnacker T, Prota AE, Beaufils F, Burke John E, Melone A, Inglis Alison J, Rageot D, Sele Alexander M, Cmiljanovic V, Cmiljanovic N, Bargsten K, Aher A, Akhmanova A, Díaz JFernando, Fabbro D, Zvelebil M, Williams Roger L, Steinmetz MO, Wymann Matthias P
NATURE COMMUNICATIONS 8, 14683 (2017).
DOI: 10.1038/ncomms14683
Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis Hamel V, Steib E, Hamelin R, Armand F, Borgers S, Flückiger I, Busso C, Olieric N, Sorzano Carlos Oscar S, Steinmetz Michel O, Guichard P, Gönczy P
CURRENT BIOLOGY 27, 2486 (2017).
DOI: 10.1016/j.cub.2017.07.011
Kinesin-4 KIF21B is a potent microtubule pausing factor van Riel W, Rai A, Bianchi S, Katrukha E, Liu Q, Heck A, Hoogenraad C, Steinmetz M, Kapitein L, Akhmanova A
ELIFE 6, - (2017).
DOI: 10.7554/eLife.24746
Mastering the magnetic susceptibility of magnetically responsive bicelles with 3?-amino-5-cholestene and complexed lanthanide ions Isabettini S, Liebi M, Kohlbrecher J, Ishikawa T, Fischer P, Windhab Erich J, Walde P, Kuster S
PHYSICAL CHEMISTRY CHEMICAL PHYSICS 19, 10820 (2017).
DOI: 10.1039/C7CP01025G
Methods for Generating Highly Magnetically Responsive Lanthanide-Chelating Phospholipid Polymolecular Assemblies Isabettini S, Baumgartner Mirjam E, Reckey Pernille Q, Kohlbrecher J, Ishikawa T, Fischer P, Windhab Erich J, Kuster S
LANGMUIR 33, 6363 (2017).
DOI: 10.1021/acs.langmuir.7b00725
Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Jiang K, Rezabkova L, Hua S, Liu Q, Capitani G, Maarten Altelaar AF, Heck AJR, Kammerer RA, Steinmetz MO, Akhmanova A
NATURE CELL BIOLOGY 19, 480 (2017).
DOI: 10.1038/NCB3511
Molecular engineering of lanthanide ion chelating phospholipids generating assemblies with a switched magnetic susceptibility Isabettini S, Massabni S, Hodzic A, Durovic D, Kohlbrecher J, Ishikawa T, Fischer P, Windhab Erich J, Walde P, Kuster S
Phys. Chem. Chem. Phys. 19, 20991 (2017).
DOI: 10.1039/C7CP03994H
OMNY PIN - A versatile sample holder for tomographic measurements at room and cryogenic temperatures Holler M, Raabe J, Wepf R, Shahmoradian SH, Diaz A, Sarafimov B, Lachat T, Walther H, Vitins M
REVIEW OF SCIENTIFIC INSTRUMENTS 88, 113701 (2017).
DOI: 10.1063/1.4996092
Perspective: Opportunities for ultrafast science at SwissFEL Abela Rafael, Beaud Paul, van Bokhoven Jeroen A, Chergui Majed, Feurer Thomas, Haase Johannes, Ingold Gerhard, Johnson Steven L, Knopp Gregor, Lemke Henrik, Milne Chris J, Pedrini Bill, Radi Peter, Schertler Gebhard, Standfuss Jorg, Staub Urs, Patthey Luc
STRUCTURAL DYNAMICS 4, 061602 (2017).
DOI: 10.1063/1.4997222
Photoactivation Mechanism of a Bacterial Light-Regulated Adenylyl Cyclase. Lindner R, Hartmann E, Tarnawski M, Winkler A, Frey D, Reinstein J, Meinhart A, Schlichting I
JOURNAL OF MOLECULAR BIOLOGY 429, 1336 (2017).
DOI: 10.1016/J.JMB.2017.03.020
Production and purification of human Hsp90? in Escherichia coli Radli M, Veprintsev Dmitry B, Rüdiger Stefan GD
PLOS ONE 12, e0180047 (2017).
DOI: 10.1371/journal.pone.0180047
Protein structure determination by electron diffraction using a single three-dimensional nanocrystal Clabbers MTB, van Genderen E, Wan W, Wiegers EL, Gruene T, Abrahams JP
Acta Crystallographica Section D Structural Biology 73, 738 (2017).
DOI: 10.1107/S2059798317010348
Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin Sharma A, Sáez-Calvo G, Olieric N, de Asís Balaguer F, Barasoain I, Lamberth C, Díaz J, Steinmetz M
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18, 1336 (2017).
DOI: 10.3390/ijms18071336
Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation. Vercellino I, Rezabkova L, Olieric V, Polyhach Y, Weinert T, Kammerer RA, Jeschke G, Korkhov VM
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114, E9821 (2017).
DOI: 10.1073/PNAS.1712621114
Selectivity determinants of GPCR?G-protein binding Flock T, Hauser Alexander S, Lund N, Gloriam David E, Balaji S, Babu M Madan
NATURE 545, 317 (2017).
DOI: 10.1038/nature22070
Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier. Aeschimann W, Staats S, Kammer S, Olieric N, Jeckelmann JM, Fotiadis D, Netscher T, Rimbach G, Cascella M, Stocker A
Scientific Reports 7, 4970 (2017).
DOI: 10.1038/S41598-017-05148-9
Serial crystallography at synchrotrons and X-ray lasers Standfuss J, Spence J
IUCRJ 4, 100 (2017).
Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons Weinert T, Olieric N, Cheng R, Brünle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Doré Andrew S, Geng T, Cooke Robert M, Liang M, Prota Andrea E, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz Michel O, Wang M, Standfuss J
NATURE COMMUNICATIONS 8, 542 (2017).
DOI: 10.1038/s41467-017-00630-4
Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends. Kumar A, Manatschal C, Rai A, Grigoriev I, Degen MS, Jaussi R, Kretzschmar I, Prota AE, Volkmer R, Kammerer RA, Akhmanova A, Steinmetz MO
STRUCTURE 25, 924 (2017).
DOI: 10.1016/J.STR.2017.04.010
Structural Basis of Microtubule Stabilization by Discodermolide Prota Andrea E, Bargsten K, Redondo M, Smith III Amos B, Yang ChiaPing H, McDaid Hayley M, Paterson I, Horwitz Susan B, Díaz J, Steinmetz Michel O
CHEMBIOCHEM , (2017).
DOI: 10.1002/cbic.201600696
Structural Basis of cis- and trans-Combretastatin Binding to Tubulin Gaspari R, Prota Andrea E, Bargsten K, Cavalli A, Steinmetz Michel O
Chem 2, 102 (2017).
DOI: 10.1016/j.chempr.2016.12.005
Structural basis of katanin p60:p80 complex formation Rezabkova L, Jiang K, Capitani G, Prota Andrea E, Akhmanova A, Steinmetz Michel O, Kammerer Richard A
Scientific Reports 7, 14893 (2017).
DOI: 10.1038/s41598-017-14194-2
Structural biology Signalling under the microscope Tsai ChingJu, Standfuss Joerg, Glaeser Robert M
NATURE 546, 36-37 (2017).
DOI: 10.1038/nature22491
Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A. Markovic-Mueller S, Stuttfeld E, Asthana M, Weinert T, Bliven S, Goldie KN, Kisko K, Capitani G, Ballmer-Hofer K
STRUCTURE 25, 341 (2017).
DOI: 10.1016/J.STR.2016.12.012
The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion Eugenin Eliseo A, Koenen A, Babendreyer A, Schumacher J, Pasqualon T, Schwarz N, Seifert A, Deupi X, Ludwig A, Dreymueller D
PLOS ONE 12, e0173486 (2017).
DOI: 10.1371/journal.pone.0173486
Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography Shahmoradian SH, Tsai EHR, Diaz A, Guizar-Sicairos M, Raabe J, Spycher L, Britschgi M, Ruf A, Stahlberg H, Holler M
Scientific Reports 7, 6291 (2017).
DOI: 10.1038/s41598-017-05587-4
Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin. Saez-Calvo G, Sharma A, Balaguer FA, Barasoain I, Rodriguez-Salarichs J, Olieric N, Munoz-Hernandez H, Berbis MA, Wendeborn S, Penalva MA, Matesanz R, Canales A, Prota AE, Jimenez-Barbero J, Andreu JM, Lamberth C, Steinmetz MO, Diaz JF
CELL CHEMICAL BIOLOGY 24, 737 (2017).
DOI: 10.1016/J.CHEMBIOL.2017.05.016
Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. Field JJ, Pera B, Gallego JE, Calvo E, Rodriguez-Salarichs J, Saez-Calvo G, Zuwerra D, Jordi M, Andreu JM, Prota AE, Menchon G, Miller JH, Altmann KH, Diaz JF
JOURNAL OF NATURAL PRODUCTS , (2017).
DOI: 10.1021/acs.jnatprod.7b00704

