Publication 2025
-
Czub MP, Uliana F, Grubić T, Padeste C, Rosowski KA, Lorenz C, et al.
Phase separation of a microtubule plus-end tracking protein into a fluid fractal network
Nature Communications. 2025; 16(1): 1165. https://doi.org/10.1038/s41467-025-56468-8
DORA PSI -
Iyer SS, Chen F, Ogunmolu FE, Moradi S, Volkov VA, van Grinsven EJ, et al.
Centriolar cap proteins CP110 and CPAP control slow elongation of microtubule plus ends
Journal of Cell Biology. 2025; 224(3): e202406061 (29 pp.). https://doi.org/10.1083/jcb.202406061
DORA PSI -
Khanppnavar B, Leka O, Pal SK, Korkhov VM, Kammerer RA
Cryo-EM structure of the botulinum neurotoxin A/SV2B complex and its implications for translocation
Nature Communications. 2025; 16(1): 1224 (16 pp.). https://doi.org/10.1038/s41467-025-56304-z
DORA PSI -
Linke J, Rohrbach T, Clark AH, Borca C, Huthwelker T, Buchauer FL, et al.
The role of Fe incorporation into Ni-MOF-74 derived oxygen evolution electrocatalysts for anion exchange membrane water electrolysis
EES Catalysis. 2025: (10 pp.). https://doi.org/10.1039/d4ey00250d
DORA PSI -
Mulder M, Hwang S, Broser M, Brünle S, Skopintsev P, Schattenberg C, et al.
Structural insights into the opening mechanism of C1C2 channelrhodopsin
Journal of the American Chemical Society. 2025; 147(1): 1282-1290. https://doi.org/10.1021/jacs.4c15402
DORA PSI
Publication 2024
-
Abel AC, Mühlethaler T, Dessin C, Schachtsiek T, Sammet B, Sharpe T, et al.
Bridging the maytansine and vinca sites: Cryptophycins target β-tubulin's T5-loop
Journal of Biological Chemistry. 2024; 300(6): 107363 (10 pp.). https://doi.org/10.1016/j.jbc.2024.107363
DORA PSI -
Alvarez N, Bruggmann R, Buchmann N, Dessimoz C, Faso C, Hofmann S, et al.
Biology community roadmap 2024. Update of Swiss community needs for research infrastructures 2029-2032
Bern: Swiss Academy of Sciences (SCNAT); 2024. Swiss Academies reports: 19/6. https://doi.org/10.5281/zenodo.14264965
DORA PSI -
Bertrand Q, Nogly P, Nango E, Kekilli D, Khusainov G, Furrer A, et al.
Structural effects of high laser power densities on an early bacteriorhodopsin photocycle intermediate
Nature Communications. 2024; 15: 10278 (11 pp.). https://doi.org/10.1038/s41467-024-54422-8
DORA PSI -
Bonifer C, Hanke W, Mühle J, Löhr F, Becker-Baldus J, Nagel J, et al.
Structural response of G protein binding to the cyclodepsipeptide inhibitor FR900359 probed by NMR spectroscopy
Chemical Science. 2024; 15(32): 12939-12956. https://doi.org/10.1039/d4sc01950d
DORA PSI -
Cellini A, Shankar MK, Nimmrich A, Hunt LA, Monrroy L, Mutisya J, et al.
Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography
Nature Chemistry. 2024; 16: 624-632. https://doi.org/10.1038/s41557-023-01413-9
DORA PSI -
Christen P, Jaussi R, Benoit R
Biochemie und Molekularbiologie. Eine Einführung in 40 Lerneinheiten
2nd ed. Berlin: Springer Nature; 2024. https://doi.org/10.1007/978-3-662-65477-4
DORA PSI -
Dessin C, Schachtsiek T, Voss J, Abel AC, Neumann B, Stammler HG, et al.
Highly cytotoxic cryptophycin derivatives with modification in unit D for conjugation
Angewandte Chemie International Edition. 2024; 63(50): e202416210 (13 pp.). https://doi.org/10.1002/anie.202416210
DORA PSI -
Ding X, Aureli S, Vaithia A, Lavriha P, Schuster D, Khanppnavar B, et al.
Structural basis of connexin-36 gap junction channel inhibition
Cell Discovery. 2024; 10(1): 68 (4 pp.). https://doi.org/10.1038/s41421-024-00691-y
DORA PSI -
Glover H, Saßmannshausen T, Bertrand Q, Trabuco M, Slavov C, Bacchin A, et al.
Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography
Nature Communications. 2024; 15(1): 10837 (13 pp.). https://doi.org/10.1038/s41467-024-55109-w
DORA PSI -
Gotthard G, Mous S, Weinert T, Maia RNA, James D, Dworkowski F, et al.
Capturing the blue-light activated state of the Phot-LOV1 domain from Chlamydomonas reinhardtii using time-resolved serial synchrotron crystallography
IUCrJ. 2024; 11(5): (17 pp.). https://doi.org/10.1107/S2052252524005608
DORA PSI -
Gotthard G, Flores-Ibarra A, Carrillo M, Kepa MW, Mason TJ, Stegmann DP, et al.
Fixed-target pump–probe SFX: eliminating the scourge of light contamination
IUCrJ. 2024; 11(5): 1-13. https://doi.org/10.1107/S2052252524005591
DORA PSI -
Herman J, Vanstreels E, Bardiot D, Prota AE, Gaillard N, Gao LJ, et al.
3-nitropyridine analogues as novel microtubule-targeting agents
PLoS One. 2024; 19(11): e0307153 (16 pp.). https://doi.org/10.1371/journal.pone.0307153
DORA PSI -
Holfeld A, Schuster D, Sesterhenn F, Gillingham AK, Stalder P, Haenseler W, et al.
