CF Publications

A list of published journal articles that have resulted from research conducted at the PSI Crystallisation facility are shown below:

  • Huang CY, Metz A, Lange R, Artico N, Potot C, Hazemann J, et al.
    Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket
    Acta Crystallographica Section D: Structural Biology. 2024; 80: 123-136. https://doi.org/10.1107/S2059798324000329
    DORA PSI
  • Huang C-Y, Aumonier S, Engilberge S, Eris D, Smith KML, Leonarski F, et al.
    Probing ligand binding of endothiapepsin by 'temperature-resolved' macromolecular crystallography
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 964-974. https://doi.org/10.1107/S205979832200612X
    DORA PSI
  • Kaminski JW, Vera L, Stegmann DP, Vering J, Eris D, Smith KML, et al.
    Fast fragment- and compound-screening pipeline at the Swiss Light Source
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 328-336. https://doi.org/10.1107/S2059798322000705
    DORA PSI
  • Mertens V, Abi Saad MJ, Coudevylle N, Wälti MA, Finke A, Marsh M, et al.
    Elucidation of a nutlin-derivative-HDM2 complex structure at the interaction site by NMR molecular replacement: a straightforward derivation
    Journal of Magnetic Resonance Open. 2022; 10-11: 100032 (5 pp.). https://doi.org/10.1016/j.jmro.2022.100032
    DORA PSI
  • Pedrini B, Finke AD, Marsh M, Luporini P, Vallesi A, Alimenti C
    Crystal structure of the pheromone Er-13 from the ciliate Euplotes raikovi, with implications for a protein-protein association model in pheromone/receptor interactions
    Journal of Structural Biology. 2022; 214(1): 107812 (10 pp.). https://doi.org/10.1016/j.jsb.2021.107812
    DORA PSI
  • Beale JH, Marsh ME
    Optimizing the growth of endothiapepsin crystals for serial crystallography experiments
    Journal of Visualized Experiments. 2021; 2021(168): e61896 (30 pp.). https://doi.org/10.3791/61896
    DORA PSI
  • Leka O, Wu Y, Li X, Kammerer RA
    Crystal structure of the catalytic domain of botulinum neurotoxin subtype A3
    Journal of Biological Chemistry. 2021; 296: 100684 (8 pp.). https://doi.org/10.1016/j.jbc.2021.100684
    DORA PSI
  • Martiel I, Beale JH, Karpik A, Huang C-Y, Vera L, Olieric N, et al.
    Versatile microporous polymer-based supports for serial macromolecular crystallography
    Acta Crystallographica Section D: Structural Biology. 2021; 77(9): 1153-1167. https://doi.org/10.1107/S2059798321007324
    DORA PSI
  • Mühlethaler T, Gioia D, Prota AE, Sharpe ME, Cavalli A, Steinmetz MO
    Comprehensive analysis of binding sites in tubulin
    Angewandte Chemie International Edition. 2021; 60(24): 13331-13342. https://doi.org/10.1002/anie.202100273
    DORA PSI
  • Sharpe ME, Wojdyla JA
    Fragment-screening and automation at the Swiss Light Source macromolecular crystallography beamlines
    Nihon Kessho Gakkaishi. 2021; 63(3): 232-235. https://doi.org/10.5940/jcrsj.63.232
    DORA PSI
  • Sutanto F, Shaabani S, Oerlemans R, Eris D, Patil P, Hadian M, et al.
    Combining high-throughput synthesis and high-throughput protein crystallography for accelerated hit identification
    Angewandte Chemie International Edition. 2021; 60(33): 18231-18239. https://doi.org/10.1002/anie.202105584
    DORA PSI
  • Bedi RK, Huang D, Wiedmer L, Li Y, Dolbois A, Wojdyla JA, et al.
    Selectively disrupting m6A-dependent protein-RNA interactions with fragments
    ACS Chemical Biology. 2020; 15(3): 618-625. https://doi.org/10.1021/acschembio.9b00894
    DORA PSI
  • Cheng R, Huang C-Y, Hennig M, Nar H, Schnapp G
    In situ crystallography as an emerging method for structure solution of membrane proteins: the case of CCR2A
    FEBS Journal. 2020; 287(5): 866-873. https://doi.org/10.1111/febs.15098
    DORA PSI
  • Guo B, Rodriguez-Gabin A, Prota AE, Mühlethaler T, Zhang N, Ye K, et al.
