Publications

PDB structures measured at X06DA


2019

  • A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine. Friedel K, Popp MA, Matern JCJ, Gazdag EM, Thiel IV, Volkmann G, Blankenfeldt W, Mootz HD
    CHEMICAL SCIENCE 10, 239 (2019).
    DOI: 10.1039/C8SC01074A
  • Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule. Tautermann CS, Binder F, Buttner FH, Eickmeier C, Fiegen D, Gross U, Grundl MA, Heilker R, Hobson S, Hoerer S, Luippold A, Mack V, Montel F, Peters S, Bhattacharya S, Vaidehi N, Schnapp G, Thamm S, Zeeb M
    JOURNAL OF MEDICINAL CHEMISTRY 62, 306 (2019).
  • Characterization of a thermostable flavin-containing monooxygenase from Nitrincola lacisaponensis (NiFMO). Loncar N, Fiorentini F, Bailleul G, Savino S, Romero E, Mattevi A, Fraaije MW
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 103, 1755 (2019).
    DOI: 10.1007/S00253-018-09579-W
  • Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, Ren H, Lambert LJ, Cosford NDP, Brandts CH, Knapp S
    BIOCHEMICAL JOURNAL 476, 875 (2019).
  • Crystal structure of a natural light-gated anion channelrhodopsin. Li H, Huang CY, Govorunova EG, Schafer CT, Sineshchekov OA, Wang M, Zheng L, Spudich JL
    ELIFE 8, (2019).
  • Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. Popow J, Arnhof H, Bader G, Berger H, Ciulli A, Covini D, Dank C, Gmaschitz T, Greb P, Karolyi-Ozguer J, Koegl M, McConnell DB, Pearson M, Rieger M, Rinnenthal J, Roessler V, Schrenk A, Spina M, Steurer S, Trainor N, Traxler E, Wieshofer C, Zoephel A, Ettmayer P
    JOURNAL OF MEDICINAL CHEMISTRY 62, 2508 (2019).
    DOI: 10.1021/ACS.JMEDCHEM.8B01826
  • Hyperbolic Pressure-Temperature Phase Diagram of the Zinc-Finger Protein apoKti11 Detected by NMR Spectroscopy. Klamt A, Nagarathinam K, Tanabe M, Kumar A, Balbach J
    JOURNAL OF PHYSICAL CHEMISTRY B 123, 792 (2019).
  • Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a. Swarts DC, Jinek M
    MOLECULAR CELL 73, 589 (2019).
    DOI: 10.1016/J.MOLCEL.2018.11.021
  • Mechanistic insights into the evolution of DUF26-containing proteins in land plants. Vaattovaara A, Brandt B, Rajaraman S, Safronov O, Veidenberg A, Luklova M, Kangasjarvi J, Loytynoja A, Hothorn M, Salojarvi J, Wrzaczek M
    Communications Biology 2, 56 (2019).
    DOI: 10.1101/493502
  • Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor. Kroupova A, Ivascu A, Reimao-Pinto MM, Ameres SL, Jinek M
    NUCLEIC ACIDS RESEARCH 47, 1030 (2019).
  • Structural studies on Ca3Al4MgO10 (C3A2M) - a ternary phase in the system CaO-Al2O3-MgO Kahlenberg V, Albrecht R, Schmidmair D, Krüger H, Krüger B, Tribus M, Pauluhn A
    JOURNAL OF THE AMERICAN CERAMIC SOCIETY 102, 2084 (2019).
    DOI: 10.1111/jace.16001
  • Structure of the heterophilic interaction between the nectin-like 4 and nectin-like 1 molecules. Liu X, An T, Li D, Fan Z, Xiang P, Li C, Ju W, Li J, Hu G, Qin B, Yin B, Wojdyla JA, Wang M, Yuan J, Qiang B, Shu P, Cui S, Peng X
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116, 2068 (2019).
    DOI: 10.1073/PNAS.1810969116
  • Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure. Dohle W, Prota AE, Menchon G, Hamel E, Steinmetz MO, Potter BVL
    ACS Omega 4, 755 (2019).
  • Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1 Leopold K, Stirpe A, Schalch T
    GENES & DEVELOPMENT , (2019).