2016

A simple and fast approach for missing-wedge invariant classification of subtomograms extracted from filamentous structures Obbineni J, Yamamoto R, Ishikawa T
JOURNAL OF STRUCTURAL BIOLOGY , (2016).
DOI: 10.1016/j.jsb.2016.08.003
A three-dimensional movie of structural changes in bacteriorhodopsin Nango Eriko, Royant Antoine, Kubo Minoru, Nakane Takanori, Wickstrand Cecilia, Kimura Tetsunari, Tanaka Tomoyuki, Tono Kensuke, Song Changyong, Tanaka Rie, Arima Toshi, Yamashita Ayumi, Kobayashi Jun, Hosaka Toshiaki, Mizohata Eiichi, Nogly Przemyslaw, Sugahara Michihiro, Nam Daewoong, Nomura Takashi, Shimamura Tatsuro, Im Dohyun, Fujiwara Takaaki, Yamanaka Yasuaki, Jeon Byeonghyun, Nishizawa Tomohiro, Oda Kazumasa, Fukuda Masahiro, Andersson Rebecka, Bath Petra, Dods Robert, Davidsson Jan, Matsuoka Shigeru, Kawatake Satoshi, Murata Michio, Nureki Osamu, Owada Shigeki, Kameshima Takashi, Hatsui Takaki, Joti Yasumasa, Schertler Gebhard, Yabashi Makina, Bondar AnaNicoleta, Standfuss Jorg, Neutze Richard, Iwata So
SCIENCE 354, 1552-1557 (2016).
DOI: 10.1126/science.aah3497
Ab initio structure determination of nanocrystals of organic pharmaceutical compounds by electron diffraction at room temperature using a Timepix quantum area direct electron detector van Genderen E, Clabbers MTB, Das PP, Stewart A, Nederlof I, Barentsen KC, Portillo Q, Pannu NS, Nicolopoulos S, Gruene T, Abrahams JP
Acta Crystallographica Section A Foundations and Advances 72, 236 (2016).
DOI: 10.1107/S2053273315022500
Accelerating the Association of the Most Stable Protein-Ligand Complex by more than Two Orders of Magnitude Giese C, Eras J, Kern A, Schärer Martin A, Capitani G, Glockshuber R
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , (2016).
DOI: 10.1002/anie.201603652
Addendum to Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography [J. Struct. Biol. 192 (2015) 461-469] Diaz A, Malkova B, Holler M, Guizar-Sicairos M, Lima E, Panneels V, Pigino G, Bittermann A, Wettstein L, Tomizaki T, Bunk O, Schertler G, Ishikawa T, Wepf R, Menzel A
JOURNAL OF STRUCTURAL BIOLOGY 193, 83 (2016).
DOI: 10.1016/j.jsb.2015.12.003
Backbone NMR reveals allosteric signal transduction networks in the beta1-adrenergic receptor Isogai S, Deupi X, Opitz C, Heydenreich Franziska M, Tsai C, Brueckner F, Schertler Gebhard FX, Veprintsev Dmitry B, Grzesiek S
NATURE 530, 237 (2016).
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Biochemie und Molekularbiologie Christen P, Jaussi R, Benoit R
Springer Verlag Berlin Heidelberg , (2016).
DOI: 10.1007/978-3-662-46430-4_1
Biophysical and Structural Characterization of the Centriolar Protein Cep104 Interaction Network. Rezabkova L, Kraatz SH, Akhmanova A, Steinmetz MO, Kammerer RA
JOURNAL OF BIOLOGICAL CHEMISTRY 291, 18496 (2016).
DOI: 10.1074/JBC.M116.739771
Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth Sharma Ashwani, Aher Amol, Dynes Nicola J, Frey Daniel, Katrukha Eugene A, Jaussi Rolf, Grigoriev Ilya, Croisier Marie, Kammerer Richard A, Akhmanova Anna, Gonczy Pierre, Steinmetz Michel O
DEVELOPMENTAL CELL 37, 362-376 (2016).
DOI: 10.1016/j.devcel.2016.04.024
Characterization of Mn(II) ion binding to the amyloid-? peptide in Alzheimer?s disease Wallin C, Kulkarni Yashraj S, Abelein A, Jarvet J, Liao Q, Strodel B, Olsson L, Luo J, Abrahams J, Sholts Sabrina B, Roos Per M, Kamerlin Shina CL, Gräslund A, Wärmländer Sebastian KTS
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY , (2016).
DOI: 10.1016/j.jtemb.2016.03.009
Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract Shen K, Calamini B, Fauerbach J, Ma B, Shahmoradian S, Serrano Lachapel I, Chiu W, Lo D, Frydman J
ELIFE 5, (2016).
DOI: 10.7554/eLife.18065
Cross-interactions between the Alzheimer Disease Amyloid-? Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis Luo J, Wärmländer Sebastian KTS, Gräslund A, Abrahams J
JOURNAL OF BIOLOGICAL CHEMISTRY 291, 16485 (2016).
DOI: 10.1074/jbc.R116.714576
Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies Burger Dominique, Stihle Martine, Sharma Ashwani, Di Lello Paola, Benz Jorg, D'Arcy Brigitte, Debulpaep Maja, Fry David, Huber Walter, Kremer Thomas, Laeremans Toon, Matile Hugues, Ross Alfred, Rufer Arne C, Schoch Guillaume, Steinmetz Michel O, Steyaert Jan, Rudolph Markus G, Thoma Ralf, Ruf Armin
JOURNAL OF BIOLOGICAL CHEMISTRY 291, 16292-16306 (2016).
DOI: 10.1074/jbc.M116.726547
Data-collection strategy for challenging native SAD phasing Olieric V, Weinert T, Finke Aaron D, Anders C, Li D, Olieric N, Borca Camelia N, Steinmetz Michel O, Caffrey M, Jinek M, Wang M
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY 72, 421 (2016).
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Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region Venkatakrishnan AJ, Deupi X, Lebon G, Heydenreich Franziska M, Flock T, Miljus T, Balaji S, Bouvier M, Veprintsev Dmitry B, Tate Christopher G, Schertler G FX, Babu MMadan
NATURE 536, 484 (2016).
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EB1 interacts with outwardly curved and straight regions of the microtubule lattice Guesdon A, Bazile F, Buey RM, Mohan R, Monier S, García R, Angevin M, Heichette C, Wieneke R, Tampé R, Duchesne L, Akhmanova A, Steinmetz MO, Chrétien D
NATURE CELL BIOLOGY 18, 1102 (2016).
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Functional map of arrestin binding to phosphorylated opsin, with and without agonist Peterhans C, Lally Ciara CM, Ostermaier Martin K, Sommer Martha E, Standfuss J
Scientific Reports 6, 28686 (2016).
DOI: 10.1038/srep28686
Functional map of arrestin binding to phosphorylated opsin, with and without agonist (vol 6, 28686, 2016) Peterhans Christian, Lally Ciara C M, Ostermaier Martin K, Sommer Martha E, Standfuss Jorg
Scientific Reports 6, 30224 (2016).
DOI: 10.1038/srep30224
Highly efficient baculovirus-mediated multigene delivery in primary cells Mansouri M, Bellon-Echeverria I, Rizk A, Ehsaei Z, Cianciolo Cosentino C, Silva Catarina S, Xie Y, Boyce Frederick M, Davis MWayne, Neuhauss Stephan CF, Taylor V, Ballmer-Hofer K, Berger I, Berger P
NATURE COMMUNICATIONS 7, 11529 (2016).
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In meso in situ In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures Huang ChiaYing, Olieric Vincent, Ma Pikyee, Howe Nicole, Vogeley Lutz, Liu Xiangyu, Warshamanage Rangana, Weinert Tobias, Panepucci Ezequiel, Kobilka Brian, Diederichs Kay, Wang Meitian, Caffrey Martin
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY 72, 93-112 (2016).
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In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures. Huang CY, Olieric V, Ma P, Howe N, Vogeley L, Liu X, Warshamanage R, Weinert T, Panepucci E, Kobilka B, Diederichs K, Wang M, Caffrey M
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 72, 93 (2016).
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Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity Kevenaar Josta T, Bianchi S, van Spronsen M, Olieric N, Lipka J, Frias Cátia P, Mikhaylova M, Harterink M, Keijzer N, Wulf Phebe S, Hilbert M, Kapitein Lukas C, de Graaff E, Ahkmanova A, Steinmetz Michel O, Hoogenraad Casper C
CURRENT BIOLOGY 26, 849 (2016).
DOI: 10.1016/j.cub.2016.01.048
Lattice filter for processing image data of three-dimensional protein nanocrystals van Genderen E, Li YW, Nederlof I, Abrahams JP
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY 72, 34 (2016).
DOI: 10.1107/S205979831502149X
Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography Nogly P, Panneels V, Nelson G, Gati C, Kimura T, Milne C, Milathianaki D, Kubo M, Wu W, Conrad C, Coe J, Bean R, Zhao Y, Båth P, Dods R, Harimoorthy R, Beyerlein Kenneth R, Rheinberger J, James D, DePonte D, Li C, Sala L, Williams Garth J, Hunter Mark S, Koglin Jason E, Berntsen P, Nango E, Iwata S, Chapman Henry N, Fromme P, Frank M, Abela R, Boutet S, Barty A, White Thomas A, Weierstall U, Spence J, Neutze R, Schertler G, Standfuss J
NATURE COMMUNICATIONS 7, 12314 (2016).
DOI: 10.1038/ncomms12314
Modern X-ray analysis on single crystals - a practical guide Gruene T
Crystallography Reviews 22, 287 (2016).
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Molecular basis of Kar9-Bim1 complex function during mating and spindle positioning Manatschal C, Farcas AM, Degen MS, Bayer M, Kumar A, Landgraf C, Volkmer R, Barral Y, Steinmetz MO
MOLECULAR BIOLOGY OF THE CELL 27, 3729 (2016).
DOI: 10.1091/mbc.E16-07-0552
Pironetin Binds Covalently to alpha Cys316 and Perturbs a Major Loop and Helix of alpha-Tubulin to Inhibit Microtubule Formation. Prota AE, Setter J, Waight AB, Bargsten K, Murga J, Diaz JF, Steinmetz MO
JOURNAL OF MOLECULAR BIOLOGY 428, 2981 (2016).
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Reciprocal Molecular Interactions between the A? Peptide Linked to Alzheimer?s Disease and Insulin Linked to Diabetes Mellitus Type II Luo J, Wärmländer Sebastian KTS, Gräslund A, Abrahams J
ACS Chemical Neuroscience 7, 269 (2016).
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Recreating the synthesis of starch granules in yeast Pfister B, Sánchez-Ferrer A, Diaz A, Lu K, Otto C, Holler M, Shaik F, Meier F, Mezzenga R, Zeeman S
ELIFE 5, e15552 (2016).
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SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture Hilbert Manuel, Noga Akira, Frey Daniel, Hamel Virginie, Guichard Paul, Kraatz Sebastian H W, Pfreundschuh Moritz, Hosner Sarah, Flueckiger Isabelle, Jaussi Rolf, Wieser Mara M, Thieltges Katherine M, Deupi Xavier, Mueller Daniel J, Kammerer Richard A, Goenczy Pierre, Hirono Masafumi, Steinmetz Michel O
NATURE CELL BIOLOGY 18, 393-+ (2016).
DOI: 10.1038/ncb3329
Seamless Insert-Plasmid Assembly at High Efficiency and Low Cost Benoit RM, Ostermeier C, Geiser M, Li JSZ, Widmer H, Auer M
PLOS ONE 11, e0153158 (2016).
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Serial Millisecond Crystallography of Membrane Proteins Jaeger K, Dworkowski F, Nogly P, Milne C, Wang M, Standfuss J
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 922, 137 (2016).
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Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics Waight AB, Bargsten K, Doronina S, Steinmetz MO, Sussman D, Prota AE
PLOS ONE 11, e0160890 (2016).
DOI: 10.1371/journal.pone.0160890
Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells Trigili C, Barasoain I, Sánchez-Murcia Pedro A, Bargsten K, Redondo-Horcajo M, Nogales A, Gardner Nicola M, Meyer A, Naylor Guy J, Gómez-Rubio E, Gago F, Steinmetz Michel O, Paterson I, Prota Andrea E, Díaz JFernando
ACS Omega 1, 1192 (2016).
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Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations Bianchi S, van Riel Wilhelmina E, Kraatz Sebastian HW, Olieric N, Frey D, Katrukha Eugene A, Jaussi R, Missimer J, Grigoriev I, Olieric V, Benoit Roger M, Steinmetz Michel O, Akhmanova A, Kammerer Richard A
Scientific Reports 6, 30668 (2016).
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Structural role of the T94I rhodopsin mutation in congenital stationary night blindness Singhal Ankita, Guo Ying, Matkovic Milos, Schertler Gebhard, Deupi Xavier, Yan Elsa C Y, Standfuss Joerg
EMBO REPORTS 17, 1431-1440 (2016).
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Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family (vol 22, pg 303, 2015) Geertsma Eric R, Chang YungNing, Shaik Farooque R, Neldner Yvonne, Pardon Els, Steyaert Jan, Dutzler Raimund
NATURE STRUCTURAL & MOLECULAR BIOLOGY 23, 462-462 (2016).
TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington?s disease Zhao X, Chen X, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau Alice L, Shahmoradian SH, Chiu W, Thompson Leslie M, Wu C, Mobley William C
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113, E5655 (2016).
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Tailoring Bicelle Morphology and Thermal Stability with Lanthanide-Chelating Cholesterol Conjugates Isabettini S, Liebi M, Kohlbrecher J, Ishikawa T, Windhab Erich J, Fischer P, Walde P, Kuster S
LANGMUIR 32 (35), 9005 (2016).
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Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes Doodhi Harinath, Prota Andrea E, Rodriguez-Garcia Ruddi, Xiao Hui, Custar Daniel W, Bargsten Katja, Katrukha Eugene A, Hilbert Manuel, Hua Shasha, Jiang Kai, Grigoriev Ilya, Yang ChiaPing H, Cox David, Horwitz Susan Band, Kapitein Lukas C, Akhmanova Anna, Steinmetz Michel O
CURRENT BIOLOGY 26, 1713-1721 (2016).
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The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding Kraatz S, Guichard P, Obbineni Jagan M, Olieric N, Hatzopoulos Georgios N, Hilbert M, Sen I, Missimer J, Gönczy P, Steinmetz Michel O
STRUCTURE 24, 1358 (2016).
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The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity Wieczorek Michal, Tcherkezian Joseph, Bernier Cynthia, Prota AE, Chaaban Sami, Rolland Yanneve, Godbout Claude, Hancock Mark A, Arezzo Joseph C, Ocal Ozhan, Rocha Cecilia, Olieric N, Hall Anita, Ding Hui, Bramoulle Alexandre, Annis Matthew G, Zogopoulos George, Harran Patrick G, Wilkie Thomas M, Brekken Rolf A, Siegel Peter M, Steinmetz MO, Shore Gordon C, Brouhard Gary J, Roulston Anne
SCIENCE TRANSLATIONAL MEDICINE 8, 365ra159 (2016).
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Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography (vol 192, pg 461, 2015) Diaz Ana, Malkova Barbora, Holler Mirko, Guizar-Sicairos Manuel, Lima Enju, Panneels Valerie, Pigino Gaia, Bittermann Anne Greet, Wettstein Larissa, Tomizaki Takashi, Bunk Oliver, Schertler Gebhard, Ishikawa Takashi, Wepf Roger, Menzel Andreas
JOURNAL OF STRUCTURAL BIOLOGY 193, 83-83 (2016).
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Understanding the fabric of protein crystals: computational classification of biological interfaces and crystal contacts Capitani G, Duarte Jose M, Baskaran K, Bliven S, Somody Joseph C
BIOINFORMATICS 32, 481 (2016).
DOI: 10.1093/bioinformatics/btv622