    Structural refinement of the tubulin ligand (+)-discodermolide to attenuate chemotherapy-mediated senescence
    Molecular Pharmacology. 2020; 98(2): 156-167. https://doi.org/10.1124/mol.119.117457
    DORA PSI
  • Huang C-Y, Meier N, Caffrey M, Wang M, Olieric V
    3D-printed holders for in meso in situ fixed-target serial X-ray crystallography
    Journal of Applied Crystallography. 2020; 53: 854-859. https://doi.org/10.1107/S1600576720002897
    DORA PSI
  • Martiel I, Huang C-Y, Villanueva-Perez P, Panepucci E, Basu S, Caffrey M, et al.
    Low-dose in situ prelocation of protein microcrystals by 2D X-ray phase-contrast imaging for serial crystallography
    IUCrJ. 2020; 7(6): 1131-1141. https://doi.org/10.1107/S2052252520013238
    DORA PSI
  • Nass K, Cheng R, Vera L, Mozzanica A, Redford S, Ozerov D, et al.
    Advances in long-wavelength native phasing at X-ray free-electron lasers
    IUCrJ. 2020; 7: 965-975. https://doi.org/10.1107/S2052252520011379
    DORA PSI
  • Skopintsev P, Ehrenberg D, Weinert T, James D, Kar RK, Johnson PJM, et al.
    Femtosecond-to-millisecond structural changes in a light-driven sodium pump
    Nature. 2020; 583: 314-318. https://doi.org/10.1038/s41586-020-2307-8
    DORA PSI
  • Apel A-K, Cheng RKY, Tautermann CS, Brauchle M, Huang C-Y, Pautsch A, et al.
    Crystal structure of CC chemokine receptor 2A in complex with an orthosteric antagonist provides insights for the design of selective antagonists
    Structure. 2019; 27(3): 427-438.e5. https://doi.org/10.1016/j.str.2018.10.027
    DORA PSI
  • Basu S, Kaminski JW, Panepucci E, Huang C-Y, Warshamanage R, Wang M, et al.
    Automated data collection and real-time data analysis suite for serial synchrotron crystallography
    Journal of Synchrotron Radiation. 2019; 26(1): 244-252. https://doi.org/10.1107/S1600577518016570
    DORA PSI
  • Basu S, Olieric V, Leonarski F, Matsugaki N, Kawano Y, Takashi T, et al.
    Long-wavelength native-SAD phasing: opportunities and challenges
    IUCrJ. 2019; 6(3): 1-14. https://doi.org/10.1107/S2052252519002756
    DORA PSI
  • Basu S, Finke A, Vera L, Wang M, Olieric V
    Making routine native SAD a reality: lessons from beamline X06DA at the Swiss Light Source
    Acta Crystallographica Section D: Structural Biology. 2019; 75(3): 262-271. https://doi.org/10.1107/S2059798319003103
    DORA PSI
  • Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asís Balaguer F, Khan T, et al.
    Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents
    European Journal of Medicinal Chemistry. 2019; 162: 290-320. https://doi.org/10.1016/j.ejmech.2018.11.004
    DORA PSI
  • Cury NM, Mühlethaler T, Laranjeira ABA, Canevarolo RR, Zenatti PP, Lucena-Agell D, et al.
    Structural basis of colchicine-site targeting acylhydrazones active against multidrug-resistant acute lymphoblastic leukemia
    iScience. 2019; 21: 95-109. https://doi.org/10.1016/j.isci.2019.10.003
    DORA PSI
  • Dohle W, Prota AE, Menchon G, Hamel E, Steinmetz MO, Potter BVL
    Tetrahydroisoquinoline sulfamates as potent microtubule disruptors: synthesis, antiproliferative and antitubulin activity of dichlorobenzyl-based derivatives, and a Tubulin cocrystal structure.
    ACS Omega. 2019; 4: 755-764. https://doi.org/10.1021/acsomega.8b02879
    DORA PSI
  • Faltova L, Jiang K, Frey D, Wu Y, Capitani G, Prota AE, et al.
    Crystal structure of a heterotetrameric katanin p60:p80 complex
    Structure. 2019; 27(9): 1375-1383.e3. https://doi.org/10.1016/j.str.2019.07.002
    DORA PSI
  • Jaeger K, Bruenle S, Weinert T, Guba W, Muehle J, Miyazaki T, et al.