Systematic identification of structure-specific protein–protein interactions
Molecular Systems Biology. 2024; 20: 651-675. https://doi.org/10.1038/s44320-024-00037-6
DORA PSI -
Homer JA, Koelln RA, Barrow AS, Gialelis TL, Boiarska Z, Steinohrt NS, et al.
Modular synthesis of functional libraries by accelerated SuFEx click chemistry
Chemical Science. 2024; 15: 3879-3892. https://doi.org/10.1039/d3sc05729a
DORA PSI -
Jiang Y, Rex DAB, Schuster D, Neely BA, Rosano GL, Volkmar N, et al.
Comprehensive overview of bottom-up proteomics using mass spectrometry
ACS Measurement Science Au. 2024; 4(4): 338-417. https://doi.org/10.1021/acsmeasuresciau.3c00068
DORA PSI -
Khanppnavar B, North RA, Ventura S, Xu Y
Advances, challenges, and opportunities in structural biology
Trends in Biochemical Sciences. 2024; 49(2): 93-96. https://doi.org/10.1016/j.tibs.2023.12.006
DORA PSI -
Khanppnavar B, Schuster D, Lavriha P, Uliana F, Özel M, Mehta V, et al.
Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics
EMBO Reports. 2024; 25: 1513-1540. https://doi.org/10.1038/s44319-024-00076-y
DORA PSI -
Khanppnavar B, Choo JPS, Hagedoorn PL, Smolentsev G, Štefanić S, Kumaran S, et al.
Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase
Nature Chemistry. 2024; 16: 1496-1504. https://doi.org/10.1038/s41557-024-01523-y
DORA PSI -
Khusainov G, Standfuss J, Weinert T
The time revolution in macromolecular crystallography
Structural Dynamics. 2024; 11(2): 020901 (17 pp.). https://doi.org/10.1063/4.0000247
DORA PSI -
Lavriha P, Qi C, Korkhov VM
Expression, purification, and nanodisc reconstitution of connexin-43 hemichannels for structural characterization by cryo-electron microscopyp
In: Mammano F, Retamal M, eds. Connexin hemichannels. Methods and protocols. Methods in molecular biology. New York, NY: Springer Nature; 2024:29-43. https://doi.org/10.1007/978-1-0716-3842-2_3
DORA PSI -
Lavriha P, Han Y, Ding X, Schuster D, Qi C, Vaithia A, et al.
Mechanism of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate
PLoS One. 2024; 19(12): e0315510 (15 pp.). https://doi.org/10.1371/journal.pone.0315510
DORA PSI -
Meier SM, Steinmetz MO, Barral Y
Microtubule specialization by +TIP networks: from mechanisms to functional implications
Trends in Biochemical Sciences. 2024; 49(4): 318-332. https://doi.org/10.1016/j.tibs.2024.01.005
DORA PSI -
Mortelmans T, Marty B, Kazazis D, Padeste C, Li X, Ekinci Y
Three-dimensional microfluidic capillary device for rapid and multiplexed immunoassays in whole blood
ACS Sensors. 2024; 9(5): 2455-2464. https://doi.org/10.1021/acssensors.4c00153
DORA PSI -
Orville AM, Nango E, Iwata S, Mous S, Standfuss J, Nogly P, et al.
Time-resolved studies of protein structural dynamics
In: Ueda K, ed. Ultrafast electronic and structural dynamics. Singapore: Springer Nature; 2024:439-476. https://doi.org/10.1007/978-981-97-2914-2_15
DORA PSI -
Reynders M, Garścia M, Müller-Deku A, Wranik M, Krauskopf K, de la Osa de la Rosa L, et al.
A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol
Chemical Science. 2024; 15(31): 12301-12309. https://doi.org/10.1039/d4sc03072a
DORA PSI -
Rodrigues MJ, Tejero O, Mühle J, Pamula F, Das I, Tsai CJ, et al.
Activating an invertebrate bistable opsin with the all-trans 6.11 retinal analog
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2024; 121(31): e2406814121 (3 pp.). https://doi.org/10.1073/pnas.2406814121
DORA PSI -
Saha S, Khanppnavar B, Maharana J, Kim H, Carino CMC, Daly C, et al.
Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor
Cell. 2024; 187(17): 4751-4769.e25. https://doi.org/10.1016/j.cell.2024.07.005
DORA PSI -
Saßmannshausen T, Glover H, Trabuco M, Neidhart W, Cheng R, Hennig M, et al.
Kinetic basis for the design of azobenzene-based photoswitchable A2a adenosine receptor ligands
Journal of the American Chemical Society. 2024; 146(47): 32670-32677. https://doi.org/10.1021/jacs.4c11995
DORA PSI -
Schuster D, Khanppnavar B, Kantarci I, Mehta V, Korkhov VM
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling
Trends in Biochemical Sciences. 2024; 49(2): 156-168. https://doi.org/10.1016/j.tibs.2023.12.002
DORA PSI -
Steinmetz MO, Prota AE
Structure-based discovery and rational design of microtubule-targeting agents
Current Opinion in Structural Biology. 2024; 87: 102845 (15 pp.). https://doi.org/10.1016/j.sbi.2024.102845
DORA PSI -
Tejero O, Pamula F, Koyanagi M, Nagata T, Afanasyev P, Das I, et al.
Active state structures of a bistable visual opsin bound to G proteins
Nature Communications. 2024; 15(1): 8928 (13 pp.). https://doi.org/10.1038/s41467-024-53208-2
DORA PSI -
Tsujino S, Sato Y, Jia S, Kepa MW, Trampari S, Tomizaki T
Inertial mixing of acoustically levitated droplets for time-lapse protein crystallography
Droplet. 2024; 3(3): e132 (11 PP.). https://doi.org/10.1002/dro2.132
DORA PSI -
Vashistha M, Breckwoldt N, Casadei CM, Hannemann T, Schertler GFX, Santra R
Theoretical framework for serial femtosecond crystallography in the presence of non-Born-Oppenheimer effects
Physical Review Research. 2024; 6(4): 043198 (16 pp.). https://doi.org/10.1103/PhysRevResearch.6.043198
DORA PSI
Publication 2023
-
Emmenegger M, De Cecco E, Lamparter D, Jacquat RPB, Riou J, Menges D, et al.
Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region
iScience. 2023; 26(2): 105928 (34 pp.). https://doi.org/10.1016/j.isci.2023.105928
DORA PSI
-
Amer M, Leka O, Jasko P, Frey D, Li X, Kammerer RA
A coiled-coil-based design strategy for the thermostabilization of G-protein-coupled receptors
Scientific Reports. 2023; 13(1): 10159 (11 pp.). https://doi.org/10.1038/s41598-023-36855-1
DORA PSI -
Barret DCA, Schuster D, Rodrigues MJ, Leitner A, Picotti P, Schertler GFX, et al.
Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2023; 120(15): e2300309120 (10 pp.). https://doi.org/10.1073/pnas.2300309120
DORA PSI -
Bertrand Q, Coquille S, Iorio A, Sterpone F, Madern D
Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases
Journal of Structural Biology. 2023; 215(4): 108039 (13 pp.). https://doi.org/10.1016/j.jsb.2023.108039
DORA PSI -
Boiarska Z, Pérez-Peña H, Abel A-C, Marzullo P, Álvarez-Bernad B, Bonato F, et al.
Maytansinol functionalization: towards useful probes for studying microtubule dynamics
Chemistry: A European Journal. 2023; 29(5): e202203431 (12 pp.). https://doi.org/10.1002/chem.202203431
DORA PSI -
Carrillo M, Mason TJ, Karpik A, Martiel I, Kepa MW, McAuley KE, et al.
Micro-structured polymer fixed targets for serial crystallography at synchrotrons and XFELs
IUCrJ. 2023; 10(6): 678-693. https://doi.org/10.1107/S2052252523007595
DORA PSI -
Casadei CM, Hosseinizadeh A, Bliven S, Weinert T, Standfuss J, Fung R, et al.
Low-pass spectral analysis of time-resolved serial femtosecond crystallography data
Structural Dynamics. 2023; 10(3): 034101 (18 pp.). https://doi.org/10.1063/4.0000178
DORA PSI -
Chen X, Portran D, Widmer LA, Stangier MM, Czub MP, Liakopoulos D, et al.
The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips
Journal of Cell Biology. 2023; 222(7): e202110126 (18 pp.). https://doi.org/10.1083/jcb.202110126
DORA PSI -
Christou N-E, Apostolopoulou V, Melo DVM, Ruppert M, Fadini A, Henkel A, et al.
Time-resolved crystallography captures light-driven DNA repair
Science. 2023; 382(6674): 1015-1020. https://doi.org/10.1126/science.adj4270
DORA PSI -
Estévez-Gallego J, Álvarez-Bernad B, Pera B, Wullschleger C, Raes O, Menche D, et al.
Chemical modulation of microtubule structure through the laulimalide/peloruside site
Structure. 2023; 31(1): 88-99.e5. https://doi.org/10.1016/j.str.2022.11.006
DORA PSI -
Giese C, Puorger C, Ignatov O, Bečárová Z, Weber ME, Schärer MA, et al.
Stochastic chain termination in bacterial pilus assembly
Nature Communications. 2023; 14(1): 7718 (21 pp.). https://doi.org/10.1038/s41467-023-43449-y
DORA PSI -
Gill R, Hora R, Alam MM, Bansal A, Bhatt TK, Sharma A
Editorial: Frontiers in malaria research
Frontiers in Microbiology. 2023; 14: 1191773 (4 pp.). https://doi.org/10.3389/fmicb.2023.1191773
DORA PSI -
Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, et al.
Ultrafast structural changes direct the first molecular events of vision
Nature. 2023; 615: 939-944. https://doi.org/10.1038/s41586-023-05863-6
DORA PSI -
Han Y, Zhuang Q, Ren R
Approaches for evolutionary, biochemical, and structural analysis of bacterial steroid 5a-reductases
In: Methods in enzymology. sine loco: Elsevier; 2023:237-261. https://doi.org/10.1016/bs.mie.2023.04.006
DORA PSI -
Leka O, Wu Y, Zanetti G, Furler S, Reinberg T, Marinho J, et al.
A DARPin promotes faster onset of botulinum neurotoxin A1 action
Nature Communications. 2023; 14(1): 8317 (12 pp.). https://doi.org/10.1038/s41467-023-44102-4
DORA PSI -
Leonarski F, Nan J, Matej Z, Bertrand Q, Furrer A, Gorgisyan I, et al.
Kilohertz serial crystallography with the JUNGFRAU detector at a fourth-generation synchrotron source
IUCrJ. 2023; 10(6): 729-737. https://doi.org/10.1107/S2052252523008618
DORA PSI -
Maestre-Reyna M, Wang P-H, Nango E, Hosokawa Y, Saft M, Furrer A, et al.
Visualizing the DNA repair process by a photolyase at atomic resolution
Science. 2023; 382(6674): eadd7795 (14 pp.). https://doi.org/10.1126/science.add7795
DORA PSI -
Meier SM, Farcas A-M, Kumar A, Ijavi M, Bill RT, Stelling J, et al.
Multivalency ensures persistence of a +TIP body at specialized microtubule ends
Nature Cell Biology. 2023; 25: 56-67. https://doi.org/10.1038/s41556-022-01035-2
DORA PSI -
Prota AE, Lucena-Agell D, Ma Y, Estevez-Gallego J, Li S, Bargsten K, et al.