    DOI: 10.1101/gad.320440.118

2018

  • A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer Colaluca IN, Basile A, Freiburger L, DUva V, Disalvatore D, Vecchi M, Confalonieri S, Tosoni D, Cecatiello V, Malabarba MG, Yang CJ, Kainosho M, Sattler M, Mapelli M, Pece S, Di Fiore PP
    The Journal of Cell Biology 217, 745 (2018).
    DOI: 10.1083/jcb.201709092
  • A close look onto structural models and primary ligands of metallo-beta-lactamases. Raczynska JE, Shabalin IG, Minor W, Wlodawer A, Jaskolski M
    DRUG RESISTANCE UPDATES 40, 1 (2018).
    DOI: 10.1016/J.DRUP.2018.08.001
  • A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities. Apetri A, Crespo R, Juraszek J, Pascual G, Janson R, Zhu X, Zhang H, Keogh E, Holland T, Wadia J, Verveen H, Siregar B, Mrosek M, Taggenbrock R, Ameijde J, Inganas H, van Winsen M, Koldijk MH, Zuijdgeest D, Borgers M, Dockx K, Stoop EJM, Yu W, Brinkman-van der Linden EC, Ummenthum K, van Kolen K, Mercken M, Steinbacher S, de Marco D, Hoozemans JJ, Wilson IA, Koudstaal W, Goudsmit J
    ACTA NEUROPATHOLOGICA 6, 43 (2018).
  • A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin. Menchon G, Prota AE, Lucena-Agell D, Bucher P, Jansen R, Irschik H, Muller R, Paterson I, Diaz JF, Altmann KH, Steinmetz MO
    NATURE COMMUNICATIONS 9, 2106 (2018).
    DOI: 10.1038/S41467-018-04535-8
  • A pi-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors Schnitzler A, Gratz A, Bollacke A, Weyrich M, Kuckländer U, Wünsch B, Götz C, Niefind K, Jose J
    Pharmaceuticals 11, 23 (2018).
    DOI: 10.3390/ph11010023
  • Another twist on nitrogenases Einsle Oliver
    Nature Microbiology 3, 263-264 (2018).
    DOI: 10.1038/s41564-018-0116-8
  • Aravaite, Ba2Ca18(SiO4)6(PO4)3(CO3)F3O: modular structure and disorder of a new mineral with single and triple antiperovskite layers Krüger B, Krüger H, Galuskin EV, Galuskina IO, Vapnik Y, Olieric V, Pauluhn A
    Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 74, 492 (2018).
    DOI: 10.1107/S2052520618012271
  • Beetle luciferases with naturally red- and blue-shifted emission Carrasco-López C, Ferreira J, Lui N, Schramm S, Berraud-Pache R, Navizet I, Panjikar S, Naumov P, Rabeh W
    Life Science Alliance 1, e201800072 (2018).
    DOI: 10.26508/lsa.201800072
  • Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. Zhu J, Dong J, Batiste L, Unzue A, Dolbois A, Pascanu V, Sledz P, Nevado C, Caflisch A
    ACS MEDICINAL CHEMISTRY LETTERS 9, 929 (2018).
  • Biophysical and structural insight into the USP8/14-3-3 interaction. Centorrino F, Ballone A, Wolter M, Ottmann C
    FEBS LETTERS 592, 1211 (2018).
  • CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain. Aher A, Kok M, Sharma A, Rai A, Olieric N, Rodriguez-Garcia R, Katrukha EA, Weinert T, Olieric V, Kapitein LC, Steinmetz MO, Dogterom M, Akhmanova A
    DEVELOPMENTAL CELL 46, 40 (2018).
  • COMP and TSP-4 interact specifically with the novel GXKGHR motif only found in fibrillar collagens. Gebauer JM, Kohler A, Dietmar H, Gompert M, Neundorf I, Zaucke F, Koch M, Baumann U
    Scientific Reports 8, 17187 (2018).
  • Cep120 promotes microtubule formation through a unique tubulin binding C2 domain Sharma A, Gerard Samuel F, Olieric N, Steinmetz Michel O
    JOURNAL OF STRUCTURAL BIOLOGY -, S1047847718300248 (2018).
    DOI: 10.1016/j.jsb.2018.01.009
  • Combinatorial use of disulfide bridges and native sulfur-SAD phasing for rapid structure determination of coiled-coils Kraatz Sebastian HW, Bianchi S, Steinmetz Michel O
    BIOSCIENCE REPORTS 38, BSR20181073 (2018).