2015

A Molecular Pharmacologist's Guide to G Protein-Coupled Receptor Crystallography Piscitelli CL, Kean J, de Graaf C, Deupi X
MOLECULAR PHARMACOLOGY 88, 536 (2015).
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A posteriori correction of camera characteristics from large image data sets Afanasyev P, Ravelli Raimond BG, Matadeen R, De Carlo S, van Duinen G, Alewijnse B, Peters Peter J, Abrahams J, Portugal Rodrigo V, Schatz M, van Heel M
Scientific Reports 5, 10317 (2015).
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Batch crystallization of rhodopsin for structural dynamics using an X-ray free-electron laser Wu W, Nogly P, Rheinberger J, M Kick L, Gati C, Nelson G, Deupi X, Standfuss J, Schertler G, Panneels V
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 71, 856 (2015).
DOI: 10.1107/S2053230X15009966
Bilayer Properties of 1,3-Diamidophospholipids Weinberger A, Tanasescu R, Stefaniu C, Fedotenko lllya A, Favarger F, Ishikawa T, Brezesinski G, Marques Carlos M, Zumbuehl A
LANGMUIR 31, 1879 (2015).
DOI: 10.1021/la5041745
Control of microtubule organization and dynamics: two ends in the limelight Akhmanova A, Steinmetz Michel O
NATURE REVIEWS MOLECULAR CELL BIOLOGY 16, 711 (2015).
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Cryo-electron tomography of motile cilia and flagella Ishikawa T
Cilia 4, 3 (2015).
DOI: 10.1186/s13630-014-0012-7
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser Kang Y, Zhou XEdward, Gao X, He Y, Liu W, Ishchenko A, Barty A, White Thomas A, Yefanov O, Han G, Xu Q, de Waal Parker W, Ke J, Tan MHEileen, Zhang C, Moeller A, West Graham M, Pascal Bruce D, Van Eps N, Caro Lydia N, Vishnivetskiy Sergey A, Lee Regina J, Suino-Powell Kelly M, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams Garth J, Messerschmidt M, Gati C, Zatsepin Nadia A, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad Chelsie E, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter Clinton S, Carragher B, Caffrey M, Jiang H, Chapman Henry N, Spence John CH, Fromme P, Weierstall U, Ernst Oliver P, Katritch V, Gurevich Vsevolod V, Griffin Patrick R, Hubbell Wayne L, Stevens Raymond C, Cherezov V, Melcher K, Xu HEric
NATURE 523, 561 (2015).
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Design of magnetically responsive phospholipid bicelles towards switchable optical hydrogels Liebi M, Kuster S, Kohlbrecher J, Ishikawa T, Walde P, Windhab EJ, Fischer P
Swiss Neutron News 45, 4 (2015).
Electron crystallography of 3D nano-crystals Clabbers Max TB, van Genderen E, Nederlof I, Li Y, Abrahams J
Acta Crystallographica Section A Foundations and Advances 71, s405 (2015).
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Electron diffraction and imaging of 3D nanocrystals of pharmaceuticals, peptides and proteins Abrahams J, van Genderen E, Nederlof I, Clabbers M, Li Y
Acta Crystallographica Section A Foundations and Advances 71, s103 (2015).
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Fast native-SAD phasing for routine macromolecular structure determination Weinert Tobias, Olieric Vincent, Waltersperger Sandro, Panepucci Ezequiel, Chen Lirong, Zhang Hua, Zhou Dayong, Rose John, Ebihara Akio, Kuramitsu Seiki, Li Dianfan, Howe Nicole, Schnapp Gisela, Pautsch Alexander, Bargsten Katja, Prota Andrea E, Surana Parag, Kottur Jithesh, Nair Deepak T, Basilico Federica, Cecatiello Valentina, Pasqualato Sebastiano, Boland Andreas, Weichenrieder Oliver, Wang Bi-Cheng, Steinmetz Michel O, Caffrey Martin, Wang Meitian
NATURE METHODS 12, 131-U163 (2015).
DOI: 10.1038/nmeth.3211
Fast native-SAD phasing for routine macromolecular structure determination (vol 12, pg 131, 2015) Weinert Tobias, Olieric Vincent, Waltersperger Sandro, Panepucci Ezequiel, Chen Lirong, Zhang Hua, Zhou Dayong, Rose John, Ebihara Akio, Kuramitsu Seiki, Li Dianfan, Howe Nicole, Schnapp Gisela, Pautsch Alexander, Bargsten Katja, Prota Andrea E, Surana Parag, Kottur Jithesh, Nair Deepak T, Basilico Federica, Cecatiello Valentina, Pasqualato Sebastiano, Boland Andreas, Weichenrieder Oliver, Wang BiCheng, Steinmetz Michel O, Caffrey Martin, Wang Meitian
NATURE METHODS 12, 692-692 (2015).
Functional roles of the hexamer organization of plant glutamate decarboxylase Astegno A, Capitani G, Dominici P
BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS AND PROTEOMICS 1854, 1229 (2015).
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In meso in situ serial X-ray crystallography of soluble and membrane proteins Huang Chia-Ying, Olieric Vincent, Ma Pikyee, Panepucci Ezequiel, Diederichs Kay, Wang Meitian, Caffrey Martin
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 71, 1238-1256 (2015).
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Large scale expression and purification of the rat 5-HT2c receptor He X, Robertson N, Jazayeri A, Gasperina A, Schertler G, Li X
PROTEIN EXPRESSION AND PURIFICATION 106, 1 (2015).
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Large-scale production and protein engineering of G protein-coupled receptors for structural studies Milic D, Veprintsev Dmitry B
Frontiers in Pharmacology 6, 66 (2015).
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Light-driven Na+ pumps as next-generation inhibitory optogenetic tools Nogly P, Standfuss J
NATURE STRUCTURAL & MOLECULAR BIOLOGY 22, 351 (2015).
DOI: 10.1038/nsmb.3017
Lipidic cubic phase serial millisecond crystallography using synchrotron radiation Nogly Przemyslaw, James Daniel, Wang Dingjie, White Thomas A, Zatsepin Nadia, Shilova Anastasya, Nelson Garrett, Liu Haiguang, Johansson Linda, Heymann Michael, Jaeger Kathrin, Metz Markus, Wickstrand Cecilia, Wu Wenting, Bath Petra, Berntsen Peter, Oberthuer Dominik, Panneels Valerie, Cherezov Vadim, Chapman Henry, Schertler Gebhard, Neutze Richard, Spence John, Moraes Isabel, Burghammer Manfred, Standfuss Joerg, Weierstall Uwe
IUCRJ 2, 168-176 (2015).
DOI: 10.1107/S2052252514026487
Low-Z polymer sample supports for fixed-target serial femtosecond X-ray crystallography Feld Geoffrey K, Heymann Michael, Benner W Henry, Pardini Tommaso, Tsai ChingJu, Boutet Sebastien, Coleman Matthew A, Hunter Mark S, Li Xiaodan, Messerschmidt Marc, Opathalage Achini, Pedrini Bill, Williams Garth J, Krantz Bryan A, Fraden Seth, Hau-Riege Stefan, Evans James E, Segelke Brent W, Frank Matthias
JOURNAL OF APPLIED CRYSTALLOGRAPHY 48, 1072-1079 (2015).
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Mammalian Expression, Purification, and Crystallization of Rhodopsin Variants Mattle D, Singhal A, Schmid G, Dawson R, Standfuss J
Methods in Molecular Biology 1271, 39 (2015).
DOI: 10.1007/978-1-4939-2330-4_3
Optochemistry to control the microtubule cytoskeleton Janke C, Steinmetz MO
The EMBO Journal 34, 2114 (2015).
DOI: 10.15252/embj.201592415
Probing Galpha_i1 protein activation at single?amino acid resolution Sun D, Flock T, Deupi X, Maeda S, Matkovic M, Mendieta S, Mayer D, Dawson R, Schertler G, Babu M, Veprintsev D
NATURE STRUCTURAL & MOLECULAR BIOLOGY 22, 686 (2015).
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RAFT synthesis of poly(vinylpyrrolidone) amine and preparation of a water-soluble C 60 -PVP conjugate Aroua S, Tiu Elisha Gabrielle V, Ayer M, Ishikawa T, Yamakoshi Y
Polym. Chem. 6, 2616 (2015).
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Stabilization of G protein-coupled receptors by point mutations Heydenreich Franziska M, Vuckovic Z, Matkovic M, Veprintsev Dmitry B
Frontiers in Pharmacology 6, 82 (2015).
DOI: 10.3389/fphar.2015.00082
Structural basis of enzymatic benzene ring reduction Weinert Tobias, Huwiler Simona G, Kung Johannes W, Weidenweber Sina, Hellwig Petra, Staerk HansJoachim, Biskup Till, Weber Stefan, Cotelesage Julien J H, George Graham N, Ermler Ulrich, Boll Matthias
NATURE CHEMICAL BIOLOGY 11, 586-U123 (2015).
DOI: 10.1038/NCHEMBIO.1849
Structural basis of enzymatic benzene ring reduction (vol 11, pg 586, 2015) Weinert Tobias, Huwiler Simona G, Kung Johannes W, Weidenweber Sina, Hellwig Petra, Staerk HansJoachim, Biskup Till, Weber Stefan, Cotelesage Julien J H, George Graham N, Ermler Ulrich, Boll Matthias
NATURE CHEMICAL BIOLOGY 11, 741-741 (2015).
Structural basis of enzymatic benzene ring reduction (vol 18, pg 586, 2015) Weinert Tobias, Huwiler Simona G, Kung Johannes W, Weidenweber Sina, Hellwig Petra, Staerk HansJoachim, Biskup Till, Weber Stefan, Cotelesage Julien J H, George Graham N, Ermler Ulrich, Boll Matthias
NATURE CHEMICAL BIOLOGY 11, 815-815 (2015).
Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family Geertsma Eric R, Chang YungNing, Shaik Farooque R, Neldner Yvonne, Pardon Els, Steyaert Jan, Dutzler Raimund
NATURE STRUCTURAL & MOLECULAR BIOLOGY 22, 803-808 (2015).
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Structure of the BoNT/A1 - receptor complex Benoit Roger M, Frey D, Wieser Mara M, Thieltges Katherine M, Jaussi R, Capitani G, Kammerer Richard A
TOXICON 107, 25 (2015).
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Subcellular object quantification with Squassh3C and SquasshAnalyst Rizk A, Mansouri M, Ballmer-Hofer K, Berger P
BIOTECHNIQUES 59, (2015).
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Synthesis of Single Crystal Nanoreactor Materials with Multiple Catalytic Functions by Incipient Wetness Impregnation and Ion Exchange Fodor D, Ishikawa T, Krumeich F, van Bokhoven Jeroen A
ADVANCED MATERIALS 27, 1919 (2015).
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TMalphaDB and TMbetaDB: web servers to study the structural role of sequence motifs in alpha-helix and beta-barrel domains of membrane proteins Perea M, Lugtenburg I, Mayol E, Cordomí A, Deupí X, Pardo L, Olivella M
BMC BIOINFORMATICS 16, 266 (2015).
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The use of ene adducts to study and engineer enoyl-thioester reductases. Rosenthal RG, Vogeli B, Quade N, Capitani G, Kiefer P, Vorholt JA, Ebert MO, Erb TJ
NATURE CHEMICAL BIOLOGY 11, 398 (2015).
DOI: 10.1038/NCHEMBIO.1794
Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography Diaz A, Malkova B, Holler M, Guizar-Sicairos M, Lima E, Panneels V, Pigino G, Bittermann A, Wettstein L, Tomizaki T, Bunk O, Schertler G, Ishikawa T, Wepf R, Menzel A
JOURNAL OF STRUCTURAL BIOLOGY 192, 461 (2015).
DOI: 10.1016/j.jsb.2015.10.008
Time-resolved structural studies with serial crystallography: A new light on retinal proteins Panneels Valerie, Wu Wenting, Tsai ChingJu, Nogly Przemek, Rheinberger Jan, Jaeger Kathrin, Cicchetti Gregor, Gati Cornelius, Kick Leonhard M, Sala Leonardo, Capitani Guido, Milne Chris, Padeste Celestino, Pedrini Bill, Li XiaoDan, Standfuss Joerg, Abela Rafael, Schertler Gebhard
STRUCTURAL DYNAMICS 2, 041718 (2015).
DOI: 10.1063/1.4922774
Universal allosteric mechanism for Galpha activation by GPCRs Flock T, Ravarani Charles NJ, Sun D, Venkatakrishnan AJ, Kayikci M, Tate Christopher G, Veprintsev Dmitry B, Babu MMadan
NATURE 524, 173 (2015).
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Viral chemokine mimicry Standfuss J
SCIENCE 347, 1071 (2015).
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alpha- and beta-Tubulin Lattice of the Axonemal Microtubule Doublet and Binding Proteins Revealed by Single Particle Cryo-Electron Microscopy and Tomography Maheshwari A, Obbineni J, Bui K, Shibata K, Toyoshima Yoko Y, Ishikawa T
STRUCTURE 23, 1584 (2015).
DOI: 10.1016/j.str.2015.06.017

2014

7 angstrom resolution in protein two-dimensional-crystal X-ray diffraction at Linac Coherent Light Source Pedrini Bill, Tsai Ching-Ju, Capitani Guido, Padeste Celestino, Hunter Mark S, Zatsepin Nadia A, Barty Anton, Benner W Henry, Boutet Sebastien, Feld Geoffrey K, Hau-Riege Stefan P, Kirian Richard A, Kupitz Christopher, Messerschmitt Marc, Ogren John I, Pardini Tommaso, Segelke Brent, Williams Garth J, Spence John C H, Abela Rafael, Coleman Matthew, Evans James E, Schertler Gebhard F X, Frank Matthias, Li Xiao-Dan
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 369, UNSP 20130500 (2014).
DOI: 10.1098/rstb.2013.0500
A Type IV Translocated Legionella Cysteine Phytase Counteracts Intracellular Growth Restriction by Phytate Weber Stephen, Stirnimann Christian U, Wieser Mara, Frey Daniel, Meier Roger, Engelhardt Sabrina, Li Xiaodan, Capitani Guido, Kammerer Richard A, Hilbi Hubert
JOURNAL OF BIOLOGICAL CHEMISTRY 289, 34175-34188 (2014).
DOI: 10.1074/jbc.M114.592568
A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family Khan MA, Rupp VM, Orpinell M, Hussain MS, Altmuller J, Steinmetz MO, Enzinger C, Thiele H, Hohne W, Nurnberg G, Baig SM, Ansar M, Nurnberg P, Vincent JB, Speicher MR, Gonczy P, Windpassinger C
HUMAN MOLECULAR GENETICS 23, 5940 (2014).
DOI: 10.1093/hmg/ddu318
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs Prota Andrea E, Bargsten Katja, Fernando Diaz J, Marsh May, Cuevas Carmen, Liniger Marc, Neuhaus Christian, Andreu Jose M, Altmann Karl-Heinz, Steinmetz Michel O
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111, 13817-13821 (2014).
DOI: 10.1073/pnas.1408124111
Actin?microtubule coordination at growing microtubule ends López M, Huber F, Grigoriev I, Steinmetz Michel O, Akhmanova A, Koenderink Gijsje H, Dogterom M
NATURE COMMUNICATIONS 5, 4778 (2014).
DOI: 10.1038/ncomms5778
Alzheimer Peptides Aggregate into Transient Nanoglobules That Nucleate Fibrils Luo J, Wärmländer Sebastian KTS, Gräslund A, Abrahams J
BIOCHEMISTRY 53, 6302 (2014).
DOI: 10.1021/bi5003579
ChemInform Abstract: Cyclic Peptides as Inhibitors of Amyloid Fibrillation Luo J, Abrahams J
ChemInform 45, no (2014).
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Conformational transitions driven by pyridoxal-5 '-phosphate uptake in the psychrophilic Serine hydroxymethyltransferase from Psychromonas ingrahamii Angelaccio Sebastiana, Dworkowski Florian, Di Bello Angela, Milano Teresa, Capitani Guido, Pascarella Stefano
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 82, 2831-2841 (2014).
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Copper-transporting P-type ATPases use a unique ion-release pathway Andersson Magnus, Mattle Daniel, Sitsel Oleg, Klymchuk Tetyana, Nielsen Anna Marie, Moller Lisbeth Birk, White Stephen H, Nissen Poul, Gourdon Pontus
NATURE STRUCTURAL & MOLECULAR BIOLOGY 21, 43-+ (2014).
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Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling Dalva M, Jayachandran R, Liu X, BoseDasgupta S, Müller P, Zhang C, Moshous D, Studer V, Schneider J, Genoud C, Fossoud C, Gambino F, Khelfaoui M, Müller C, Bartholdi D, Rossez H, Stiess M, Houbaert X, Jaussi R, Frey D, Kammerer Richard A, Deupi X, de Villartay J, Lüthi A, Humeau Y, Pieters J
PLOS BIOLOGY 12, e1001820 (2014).
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Crystallization Scale Preparation of a Stable GPCR Signaling Complex between Constitutively Active Rhodopsin and G-Protein Garriga P, Maeda S, Sun D, Singhal A, Foggetta M, Schmid G, Standfuss J, Hennig M, Dawson Roger JP, Veprintsev Dmitry B, Schertler Gebhard FX
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Cyclic Peptides as Inhibitors of Amyloid Fibrillation Luo J, Abrahams J
CHEMISTRY - A EUROPEAN JOURNAL 20, 2410 (2014).
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Endogenous Polyamines Reduce the Toxicity of Soluble A? Peptide Aggregates Associated with Alzheimer?s Disease Luo J, Mohammed I, Wärmländer Sebastian KTS, Hiruma Y, Gräslund A, Abrahams J
BIOMACROMOLECULES 15, 1985 (2014).
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Femtosecond X-ray diffraction from two-dimensional protein crystals Frank Matthias, Carlson David B, Hunter Mark S, Williams Garth J, Messerschmidt Marc, Zatsepin Nadia A, Barty Anton, Benner W Henry, Chu Kaiqin, Graf Alexander T, Hau-Riege Stefan P, Kirian Richard A, Padeste Celestino, Pardini Tommaso, Pedrini Bill, Segelke Brent, Seibert M Marvin, Spence John C H, Tsai ChingJu, Lane Stephen M, Li XiaoDan, Schertler Gebhard, Boutet Sebastien, Coleman Matthew, Evans James E
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Functional and structural characterization of the kinase insert and the carboxy terminal domain in VEGF receptor 2 activation Manni Sandro, Kisko Kaisa, Schleier Thomas, Missimer Jack, Ballmer-Hofer Kurt
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How Periplasmic Thioredoxin TlpA Reduces Bacterial Copper Chaperone ScoI and Cytochrome Oxidase Subunit II (CoxB) Prior to Metallation Abicht Helge K, Schaerer Martin A, Quade Nick, Ledermann Raphael, Mohorko Elisabeth, Capitani Guido, Hennecke Hauke, Glockshuber Rudi
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Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action Karagöz G Elif, Duarte Afonso MS, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues Bryce A, Veprintsev Dmitry B, Dickey Chad A, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger Stefan GD
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Influence of Fluorination and Molecular Weight on the Morphology and Performance of PTB7:PC71BM Solar Cells He X, Mukherjee S, Watkins S, Chen M, Qin T, Thomsen L, Ade H, Mcneill C
JOURNAL OF PHYSICAL CHEMISTRY C 118, 9918 (2014).
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Localizing Chemical Groups while Imaging Single Native Proteins by High-Resolution Atomic Force Microscopy Pfreundschuh Moritz, Alsteens David, Hilbert Manuel, Steinmetz Michel O, Mueller Daniel J
NANO LETTERS 14, 2957-2964 (2014).
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Magnetically Enhanced Bicelles Delivering Switchable Anisotropy in Optical Gels Liebi M, Kuster S, Kohlbrecher J, Ishikawa T, Fischer P, Walde P, Windhab EJ
ACS APPLIED MATERIALS & INTERFACES 6, 1100-1105 (2014).
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NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation Koch S, van Meeteren Laurens A, Morin E, Testini C, Weström S, Björkelund H, Le Jan S, Adler J, Berger P, Claesson-Welsh L
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Non-chaperone Proteins Can Inhibit Aggregation and Cytotoxicity of Alzheimer Amyloid ? Peptide Luo J, Wärmländer Sebastian KTS, Gräslund A, Abrahams J
JOURNAL OF BIOLOGICAL CHEMISTRY 289, 27766 (2014).
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Preparation of Primary Neurons for Visualizing Neurites in a Frozen-hydrated State Using Cryo-Electron Tomography Shahmoradian SH, Galiano Mauricio R, Wu C, Chen S, Rasband Matthew N, Mobley William C, Chiu W
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Protein tagging reveals new insights into signaling in flagella Ishikawa T
The Journal of Cell Biology 204, 631 (2014).
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Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein Duellberg C, Trokter M, Jha R, Sen I, Steinmetz Michel O, Surrey T
NATURE CELL BIOLOGY 16, 804 (2014).
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Reconstitution of a hierarchical plus TIP interaction network controlling microtubule end tracking of dynein Duellberg Christian, Trokter Martina, Jha Rupam, Sen Indrani, Steinmetz Michel O, Surrey Thomas
NATURE CELL BIOLOGY 16, 804-U314 (2014).
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Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia Hulse R P, Beazley-Long N, Hua J, Kennedy H, Prager J, Bevan H, Qiu Y, Fernandes E S, Gammons M V, Ballmer-Hofer K, de Groot A C Gittenberger, Churchill A J, Harper S J, Brain S D, Bates D O, Donaldson L F
NEUROBIOLOGY OF DISEASE 71, 245-259 (2014).
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Segmentation and quantification of subcellular structures in fluorescence microscopy images using Squassh Rizk A, Paul G, Incardona P, Bugarski M, Mansouri M, Niemann A, Ziegler U, Berger P, Sbalzarini I
NATURE PROTOCOLS 9, 586 (2014).
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Strategies for multigene expression in eukaryotic cells Mansouri M, Berger P
PLASMID 75, 12 (2014).
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Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A Prota Andrea E, Bargsten Katja, Northcote Peter T, Marsh May, Altmann Karl-Heinz, Miller John H, Fernando Diaz Jose, Steinmetz Michel O
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53, 1621-1625 (2014).
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Structural and Functional Characterization of Alternative Transmembrane Domain Conformations in VEGF Receptor 2 Activation Manni Sandro, Mineev Konstantin S, Usmanova Dinara, Lyukmanova Ekaterina N, Shulepko Mikhail A, Kirpichnikov Mikhail P, Winter Jonas, Matkovic Milos, Deupi Xavier, Arseniev Alexander S, Ballmer-Hofer Kurt
STRUCTURE 22, 1077-1089 (2014).
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Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A Benoit Roger M, Frey Daniel, Hilbert Manuel, Kevenaar Josta T, Wieser Mara M, Stirnimann Christian U, McMillan David, Ceska Tom, Lebon Florence, Jaussi Rolf, Steinmetz Michel O, Schertler Gebhard F X, Hoogenraad Casper C, Capitani Guido, Kammerer Richard A
NATURE 505, 108-+ (2014).
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Structural basis for-10 promoter element melting by environmentally induced sigma factors Campagne Sebastien, Marsh May E, Capitani Guido, Vorholt Julia A, Allain Frederic H-T
NATURE STRUCTURAL & MOLECULAR BIOLOGY 21, 269-276 (2014).
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Structure of AMP-PNP-bound BtuCD and mechanism of ATP-powered vitamin B12 transport by BtuCD-F Korkhov Vladimir M, Mireku Samantha A, Veprintsev Dmitry B, Locher Kaspar P
NATURE STRUCTURAL & MOLECULAR BIOLOGY 21, 1097-1099 (2014).
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Structure of dimeric axonemal dynein in cilia suggests an alternative mechanism of force generation Ueno H, Bui K, Ishikawa T, Imai Y, Yamaguchi T, Ishikawa T
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Structure, Activity, and Stability of Atomically Dispersed Rh in Methane Steam Reforming Duarte RB, Krumeich F, van Bokhoven JA
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The A- peptide forms non-amyloid fibrils in the presence of carbon nanotubes Luo J, Waermlaender Sebastian KTS, Yu C, Muhammad K, Graeslund A, Abrahams JP
NANOSCALE 6, 6720 (2014).
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The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization Prota Andrea E, Danel Franck, Bachmann Felix, Bargsten Katja, Buey Ruben M, Pohlmann Jens, Reinelt Stefan, Lane Heidi, Steinmetz Michel O
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The hairpin conformation of the amyloid ? peptide is an important structural motif along the aggregation pathway Abelein A, Abrahams J, Danielsson J, Gräslund A, Jarvet J, Luo J, Tiiman A, Wärmländer Sebastian KTS
JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 19, 623 (2014).
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Transient Mechanistic Studies of Methane Steam Reforming over Ceria-Promoted Rh/Al2O3 Catalysts Duarte RB, Olea M, Iro E, Sasaki T, Itako K, van Bokhoven JA
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Transport Pathway in Cu+ P-Type ATPases Andersson Magnus, Mattle Daniel, Sitsel Oleg, Nielsen Anna Marie, Lindahl Erik, White Stephen H, Nissen Poul, Gourdon Pontus
BIOPHYSICAL JOURNAL 106, 427A-427A (2014).
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2013