Structural insight into the stabilization of microtubules by taxanes
eLife. 2023; 12: e84791 (35 pp.). https://doi.org/10.7554/elife.84791
DORA PSI -
Pérez-Peña H, Abel AC, Shevelev M, Prota AE, Pieraccini S, Horvath D
Computational approaches to the rational design of tubulin-targeting agents
Biomolecules. 2023; 13(2): 285 (35 pp.). https://doi.org/10.3390/biom13020285
DORA PSI -
Qi C, Gutierrez SA, Lavriha P, Othman A, Lopez-Pigozzi D, Bayraktar E, et al.
Structure of the connexin-43 gap junction channel in a putative closed state
eLife. 2023; 12: RP87616 (27 pp.). https://doi.org/10.7554/eLife.87616
DORA PSI -
Qi C, Lavriha P, Bayraktar E, Vaithia A, Schuster D, Pannella M, et al.
Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels
Science Advances. 2023; 9(35): eadh4890 (14 pp.). https://doi.org/10.1126/sciadv.adh4890
DORA PSI -
Ramirez-Rios S, Choi SR, Sanyal C, Blum TB, Bosc C, Krichen F, et al.
VASH1–SVBP and VASH2–SVBP generate different detyrosination profiles on microtubules
Journal of Cell Biology. 2023; 222(2): e202205096 (30 pp.). https://doi.org/10.1083/jcb.202205096
DORA PSI -
Robin AY, Brochier-Armanet C, Bertrand Q, Barette C, Girard E, Madern D
Deciphering evolutionary trajectories of lactate dehydrogenases provides new insights into allostery
Molecular Biology and Evolution. 2023; 40(10): msad223 (22 pp.). https://doi.org/10.1093/molbev/msad223
DORA PSI -
Rodrigues MJ, Casadei CM, Weinert T, Panneels V, Schertler GFX
Correction of rhodopsin serial crystallography diffraction intensities for a lattice-translocation defect
Acta Crystallographica Section D: Structural Biology. 2023; 79(3): D79 (10 pp.). https://doi.org/10.1107/S2059798323000931
DORA PSI -
Seo D, Kammerer RA, Alexandrescu AT
Solution NMR assignments and structure for the dimeric kinesin neck domain
Biomolecular NMR Assignments. 2023; 17: 301-307. https://doi.org/10.1007/s12104-023-10159-x
DORA PSI -
Wranik M, Kepa MW, Beale EV, James D, Bertrand Q, Weinert T, et al.
A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers
Nature Communications. 2023; 14(1): 7956 (12 pp.). https://doi.org/10.1038/s41467-023-43523-5
DORA PSI -
Wranik M, Weinert T, Slavov C, Masini T, Furrer A, Gaillard N, et al.
Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
Nature Communications. 2023; 14(1): 903 (12 pp.). https://doi.org/10.1038/s41467-023-36481-5
DORA PSI -
Wu D, Gucwa M, Czub MP, Cooper DR, Shabalin IG, Fritzen R, et al.
Structural and biochemical characterisation of Co2+-binding sites on serum albumins and their interplay with fatty acids
Chemical Science. 2023; 14(23): 6244-6258. https://doi.org/10.1039/d3sc01723k
DORA PSI
Publication 2022
-
Isaikina P, Tsai C-J, Petrovic I, Rogowski M, Meng Dürr A, Grzesiek S
Preparation of a stable CCL5·CCR5·Gi signaling complex for cryo-EM analysis
In: Shukla AK, ed. Biomolecular interactions part B. Methods in cell biology. Cambridge: Elsevier; 2022:115-141. https://doi.org/10.1016/bs.mcb.2022.03.001
DORA PSI
-
Barreca M, Spanò V, Rocca R, Bivacqua R, Abel AC, Maruca A, et al.
Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: further chemical modifications and potential therapeutic effects against lymphomas
European Journal of Medicinal Chemistry. 2022; 243: 114744 (25 pp.). https://doi.org/10.1016/j.ejmech.2022.114744
DORA PSI -
Bleuler-Martinez S, Varrot A, Olieric V, Schubert M, Vogt E, Fetz C, et al.
Structure–function relationship of a novel fucoside-binding fruiting body lectin from Coprinopsis cinerea exhibiting nematotoxic activity
Glycobiology. 2022; 32(7): 600-615. https://doi.org/10.1093/glycob/cwac020
DORA PSI -
Botte M, Ni D, Schenck S, Zimmermann I, Chami M, Bocquet N, et al.
Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation
Nature Communications. 2022; 13(1): 1826 (10 pp.). https://doi.org/10.1038/s41467-022-29459-2
DORA PSI -
Båth P, Banacore A, Börjesson P, Bosman R, Wickstrand C, Safari C, et al.
Lipidic cubic phase serial femtosecond crystallography structure of a photosynthetic reaction centre
Acta Crystallographica Section D: Structural Biology. 2022; 78(6): 698-708. https://doi.org/10.1107/S2059798322004144
DORA PSI -
Cellini A, Shankar MK, Wahlgren WY, Nimmrich A, Furrer A, James D, et al.
Structural basis of the radical pair state in photolyases and cryptochromes
Chemical Communications. 2022; 58(31): 4889-4892. https://doi.org/10.1039/D2CC00376G
DORA PSI -
Czub MP, Stewart AJ, Shabalin IG, Minor W
Organism-specific differences in the binding of ketoprofen to serum albumin
IUCrJ. 2022; 9(5): 551-561. https://doi.org/10.1107/S2052252522006820
DORA PSI -
Fatton M, Filippidou S, Junier T, Cailleau G, Berge M, Poppleton D, et al.
Cryptosporulation in Kurthia spp. forces a rethinking of asporogenesis in Firmicutes
Environmental Microbiology. 2022; 24(12): 6320-6335. https://doi.org/10.1111/1462-2920.16145
DORA PSI -
Gao L, Meiring JCM, Varady A, Ruider IE, Heise C, Wranik M, et al.
In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M
Journal of the American Chemical Society. 2022; 144(12): 5614-5628. https://doi.org/10.1021/jacs.2c01020
DORA PSI -
Guyomar C, Bousquet C, Ku S, Heumann JM, Guilloux G, Gaillard N, et al.