    DOI: 10.1042/BSR20181073
  • Conformational flexibility of pore loop-1 gives insights into substrate translocation by the AAA+protease FtsH. Uthoff M, Baumann U
    JOURNAL OF STRUCTURAL BIOLOGY 204, 199 (2018).
    DOI: 10.1016/J.JSB.2018.08.009
  • Conformational states during vinculin unlocking differentially regulate focal adhesion properties. Chorev DS, Volberg T, Livne A, Eisenstein M, Martins B, Kam Z, Jockusch BM, Medalia O, Sharon M, Geiger B
    Scientific Reports 8, 2693 (2018).
  • Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain: Engineering a minimalistic allosteric system. Rabbani S, Fiege B, Eris D, Silbermann M, Jakob RP, Navarra G, Maier T, Ernst B
    JOURNAL OF BIOLOGICAL CHEMISTRY 293, 1835 (2018).
  • Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists Apel A, Cheng Robert KY, Tautermann Christofer S, Brauchle M, Huang CY, Pautsch A, Hennig M, Nar H, Schnapp G
    STRUCTURE 27, S0969212618303885 (2018).
    DOI: 10.1016/j.str.2018.10.027
  • Crystal Structures of Fungal Tectonin in Complex with O-Methylated Glycans Suggest Key Role in Innate Immune Defense Sommer R, Makshakova Olga N, Wohlschlager T, Hutin S, Marsh M, Titz A, Künzler M, Varrot A
    STRUCTURE 26, 391 (2018).
    DOI: 10.1016/j.str.2018.01.003
  • Crystal Structures of R-Type Bacteriocin Sheath and Tube Proteins CD1363 and CD1364 FromClostridium difficilein the Pre-assembled State. Schwemmlein N, Pippel J, Gazdag EM, Blankenfeldt W
    Frontiers in Microbiology 9, 1750 (2018).
    DOI: 10.3389/FMICB.2018.01750
  • Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor. Hochscherf J, Pietsch M, Tieu W, Kuan K, Abell AD, Gutschow M, Niefind K
    Acta Crystallographica Section F Structural Biology and Crystallization Communications 74, 480 (2018).
    DOI: 10.1107/S2053230X1800537X
  • Crystal structures of two tandem malectin-like receptor kinases involved in plant reproduction. Moussu S, Augustin S, Roman AO, Broyart C, Santiago J
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 74, 671 (2018).
  • DA+ data acquisition and analysis software at the Swiss Light Source macromolecular crystallography beamlines Wojdyla J, Kaminski Jakub W, Panepucci E, Ebner S, Wang X, Gabadinho J, Wang M
    JOURNAL OF SYNCHROTRON RADIATION 25, 293 (2018).
    DOI: 10.1107/S1600577517014503
  • Demonstration of femtosecond X-ray pump X-ray probe diffraction on protein crystals Opara Nadia L, Mohacsi I, Makita M, Castano-Diez D, Diaz A, Juranic P, Marsh M, Meents A, Milne Christopher, Mozzanica A, Padeste C, Panneels V, Sikorski M, Song S, Stahlberg H, Vartiainen I, Vera L, Wang M, Willmott Philip R, David C
    STRUCTURAL DYNAMICS 5, 054303 (2018).
    DOI: 10.1063/1.5050618
  • Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase. Crespo I, Gimenez-Dejoz J, Porte S, Cousido-Siah A, Mitschler A, Podjarny A, Pratsinis H, Kletsas D, Pares X, Ruiz FX, Metwally K, Farres J
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 152, 160 (2018).
  • Direct observation of the ZrIVinteraction with the carboxamide bond in a noncovalent complex between Hen Egg White Lysozyme and a Zr-substituted Keggin polyoxometalate. Vandebroek L, Van Meervelt L, Parac-Vogt TN
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS 74, 1348 (2018).
    DOI: 10.1107/S2053229618010690
  • Directed Evolution of an Artificial Imine Reductase. Hestericova M, Heinisch T, Alonso-Cotchico L, Marechal JD, Vidossich P, Ward TR
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57, 1863 (2018).