(4R)- and (4S)-Fluoroproline in the Conserved cis-Prolyl Peptide Bond of the Thioredoxin Fold: Tertiary Structure Context Dictates Ring Puckering Rubini Marina, Schaerer Martin A, Capitani Guido, Glockshuber Rudi
CHEMBIOCHEM 14, 1053-1057 (2013).
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A Medipix quantum area detector allows rotation electron diffraction data collection from submicrometre three-dimensional protein crystals Nederlof I, van Genderen E, Li Y, Abrahams J
ACTA CRYSTALLOGRAPHICA SECTION D - BIOLOGICAL CRYSTALLOGRAPHY 69, 1223 (2013).
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AAscan, PCRdesign and MutantChecker: A Suite of Programs for Primer Design and Sequence Analysis for High-Throughput Scanning Mutagenesis Sun D, Ostermaier Martin K, Heydenreich Franziska M, Mayer D, Jaussi R, Standfuss J, Veprintsev Dmitry B
PLOS ONE 8, e78878 (2013).
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An efficient nanolitre-volume multi-channel device for highly viscous materials used in membrane protein crystallization Luo J, Zwier R, Abrahams J
JOURNAL OF APPLIED CRYSTALLOGRAPHY 46, 829 (2013).
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Anomalous signal from S atoms in protein crystallographic data from an X-ray free-electron laser Barends Thomas R M, Foucar Lutz, Shoeman Robert L, Bari Sadia, Epp Sascha W, Hartmann Robert, Hauser Gunter, Huth Martin, Kieser Christian, Lomb Lukas, Motomura Koji, Nagaya Kiyonobu, Schmidt Carlo, Strecker Rafael, Anielski Denis, Boll Rebecca, Erk Benjamin, Fukuzawa Hironobu, Hartmann Elisabeth, Hatsui Takaki, Holl Peter, Inubushi Yuichi, Ishikawa Tetsuya, Kassemeyer Stephan, Kaiser Christian, Koeck Frank, Kunishima Naoki, Kurka Moritz, Rolles Daniel, Rudek Benedikt, Rudenko Artem, Sato Takahiro, Schroeter Claus-Dieter, Soltau Heike, Strueder Lothar, Tanaka Tomoyuki, Togashi Tadashi, Tono Kensuke, Ullrich Joachim, Yase Satoshi, Wada Shin-ichi, Yao Makoto, Yabashi Makina, Ueda Kiyoshi, Schlichting Ilme
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 69, 838-842 (2013).
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Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry Hilbert M, Erat MC, Hachet V, Guichard P, Blank ID, Fluckiger I, Slater L, Lowe ED, Hatzopoulos GN, Steinmetz MO, Gonczy P, Vakonakis I
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110, 11373 (2013).
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Capture of unstable protein complex on the streptavidin-coated single-walled carbon nanotubes Liu Z, Voskamp P, Zhang Y, Chu F, Abrahams J
JOURNAL OF NANOPARTICLE RESEARCH 15, (2013).
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Cellular Polyamines Promote Amyloid-Beta (A?) Peptide Fibrillation and Modulate the Aggregation Pathways Luo J, Yu C, Yu H, Borstnar R, Kamerlin Shina CL, Gräslund A, Abrahams J, Wärmländer Sebastian KTS
ACS Chemical Neuroscience 4, 454 (2013).
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Cholesterol-Diethylenetriaminepentaacetate Complexed with Thulium Ions Integrated into Bicelles To Increase Their Magnetic Alignability Liebi M, Kuster S, Kohlbrecher J, Ishikawa T, Fischer P, Walde P, Windhab Erich J
JOURNAL OF PHYSICAL CHEMISTRY B 117, 14743 (2013).
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Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding Vishnivetskiy SergeyA, Ostermaier Martin K, Singhal A, Panneels V, Homan Kristoff T, Glukhova A, Sligar Stephen G, Tesmer John JG, Schertler Gebhard FX, Standfuss J, Gurevich Vsevolod V
CELLULAR SIGNALLING 25, 2155 (2013).
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Coordination of VEGF receptor trafficking and signaling by coreceptors Nakayama M, Berger P
EXPERIMENTAL CELL RESEARCH 319, 1340 (2013).
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Cryo-scanning x-ray diffraction microscopy of frozen-hydrated yeast Lima E, Diaz A, Guizar-Sicairos M, Gorelick S, Pernot P, Schleier T, Menzel A
JOURNAL OF MICROSCOPY 249, 1-7 (2013).
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End Binding Proteins Are Obligatory Dimers Wiche G, Sen I, Veprintsev D, Akhmanova A, Steinmetz Michel O
PLOS ONE 8, e74448 (2013).
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End-binding proteins sensitize microtubules to the action of microtubule-targeting agents Mohan Renu, Katrukha Eugene A, Doodhi Harinath, Smal Ihor, Meijering Erik, Kapitein Lukas C, Steinmetz Michel O, Akhmanova Anna
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110, 8900-8905 (2013).
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Human lysozyme inhibits the in vitro aggregation of A? peptides, which in vivo are associated with Alzheimer's disease Luo J, Wärmländer Sebastian KTS, Gräslund A, Abrahams J
CHEMICAL COMMUNICATIONS 49, 6507 (2013).
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Imaging protein three-dimensional nanocrystals with cryo-EM Nederlof I, Li Y, van Heel M, Abrahams J
ACTA CRYSTALLOGRAPHICA SECTION D - BIOLOGICAL CRYSTALLOGRAPHY 69, 852 (2013).
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Insights into congenital stationary night blindness based on the structure of G90D rhodopsin Singhal Ankita, Ostermaier Martin K, Vishnivetskiy Sergey A, Panneels Valerie, Homan Kristoff T, Tesmer John J G, Veprintsev Dmitry, Deupi Xavier, Gurevich Vsevolod V, Schertler Gebhard F X, Standfuss Joerg
EMBO REPORTS 14, 520-526 (2013).
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Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents Prota Andrea E, Bargsten Katja, Zurwerra Didier, Field Jessica J, Fernando Diaz Jose, Altmann Karl-Heinz, Steinmetz Michel O
SCIENCE 339, 587-590 (2013).
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Molecular signatures of G-protein-coupled receptors Venkatakrishnan A J, Deupi Xavier, Lebon Guillaume, Tate Christopher G, Schertler Gebhard F, Babu M Madan
NATURE 494, 185-194 (2013).
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Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry Guichard P, Hachet V, Majubu N, Neves A, Demurtas D, Olieric N, Fluckiger I, Yamada A, Kihara K, Nishida Y, Moriya S, Steinmetz Michel O, Hongoh Y, Gönczy P
CURRENT BIOLOGY 23, 1620 (2013).
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Quaternary Dynamics of the SecA Motor Drive Translocase Catalysis Gouridis G, Karamanou S, Sardis MF, Schaerer MA, Capitani G, Economou A
MOLECULAR CELL 52, 655-666 (2013).
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Relation between sequence and structure in membrane proteins Olivella Mireia, Gonzalez Angel, Pardo Leonardo, Deupi Xavier
BIOINFORMATICS 29, 1589-1592 (2013).
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Structural Basis for Universal Corrinoid Recognition by the Cobalamin Transport Protein Haptocorrin Furger E, Frei DC, Schibli R, Fischer E, Prota AE
JOURNAL OF BIOLOGICAL CHEMISTRY 288, 25466 (2013).
Structural Basis for the Oligomerization-State Switch from a Dimer to a Trimer of an Engineered Cortexillin-1 Coiled-Coil Variant Bjelic Sasa, Wieser Mara, Frey Daniel, Stirnimann Christian U, Chance Mark R, Jaussi Rolf, Steinmetz Michel O, Kammerer Richard A
PLOS ONE 8, e63370 (2013).
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Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation Leppanen Veli-Matti, Tvorogov Denis, Kisko Kaisa, Prota Andrea E, Jeltsch Michael, Anisimov Andrey, Markovic-Mueller Sandra, Stuttfeld Edward, Goldie Kenneth N, Ballmer-Hofer Kurt, Alitalo Kari
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110, 12960-12965 (2013).
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Structural basis of tubulin tyrosination by tubulin tyrosine ligase Prota Andrea E, Magiera Maria M, Kuijpers Marijn, Bargsten Katja, Frey Daniel, Wieser Mara, Jaussi Rolf, Hoogenraad Casper C, Kammerer Richard A, Janke Carsten, Steinmetz Michel O
JOURNAL OF CELL BIOLOGY 200, 259-270 (2013).
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Structure of beta-Adrenergic Receptors Brueckner Florian, Piscitelli Chayne L, Tsai Ching-Ju, Standfuss Joerg, Deupi Xavier, Schertler Gebhard F X
G PROTEIN COUPLED RECEPTORS: STRUCTURE 520, 117-151 (2013).
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TRiC?s tricks inhibit huntingtin aggregation Shahmoradian S, Galaz-Montoya J, Schmid M, Cong Y, Ma B, Spiess C, Frydman J, Ludtke S, Chiu W
ELIFE 2, - (2013).
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Two Alternative Conformations of a Voltage-Gated Sodium Channel Tsai C, Tani K, Irie K, Hiroaki Y, Shimomura T, McMillan Duncan G, Cook Gregory M, Schertler Gebhard FX, Fujiyoshi Y, Li X
JOURNAL OF MOLECULAR BIOLOGY 425, 4074 (2013).
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Visualizing the localization of transfection complexes during graphene nanoparticle-based transfection Bruggencate F, Laroche F, Zhang Y, Song G, Yin S, Abrahams J, Liu Z
JOURNAL OF MATERIALS CHEMISTRY B 1, 6353 (2013).
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2012