Changes in seam number and location induce holes within microtubules assembled from porcine brain tubulin and in Xenopus egg cytoplasmic extracts
eLife. 2022; 11: e83021 (26 pp.). https://doi.org/10.7554/eLife.83021
DORA PSI -
Heydenreich FM, Plouffe B, Rizk A, Milić D, Zhou J, Breton B, et al.
Michaelis-Menten quantification of ligand signaling bias applied to the promiscuous vasopressin V2 receptor
Molecular Pharmacology. 2022; 102(3): 139-149. https://doi.org/10.1124/molpharm.122.000497
DORA PSI -
Hogrel G, Guild A, Graham S, Rickman H, Grüschow S, Bertrand Q, et al.
Cyclic nucleotide-induced helical structure activates a TIR immune effector
Nature. 2022; 608: 808-812. https://doi.org/10.1038/s41586-022-05070-9
DORA PSI -
Kepa MW, Tomizaki T, Sato Y, Ozerov D, Sekiguchi H, Yasuda N, et al.
Acoustic levitation and rotation of thin films and their application for room temperature protein crystallography
Scientific Reports. 2022; 12: 5349 (14 pp.). https://doi.org/10.1038/s41598-022-09167-z
DORA PSI -
Khanppnavar B, Maier J, Herborg F, Gradisch R, Lazzarin E, Luethi D, et al.
Structural basis of organic cation transporter-3 inhibition
Nature Communications. 2022; 13: 6714 (13 pp.). https://doi.org/10.1038/s41467-022-34284-8
DORA PSI -
Lyapina E, Marin E, Gusach A, Orekhov P, Gerasimov A, Luginina A, et al.
Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
Nature Communications. 2022; 13(1): 4736 (14 pp.). https://doi.org/10.1038/s41467-022-32447-1
DORA PSI -
Marzullo P, Boiarska Z, Pérez-Peña H, Abel AC, Álvarez-Bernad B, Lucena-Agell D, et al.
Maytansinol derivatives: side reactions as a chance for new tubulin binders
Chemistry: A European Journal. 2022; 28(2): e202103520 (10 pp.). https://doi.org/10.1002/chem.202103520
DORA PSI -
Mehta V, Khanppnavar B, Schuster D, Kantarci I, Vercellino I, Kosturanova A, et al.
Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases
eLife. 2022; 11: e77032 (21 pp.). https://doi.org/10.7554/ELIFE.77032
DORA PSI -
Mitola S, Ravelli C, Corsini M, Gianoncelli A, Galvagni F, Ballmer-Hofer K, et al.
Production and biochemical characterization of dimeric recombinant gremlin-1
International Journal of Molecular Sciences. 2022; 23(3): 1151 (10 pp.). https://doi.org/10.3390/ijms23031151
DORA PSI -
Mortelmans T, Kazazis D, Padeste C, Berger P, Li X, Ekinci Y
Poly(methyl methacrylate)-based nanofluidic device for rapid and multiplexed serological antibody detection of SARS-CoV-2
ACS Applied Nano Materials. 2022; 5(1): 517-526. https://doi.org/10.1021/acsanm.1c03309
DORA PSI -
Mous S, Gotthard G, Ehrenberg D, Sen S, Weinert T, Johnson PJM, et al.
Dynamics and mechanism of a light-driven chloride pump
Science. 2022; 375(6583): 845-851. https://doi.org/10.1126/science.abj6663
DORA PSI -
Mühlethaler T, Olieric N, Ehrhard VA, Wranik M, Standfuss J, Sharma A, et al.
Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes
In: Inaba H, ed. Microtubules. Methods and protocols. Methods in molecular biology. New York: Humana Press; 2022:349-374. https://doi.org/10.1007/978-1-0716-1983-4_23
DORA PSI -
Mühlethaler T, Milanos L, Ortega JA, Blum TB, Gioia D, Roy B, et al.
Rational design of a novel tubulin inhibitor with a unique mechanism of action
Angewandte Chemie International Edition. 2022; 61(25): e202204052 (11 pp.). https://doi.org/10.1002/anie.202204052
DORA PSI -
Nass KJ, Ilie IM, Saller MJ, Driessen AJM, Caflisch A, Kammerer RA, et al.
The role of the N-terminal amphipathic helix in bacterial YidC: insights from functional studies, the crystal structure and molecular dynamics simulations
Biochimica et Biophysica Acta: Biomembranes. 2022; 1864(3): 183825 (9 pp.). https://doi.org/10.1016/j.bbamem.2021.183825
DORA PSI -
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, et al.
Structural basis of adenylyl cyclase 9 activation
Nature Communications. 2022; 13(1): 1045 (11 pp.). https://doi.org/10.1038/s41467-022-28685-y
DORA PSI -
Quast JP, Schuster D, Picotti P
protti: an R package for comprehensive data analysis of peptide- and protein-centric bottom-up proteomics data
Bioinformatics Advances. 2022; 2(1): vbab041 (3 pp.). https://doi.org/10.1093/bioadv/vbab041
DORA PSI -
Trebosc V, Lucchini V, Narwal M, Wicki B, Gartenmann S, Schellhorn B, et al.
Targeting virulence regulation to disarm Acinetobacter baumannii pathogenesis
Virulence. 2022; 13(1): 1868-1883. https://doi.org/10.1080/21505594.2022.2135273
DORA PSI -
Wang H, Mörman C, Sternke-Hoffmann R, Huang CY, Prota A, Ma P, et al.
Cu2+ ions modulate the interaction between α-synuclein and lipid membranes
Journal of Inorganic Biochemistry. 2022; 236: 111945 (10 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111945
DORA PSI -
de la Roche NM, Mühlethaler T, Di Martino RMC, Ortega JA, Gioia D, Roy B, et al.
Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents
European Journal of Medicinal Chemistry. 2022; 241: 114614 (12 pp.). https://doi.org/10.1016/j.ejmech.2022.114614
DORA PSI
Publication 2021
-
Wu N, Olechwier AM, Brunner C, Edwards PC, Tsai C-J, Tate CG, et al.
High-mass MALDI-MS unravels ligand-mediated G protein-coupling selectivity to GPCRs
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2021; 118(31): e2024146118 (9 pp.). https://doi.org/10.1073/pnas.2024146118
DORA PSI -
Isaikina P, Tsai C-J, Dietz N, Pamula F, Grahl A, Goldie KN, et al.
Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist
Science Advances. 2021; 7(25): eabg8685 (11 pp.). https://doi.org/10.1126/sciadv.abg8685
DORA PSI -
Pamula F, Tsai C-J
Biochemical characterization of GPCR-G protein complex formation
In: Schmidt-Krey I, Gumbart JC, eds. Structure and function of membrane proteins. Methods in molecular biology. New York, NY: Humana; 2021:37-48. https://doi.org/10.1007/978-1-0716-1394-8_3
DORA PSI
-
Blum TB, Housset D, Clabbers MTB, van Genderen E, Bacia-Verloop M, Zander U, et al.
Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals
Acta Crystallographica Section D: Structural Biology. 2021; 77: 75-85. https://doi.org/10.1107/S2059798320014540
DORA PSI -
Choo JPS, Kammerer RA, Li X, Li Z
High-Level Production of Phenylacetaldehyde using Fusion-Tagged Styrene Oxide Isomerase
Advanced Synthesis and Catalysis. 2021; 363(6): 1714-1721. https://doi.org/10.1002/adsc.202001500
DORA PSI -
Gaillard N, Sharma A, Abbaali I, Liu T, Shilliday F, Cook AD, et al.
Inhibiting parasite proliferation using a rationally designed anti-tubulin agent
EMBO Molecular Medicine. 2021; 13(11): e13818 (12 pp.). https://doi.org/10.15252/emmm.202013818
DORA PSI -
Gao L, Meiring JCM, Kraus Y, Wranik M, Weinert T, Pritzl SD, et al.
A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton
Cell Chemical Biology. 2021; 28(2): 228-241. https://doi.org/10.1016/j.chembiol.2020.11.007
DORA PSI -
Harwood CR, Sykes DA, Hoare BL, Heydenreich FM, Uddin R, Poyner DR, et al.
Functional solubilization of the β2-adrenoceptor using diisobutylene maleic acid
iScience. 2021; 24(12): 103362 (13 pp.). https://doi.org/10.1016/j.isci.2021.103362
DORA PSI -
Ijavi M, Style RW, Emmanouilidis L, Kumar A, Meier SM, Torzynski AL, et al.
Surface tensiometry of phase separated protein and polymer droplets by the sessile drop method
Soft Matter. 2021; 17(6): 1655-1662. https://doi.org/10.1039/d0sm01319f
DORA PSI -
Jernigan F, Branstrom A, Baird JD, Cao L, Dali M, Furia B, et al.
Preclinical and early clinical development of PTC596, a novel small-molecule tubulin-binding agent
Molecular Cancer Therapeutics. 2021; 20(10): 1846-1857. https://doi.org/10.1158/1535-7163.MCT-20-0774
DORA PSI -
Kepa MW, Tomizaki T, Tsujino S
Development of on-demand sample loading of ultrasound acoustic levitators by focused acoustic radiation
In: IEEE international ultrasonics symposium (IUS 2021). Danvers, MA: IEEE; 2021:(3 pp.). https://doi.org/10.1109/IUS52206.2021.9593735
DORA PSI -
Kumar A, Meier SM, Farcas A-M, Manatschal C, Barral Y, Steinmetz MO
Structure and regulation of the microtubule plus-end tracking protein Kar9
Structure. 2021; 29(11): 1266-1278.e4. https://doi.org/10.1016/j.str.2021.06.012
DORA PSI -
Kutomi O, Yamamoto R, Hirose K, Mizuno K, Nakagiri Y, Imai H, et al.
A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light
Science Advances. 2021; 7(9): eabf3621 (12 pp.). https://doi.org/10.1126/sciadv.abf3621
DORA PSI -
Leka O, Wu Y, Li X, Kammerer RA
Crystal structure of the catalytic domain of botulinum neurotoxin subtype A3
Journal of Biological Chemistry. 2021; 296: 100684 (8 pp.). https://doi.org/10.1016/j.jbc.2021.100684
DORA PSI -
Lentini G, Ben Chaabene R, Vadas O, Ramakrishnan C, Mukherjee B, Mehta V, et al.
Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion
Nature Communications. 2021; 12(1): 3788 (17 pp.). https://doi.org/10.1038/s41467-021-24083-y
DORA PSI -
Martiel I, Beale JH, Karpik A, Huang C-Y, Vera L, Olieric N, et al.
Versatile microporous polymer-based supports for serial macromolecular crystallography
Acta Crystallographica Section D: Structural Biology. 2021; 77(9): 1153-1167. https://doi.org/10.1107/S2059798321007324
DORA PSI -
Matthew S, Chen Q-Y, Ratnayake R, Fermaintt CS, Lucena-Agell D, Bonato F, et al.
Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2021; 118(9): e2021847118 (11 pp.). https://doi.org/10.1073/pnas.2021847118
DORA PSI -
Mühlethaler T, Gioia D, Prota AE, Sharpe ME, Cavalli A, Steinmetz MO
Comprehensive analysis of binding sites in tubulin
Angewandte Chemie International Edition. 2021; 60(24): 13331-13342. https://doi.org/10.1002/anie.202100273
DORA PSI -
Nass K, Bacellar C, Cirelli C, Dworkowski F, Gevorkov Y, James D, et al.