    DOI: 10.1002/ANIE.201711016
  • Discovery of Inhibitor of Wnt Production 2 (IWP-2) and related compounds as selective ATP-competitive inhibitors of Casein Kinase 1 (CK1) delta / epsilon García-Reyes B, Witt L, Jansen B, Karasu E, Gehring T, Leban J, Henne-Bruns D, Pichlo C, Brunstein E, Baumann U, Wesseler F, Rathmer B, Schade D, Peifer C, Knippschild U
    JOURNAL OF MEDICINAL CHEMISTRY 61, 4087 (2018).
    DOI: 10.1021/acs.jmedchem.8b00095
  • Discovery of a Potent, Orally Bioavailable PI4KIII beta Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo. Reuberson J, Horsley H, Franklin RJ, Ford D, Neuss J, Brookings D, Huang Q, Vanderhoydonck B, Gao LJ, Jang MY, Herdewijn P, Ghawalkar A, Fallah-Arani F, Khan AR, Henshall J, Jairaj M, Malcolm S, Ward E, Shuttleworth L, Lin Y, Li S, Louat T, Waer M, Herman J, Payne A, Ceska T, Doyle C, Pitt W, Calmiano M, Augustin M, Steinbacher S, Lammens A, Allen R
    JOURNAL OF MEDICINAL CHEMISTRY 61, 6705 (2018).
  • Driving Protein Conformational Changes with Light: Photoinduced Structural Rearrangement in a Heterobimetallic Oxidase. Maugeri PT, Griese JJ, Branca RM, Miller EK, Smith ZR, Eirich J, Hogbom M, Shafaat HS
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140, 1471 (2018).
    DOI: 10.1021/JACS.7B11966
  • Dynamic control of RSK complexes by phosphoswitch-based regulation. Gogl G, Biri-Kovacs B, Poti AL, Vadaszi H, Szeder B, Bodor A, Schlosser G, Acs A, Turiak L, Buday L, Alexa A, Nyitray L, Remenyi A
    FEBS JOURNAL 285, 46 (2018).
  • E. colisurface display of streptavidin for directed evolution of an allylic deallylase. Heinisch T, Schwizer F, Garabedian B, Csibra E, Jeschek M, Vallapurackal J, Pinheiro VB, Marliere P, Panke S, Ward TR
    CHEMICAL SCIENCE 9, 5383 (2018).
  • Estimation of Drug-Target Residence Times by tau-Random Acceleration Molecular Dynamics Simulations. Kokh DB, Amaral M, Bomke J, Gradler U, Musil D, Buchstaller HP, Dreyer MK, Frech M, Lowinski M, Vallee F, Bianciotto M, Rak A, Wade RC
    JOURNAL OF CHEMICAL THEORY AND COMPUTATION 14, 3859 (2018).
  • Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition. Kumari P, Aeschimann F, Gaidatzis D, Keusch JJ, Ghosh P, Neagu A, Pachulska-Wieczorek K, Bujnicki JM, Gut H, Grosshans H, Ciosk R
    NATURE COMMUNICATIONS 9, 1549 (2018).
  • Genetic Algorithm Based Design and Experimental Characterization of a Highly Thermostable Metalloprotein. Bozkurt E, Perez MAS, Hovius R, Browning NJ, Rothlisberger U
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140, 4517 (2018).
  • Genetic Engineering of an Artificial Metalloenzyme for Transfer Hydrogenation of a Self-Immolative Substrate in Escherichia coli's Periplasm. Zhao J, Rebelein JG, Mallin H, Trindler C, Pellizzoni MM, Ward TR
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140, 13171 (2018).
  • Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs. Nishimura T, Fakim H, Brandmann T, Youn JY, Gingras AC, Jinek M, Fabian MR
    NUCLEIC ACIDS RESEARCH 46, 12008 (2018).
  • Identification and Characterization of a Single High-Affinity Fatty Acid Binding Site in Human Serum Albumin. Wenskowsky L, Schreuder H, Derdau V, Matter H, Volkmar J, Nazare M, Opatz T, Petry S
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57, 1044 (2018).
  • Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer. Pichlo C, Toelzer C, Chojnacki K, Ocal S, Uthoff M, Ruegenberg S, Hermanns T, Schacherl M, Denzel MS, Hofmann K, Niefind K, Baumann U
    Acta Crystallographica Section F Structural Biology and Crystallization Communications 74, 307 (2018).
    DOI: 10.1107/S2053230X18005253
  • In Silico Identification of JMJD3 Demethylase Inhibitors. Esposito C, Wiedmer L, Caflisch A
    Journal of Chemical Information and Modeling 58, 2151 (2018).
  • Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination. Kalayil S, Bhogaraju S, Bonn F, Shin D, Liu Y, Gan N, Basquin J, Grumati P, Luo ZQ, Dikic I
    NATURE 557, 734 (2018).
    DOI: 10.1038/S41586-018-0145-8
  • Membrane insertion of alpha-xenorhabdolysin in near-atomic detail. Schubert E, Vetter IR, Prumbaum D, Penczek PA, Raunser S
    ELIFE 7, (2018).
  • Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity. Gerlach D, Guo Y, De Castro C, Kim SH, Schlatterer K, Xu FF, Pereira C, Seeberger PH, Ali S, Codee J, Sirisarn W, Schulte B, Wolz C, Larsen J, Molinaro A, Lee BL, Xia G, Stehle T, Peschel A
    NATURE 563, 705 (2018).
    DOI: 10.1038/S41586-018-0730-X
  • Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds. Prosdocimi T, Mollica L, Donini S, Semrau MS, Lucarelli AP, Aiolfi E, Cavalli A, Storici P, Alfei S, Brullo C, Bruno O, Parisini E
    BIOCHEMISTRY 57, 2876 (2018).
  • Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes Brandmann T, Fakim H, Padamsi Z, Youn J, Gingras A, Fabian M, Jinek M
    The EMBO Journal 37, e97869 (2018).
    DOI: 10.15252/embj.201797869
  • Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3 Scietti L, Chiapparino A, De Giorgi F, Fumagalli M, Khoriauli L, Nergadze S, Basu S, Olieric V, Cucca L, Banushi B, Profumo A, Giulotto E, Gissen P, Forneris F
    NATURE COMMUNICATIONS 9, 3163 (2018).
    DOI: 10.1038/s41467-018-05631-5
  • Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3 (vol 9, 3163, 2018) Scietti Luigi, Chiapparino Antonella, De Giorgi Francesca, Fumagalli Marco, Khoriauli Lela, Nergadze Solomon, Basu Shibom, Olieric Vincent, Cucca Lucia, Banushi Blerida, Profumo Antonella, Giulotto Elena, Gissen Paul, Forneris Federico
    NATURE COMMUNICATIONS 9, 3912 (2018).
    DOI: 10.1038/s41467-018-06481-x
  • New Mineral with Modular Structure Derived from Hatrurite from the Pyrometamorphic Rocks of the Hatrurim Complex: Ariegilatite, BaCa12(SiO4)4(PO4)2F2O, from Negev Desert, Israel Galuskin E, Krüger B, Galuskina I, Krüger H, Vapnik Y, Wojdyla J, Murashko M
    Minerals 8, 109 (2018).
    DOI: 10.3390/min8030109
  • New Occurrence of Rusinovite, Ca10(Si2O7)3Cl2: Composition, Structure and Raman Data of Rusinovite from Shadil-Khokh Volcano, South Ossetia and Bellerberg Volcano, Germany Srodek D, Juroszek R, Krüger H, Krüger B, Galuskina I, Gazeev V
    Minerals 8, 399 (2018).
    DOI: 10.3390/min8090399
  • PASTA repeats of the protein kinase StkP interconnect cell constriction and separation of Streptococcus pneumoniae. Zucchini L, Mercy C, Garcia PS, Cluzel C, Gueguen-Chaignon V, Galisson F, Freton C, Guiral S, Brochier-Armanet C, Gouet P, Grangeasse C
    Nature Microbiology 3, 197 (2018).
  • Pneumocystis Cytochrome b Mutants Associated With Atovaquone Prophylaxis Failure as the Cause of Pneumocystis Infection Outbreak Among Heart Transplant Recipients Argy N, Le Gal S, Coppée R, Song Z, Vindrios W, Massias L, Kao W, Hunte C, Yazdanpanah Y, Lucet J, Houzé S, Clain J, Nevez G
    CLINICAL INFECTIOUS DISEASES 67, 913 (2018).
    DOI: 10.1093/cid/ciy154
  • Preparation and characterization of Na1.5K0.5Ca6Si4O15 (Na1.5K0.5Ca6[SiO4]2[Si2O7]) and Na1.41K0.19Ca2.20Si2O7: two new phases in the system Na2O?K2O?CaO?SiO2 Kahlenberg V, Mayerl M, Schmidmair D, Krueger H, Tribus M
    EUROPEAN JOURNAL OF MINERALOGY 30, 957 (2018).