A Proteome-wide Screen for Mammalian SxIP Motif-Containing Microtubule Plus-End Tracking Proteins Jiang K, Toedt G, Montenegro Gouveia S, Davey Norman E, Hua S, van der Vaart B, Grigoriev I, Larsen J, Pedersen Lotte B, Bezstarosti K, Lince-Faria M, Demmers J, Steinmetz Michel O, Gibson Toby J, Akhmanova A
CURRENT BIOLOGY 22, 1800 (2012).
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An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid de la Roche Marc, Rutherford Trevor J, Gupta Deepti, Veprintsev Dmitry B, Saxty Barbara, Freund Stefan M, Bienz Mariann
NATURE COMMUNICATIONS 3, 680 (2012).
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Bin2 Is a Membrane Sculpting N-BAR Protein That Influences Leucocyte Podosomes, Motility and Phagocytosis Soldati T, Sánchez-Barrena M, Vallis Y, Clatworthy Menna R, Doherty Gary J, Veprintsev Dmitry B, Evans Philip R, McMahon Harvey T
PLOS ONE 7, e52401 (2012).
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Characterisation of a counting imaging detector for electron detection in the energy range 10?20keV Moldovan G, Sikharulidze I, Matheson J, Derbyshire G, Kirkland AI, Abrahams JP
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Dectectors and Associated Equipment 681, 21 (2012).
DOI: 10.1016/j.nima.2012.03.033
Comparative structural analysis of eukaryotic flagella and cilia from Chlamydomonas, Tetrahymena, and sea urchins Pigino G, Maheshwari A, Bui K, Shingyoji C, Kamimura S, Ishikawa T
JOURNAL OF STRUCTURAL BIOLOGY 178, 199 (2012).
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Conformation Effects of CpG Methylation on Single-Stranded DNA Oligonucleotides: Analysis of the Opioid Peptide Dynorphin-Coding Sequences Taqi M, Wärmländer Sebastian KTS, Yamskova O, Madani F, Bazov I, Luo J, Zubarev R, Verbeek D, Gräslund A, Bakalkin G
PLOS ONE 7, e39605 (2012).
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Conserved activation pathways in G-protein-coupled receptors Deupi X, Standfuss J, Schertler G
BIOCHEMICAL SOCIETY TRANSACTIONS 40, 383-388 (2012).
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Cooperative Stabilization of Microtubule Dynamics by EB1 and CLIP-170 Involves Displacement of Stably Bound P i at Microtubule Ends Lopus M, Manatschal C, Buey Ruben M, Bjelic S, Miller Herbert P, Steinmetz Michel O, Wilson L
BIOCHEMISTRY 51, 3021 (2012).
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Functionalized Low-Density Lipoprotein Nanoparticles for in Vivo Enhancement of Atherosclerosis on Magnetic Resonance Images Lowell Andrew N, Qiao H, Liu T, Ishikawa T, Zhang H, Oriana S, Wang M, Ricciotti E, FitzGerald Garret A, Zhou R, Yamakoshi Y
BIOCONJUGATE CHEMISTRY 23, 2313 (2012).
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Influence of 63Ser Phosphorylation and Dephosphorylation on the Structure of the Stathmin Helical Nucleation Sequence: A Molecular Dynamics Study Missimer John H, Steinmetz Michel O, van Gunsteren Wilfred F, Dolenc Jozica
BIOCHEMISTRY 51, 8455-8463 (2012).
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Interaction of mammalian end binding proteins with CAP-Gly domains of CLIP-170 and p150(glued) Bjelic S, De Groot CO, Scharer MA, Jaussi R, Bargsten K, Salzmann M, Frey D, Capitani G, Kammerer RA, Steinmetz MO
JOURNAL OF STRUCTURAL BIOLOGY 177, 160 (2012).
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Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2 Vogel SM, Bauer MR, Joerger AC, Wilcken R, Brandt T, Veprintsev DB, Rutherford TJ, Fersht AR, Boeckler FM
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109, 16906 (2012).
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Molecular Basis for Modulation of the p53 Target Selectivity by KLF4 Mayer C, Brandt T, Townsley Fiona M, Teufel Daniel P, Freund Stefan MV, Veprintsev Dmitry B
PLOS ONE 7, e48252 (2012).
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Mouse respiratory cilia with the asymmetric axonemal structure on sparsely distributed ciliary cells can generate overall directional flow Ueno H, Ishikawa T, Bui K, Gonda K, Ishikawa T, Yamaguchi T
Nanomedicine: Nanotechnology, Biology and Medicine 8, 1081 (2012).
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Polarity and asymmetry in the arrangement of dynein and related structures in the Chlamydomonas axoneme Bui K, Yagi T, Yamamoto R, Kamiya R, Ishikawa T
The Journal of Cell Biology 198, 913 (2012).
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Practical Aspects in Expression and Purification of Membrane Proteins for Structural Analysis Vinothkumar Kutti R, Edwards Patricia C, Standfuss J
Methods in Molecular Biology 955, 17 (2012).
DOI: 10.1007/978-1-62703-176-9_2
Probing the Structure and Dynamics of Proteins by Combining Molecular Dynamics Simulations and Experimental NMR Data Allison Jane R, Hertig S, Missimer John H, Smith Lorna J, Steinmetz Michel O, Dolenc J
JOURNAL OF CHEMICAL THEORY AND COMPUTATION 8, 3430 (2012).
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Protein interface classification by evolutionary analysis Duarte JM, Srebniak A, Scharer MA, Capitani G
BMC BIOINFORMATICS 13, 334 (2012).
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Quality control of disulfide bond formation in pilus subunits by the chaperone FimC Crespo MD, Puorger C, Scharer MA, Eidam O, Grutter MG, Capitani G, Glockshuber R
NATURE CHEMICAL BIOLOGY 8, 707-713 (2012).
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Revisiting the Supramolecular Organization of Photosystem II in Chlamydomonas reinhardtii Tokutsu R, Kato N, Bui KH, Ishikawa T, Minagawa J
JOURNAL OF BIOLOGICAL CHEMISTRY 287, 31574 (2012).
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Sequence Determinants of a Microtubule Tip Localization Signal (MtLS) Buey RM, Sen I, Kortt O, Mohan R, Gfeller D, Veprintsev D, Kretzschmar I, Scheuermann J, Neri D, Zoete V, Michielin O, de Pereda JM, Akhmanova A, Volkmer R, Steinmetz MO
JOURNAL OF BIOLOGICAL CHEMISTRY 287, 28227 (2012).
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Single-Walled Carbon Nanotubes as Scaffolds to Concentrate DNA for the Study of DNA-Protein Interactions Liu Z, Galli F, Waterreus W, Meulenbroek E, Koning Roman I, Lamers Gerda EM, Olsthoorn René CL, Pannu N, Oosterkamp TjerkH, Koster Abraham J, Dame Remus T, Abrahams J
CHEMPHYSCHEM 13, 1569 (2012).
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Specific Recognition of p53 Tetramers by Peptides Derived from p53 Interacting Proteins Jones D, Gabizon R, Brandt T, Sukenik S, Lahav N, Lebendiker M, Shalev Deborah E, Veprintsev D, Friedler A
PLOS ONE 7, e38060 (2012).
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Stability of p53 Homologs Jones DDafydd, Brandt T, Kaar Joel L, Fersht Alan R, Veprintsev Dmitry B
PLOS ONE 7, e47889 (2012).
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Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II Deupi X, Edwards P, Singhal A, Nickle B, Oprian D, Schertler G, Standfuss J
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109, 119 (2012).
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Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy Rahmeh R, Damian M, Cottet M, Orcel H, Mendre C, Durroux T, Sharma KS, Durand G, Pucci B, Trinquet E, Zwier JM, Deupi X, Bron P, Baneres JL, Mouillac B, Granier S
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109, 6733-6738 (2012).
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Structure of a post-translationally processed heterodimeric double-headed Kunitz-type serine protease inhibitor from potato Meulenbroek Elisabeth M, Thomassen Ellen AJ, Pouvreau L, Abrahams J, Gruppen H, Pannu Navraj S
ACTA CRYSTALLOGRAPHICA SECTION D - BIOLOGICAL CRYSTALLOGRAPHY 68, 794 (2012).
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Supramolecular Non-Amyloid Intermediates in the Early Stages of ?-Synuclein Aggregation Fauerbach Jonathan A, Yushchenko Dmytro A, Shahmoradian Sarah H, Chiu W, Jovin Thomas M, Jares-Erijman Elizabeth A
BIOPHYSICAL JOURNAL 102, 1127 (2012).
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Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization Brozzo MS, Bjelic S, Kisko K, Schleier T, Leppanen VM, Alitalo K, Winkler FK, Ballmer-Hofer K
BLOOD 119, 1781 (2012).
DOI: 10.1182/blood-2011-11-390922
Tyrosine-dependent capture of CAP-Gly domain-containing proteins in complex mixture by EB1 C-terminal peptidic probes Calligaris D, Manatschal C, Marcellin M, Villard C, Monsarrat B, Burlet-Schiltz O, Steinmetz Michel O, Braguer D, Lafitte D, Verdier-Pinard P
Journal of Proteomics 75, 3605 (2012).
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Ultra-small graphene oxide functionalized with polyethylenimine (PEI) for very efficient gene delivery in cell and zebrafish embryos Zhou X, Laroche F, Lamers Gerda EM, Torraca V, Voskamp P, Lu T, Chu F, Spaink Herman P, Abrahams J, Liu Z
Nano Research 5, 703 (2012).
DOI: 10.1007/s12274-012-0254-x

2011

A Prokaryotic S1P Lyase Degrades Extracellular S1P In Vitro and In Vivo: Implication for Treating Hyperproliferative Disorders Ho P, Huwiler A, Bourquin F, Kotelevets N, Pastukhov O, Capitani G, Grütter Markus G, Zangemeister-Wittke U
PLOS ONE 6, e22436 (2011).
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A Straightforward and Robust Method for Introducing Human Hair as a Nucleant into High Throughput Crystallization Trials Nederlof I, Hosseini R, Georgieva D, Luo J, Li D, Abrahams J
CRYSTAL GROWTH & DESIGN 11, 1170 (2011).
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A direct way of redox sensing Benoit Roger M, Auer Manfred
RNA BIOLOGY 8, 18-23 (2011).
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Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration Arbely E, Natan E, Brandt T, Allen MD, Veprintsev DB, Robinson CV, Chin JW, Joerger AC, Fersht AR
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108, 8251 (2011).
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Advances in the CRANK software suite for automated crystal structure solution Waterreus WJ, Skubák P, Sikharulidze I, Abrahams JP, de Graaff RAG, Pannu NS
Acta Crystallographica Section A Foundations of Crystallography 67, C659 (2011).
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CMView: Interactive contact map visualization and analysis Vehlow C, Stehr H, Winkelmann M, Duarte JM, Petzold L, Dinse J, Lappe M
BIOINFORMATICS 27, 1573 (2011).
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Cholesterol attenuates and prevents bilayer damage and breakdown in lipoperoxidized model membranes. A spin labeling EPR study Megli Francesco M, Conte E, Ishikawa T
Biochimica et Biophysica Acta (BBA) - Biomembranes 1808, 2267 (2011).
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Cryoelectron tomography of radial spokes in cilia and flagella Pigino G, Bui K, Maheshwari A, Lupetti P, Diener D, Ishikawa T
The Journal of Cell Biology 195, 673 (2011).
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Crystal structure of the GlnZ-DraG complex reveals a different form of P-II-target interaction Rajendran C, Gerhardt ECM, Bjelic S, Gasperina A, Scarduelli M, Pedrosa FO, Chubatsu LS, Merrick M, Souza EM, Winkler FK, Huergo LF, Li XD
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108, 18972 (2011).
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EDIFF : a program for automated unit-cell determination and indexing of electron diffraction data Jiang L, Georgieva D, Abrahams J
JOURNAL OF APPLIED CRYSTALLOGRAPHY 44, 1132 (2011).
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ELM--the database of eukaryotic linear motifs Dinkel H, Michael S, Weatheritt RJ, Davey NE, Van Roey K, Altenberg B, Toedt G, Uyar B, Seiler M, Budd A, Jodicke L, Dammert MA, Schroeter C, Hammer M, Schmidt T, Jehl P, McGuigan C, Dymecka M, Chica C, Luck K, Via A, Chatr-aryamontri A, Haslam N, Grebnev G, Edwards RJ, Steinmetz MO, Meiselbach H, Diella F, Gibson TJ
NUCLEIC ACIDS RESEARCH 40, D242 (2011).
DOI: 10.1093/nar/gkr1064
Electron diffraction of submicron three-dimensional protein crystals Nederlof I, Georgieva D, Abrahams JP
Acta Crystallographica Section A Foundations of Crystallography 67, C228 (2011).
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Evaluation of Medipix2 detector for recording electron diffraction data in low dose conditions Georgieva D, Jansen J, Sikharulidze I, Jiang L, Zandbergen H, Abrahams J
JOURNAL OF INSTRUMENTATION 6, C01033 (2011).
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IMPROVED IMAGING IN LOW ENERGY ELECTRON MICROSCOPY AND PHOTO EMISSION ELECTRON MICROSCOPY USING MEDIPIX2 PIXEL DETECTOR SIKHARULIDZE I, van GASTEL R, SCHRAMM S, ABRAHAMS JP, POELSEMA B, TROM RM, van der MOLEN SJ
Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications , (2011).
DOI: 10.1142/9789814307529_0023
Image Processing and Lattice Determination for Three-Dimensional Nanocrystals Jiang L, Georgieva D, Nederlof I, Liu Z, Abrahams J
MICROSCOPY AND MICROANALYSIS 17, 879 (2011).
DOI: 10.1017/S1431927611012244
Insights into EB1 structure and the role of its C-terminal domain for discriminating microtubule tips from the lattice Buey RM, Mohan R, Leslie K, Walzthoeni T, Missimer JH, Menzel A, Bjelic S, Bargsten K, Grigoriev I, Smal I, Meijering E, Aebersold R, Akhmanova A, Steinmetz MO
MOLECULAR BIOLOGY OF THE CELL 22, 2912 (2011).
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Integration of multiple expression cassettes into mammalian genomes in a single step Kriz A, Schmid K, Ballmer K, Berger P
Protocol Exchange , (2011).
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Low energy electron microscopy imaging using Medipix2 detector Sikharulidze I, van Gastel R, Schramm S, Abrahams JP, Poelsema B, Tromp RM, van der Molen SJ
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Dectectors and Associated Equipment 633, S239 (2011).
DOI: 10.1016/j.nima.2010.06.177
Low-resolution electron crystallography challenges in organic and inorganic crystals with transmission electron microscope (TEM) Nicolopoulos S, Rauch E, Georgieva D, Abrahams JP
Acta Crystallographica Section A Foundations of Crystallography 67, C188 (2011).
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Microtubule End Binding: EBs Sense the Guanine Nucleotide State Akhmanova A, Steinmetz MO
CURRENT BIOLOGY 21, R283 (2011).
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Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output Ballmer-Hofer K, Andersson AE, Ratcliffe LE, Berger P
BLOOD 118, 816 (2011).
DOI: 10.1182/blood-2011-01-328773
Preparation of an Activated Rhodopsin/Transducin Complex Using a Constitutively Active Mutant of Rhodopsin Xie G, D?Antona Aaron M, Edwards Patricia C, Fransen M, Standfuss J, Schertler Gebhard FX, Oprian Daniel D
BIOCHEMISTRY 50, 10399 (2011).
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Quaternary Structure of the Oxaloacetate Decarboxylase Membrane Complex and Mechanistic Relationships to Pyruvate Carboxylases Balsera M, Buey RM, Li XD
JOURNAL OF BIOLOGICAL CHEMISTRY 286, 9457 (2011).
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RNA polymerase I?specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle Albert B, Léger-Silvestre I, Normand C, Ostermaier M, Pérez-Fernández J, Panov Kostya I, Zomerdijk Joost CBM, Schultz P, Gadal O
The Journal of Cell Biology 192, 277 (2011).
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Recent advances in the CRANK software suite for experimental phasing Pannu Navraj S, Waterreus W, Skubák P, Sikharulidze I, Abrahams J, de Graaff Rudolf AG
ACTA CRYSTALLOGRAPHICA SECTION D - BIOLOGICAL CRYSTALLOGRAPHY 67, 331 (2011).
DOI: 10.1107/S0907444910052224
SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase van der Vaart B, Manatschal C, Grigoriev I, Olieric V, Gouveia SM, Bjelic S, Demmers J, Vorobjev I, Hoogenraad CC, Steinmetz MO, Akhmanova A
JOURNAL OF CELL BIOLOGY 193, 1083 (2011).
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Structural Basis of the 9-Fold Symmetry of Centrioles Kitagawa D, Vakonakis I, Olieric N, Hilbert M, Keller D, Olieric V, Bortfeld M, Erat MC, Fluckiger I, Gonczy P, Steinmetz MO
CELL 144, 364 (2011).
DOI: 10.1016/j.cell.2011.01.008
Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering Kisko K, Brozzo MS, Missimer J, Schleier T, Menzel A, Leppanen VM, Alitalo K, Walzthoeni T, Aebersold R, Ballmer-Hofer K
FASEB JOURNAL 25, 2980 (2011).
DOI: 10.1096/fj.11-185397
Structural basis for reduced activity of 1-aminocyclopropane-1-carboxylate synthase affected by a mutation linked to andromonoecy Scharer MA, Eliot AC, Grutter MG, Capitani G
FEBS LETTERS 585, 111 (2011).
DOI: 10.1016/j.febslet.2010.11.013
Structural determinants of vascular endothelial growth factor-D receptor binding and specificity Leppanen VM, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, Toivanen P, Yla-Herttuala S, Ballmer-Hofer K, Alitalo K
BLOOD 117, 1507 (2011).
DOI: 10.1182/blood-2010-08-301549
Structural insights into agonist-induced activation of G-protein-coupled receptors Deupi X, Standfuss J
CURRENT OPINION IN STRUCTURAL BIOLOGY 21, 541 (2011).
DOI: 10.1016/j.sbi.2011.06.002
Structures of SAS-6 Suggest Its Organization in Centrioles van Breugel M, Hirono M, Andreeva A, Yanagisawa Ha, Yamaguchi S, Nakazawa Y, Morgner N, Petrovich M, Ebong IO, Robinson CV, Johnson CM, Veprintsev D, Zuber B
SCIENCE 331, 1196 (2011).
DOI: 10.1126/science.1199325
Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers Rossmann M, Sukumaran M, Penn A, Veprintsev D, Babu M, Greger I
The EMBO Journal 30, 959 (2011).
DOI: 10.1038/emboj.2011.16
The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signalling Berger P, Tersar K, Ballmer-Hofer K, Suter U
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 15, 307 (2011).
DOI: 10.1111/j.1582-4934.2009.00967.x
The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger Eustermann S, Videler H, Yang J, Cole Paul T, Gruszka D, Veprintsev D, Neuhaus D
JOURNAL OF MOLECULAR BIOLOGY 407, 149 (2011).
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The structural basis for agonist and partial agonist action on a beta(1)-adrenergic receptor Warne T, Moukhametzianov R, Baker JG, Nehme R, Edwards PC, Leslie AGW, Schertler GFX, Tate CG
NATURE 469, 241 (2011).
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The structural basis of agonist-induced activation in constitutively active rhodopsin Standfuss J, Edwards PC, D'Antona A, Fransen M, Xie GF, Oprian DD, Schertler GFX
NATURE 471, 656 (2011).
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The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors Stehr H, Jang S, Duarte J, Wierling C, Lehrach H, Lappe M, Lange B
Molecular Cancer 10, 54 (2011).
DOI: 10.1186/1476-4598-10-54
Two distinct conformations of helix 6 observed in antagonist-bound structures of a beta(1)-adrenergic receptor Moukhametzianov R, Warne T, Edwards PC, Serrano-Vega MJ, Leslie AGW, Tate CG, Schertler GFX
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108, 8228 (2011).
DOI: 10.1073/pnas.1100185108