    Structural basis for allosteric ligand recognition in the human CC chemokine receptor 7
    Cell. 2019; 178(5): 1222-1230. https://doi.org/10.1016/j.cell.2019.07.028
    DORA PSI
  • La Sala G, Olieric N, Sharma A, Viti F, de Asis Balaguer Perez F, Huang L, et al.
    Structure, thermodynamics, and kinetics of plinabulin binding to two tubulin isotypes
    Chem. 2019; 5(11): 2969-2986. https://doi.org/10.1016/j.chempr.2019.08.022
    DORA PSI
  • Varma N, Mutt E, Mühle J, Panneels V, Terakita A, Deupi X, et al.
    Crystal structure of jumping spider rhodopsin-1 as a light sensitive GPCR
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(29): 14547-14556. https://doi.org/10.1073/pnas.1902192116
    DORA PSI
  • Wang N, Bosc C, Ryul Choi S, Boulan B, Peris L, Olieric N, et al.
    Structural basis of tubulin detyrosination by the vasohibin–SVBP enzyme complex
    Nature Structural and Molecular Biology. 2019; 26(7): 571-582. https://doi.org/10.1038/s41594-019-0241-y
    DORA PSI
  • Weinert T, Skopintsev P, James D, Dworkowski F, Panepucci E, Kekilli D, et al.
    Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography
    Science. 2019; 365(6448): 61-65. https://doi.org/10.1126/science.aaw8634
    DORA PSI
  • de Asís Balaguer F, Mühlethaler T, Estévez-Gallego J, Calvo E, Giménez-Abián JF, Risinger AL, et al.
    Crystal structure of the cyclostreptin-tubulin adduct: implications for tubulin activation by taxane-site ligands
    International Journal of Molecular Sciences. 2019; 20(6): 1392 (17 pp.). https://doi.org/10.3390/ijms20061392
    DORA PSI
  • Żyła DS, Prota AE, Capitani G, Glockshuber R
    Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria
    Journal of Biological Chemistry. 2019; 294(27): 10553-10563. https://doi.org/10.1074/jbc.RA119.008610
    DORA PSI
  • Aher A, Kok M, Sharma A, Rai A, Olieric N, Rodriguez-Garcia R, et al.
    CLASP suppresses microtubule catastrophes through a single TOG domain
    Developmental Cell. 2018; 46(1): 40-58.e8. https://doi.org/10.1016/j.devcel.2018.05.032
    DORA PSI
  • Bueno O, Estévez Gallego J, Martins S, Prota AE, Gago F, Gómez-SanJuan A, et al.
    High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design
    Scientific Reports. 2018; 8(1): 4242 (17 pp.). https://doi.org/10.1038/s41598-018-22382-x
    DORA PSI
  • Dohle W, Jourdan FL, Menchon G, Prota AE, Foster PA, Mannion P, et al.
    Quinazolinone-based anticancer agents: synthesis, antiproliferative SAR, antitubulin activity, and tubulin Co-crystal structure
    Journal of Medicinal Chemistry. 2018; 61(3): 1031-1044. https://doi.org/10.1021/acs.jmedchem.7b01474
    DORA PSI
  • Field JJ, Pera B, Estévez Gallego J, Calvo E, Rodríguez-Salarichs J, Sáez-Calvo G, et al.
    Zampanolide binding to tubulin indicates cross-talk of taxane site with colchicine and nucleotide sites
    Journal of Natural Products. 2018; 81(3): 494-505. https://doi.org/10.1021/acs.jnatprod.7b00704
    DORA PSI
  • Huang C-Y, Olieric V, Howe N, Warshamanage R, Weinert T, Panepucci E, et al.
    In situ serial crystallography for rapid de novo membrane protein structure determination.
    Communications Biology. 2018; 1: 124 (8 pp.). https://doi.org/10.1038/S42003-018-0123-6
    DORA PSI
  • Jiang K, Faltova L, Hua S, Capitani G, Prota AE, Landgraf C, et al.
    Structural basis of formation of the microtubule minus-end-regulating CAMSAP-katanin complex
    Structure. 2018; 26(3): 375-382. https://doi.org/10.1016/j.str.2017.12.017
    DORA PSI
  • Kraatz SHW, Bianchi S, Steinmetz MO
    Combinatorial use of disulfide bridges and native sulfur-SAD phasing for rapid structure determination of coiled-coils
    Bioscience Reports. 2018; 38(5): BSR20181073 (11 pp.). https://doi.org/10.1042/BSR20181073
    DORA PSI
  • Leonarski F, Redford S, Mozzanica A, Lopez-Cuenca C, Panepucci E, Nass K, et al.