    DOI: 10.1127/ejm/2018/0030-2767
  • Proteins as Sustainable Building Blocks for the Next Generation of Bioinorganic Nanomaterials Lach M, Künzle M, Beck T
    BIOCHEMISTRY , acs.biochem.8b00966 (2018).
    DOI: 10.1021/acs.biochem.8b00966
  • Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure Dohle W, Jourdan Fabrice L, Menchon G, Prota Andrea E, Foster Paul A, Mannion P, Hamel E, Thomas Mark P, Kasprzyk Philip G, Ferrandis E, Steinmetz Michel O, Leese Mathew P, Potter Barry VL
    JOURNAL OF MEDICINAL CHEMISTRY , acs.jmedchem.7b01474 (2018).
    DOI: 10.1021/acs.jmedchem.7b01474
  • Sequence-Specific Solution NMR Assignments of the beta-Barrel Insertase BamA to Monitor Its Conformational Ensemble at the Atomic Level. Hartmann JB, Zahn M, Burmann IM, Bibow S, Hiller S
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140, 11252 (2018).
  • Sharyginite, Ca3TiFe2O8, A New Mineral from the Bellerberg Volcano, Germany Juroszek R, Krüger H, Galuskina I, Krüger B, Jezak L, Ternes B, Wojdyla J, Krzykawski T, Pautov L, Galuskin E
    Minerals 8, 308 (2018).
    DOI: 10.3390/min8070308
  • Snapshots of a modified nucleotide moving through the confines of a DNA polymerase. Kropp HM, Durr SL, Peter C, Diederichs K, Marx A
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115, 9992 (2018).
  • Stracherite, BaCa6(SiO4)2[(PO4)(CO3)]F, the first CO3-bearing intercalated hexagonal antiperovskite from Negev Desert, Israel Galuskin EV, Krüger B, Galuskina IO, Krüger H, Vapnik Y, Pauluhn A, Olieric V
    AMERICAN MINERALOGIST 103, 1699 (2018).
    DOI: 10.2138/am-2018-6493
  • Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex Jiang K, Faltova L, Hua S, Capitani G, Prota Andrea E, Landgraf C, Volkmer R, Kammerer Richard A, Steinmetz Michel O, Akhmanova A
    STRUCTURE -, S0969212617304422 (2018).
    DOI: 10.1016/j.str.2017.12.017
  • Structural Basis of Outstanding Multivalent Effects in Jack Bean alpha-Mannosidase Inhibition. Howard E, Cousido-Siah A, Lepage ML, Schneider JP, Bodlenner A, Mitschler A, Meli A, Izzo I, Alvarez HA, Podjarny A, Compain P
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57, 8002 (2018).
  • Structural Insight Into Conformational Changes Induced by ATP Binding in a Type III Secretion-Associated ATPase From Shigella flexneri Gao X, Mu Z, Yu X, Qin B, Wojdyla J, Wang M, Cui S
    Frontiers in Microbiology 9, 1468 (2018).
    DOI: 10.3389/fmicb.2018.01468
  • Structural Insights into the Altering Function of CRMP2 by Phosphorylation. Sumi T, Imasaki T, Aoki M, Sakai N, Nitta E, Shirouzu M, Nitta R
    CELL STRUCTURE AND FUNCTION 43, 15 (2018).
  • Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38 alpha Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3. Ansideri F, Macedo JT, Eitel M, El-Gokha A, Zinad DS, Scarpellini C, Kudolo M, Schollmeyer D, Boeckler FM, Blaum BS, Laufer SA, Koch P
    ACS Omega 3, 7809 (2018).
    DOI: 10.1021/ACSOMEGA.8B00668
  • Structural analyses unravel the molecular mechanism of cyclic di-GMP regulation of bacterial chemotaxis via a PilZ adaptor protein. Yan XF, Xin L, Yen JT, Zeng Y, Jin S, Cheang QW, Fong RACY, Chiam KH, Liang ZX, Gao YG
    JOURNAL OF BIOLOGICAL CHEMISTRY 293, 100 (2018).
  • Structural basis for the inhibition of poxvirus assembly by the antibiotic rifampicin. Garriga D, Headey S, Accurso C, Gunzburg M, Scanlon M, Coulibaly F
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115, 8424 (2018).