2010

A Graphene Oxide?Streptavidin Complex for Biorecognition - Towards Affinity Purification Liu Z, Jiang L, Galli F, Nederlof I, Olsthoorn René CL, Lamers Gerda EM, Oosterkamp TjerkH, Abrahams J
ADVANCED FUNCTIONAL MATERIALS 20, 2857 (2010).
DOI: 10.1002/adfm.201000761
A New P-II Protein Structure Identifies the 2-Oxoglutarate Binding Site Truan D, Huergo LF, Chubatsu LS, Merrick M, Li XD, Winkler FK
JOURNAL OF MOLECULAR BIOLOGY 400, 531 (2010).
DOI: 10.1016/j.jmb.2010.05.036
A novel approximation method of CTF amplitude correction for 3D single particle reconstruction Jiang L, Liu Z, Georgieva D, Kuil Maxim E, Abrahams J
ULTRAMICROSCOPY 110, 350 (2010).
DOI: 10.1016/j.ultramic.2010.01.011
A plasmid-based multigene expression system for mammalian cells Kriz A, Schmid K, Baumgartner N, Ziegler U, Berger I, Ballmer-Hofer K, Berger P
NATURE COMMUNICATIONS 1, 120 (2010).
DOI: 10.1038/ncomms1120
Automated seamless DNA co-transformation cloning with direct expression vectors applying positive or negative insert selection Olieric N, Kuchen M, Wagen S, Sauter M, Crone S, Edmondson S, Frey D, Ostermeier C, Steinmetz M, Jaussi R
BMC BIOTECHNOLOGY 10, 56 (2010).
DOI: 10.1186/1472-6750-10-56
CRK: An evolutionary approach for distinguishing biologically relevant interfaces from crystal contacts Scharer MA, Grutter MG, Capitani G
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 78, 2707 (2010).
DOI: 10.1002/prot.22787
Dissecting the Relation between a Nuclear Receptor and GATA: Binding Affinity Studies of Thyroid Hormone Receptor and GATA2 on TSH? Promoter Pazin Michael J, Figueira A, Polikarpov I, Veprintsev D, Santos G
PLOS ONE 5, e12628 (2010).
DOI: 10.1371/journal.pone.0012628
Drosophila Stathmins Bind Tubulin Heterodimers with High and Variable Stoichiometries Lachkar S, Lebois M, Steinmetz MO, Guichet A, Lal N, Curmi PA, Sobel A, Ozon S
JOURNAL OF BIOLOGICAL CHEMISTRY 285, 11667 (2010).
DOI: 10.1074/jbc.M109.096727
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA Melero R, Rajagopalan S, Lazaro M, Joerger AC, Brandt T, Veprintsev DB, Lasso G, Gil D, Scheres SHW, Carazo JM, Fersht AR, Valle M
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108, 557 (2010).
DOI: 10.1073/pnas.1015520107
Exploring the trigger sequence of the GCN4 coiled-coil: Biased molecular dynamics resolves apparent inconsistencies in NMR measurements Missimer JH, Dolenc J, Steinmetz MO, van Gunsteren WF
PROTEIN SCIENCE 19, 2462 (2010).
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Features critical for membrane binding revealed by DivIVA crystal structure Oliva M, Halbedel S, Freund S, Dutow P, Leonard T, Veprintsev D, Hamoen L, Löwe J
The EMBO Journal 29, 1988 (2010).
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Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2 Mitola S, Ravelli C, Moroni E, Salvi V, Leali D, Ballmer-Hofer K, Zammataro L, Presta M
BLOOD 116, 3677 (2010).
DOI: 10.1182/blood-2010-06-291930
In Vitro Reconstitution of the Functional Interplay between MCAK and EB3 at Microtubule Plus Ends Gouveia SM, Leslie K, Kapitein LC, Buey RM, Grigoriev I, Wagenbach M, Smal I, Meijering E, Hoogenraad CC, Wordeman L, Steinmetz MO, Akhmanova A
CURRENT BIOLOGY 20, 1717 (2010).
DOI: 10.1016/j.cub.2010.08.020
Insights into Peroxisome Function from the Structure of PEX3 in Complex with a Soluble Fragment of PEX19 Schmidt F, Treiber N, Zocher G, Bjelic S, Steinmetz MO, Kalbacher H, Stehle T, Dodt G
JOURNAL OF BIOLOGICAL CHEMISTRY 285, 25410 (2010).
DOI: 10.1074/jbc.M110.138503
Laminin chain assembly is regulated by specific coiled-coil interactions Macdonald PR, Lustig A, Steinmetz MO, Kammerer RA
JOURNAL OF STRUCTURAL BIOLOGY 170, 398 (2010).
DOI: 10.1016/j.jsb.2010.02.004
Methods of NMR structure refinement: molecular dynamics simulations improve the agreement with measured NMR data of a C-terminal peptide of GCN4-p1 Dolenc J, Missimer John H, Steinmetz Michel O, van Gunsteren Wilfred F
JOURNAL OF BIOMOLECULAR NMR 47, 221 (2010).
DOI: 10.1007/s10858-010-9425-9
Microtubule plus TIPs at a glance Akhmanova A, Steinmetz MO
JOURNAL OF CELL SCIENCE 123, 3415 (2010).
DOI: 10.1242/jcs.062414
Molecular Insights into Mammalian End-binding Protein Heterodimerization De Groot CO, Jelesarov I, Damberger FF, Bjelic S, Scharer MA, Bhavesh NS, Grigoriev I, Buey RM, Wuthrich K, Capitani G, Akhmanova A, Steinmetz MO
JOURNAL OF BIOLOGICAL CHEMISTRY 285, 5802 (2010).
DOI: 10.1074/jbc.M109.068130
Molecular basis of coiled-coil oligomerization-state specificity Ciani B, Bjelic S, Honnappa S, Jawhari H, Jaussi R, Payapilly A, Jowitt T, Steinmetz MO, Kammerer RA
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107, 19850 (2010).
DOI: 10.1073/pnas.1008502107
Nucleotide-induced global conformational changes of flagellar dynein arms revealed by in situ analysis Movassagh T, Bui K, Sakakibara H, Oiwa K, Ishikawa T
NATURE STRUCTURAL & MOLECULAR BIOLOGY 17, 761 (2010).
DOI: 10.1038/nsmb.1832
Optimal contact definition for reconstruction of Contact Maps Duarte J, Sathyapriya R, Stehr H, Filippis I, Lappe M
BMC BIOINFORMATICS 11, 283 (2010).
DOI: 10.1186/1471-2105-11-283
PDBWiki: added value through community annotation of the Protein Data Bank Stehr H, Duarte JM, Lappe M, Bhak J, Bolser DM
Database 2010, baq009 (2010).
DOI: 10.1093/database/baq009
Phage-Derived Fully Human Monoclonal Antibody Fragments to Human Vascular Endothelial Growth Factor-C Block Its Interaction with VEGF Receptor-2 and 3 Rinderknecht M, Villa A, Ballmer-Hofer K, Neri D, Detmar M
PLOS ONE 5, e11941 (2010).
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Spial: analysis of subtype-specific features in multiple sequence alignments of proteins Wuster A, Venkatakrishnan AJ, Schertler GFX, Babu MM
BIOINFORMATICS 26, 2906 (2010).
DOI: 10.1093/bioinformatics/btq552
Stable Single-Walled Carbon Nanotube-Streptavidin Complex for Biorecognition Liu Z, Galli F, Janssen Kjeld GH, Jiang L, van der Linden Heiko J, de Geus Daniel C, Voskamp P, Kuil Maxim E, Olsthoorn Rene CL, Oosterkamp TjerkH, Hankemeier T, Abrahams J
JOURNAL OF PHYSICAL CHEMISTRY C 114, 4345 (2010).
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Structural determinants of growth factor binding and specificity by VEGF receptor 2 Leppanen VM, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, Lankinen H, Goldman A, Ballmer-Hofer K, Alitalo K
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107, 2425 (2010).
DOI: 10.1073/pnas.0914318107
Structure and Function of Sphingosine-1-Phosphate Lyase, a Key Enzyme of Sphingolipid Metabolism Bourquin F, Riezman H, Capitani G, Grutter MG
STRUCTURE 18, 1054 (2010).
DOI: 10.1016/j.str.2010.05.011
Structure of full-length arrestin2 in a dimeric crystal form Zhou H G, Standfuss J, Watson K A, Krasel C
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 381, 13-13 (2010).
Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling Grunewald FS, Prota AE, Giese A, Ballmer-Hofer K
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1804, 567 (2010).
DOI: 10.1016/j.bbapap.2009.09.002
The strong phase object approximation may allow extending crystallographic phases of dynamical electron diffraction patterns of 3D protein nano-crystals Abrahams J
ZEITSCHRIFT FUR KRISTALLOGRAPHIE 225, (2010).
DOI: 10.1524/zkri.2010.1216
Three-dimensional structural analysis of eukaryotic flagella/cilia by electron cryo-tomography Bui K, Pigino G, Ishikawa T
JOURNAL OF SYNCHROTRON RADIATION 18, 2 (2010).
DOI: 10.1107/s0909049510036812
Transmembrane domain-mediated orientation of receptor monomers in active VEGFR-2 dimers Dosch DD, Ballmer-Hofer K
FASEB JOURNAL 24, 32 (2010).
DOI: 10.1096/fj.09-132670