    Fast and accurate data collection for macromolecular crystallography using the JUNGFRAU detector
    Nature Methods. 2018; 15(10): 799-804. https://doi.org/10.1038/s41592-018-0143-7
    DORA PSI
  • Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, et al.
    Ligand channel in pharmacologically stabilized rhodopsin
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2018; 115(14): 3640-3645. https://doi.org/10.1073/pnas.1718084115
    DORA PSI
  • Opara NL, Mohacsi I, Makita M, Castano-Diez D, Diaz A, Juranić P, et al.
    Demonstration of femtosecond X-ray pump X-ray probe diffraction on protein crystals
    Structural Dynamics. 2018; 5(5): 054303 (15 pp.). https://doi.org/10.1063/1.5050618
    DORA PSI
  • Sharma A, Gerard SF, Olieric N, Steinmetz MO
    Cep120 promotes microtubule formation through a unique tubulin binding C2 domain
    Journal of Structural Biology. 2018; 203(1): 62-70. https://doi.org/10.1016/j.jsb.2018.01.009
    DORA PSI
  • Smedley CJ, Stanley PA, Qazzaz ME, Prota AE, Olieric N, Collins H, et al.
    Sustainable syntheses of (-)-jerantinines A & E and structural characterisation of the jerantinine-tubulin complex at the colchicine binding site
    Scientific Reports. 2018; 8(1): 10617 (7 pp.). https://doi.org/10.1038/s41598-018-28880-2
    DORA PSI
  • Sommer R, Makshakova ON, Wohlschlager T, Hutin S, Marsh M, Titz A, et al.
    Crystal structures of fungal tectonin in complex with O-methylated glycans suggest key role in innate immune defense
    Structure. 2018; 26(3): 391-402. https://doi.org/10.1016/j.str.2018.01.003
    DORA PSI
  • Stangier MM, Kumar A, Chen X, Farcas A-M, Barral Y, Steinmetz MO
    Structure-function relationship of the Bik1-Bim1 complex
    Structure. 2018; 26(4): 607-618.e4. https://doi.org/10.1016/j.str.2018.03.003
    DORA PSI
  • Thieltges KM, Avramovic D, Piscitelli CL, Markovic-Mueller S, Binz HK, Ballmer-Hofer K
    Characterization of a drug-targetable allosteric site regulating vascular endothelial growth factor signaling
    Angiogenesis. 2018; 21(3): 533-543. https://doi.org/10.1007/s10456-018-9606-9
    DORA PSI
  • Tsai C-J, Pamula F, Nehmé R, Mühle J, Weinert T, Flock T, et al.
    Crystal structure of rhodopsin in complex with a mini-Go sheds light on the principles of G protein selectivity
    Science Advances. 2018; 4(9): aat7052 (9 pp.). https://doi.org/10.1126/sciadv.aat7052
    DORA PSI
  • Atherton J, Jiang K, Stangier MM, Luo Y, Hua S, Houben K, et al.
    A structural model for microtubule minus-end recognition and protection by CAMSAP proteins
    Nature Structural and Molecular Biology. 2017; 24(11): 931-943. https://doi.org/10.1038/nsmb.3483
    DORA PSI
  • Benoit RM, Schärer MA, Wieser MM, Li X, Frey D, Kammerer RA
    Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C
    Scientific Reports. 2017; 7: 43588 (7 pp.). https://doi.org/10.1038/srep43588
    DORA PSI
  • Canela M-D, Noppen S, Bueno O, Prota AE, Bargsten K, Sáez-Calvo G, et al.
    Antivascular and antitumor properties of the tubulin-binding chalcone TUB091
    Oncotarget. 2017; 8(9): 14325-14342. https://doi.org/10.18632/oncotarget.9527
    DORA PSI
  • Gaspari R, Prota AE, Bargsten K, Cavalli A, Steinmetz MO
    Structural basis of cis- and trans-combretastatin binding to tubulin
    Chem. 2017; 2(1): 102-113. https://doi.org/10.1016/j.chempr.2016.12.005
    DORA PSI
  • Jiang K, Rezabkova L, Hua S, Liu Q, Capitani G, Altelaar AFM, et al.
    Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex
    Nature Cell Biology. 2017; 19(5): 480-492. https://doi.org/10.1038/ncb3511
    DORA PSI
  • Kumar A, Manatschal C, Rai A, Grigoriev I, Steiner Degen M, Jaussi R, et al.
    Short linear sequence motif LxxPTPh targets diverse proteins to growing microtubule ends
    Structure. 2017; 25(6): 924-932. https://doi.org/10.1016/j.str.2017.04.010
    DORA PSI
  • Markovic-Mueller S, Stuttfeld E, Asthana M, Weinert T, Bliven S, Goldie KN, et al.
    Structure of the full-length VEGFR-1 extracellular domain in complex with VEGF-A
    Structure. 2017; 25(2): 341-352. https://doi.org/10.1016/j.str.2016.12.012
    DORA PSI
  • Prota AE, Bargsten K, Redondo-Horcajo M, Smith AB, Yang C-PH, McDaid HM, et al.
    Structural basis of microtubule stabilization by discodermolide
    ChemBioChem. 2017; 18(10): 905-909. https://doi.org/10.1002/cbic.201600696
    DORA PSI
  • Rezabkova L, Jiang K, Capitani G, Prota AE, Akhmanova A, Steinmetz MO, et al.
    Structural basis of katanin p60:p80 complex formation
    Scientific Reports. 2017; 7: 14893 (8 pp.). https://doi.org/10.1038/s41598-017-14194-2
    DORA PSI
  • Ruiz FX, Crespo I, Álvarez S, Porté S, Giménez-Dejoz J, Cousido-Siah A, et al.
    Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008
    Chemico-Biological Interactions. 2017; 276: 174-181. https://doi.org/10.1016/j.cbi.2017.01.026
    DORA PSI
  • Sharma A, Sáez-Calvo G, Olieric N, de Asís Balaguer F, Barasoain I, Lamberth C, et al.
    Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin
    International Journal of Molecular Sciences. 2017; 18(7): 1336 (11 pp.). https://doi.org/10.3390/ijms18071336
    DORA PSI
  • Vercellino I, Rezabkova L, Olieric V, Polyhach Y, Weinert T, Kammerer RA, et al.
    Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2017; 114(46): E9821-E9828. https://doi.org/10.1073/pnas.1712621114
    DORA PSI
  • Weinert T, Olieric N, Cheng R, Brünle S, James D, Ozerov D, et al.
    Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons
    Nature Communications. 2017; 8(1): 542 (11 pp.). https://doi.org/10.1038/s41467-017-00630-4
    DORA PSI
  • Bianchi S, van Riel WE, Kraatz SHW, Olieric N, Frey D, Katrukha EA, et al.
    Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations
    Scientific Reports. 2016; 6: 30668 (16 pp.). https://doi.org/10.1038/srep30668
    DORA PSI
  • Burger D, Stihle M, Sharma A, Di Lello P, Benz J, D'Arcy B, et al.
    Crystal structures of the human doublecortin C- and N-terminal domains in complex with specific antibodies
    Journal of Biological Chemistry. 2016; 291(31): 16292-16306. https://doi.org/10.1074/jbc.M116.726547
    DORA PSI
  • Chatterjee A, Mallin H, Klehr J, Vallapurackal J, Finke AD, Vera L, et al.
    An enantioselective artificial Suzukiase based on the biotin-streptavidin technology
    Chemical Science. 2016; 7(1): 673-677. https://doi.org/10.1039/c5sc03116h
    DORA PSI
  • Doodhi H, Prota AE, Rodríguez-García R, Xiao H, Custar DW, Bargsten K, et al.
    Termination of protofilament elongation by eribulin induces lattice defects that promote microtubule catastrophes
    Current Biology. 2016; 26(13): 1713-1721. https://doi.org/10.1016/j.cub.2016.04.053
    DORA PSI
  • Hilbert M, Noga A, Frey D, Hamel V, Guichard P, Kraatz SHW, et al.
    SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture
    Nature Cell Biology. 2016; 18(4): 393-403. https://doi.org/10.1038/ncb3329
    DORA PSI
  • Kraatz S, Guichard P, Obbineni JM, Olieric N, Hatzopoulos GN, Hilbert M, et al.