Pink-beam serial femtosecond crystallography for accurate structure-factor determination at an X-ray free-electron laser
IUCrJ. 2021; 8: 905-920. https://doi.org/10.1107/S2052252521008046
DORA PSI -
Panneels V, Diaz A, Imsand C, Guizar-Sicairos M, Müller E, Bittermann AG, et al.
Imaging of retina cellular and subcellular structures using ptychographic hard X-ray tomography
Journal of Cell Science. 2021; 134(19): jcs258561 (8 pp.). https://doi.org/10.1242/jcs.258561
DORA PSI -
Sharma A, Olieric N, Steinmetz MO
Centriole length control
Current Opinion in Structural Biology. 2021; 66: 89-95. https://doi.org/10.1016/j.sbi.2020.10.011
DORA PSI -
Wu J, Blum TB, Farrell DP, DiMaio F, Abrahams JP, Luo J
Cryo-electron microscopy imaging of Alzheimer's amyloid-beta 42 oligomer displayed on a functionally and structurally relevant scaffold
Angewandte Chemie International Edition. 2021; 60(34): 18680-18687. https://doi.org/10.1002/anie.202104497
DORA PSI -
Xiao X, Willemse J, Voskamp P, Li X, Prota AE, Lamers M, et al.
Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in Streptomyces
Open Biology. 2021; 11(2): 200409 (14 pp.). https://doi.org/10.1098/rsob.200409
DORA PSI -
Yong C, Devine SM, Abel A-C, Tomlins SD, Muthiah D, Gao X, et al.
1,3-benzodioxole-modified noscapine analogues: synthesis, antiproliferative activity, and tubulin-bound structure
ChemMedChem. 2021; 16(18): 2882-2894. https://doi.org/10.1002/cmdc.202100363
DORA PSI -
Zhang X, Pizzoni A, Hong K, Naim N, Qi C, Korkhov V, et al.
CAP1 binds and activates adenylyl cyclase in mammalian cells
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2021; 118(24): e2024576118 (10 pp.). https://doi.org/10.1073/pnas.2024576118
DORA PSI
Publication 2020
-
Pamula F, Mühle J, Blanc A, Nehmé R, Edwards PC, Tate CG, et al.
Strategic screening and characterization of the visual GPCR-mini-G protein signaling complex for successful crystallization
Journal of Visualized Experiments. 2020; 2020(157): e60747 (10 pp.). https://doi.org/10.3791/60747
DORA PSI
-
Atherton J, Hummel JJA, Olieric N, Locke J, Peña A, Rosenfeld SS, et al.
The mechanism of kinesin inhibition by kinesin binding protein
eLife. 2020; 9: e61481 (30 pp.). https://doi.org/10.7554/eLife.61481
DORA PSI -
Brunner JD, Schenck S
Production and application of nanobodies for membrane protein structural biology
In: Perez C, Maier T, eds. Expression, purification, and structural biology of membrane proteins. Methods in molecular biology. New York: Humana; 2020:167-184. https://doi.org/10.1007/978-1-0716-0373-4_12
DORA PSI -
Brunner JD, Jakob RP, Schulze T, Neldner Y, Moroni A, Thiel G, et al.
Structural basis for ion selectivity in TMEM175 K+ channels
eLife. 2020; 9: e53683 (24 pp.). https://doi.org/10.7554/eLife.53683
DORA PSI -
Cannac F, Qi C, Falschlunger J, Hausmann G, Basler K, Korkhov VM
Cryo-EM structure of the Hedgehog release protein Dispatched
Science Advances. 2020; 6(16): eaay7928 (8 pp.). https://doi.org/10.1126/sciadv.aay7928
DORA PSI -
Estévez-Gallego J, Josa-Prado F, Ku S, Buey RM, Balaguer FA, Prota AE, et al.
Structural model for differential cap maturation at growing microtubule ends
eLife. 2020; 9: e50155 (26 pp.). https://doi.org/10.7554/eLife.50155
DORA PSI -
Fiedler T, Fabrice TN, Studer V, Vinet A, Faltova L, Kammerer RA, et al.
Homodimerization of coronin A through the C-terminal coiled-coil domain is essential for multicellular differentiation of Dictyostelium discoideum
FEBS Letters. 2020; 594(13): 2116-2127. https://doi.org/10.1002/1873-3468.13787
DORA PSI -
Graeber E, Korkhov VM
Affinity purification of membrane proteins
In: Perez C, Maier T, eds. Expression, purification, and structural biology of membrane proteins. Methods in molecular biology. New York: Humana; 2020:129-137. https://doi.org/10.1007/978-1-0716-0373-4_9
DORA PSI -
Guo B, Rodriguez-Gabin A, Prota AE, Mühlethaler T, Zhang N, Ye K, et al.
Structural refinement of the tubulin ligand (+)-discodermolide to attenuate chemotherapy-mediated senescence
Molecular Pharmacology. 2020; 98(2): 156-167. https://doi.org/10.1124/mol.119.117457
DORA PSI -
Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, et al.
Pharmaceutical-grade rigosertib is a microtubule-destabilizing agent
Molecular Cell. 2020; 79(1): 191-198.e3. https://doi.org/10.1016/j.molcel.2020.06.008
DORA PSI -
Khannpnavar B, Mehta V, Qi C, Korkhov V
Structure and function of adenylyl cyclases, key enzymes in cellular signaling
Current Opinion in Structural Biology. 2020; 63: 34-41. https://doi.org/10.1016/j.sbi.2020.03.003
DORA PSI -
Krammer W, Missimer JH, Habegger S, Pastore-Wapp M, Wiest R, Weder BJ
Sensing form - finger gaiting as key to tactile object exploration - a data glove analysis of a prototypical daily task
Journal of NeuroEngineering and Rehabilitation. 2020; 17(133): 1-17. https://doi.org/10.1186/s12984-020-00755-6
DORA PSI -
Li X, Brunner C, Wu Y, Leka O, Schneider G, Kammerer RA
Structural insights into the interaction of botulinum neurotoxin a with its neuronal receptor SV2C
Toxicon. 2020; 175: 36-43. https://doi.org/10.1016/j.toxicon.2019.11.010
DORA PSI -
Makarov S, Pikuz S, Ryazantsev S, Pikuz T, Buzmakov A, Rose M, et al.