2009

A Common Structural Basis for pH- and Calmodulin-mediated Regulation in Plant Glutamate Decarboxylase Gut H, Dominici P, Pilati S, Astegno A, Petoukhov MV, Svergun DI, Grutter MG, Capitani G
JOURNAL OF MOLECULAR BIOLOGY 392, 334 (2009).
DOI: 10.1016/j.jmb.2009.06.080
An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal Honnappa S, Gouveia SM, Weisbrich A, Damberger FF, Bhavesh NS, Jawhari H, Grigoriev I, van Rijssel FJA, Buey RM, Lawera A, Jelesarov I, Winkler FK, Wuthrich K, Akhmanova A, Steinmetz MO
CELL 138, 366 (2009).
DOI: 10.1016/j.cell.2009.04.065
An Intelligent Peak Search Program for Digital Electron Diffraction Images of 3D Nano-Crystals Jiang L, Georgieva D, IJspeert K, Abrahams J
2009 2nd International Congress on Image and Signal Processing , (2009).
DOI: 10.1109/CISP.2009.5301421
Asymmetry of inner dynein arms and inter-doublet links in Chlamydomonas flagella Bui K, Sakakibara H, Movassagh T, Oiwa K, Ishikawa T
The Journal of Cell Biology 186, 437 (2009).
DOI: 10.1083/jcb.200903082
Automated unrestricted multigene recombineering for multiprotein complex production Bieniossek C, Nie Y, Frey D, Olieric N, Schaffitzel C, Collinson I, Romier C, Berger P, Richmond T, Steinmetz M, Berger I
NATURE METHODS 6, 447 (2009).
DOI: 10.1038/nmeth.1326
Characterization of a diagnostic Fab fragment binding trimeric Lewis X de Geus Daniël C, van Roon AnneMarie M, Thomassen Ellen AJ, Hokke Cornelis H, Deelder André M, Abrahams J
PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS 76, 439 (2009).
DOI: 10.1002/prot.22356
Crystal Structure of Chlorite Dismutase, a Detoxifying Enzyme Producing Molecular Oxygen de Geus Daniël C, Thomassen Ellen AJ, Hagedoorn P, Pannu Navraj S, van Duijn E, Abrahams J
JOURNAL OF MOLECULAR BIOLOGY 387, 192 (2009).
DOI: 10.1016/j.jmb.2009.01.036
Engineering G protein-coupled receptors to facilitate their structure determination Tate CG, Schertler GFX
CURRENT OPINION IN STRUCTURAL BIOLOGY 19, 386 (2009).
DOI: 10.1016/j.sbi.2009.07.004
Identification and structural analysis of type I collagen sites in complex with fibronectin fragments Erat MC, Slatter DA, Lowe ED, Millard CJ, Farndale RW, Campbell ID, Vakonakis I
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106, 4195 (2009).
DOI: 10.1073/pnas.0812516106
Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models Leal A, Huehne K, Bauer F, Sticht H, Berger P, Suter U, Morera B, Del Valle G, Lupski James R, Ekici A, Pasutto F, Endele S, Barrantes R, Berghoff C, Berghoff M, Neundörfer B, Heuss D, Dorn T, Young P, Santolin L, Uhlmann T, Meisterernst M, Sereda M, zu Horste G, Nave K, Reis A, Rautenstrauss B
NEUROGENETICS 10, 275 (2009).
DOI: 10.1007/s10048-009-0183-3
Involvement of a carboxylated lysine in UV damage endonuclease Meulenbroek Elisabeth M, Paspaleva K, Thomassen Ellen AJ, Abrahams J, Goosen N, Pannu Navraj S
PROTEIN SCIENCE 18, 549 (2009).
DOI: 10.1002/pro.54
Latrophilin Signaling Links Anterior-Posterior Tissue Polarity and Oriented Cell Divisions in the C. elegans Embryo Langenhan T, Promel S, Mestek L, Esmaeili B, Waller-Evans H, Hennig C, Kohara Y, Avery L, Vakonakis I, Schnabel R, Russ AP
DEVELOPMENTAL CELL 17, 494 (2009).
DOI: 10.1016/j.devcel.2009.08.008
Macromolecular electron crystallography Abrahams J, Jiang L, Sikhuralidze I, Nederloff I, Zandbergen H, Georgieva D
Acta Crystallographica Section A Foundations of Crystallography 65, s7 (2009).
DOI: 10.1107/S0108767309099875
Mammalian Navigators are microtubule plus-end tracking proteins that can reorganize the cytoskeleton to induce neurite-like extensions van Haren J, Draegestein K, Keijzer N, Abrahams J, Grosveld F, Peeters P, Moechars D, Galjart N
Cell Motility and the Cytoskeleton 66, 824 (2009).
DOI: 10.1002/cm.20370
Mammalian end binding proteins control persistent microtubule growth Komarova Y, De Groot CO, Grigoriev I, Gouveia SM, Munteanu EL, Schober JM, Honnappa S, Buey RM, Hoogenraad CC, Dogterom M, Borisy GG, Steinmetz MO, Akhmanova A
JOURNAL OF CELL BIOLOGY 184, 691 (2009).
DOI: 10.1083/jcb.200807179
Medipix 2 detector applied to low energy electron microscopy van Gastel R, Sikharulidze I, Schramm S, Abrahams JP, Poelsema B, Tromp RM, van der Molen SJ
ULTRAMICROSCOPY 110, 33 (2009).
DOI: 10.1016/j.ultramic.2009.09.002
Motogenic Sites in Human Fibronectin Are Masked by Long Range Interactions Vakonakis I, Staunton D, Ellis IR, Sarkies P, Flanagan A, Schor AM, Schor SL, Campbell ID
JOURNAL OF BIOLOGICAL CHEMISTRY 284, 15668 (2009).
DOI: 10.1074/jbc.M109.003673
Mutation of His465 Alters the pH-dependent Spectroscopic Properties of Escherichia coli Glutamate Decarboxylase and Broadens the Range of Its Activity toward More Alkaline pH Pennacchietti E, Lammens TM, Capitani G, Franssen MCR, John RA, Bossa F, De Biase D
JOURNAL OF BIOLOGICAL CHEMISTRY 284, 31587 (2009).
DOI: 10.1074/jbc.M109.049577
Mutational studies of Pa-AGOG DNA glycosylase from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum Lingaraju Gondichatnahalli M, Prota AE, Winkler FK
DNA REPAIR 8, 857 (2009).
DOI: 10.1016/j.dnarep.2009.03.009
Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency Schulz BL, Stirnimann CU, Grimshaw JPA, Brozzo MS, Fritsch F, Mohorko E, Capitani G, Glockshuber R, Grutter MG, Aebi M
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106, 11061 (2009).
DOI: 10.1073/pnas.0812515106
Recent advances in CRANK Waterreus W, Pannu N, Skubák P, Sikharulidze I, Abrahams J, de Graaff RAG
Acta Crystallographica Section A Foundations of Crystallography 65, s160 (2009).
DOI: 10.1107/S0108767309096743
Recycling of Aborted Ribosomal 50S Subunit-Nascent Chain-tRNA Complexes by the Heat Shock Protein Hsp15 Jiang L, Schaffitzel C, Bingel-Erlenmeyer R, Ban N, Korber P, Koning Roman I, de Geus Daniël C, Plaisier Jasper R, Abrahams J
JOURNAL OF MOLECULAR BIOLOGY 386, 1357 (2009).
DOI: 10.1016/j.jmb.2008.10.079
Regulation of Microtubule Dynamic Instability in Vitro by Differentially Phosphorylated Stathmin Manna T, Thrower DA, Honnappa S, Steinmetz MO, Wilson L
JOURNAL OF BIOLOGICAL CHEMISTRY 284, 15640 (2009).
DOI: 10.1074/jbc.M900343200
Solid-State NMR Spectroscopy Reveals that E. coli Inclusion Bodies of HET-s(218 - 289) are Amyloids Wasmer C, Benkemoun L, Sabaté R, Steinmetz Michel O, Coulary-Salin B, Wang L, Riek R, Saupe Sven J, Meier Beat H
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 48, 4858 (2009).
DOI: 10.1002/anie.200806100
Terminal Adenosyl Transferase Activity of Posttranscriptional Regulator HuR Revealed by Confocal On-Bead Screening Meisner N, Hintersteiner M, Seifert J, Bauer R, Benoit R, Widmer A, Schindler T, Uhl V, Lang M, Gstach H, Auer M
JOURNAL OF MOLECULAR BIOLOGY 386, 435 (2009).
DOI: 10.1016/j.jmb.2008.12.020
The Max-Inf2/Lorentz Center workshop on New algorithms in macromolecular crystallography and electron microscopy Pannu Navraj S, Ravelli Raimond BG, Abrahams J
ACTA CRYSTALLOGRAPHICA SECTION D - BIOLOGICAL CRYSTALLOGRAPHY 65, 623 (2009).
DOI: 10.1107/S0907444909020861
The second level trigger system of FAST Martinez G, Barcyzk A, Berdugo J, Casaus J, Casella C, De Laere S, Deiters K, Dick P, Kirkby J, Malgeri L, Mana C, Marin J, Pohl M, Petitjean C, Sanchez E, Willmott C
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 609, 235 (2009).
DOI: 10.1016/j.nima.2009.07.097
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction Anthis NJ, Wegener KL, Ye F, Kim C, Goult BT, Lowe ED, Vakonakis I, Bate N, Critchley DR, Ginsberg MH, Campbell ID
EMBO JOURNAL 28, 3623 (2009).
DOI: 10.1038/emboj.2009.287
Unit-cell determination from randomly oriented electron-diffraction patterns Jiang L, Georgieva D, Zandbergen Henny W, Abrahams J
ACTA CRYSTALLOGRAPHICA SECTION D - BIOLOGICAL CRYSTALLOGRAPHY 65, 625 (2009).
DOI: 10.1107/S0907444909003163

2008

A proangiogenic peptide derived from vascular endothelial growth factor receptor-1 acts through alpha 5 beta 1 integrin Soro S, Orecchia A, Morbidelli L, Lacal PM, Morea V, Ballmer-Hofer K, Ruffini F, Ziche M, D'Atri S, Zambruno G, Tramontano A, Failla CM
BLOOD 111, 3479 (2008).
DOI: 10.1182/blood-2007-03-077537
Anti-Mullerian-hormone-dependent regulation of the brain serine-protease inhibitor neuroserpin Lebeurrier N, Launay S, Macrez R, Maubert E, Legros H, Leclerc A, Jamin SP, Picard JY, Marret S, Laudenbach V, Berger P, Sonderegger P, Ali C, di Clemente N, Vivien D
JOURNAL OF CELL SCIENCE 121, 3357 (2008).
DOI: 10.1242/jcs.031872
Atomic models of de novo designed cc beta-met amyloid-like fibrils Steinmetz MO, Gattin Z, Verel R, Ciani B, Stromer T, Green JM, Tittmann P, Schulze-Bdese C, Gross H, van Gunsteren WF, Meier BH, Serpell LC, Muller SA, Kammerer RA
JOURNAL OF MOLECULAR BIOLOGY 376, 898 (2008).
DOI: 10.1016/j.jmb.2007.11.100
Capturing protein tails by CAP-Gly domains Steinmetz Michel O, Akhmanova A
TRENDS IN BIOCHEMICAL SCIENCES 33, 535 (2008).
DOI: 10.1016/j.tibs.2008.08.006
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of chlorite dismutase: a detoxifying enzyme producing molecular oxygen de Geus Daniël C, Thomassen Ellen AJ, van der Feltz Clarisse L, Abrahams J
Acta Crystallographica Section F Structural Biology and Crystallization Communications 64, 730 (2008).
DOI: 10.1107/S1744309108020551
Crystal structure of the ternary FimC-FimF(t)-FimD(N) complex indicates conserved pilus chaperone-subunit complex recognition by the usher FimD Eidam O, Dworkowski FSN, Glockshuber R, Grutter MG, Capitani G
FEBS LETTERS 582, 651 (2008).
DOI: 10.1016/j.febslet.2008.01.030
DsbL and DsbI form a specific dithiol oxidase system for periplasmic arylsulfate sulfotransferase in uropathogenic Escherichia coli Grimshaw JPA, Stirnimann CU, Brozzo MS, Malojcic G, Gruetter MG, Capitani G, Glockshuber R
JOURNAL OF MOLECULAR BIOLOGY 380, 667 (2008).
DOI: 10.1016/j.jmb.2008.05.031
Evidence for proton shuffling in a thioredoxin-like protein during catalysis Narzi D, Siu SWI, Stirnimann CU, Grimshaw JPA, Glockshuber R, Capitani G, Bockmann RA
JOURNAL OF MOLECULAR BIOLOGY 382, 978 (2008).
DOI: 10.1016/j.jmb.2008.07.061
Exploring the Conserved Water Site and Hydration of a Coiled-Coil Trimerisation Motif: A MD Simulation Study Dolenc J, Baron R, Missimer John H, Steinmetz Michel O, van Gunsteren Wilfred F
CHEMBIOCHEM 9, 1749 (2008).
DOI: 10.1002/cbic.200800096
High-level Expression and Purification of a Designed Angiopoietin-1 Chimeric Protein, COMP-Ang1, Produced in Chinese Hamster Ovary Cells Hwang S, Kim S, Kim H, Steinmetz Michel O, Koh G, Lee G
THE PROTEIN JOURNAL 27, 319 (2008).
DOI: 10.1007/s10930-008-9140-5
Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro Mukhopadhyay D, Howell KS, Riezman H, Capitani G
JOURNAL OF BIOLOGICAL CHEMISTRY 283, 20159 (2008).
DOI: 10.1074/jbc.M709753200
Infinite kinetic stability against dissociation of supramolecular protein complexes through donor strand complementation Puorger C, Eidam O, Capitani G, Erilov D, Grutter MG, Glockshuber R
STRUCTURE 16, 631 (2008).
DOI: 10.1016/j.str.2008.01.013
Microtubule Plus-End Conformations and Dynamics in the Periphery of Interphase Mouse Fibroblasts Zovko S, Abrahams JP, Koster AJ, Galjart N, Mommaas AM
MOLECULAR BIOLOGY OF THE CELL 19, 3138 (2008).
DOI: 10.1091/mbc.E07-07-0681
Molecular architecture of inner dynein arms in situ in Chlamydomonas reinhardtii flagella Bui K, Sakakibara H, Movassagh T, Oiwa K, Ishikawa T
The Journal of Cell Biology 183, 923 (2008).
DOI: 10.1083/jcb.200808050
Molecular evolution of B6 enzymes: Binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme Vacca R, Giannattasio S, Capitani G, Marra E, Christen P
BMC BIOCHEMISTRY 9, 17 (2008).
DOI: 10.1186/1471-2091-9-17
Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization Kawamura H, Li XJ, Goishi K, van Meeteren LA, Jakobsson L, Cebe-Suarez S, Shimizu A, Edholm D, Ballmer-Hofer K, Kjellen L, Klagsbrun M, Claesson-Welsh L
BLOOD 112, 3638 (2008).
DOI: 10.1182/blood-2007-12-125856
Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR Cebe-Suarez P, Grunewald FS, Jaussi R, Li XJ, Claesson-Welsh L, Spillmann D, Mercer AA, Prota AE, Ballmer-Hofer K
FASEB JOURNAL 22, 3078 (2008).
DOI: 10.1096/fj.08-107219
Polymorphism in an Amyloid-Like Fibril-Forming Model Peptide Verel R, Tomka Ivan T, Bertozzi C, Cadalbert R, Kammerer Richard A, Steinmetz MO, Meier Beat H
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 47, 5842 (2008).
DOI: 10.1002/anie.200800021
Prospects for structure solution by electron diffraction of three-dimensional protein crystals Abrahams JP, Georgieva D, Jiang L, Zandbergen HW
Acta Crystallographica Section A Foundations of Crystallography 64, C75 (2008).
DOI: 10.1107/S0108767308097584
STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER Grigoriev I, Gouveia S, Van der Vaart B, Demmers J, Smyth JT, Honnappa S, Splinter D, Steinmetz MO, Putney JW, Hoogenraad CC, Akhmanova A
CURRENT BIOLOGY 18, 177 (2008).
DOI: 10.1016/j.cub.2007.12.050
Suppression of Microtubule Dynamic Instability by the +TIP Protein EB1 and Its Modulation by the CAP-Gly Domain of p150 Glued ? Manna T, Honnappa S, Steinmetz Michel O, Wilson L
BIOCHEMISTRY 47, 779 (2008).
DOI: 10.1021/bi701912g
Suppression of microtubule dynamic instability by the plus TIP protein EB1 and its modulation by the CAP-Gly domain of p150(Glued) Manna Tapas, Honnappa Srinivas, Steinmetz Michel O, Wilson Leslie
BIOCHEMISTRY 47, 779-786 (2008).
DOI: 10.1021/bi701912g
Tracking the ends: a dynamic protein network controls the fate of microtubule tips Akhmanova A, Steinmetz Michel O
NATURE REVIEWS MOLECULAR CELL BIOLOGY 9, 309 (2008).
DOI: 10.1038/nrm2369