    The human centriolar protein CEP135 contains a two-stranded coiled-coil domain critical for microtubule binding
    Structure. 2016; 24(8): 1358-1371. https://doi.org/10.1016/j.str.2016.06.011
    DORA PSI
  • Moschetti T, Sharpe T, Fischer G, Marsh ME, Ng HK, Morgan M, et al.
    Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51
    Journal of Molecular Biology. 2016; 428(23): 4589-4607. https://doi.org/10.1016/j.jmb.2016.10.009
    DORA PSI
  • Nogly P, Panneels V, Nelson G, Gati C, Kimura T, Milne C, et al.
    Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography
    Nature Communications. 2016; 7: 12314 (9 pp.). https://doi.org/10.1038/ncomms12314
    DORA PSI
  • Olieric V, Weinert T, Finke AD, Anders C, Li D, Olieric N, et al.
    Data-collection strategy for challenging native SAD phasing
    Acta Crystallographica Section D: Structural Biology. 2016; 72(3): 421-429. https://doi.org/10.1107/S2059798315024110
    DORA PSI
  • Orts J, Wälti MA, Marsh M, Vera L, Gossert AD, Güntert P, et al.
    NMR-based determination of the 3D structure of the ligand-protein interaction site without protein resonance assignment
    Journal of the American Chemical Society. 2016; 138(13): 4393-4400. https://doi.org/10.1021/jacs.5b12391
    DORA PSI
  • Prota AE, Setter J, Waight AB, Bargsten K, Murga J, Diaz JF, et al.
    Pironetin binds covalently to αCys316 and perturbs a major loop and helix of α-tubulin to inhibit microtubule formation
    Journal of Molecular Biology. 2016; 428(15): 2981-2988. https://doi.org/10.1016/j.jmb.2016.06.023
    DORA PSI
  • Rezabkova L, Kraatz SHW, Akhmanova A, Steinmetz MO, Kammerer RA
    Biophysical and structural characterization of the centriolar protein CEP104 interaction network
    Journal of Biological Chemistry. 2016; 291(35): 18496-18504. https://doi.org/10.1074/jbc.M116.739771
    DORA PSI
  • Scott DE, Marsh M, Blundell TL, Abell C, Hyvönen M
    Structure-activity relationship of the peptide binding-motif mediating the BRCA2:RAD51 protein-protein interaction
    FEBS Letters. 2016; 590(8): 1094-1102. https://doi.org/10.1002/1873-3468.12139
    DORA PSI
  • Sharma A, Aher A, Dynes NJ, Frey D, Katrukha EA, Jaussi R, et al.
    Centriolar CPAP/SAS-4 imparts slow processive microtubule growth
    Developmental Cell. 2016; 37(4): 362-376. https://doi.org/10.1016/j.devcel.2016.04.024
    DORA PSI
  • Singhal A, Guo Y, Matkovic M, Schertler G, Deupi X, Yan ECY, et al.
    Structural role of the T94I rhodopsin mutation in congenital stationary night blindness
    EMBO Reports. 2016; 17(10): 1431-1440. https://doi.org/10.15252/embr.201642671
    DORA PSI
  • Trigili C, Barasoain I, Sánchez-Murcia PA, Bargsten K, Redondo-Horcajo M, Nogales A, et al.
    Structural determinants of the dictyostatin chemotype for tubulin binding affinity and antitumor activity against taxane- and epothilone-resistant cancer cells
    ACS Omega. 2016; 1(6): 1192-1204. https://doi.org/10.1021/acsomega.6b00317
    DORA PSI
  • Waight AB, Bargsten K, Doronina S, Steinmetz MO, Sussman D, Prota AE
    Structural basis of microtubule destabilization by potent auristatin anti-mitotics
    PLoS One. 2016; 11(8): e0160890 (14 pp.). https://doi.org/10.1371/journal.pone.0160890
    DORA PSI
  • Wojdyla JA, Panepucci E, Martiel I, Ebner S, Huang C-Y, Caffrey M, et al.
    Fast two-dimensional grid and transmission X-ray microscopy scanning methods for visualizing and characterizing protein crystals
    Journal of Applied Crystallography. 2016; 49: 944-952. https://doi.org/10.1107/S1600576716006233
    DORA PSI
  • Christen M, Marcaida MJ, Lamprakis C, Aeschimann W, Vaithilingam J, Schneider P, et al.