Soft X-ray diffraction patterns measured by a LiF detector with sub-micrometre resolution and an ultimate dynamic range
Journal of Synchrotron Radiation. 2020; 27: 625-632. https://doi.org/10.1107/S1600577520002192
DORA PSI -
Menzi S, Knopp G, Al Haddad A, Augustin S, Borca C, Gashi D, et al.
Generation and simple characterization of flat, liquid jets
Review of Scientific Instruments. 2020; 91(10): 105109 (10 pp.). https://doi.org/10.1063/5.0007228
DORA PSI -
Miljus T, Sykes DA, Harwood CR, Vuckovic Z, Veprintsev DB
GPCR solubilization and quality control
In: Perez C, Maier T, eds. Expression, purification, and structural biology of membrane proteins. Methods in molecular biology. New York: Humana; 2020:105-127. https://doi.org/10.1007/978-1-0716-0373-4_8
DORA PSI -
Mortelmans T, Kazazis D, Guzenko VA, Padeste C, Braun T, Li X, et al.
Grayscale e-beam lithography: effects of a delayed development for well-controlled 3D patterning
Microelectronic Engineering. 2020; 225: 111272 (5 pp.). https://doi.org/10.1016/j.mee.2020.111272
DORA PSI -
Nass K, Cheng R, Vera L, Mozzanica A, Redford S, Ozerov D, et al.
Advances in long-wavelength native phasing at X-ray free-electron lasers
IUCrJ. 2020; 7: 965-975. https://doi.org/10.1107/S2052252520011379
DORA PSI -
Oliva MA, Prota AE, Rodríguez-Salarichs J, Bennani YL, Jiménez-Barbero J, Bargsten K, et al.
Structural basis of noscapine activation for tubulin binding
Journal of Medicinal Chemistry. 2020; 63(15): 8495-8501. https://doi.org/10.1021/acs.jmedchem.0c00855
DORA PSI -
Poghosyan E, Iacovache I, Faltova L, Leitner A, Yang P, Diener DR, et al.
The structure and symmetry of the radial spoke protein complex in Chlamydomonas flagella
Journal of Cell Science. 2020; 133(16): jcs245233 (9 pp.). https://doi.org/10.1242/jcs.245233
DORA PSI -
Rai A, Liu T, Glauser S, Katrukha EA, Estévez-Gallego J, Rodríguez-García R, et al.
Taxanes convert regions of perturbed microtubule growth into rescue sites
Nature Materials. 2020; 19: 355-365. https://doi.org/10.1038/s41563-019-0546-6
DORA PSI -
Rodríguez-García R, Volkov VA, Chen C-Y, Katrukha EA, Olieric N, Aher A, et al.
Mechanisms of motor-independent membrane remodeling driven by dynamic microtubules
Current Biology. 2020; 30(6): 972-987. https://doi.org/10.1016/j.cub.2020.01.036
DORA PSI -
Rößler P, Mayer D, Tsai C-J, Veprintsev DB, Schertler GFX, Gossert AD
GPCR activation states induced by nanobodies and mini-G proteins compared by NMR spectroscopy
Molecules. 2020; 25(24): 5984 (17 pp.). https://doi.org/10.3390/molecules25245984
DORA PSI -
Skopintsev P, Ehrenberg D, Weinert T, James D, Kar RK, Johnson PJM, et al.
Femtosecond-to-millisecond structural changes in a light-driven sodium pump
Nature. 2020; 583: 314-318. https://doi.org/10.1038/s41586-020-2307-8
DORA PSI -
Smolentsev G, Milne CJ, Guda A, Haldrup K, Szlachetko J, Azzaroli N, et al.
Taking a snapshot of the triplet excited state of an OLED organometallic luminophore using X-rays
Nature Communications. 2020; 11: 2131 (9 pp.). https://doi.org/10.1038/s41467-020-15998-z
DORA PSI -
Steib E, Laporte MH, Gambarotto D, Olieric N, Zheng C, Borgers S, et al.
WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity
eLife. 2020; 9: e57205 (28 pp.). https://doi.org/10.7554/ELIFE.57205
DORA PSI -
Weinert T, Panneels V
Membrane protein preparation for serial crystallography using high-viscosity injectors: rhodopsin as an example
In: Perez C, Maier T, eds. Expression, purification, and structural biology of membrane proteins. Methods in molecular biology. New York: Humana; 2020:321-338. https://doi.org/10.1007/978-1-0716-0373-4_21
DORA PSI -
Wickstrand C, Katona G, Nakane T, Nogly P, Standfuss J, Nango E, et al.
A tool for visualizing protein motions in time-resolved crystallography
Structural Dynamics. 2020; 7: 024701 (12 pp.). https://doi.org/10.1063/1.5126921
DORA PSI -
Xiao X, Elsayed SS, Wu C, van der Heul HU, Metsä-Ketelä M, Du C, et al.
Functional and structural insights into a novel promiscuous ketoreductase of the lugdunomycin biosynthetic pathway
ACS Chemical Biology. 2020; 15(9): 2529-2538. https://doi.org/10.1021/acschembio.0c00564
DORA PSI -
Zook J, Shekhar M, Hansen D, Conrad C, Grant T, Gupta C, et al.
XFEL and NMR structures of Francisella lipoprotein reveal conformational space of drug target against tularemia
Structure. 2020; 28(5): 540-547.e3. https://doi.org/10.1016/j.str.2020.02.005
DORA PSI