2007

Announcement of the editor-in-chief Cebe-Suarez S, Zehnder-Fjallman A, Ballmer-Hofer K
CELLULAR AND MOLECULAR LIFE SCIENCES 64, I (2007).
DOI: 10.1007/s00018-007-7003-4
Configurational entropy elucidates the role of salt-bridge networks in protein thermostability Missimer JH, Steinmetz MO, Baron R, Winkler FK, Kammerer Richard A, Daura X, van Gunsteren Wilfred F
PROTEIN SCIENCE 16, 1349 (2007).
DOI: 10.1110/ps.062542907
Crystal Structure of the DNA Repair Enzyme Ultraviolet Damage Endonuclease Paspaleva K, Thomassen E, Pannu Navraj S, Iwai S, Moolenaar Geri F, Goosen N, Abrahams J
STRUCTURE 15, 1316 (2007).
DOI: 10.1016/j.str.2007.05.010
Cyclops: New modular software suite for cryo-EM Plaisier JR, Jiang L, Abrahams JP
JOURNAL OF STRUCTURAL BIOLOGY 157, 19 (2007).
DOI: 10.1016/j.jsb.2006.07.002
Early segregation of layered projections from the lateral superior olivary nucleus to the central nucleus of the inferior colliculus in the neonatal cat Gabriele Mark L, Shahmoradian SH, French Christopher C, Henkel Craig K, McHaffie John G
BRAIN RESEARCH 1173, 66 (2007).
DOI: 10.1016/j.brainres.2007.07.055
Heterogeneous nucleation of three-dimensional protein nanocrystals Georgieva Dilyana G, Kuil Maxim E, Oosterkamp Tjerk H, Zandbergen Henny W, Abrahams J
ACTA CRYSTALLOGRAPHICA SECTION D - BIOLOGICAL CRYSTALLOGRAPHY 63, 564 (2007).
DOI: 10.1107/S0907444907007810
Molecular basis of coiled-coil formation Steinmetz MO, Jelesarov I, Matousek WM, Honnappa S, Jahnke W, Missimer JH, Frank S, Alexandrescu AT, Kammerer RA
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104, 7062 (2007).
DOI: 10.1073/pnas.0700321104
Motor Neuron Disease-Associated Mutant Vesicle-Associated Membrane Protein-Associated Protein (VAP) B Recruits Wild-Type VAPs into Endoplasmic Reticulum-Derived Tubular Aggregates Teuling E, Ahmed S, Haasdijk E, Demmers J, Steinmetz MO, Akhmanova A, Jaarsma D, Hoogenraad CC
JOURNAL OF NEUROSCIENCE 27, 9801 (2007).
DOI: 10.1523/jneurosci.2661-07.2007
Mtmr13/Sbf2-deficient mice: an animal model for CMT4B2 Tersar K, Boentert M, Berger P, Bonneick S, Wessig C, Toyka KV, Young P, Suter U
HUMAN MOLECULAR GENETICS 16, 2991 (2007).
DOI: 10.1093/hmg/ddm257
Multiprotein Expression Strategy for Structural Biology of Eukaryotic Complexes Fitzgerald Daniel J, Schaffitzel C, Berger P, Wellinger R, Bieniossek C, Richmond Timothy J, Berger I
STRUCTURE 15, 275 (2007).
DOI: 10.1016/j.str.2007.01.016
Production of in vitro amplified DNA pseudolibraries and high-throughput cDNA target amplification Frey D, Kambach C, Steinmetz M, Jaussi R
BMC BIOTECHNOLOGY 7, 31 (2007).
DOI: 10.1186/1472-6750-7-31
Recent advances in the CRANK automated structure solution suite Pannu NS, Skubak P, Sikharulidze I, Abrahams JP, de Graaff RAG
Acta Crystallographica Section A Foundations of Crystallography 63, s116 (2007).
DOI: 10.1107/S0108767307097516
Solving Ab-initio Protein and Nanostructures with Precession Electron Diffraction Georgieva D, Abrahams J, Zandbergen H, Nikolopoulos S, Boulahya K
MICROSCOPY AND MICROANALYSIS 13, (2007).
DOI: 10.1017/S1431927607072698
Structural and mechanistic aspects of Amt/Rh proteins Javelle A, Lupo D, Li X, Merrick M, Chami M, Ripoche P, Winkler FK
JOURNAL OF STRUCTURAL BIOLOGY 158, 472 (2007).
DOI: 10.1016/j.jsb.2007.01.004
Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis (vol 104, July, pg 12151, 2007) Scherr N, Hormappa S, Kunz GR, Mueller P, Jayachandran R, Winkler F, Pieters J, Steinmetz MO
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104, 16388 (2007).
DOI: 10.1073/pnas.0708192104
Structure and thermodynamics of the tubulin?stathmin interaction Steinmetz Michel O
JOURNAL OF STRUCTURAL BIOLOGY 158, 137 (2007).
DOI: 10.1016/j.jsb.2006.07.018
Structure of a VEGF-VEGF receptor complex determined by electron microscopy Ruch C, Skiniotis G, Steinmetz MO, Walz T, Ballmer-Hofer K
NATURE STRUCTURAL AND MOLECULAR BIOLOGY 14, 249 (2007).
DOI: 10.1038/nsmb1202
Structure of the E. coli signal recognition particle bound to a translating ribosome Schaffitzel C, Oswald M, Berger I, Ishikawa T, Abrahams J, Koerten Henk K, Koning Roman I, Ban N
NATURE 448, 1076 (2007).
DOI: 10.1038/nature06169
Structure-function relationship of CAP-Gly domains Weisbrich A, Honnappa S, Jaussi R, Okhrimenko O, Frey D, Jelesarov I, Akhmanova A, Steinmetz MO
NATURE STRUCTURAL AND MOLECULAR BIOLOGY 14, 959 (2007).
DOI: 10.1038/nsmb1291
The 1.3-A resolution structure of nitrosomas erropea Rh50 and mechanistic implications for NH3 transport by Rhesus family proteins Lupo D, Li XD, Durand A, Tomizaki T, Cherif-zahar B, Matassi G, Merrik M, Winkler FK
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 50, 577 (2007).
The Caenorhabditis elegans septin complex is nonpolar John C, Hite R, Weirich C, Fitzgerald D, Jawhari H, Faty M, Schläpfer D, Kroschewski R, Winkler F, Walz T, Barral Y, Steinmetz M
The EMBO Journal 26, 3296 (2007).
DOI: 10.1038/sj.emboj.7601775
The crystal structure of the Escherichia coli AmtB-GlnK complex reveals how GlnK regulates the ammonia channel Conroy MJ, Durand A, Lupo D, Li XD, Bullough PA, Winkler FK, Merrick M
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104, 1213 (2007).
DOI: 10.1073/pnas.0610348104

2006

13C, 15N Resonance Assignment of Parts of the HET-s Prion Protein in its Amyloid Form Siemer Ansgar B, Ritter C, Steinmetz Michel O, Ernst M, Riek R, Meier Beat H
JOURNAL OF BIOMOLECULAR NMR 34, 75 (2006).
DOI: 10.1007/s10858-005-5582-7
An improved method for fast, robust, and seamless integration of DNA fragments into multiple plasmids Benoit RM, Wilhelm RN, Scherer-Becker D, Ostermeier C
PROTEIN EXPRESSION AND PURIFICATION 45, 66-71 (2006).
DOI: 10.1016/j.pep.2005.09.022
C-13, N-15 resonance assignment of parts of the HET-s prion protein in its amyloid form Siemer AB, Ritter C, Steinmetz MO, Ernst M, Riek R, Meier BH
JOURNAL OF BIOMOLECULAR NMR 34, 75-87 (2006).
DOI: 10.1007/s10858-005-5582-7
Control of Intrinsically Disordered Stathmin by Multisite Phosphorylation Honnappa S, Jahnke W, Seelig J, Steinmetz MO
JOURNAL OF BIOLOGICAL CHEMISTRY 281, 16078 (2006).
DOI: 10.1074/jbc.M513524200
De novo design of a two-stranded coiled-coil switch peptide Kammerer Richard A, Steinmetz MO
JOURNAL OF STRUCTURAL BIOLOGY 155, 146 (2006).
DOI: 10.1016/j.jsb.2006.01.017
Evidence for a novel domain of bacterial outer membrane ushers Capitani G, Eidam O, Grutter MG
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 65, 816 (2006).
DOI: 10.1002/prot.21147
Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2 Berger P, Berger I, Schaffitzel C, Tersar K, Volkmer B, Suter U
HUMAN MOLECULAR GENETICS 15, 569 (2006).
DOI: 10.1093/hmg/ddi473
Nano-dispensing by electrospray for biotechnology Kuil Maxim E, Abrahams J, Marijnissen Jan CM
Biotechnology Journal 1, 969 (2006).
DOI: 10.1002/biot.200600062
Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease Niemann A, Berger P, Suter U
NEUROMOLECULAR MEDICINE 8, 217 (2006).
DOI: 10.1385/NMM:8:1:217
Protein complex expression by using multigene baculoviral vectors Fitzgerald D, Berger P, Schaffitzel C, Yamada K, Richmond T, Berger I
NATURE METHODS 3, 1021 (2006).
DOI: 10.1038/nmeth983
Schwann cells and the pathogenesis of inherited motor and sensory neuropathies (Charcot-Marie-Tooth disease) Berger P, Niemann A, Suter U
GLIA 54, 243 (2006).
DOI: 10.1002/glia.20386
Structural and functional insights into the AmtB/Mep/Rh protein family Li XD, Lupo D, Zheng L, Winkler F
TRANSFUSION CLINIQUE ET BIOLOGIQUE 13, 65 (2006).
DOI: 10.1016/j.tracli.2006.02.014
Structure of the E. coli signal recognition particle bound to a translating ribosome Schaffitzel C, Oswald M, Berger I, Ishikawa T, Abrahams J, Koerten Henk K, Koning Roman I, Ban N
NATURE 444, 503 (2006).
DOI: 10.1038/nature05182
Structure of the Extracellular Domain of Tie Receptor Tyrosine Kinases and Localization of the Angiopoietin-binding Epitope Macdonald PR, Progias P, Ciani B, Patel S, Mayer U, Steinmetz MO, Kammerer RA
JOURNAL OF BIOLOGICAL CHEMISTRY 281, 28408 (2006).
DOI: 10.1074/jbc.M605219200
The Impact of Single Amino Acid Substitutions in CD3? on the CD3?? Interaction and T-Cell Receptor?CD3 Complex Formation Thomassen EAJ, Dekking EHA, Thompson A, Franken KL, Sanal Ö, Abrahams JP, van Tol MJD, Koning F
HUMAN IMMUNOLOGY 67, 579 (2006).
DOI: 10.1016/j.humimm.2006.04.015

2005

A conserved trimerization motif controls the topology of short coiled coils Kammerer RA, Kostrewa D, Progias P, Honnappa S, Avila D, Lustig A, Winkler FK, Pieters J, Steinmetz MO
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102, 13891-13896 (2005).
DOI: 10.1073/pnas.0502390102
Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules Gatfield J, Albrecht I, Zanolari B, Steinmetz MO, Pieters J
MOLECULAR BIOLOGY OF THE CELL 16, 2786-2798 (2005).
Design of a coiled-coil-based model peptide system to explore the fundamentals of amyloid fibril formation Steinmetz MO, Garcia-Echeverria C, Kammerer RA
International Journal of Peptide Research and Therapeutics 11, 43-52 (2005).
DOI: 10.1007/s10989-004-1720-4
Molecular-dynamics simulations of C- and N-terminal peptide derivatives of GCN4-p1 in aqueous solution Missimer JH, Steinmetz MO, Jahnke W, Winkler FK, van Gunsteren WF, Daura X
Chemistry & Biodiversity 2, 1086-1104 (2005).
Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2 Kim KT, Choi HH, Steinmetz MO, Maco B, Kammerer RA, Ahn SY, Kim HZ, Lee GM, Koh GY
JOURNAL OF BIOLOGICAL CHEMISTRY 280, 20126-20131 (2005).
DOI: 10.1074/jbc.M500292200
Structural and functional analysis of coronin 1 Albrecht I, Gatfield J, Zanolari B, Steinmetz MO, Pieters J
FEBS JOURNAL 272, 320-321 (2005).
Structural basis for the regulation of tubulin by vinblastine Gigant B, Wang CG, Ravelli RBG, Roussi F, Steinmetz MO, Curmi PA, Sobel A, Knossow M
NATURE 435, 519-522 (2005).
DOI: 10.1038/nature03566
Structural insights into the EB1-APC interaction Honnappa S, John CM, Kostrewa D, Winkler FK, Steinmetz MO
EMBO JOURNAL 24, 261 (2005).
DOI: 10.1038/sj.emboj.7600529
Structural insights into the EB1-APC interaction (vol 24, pg 261, 2005) Honnappa S, John CM, Kostrewa D, Winkler FK, Steinmetz MO
EMBO JOURNAL 24, 872-872 (2005).
DOI: 10.1038/sj.emboj.7600590

2004

A Molecular Dynamics Study of Reovirus Attachment Protein ?1 Reveals Conformational Changes in ?1 Structure Cavalli A, Prota AE, Stehle T, Dermody Terence S, Recanatini M, Folkers G, Scapozza L
BIOPHYSICAL JOURNAL 86, 3423 (2004).
DOI: 10.1529/biophysj.103.030825
COMP-Ang1: A designed angiopoietin-1 variant with nonleaky angiogenic activity Cho CH, Kammerer RA, Lee HJ, Steinmetz MO, Ryu YS, Lee SH, Yasunaga K, Kim KT, Kim I, Choi HH, Kim W, Kim SH, Park SK, Lee GM, Koh GY
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101, 5547-5552 (2004).
DOI: 10.1073/pnas.0307574101
Exploring amyloid formation by a de novo design Kammerer RA, Kostrewa D, Zurdo J, Detken A, Garcia-Echeverria C, Green JD, Muller SA, Meier BH, Winkler FK, Dobson CM, Steinmetz MO
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101, 4435-4440 (2004).
DOI: 10.1073/pnas.0306786101

2003

Crystal structure of human junctional adhesion molecule 1: Implications for reovirus binding Prota AE, Campbell JA, Schelling P, Forrest JC, Watson MJ, Peters TR, Aurrand-Lions M, Imhof BA, Dermody TS, Stehle T
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100, 5366 (2003).
DOI: 10.1073/pnas.0937718100
Thermodynamics of the Op18/stathmin-tubulin interaction Honnappa S, Cutting B, Jahnke W, Seelig J, Steinmetz MO
JOURNAL OF BIOLOGICAL CHEMISTRY 278, 38926-38934 (2003).
DOI: 10.1074/jbc.M305546200

2002

The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding Prota AE, Sage DR, Stehle T, Fingeroth JD
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99, 10641 (2002).
DOI: 10.1073/pnas.162360499

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Dr. Jörg Standfuss

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joerg.standfuss@psi.ch

+41 56 310 25 86

Anita Strittmatter Hähnke

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anita.strittmatter@psi.ch

+41 56 310 20 35

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