    Structural insights on cholesterol endosynthesis: binding of squalene and 2,3-oxidosqualene to supernatant protein factor
    Journal of Structural Biology. 2015; 190(3): 261-270. https://doi.org/10.1016/j.jsb.2015.05.001
    DORA PSI
  • Dong J, Zhao H, Zhou T, Spiliotopoulos D, Rajendran C, Li X-D, et al.
    Structural analysis of the binding of type I, I1/2, and II inhibitors to Eph tyrosine kinases
    ACS Medicinal Chemistry Letters. 2015; 6(1): 79-83. https://doi.org/10.1021/ml500355x
    DORA PSI
  • Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, et al.
    Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
    Nature. 2015; 523: 561-567. https://doi.org/10.1038/nature14656
    DORA PSI
  • Pinker F, Giegé P, Sauter C
    Crystallization and crystallographic analysis of an arabidopsis nuclear proteinaceous RNase P
    Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2015; 71: 1372-1377. https://doi.org/10.1107/S2053230X15017033
    DORA PSI
  • Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, et al.
    Fast native-SAD phasing for routine macromolecular structure determination
    Nature Methods. 2015; 12(2): 131-133. https://doi.org/10.1038/nmeth.3211
    DORA PSI
  • Wu W, Nogly P, Rheinberger J, Kick LM, Gati C, Nelson G, et al.
    Batch crystallization of rhodopsin for structural dynamics using an X-ray free-electron laser
    Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2015; 71: 856-860. https://doi.org/10.1107/S2053230X15009966
    DORA PSI
  • Benoit RM, Frey D, Hilbert M, Kevenaar JT, Wieser MM, Stirnimann CU, et al.
    Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A
    Nature. 2014; 505(7481): 108-111. https://doi.org/10.1038/nature12732
    DORA PSI
  • Campagne S, Marsh ME, Capitani G, Vorholt JA, Allain FH-T
    Structural basis for -10 promoter element melting by environmentally induced sigma factors
    Nature Structural and Molecular Biology. 2014; 21(3): 269-276. https://doi.org/10.1038/nsmb.2777
    DORA PSI
  • Manni S, Mineev KS, Usmanova D, Lyukmanova EN, Shulepko MA, Kirpichnikov MP, et al.
    Structural and functional characterization of alternative transmembrane domain conformations in VEGF receptor 2 activation
    Structure. 2014; 22(8): 1077-1089. https://doi.org/10.1016/j.str.2014.05.010
    DORA PSI
  • Prota AE, Bargsten K, Diaz JF, Marsh M, Cuevas C, Liniger M, et al.
    A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2014; 111(38): 13817-13821. https://doi.org/10.1073/pnas.1408124111
    DORA PSI
  • Prota AE, Bargsten K, Northcote PT, Marsh M, Altmann K-H, Miller JH, et al.
    Structural basis of microtubule stabilization by laulimalide and peloruside A
    Angewandte Chemie International Edition. 2014; 53(6): 1621-1625. https://doi.org/10.1002/anie.201307749
    DORA PSI
  • Prota AE, Danel F, Bachmann F, Bargsten K, Buey RM, Pohlmann J, et al.
    The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization
    Journal of Molecular Biology. 2014; 426(8): 1848-1860. https://doi.org/10.1016/j.jmb.2014.02.005
    DORA PSI
  • Truan D, Bjelić S, Li X-D, Winkler FK
    Structure and thermodynamics of effector molecule binding to the nitrogen signal transduction PII protein GlnZ from Azospirillum brasilense
    Journal of Molecular Biology. 2014; 426(15): 2783-2799. https://doi.org/10.1016/j.jmb.2014.05.008
    DORA PSI
  • Weber S, Stirnimann CU, Wieser M, Frey D, Meier R, Engelhardt S, et al.
    A type IV translocated Legionella cysteine phytase counteracts intracellular growth restriction by phytate
    Journal of Biological Chemistry. 2014; 289(49): 34175-34188. https://doi.org/10.1074/jbc.M114.592568
    DORA PSI
  • Abakumov AM, Batuk D, Tsirlin AA, Prescher C, Dubrovinsky L, Sheptyakov DV, et al.
    Frustrated pentagonal Cairo lattice in the non-collinear antiferromagnet Bi4Fe5O13F
    Physical Review B. 2013; 87(2): 024423 (9 pp.). https://doi.org/10.1103/PhysRevB.87.024423
    DORA PSI