    DOI: 10.1073/PNAS.1810398115
  • Structural basis of IMP3 RRM12 recognition of RNA. Jia M, Gut H, Chao JA
    RNA-A PUBLICATION OF THE RNA SOCIETY 24, 1659 (2018).
  • Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus. Noldeke ER, Muckenfuss LM, Niemann V, Muller A, Stork E, Zocher G, Schneider T, Stehle T
    Scientific Reports 8, 12953 (2018).
    DOI: 10.1038/S41598-018-31098-X
  • Structural characterization of free-state and product-stateMycobacterium tuberculosismethionyl-tRNA synthetase reveals an induced-fit ligand-recognition mechanism Wang W, Qin B, Wojdyla JA, Wang M, Gao X, Cui S
    IUCRJ 5, 478 (2018).
    DOI: 10.1107/S2052252518008217
  • Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody. Oganesyan V, Peng L, Bee JS, Li J, Perry SR, Comer F, Xu L, Cook K, Senthil K, Clarke L, Rosenthal K, Gao C, Damschroder M, Wu H, Dall'Acqua W
    JOURNAL OF BIOLOGICAL CHEMISTRY 293, 8439 (2018).
    DOI: 10.1074/JBC.M117.818013
  • Structural investigations on bredigite from the Hatrurim Complex Kahlenberg V, Galuskina I, Krüger B, Pauluhn A, Galuskin E
    MINERALOGY AND PETROLOGY , (2018).
    DOI: 10.1007/s00710-018-0646-z
  • Structural rearrangements occurring upon cofactor binding in the Mycobacterium smegmatis beta-ketoacyl-acyl carrier protein reductase MabA. Kussau T, Flipo M, Van Wyk N, Viljoen A, Olieric V, Kremer L, Blaise M
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 74, 383 (2018).
  • Structure and function of wild-type and subunit-depleted photosystem I in Synechocystis. Malavath T, Caspy I, Netzer-El SY, Klaiman D, Nelson N
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA 1859, 645 (2018).
  • Structure of a glutamine donor mimicking inhibitory peptide shaped by the catalytic cleft of microbial transglutaminase. Juettner NE, Schmelz S, Kraemer A, Knapp S, Becker B, Kolmar H, Scrima A, Fuchsbauer HL
    FEBS JOURNAL 285, 4684 (2018).
  • Structure of a volume-regulated anion channel of the LRRC8 family. Deneka D, Sawicka M, Lam AKM, Paulino C, Dutzler R
    NATURE 558, 254 (2018).
    DOI: 10.1038/S41586-018-0134-Y
  • Structure of the replication regulator Sap1 reveals functionally important interfaces. Jorgensen MM, Ekundayo B, Zaratiegui M, Skriver K, Thon G, Schalch T
    Scientific Reports 8, 10930 (2018).
  • Structure-Based Engineering of Phanerochaete chrysosporium Alcohol Oxidase for Enhanced Oxidative Power toward Glycerol. Nguyen QT, Romero E, Dijkman WP, de Vasconcellos SP, Binda C, Mattevi A, Fraaije MW
    BIOCHEMISTRY 57, 6209 (2018).
  • Structure-Function Relationship of the Bik1-Bim1 Complex. Stangier MM, Kumar A, Chen X, Farcas AM, Barral Y, Steinmetz MO
    STRUCTURE 26, 607 (2018).
  • Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents. Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asis Balaguer F, Khan T, Grillo A, Chemi G, Menchon G, Prota AE, Olieric N, Lucena-Agell D, Barasoain I, Diaz JF, Nebbioso A, Conte M, Lopresti L, Magnano S, Amet R, Kinsella P, Zisterer DM, Ibrahim O, OSullivan J, Morbidelli L, Spaccapelo R, Baldari C, Butini S, Novellino E, Campiani G, Altucci L, Steinmetz MO, Brogi S
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 162, 290 (2018).
  • Structure-based discovery of selective BRPF1 bromodomain inhibitors. Zhu J, Zhou C, Caflisch A
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 155, 337 (2018).
  • Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. Bonnard D, Le Rouzic E, Eiler S, Amadori C, Orlov I, Bruneau JM, Brias J, Barbion J, Chevreuil F, Spehner D, Chasset S, Ledoussal B, Moreau F, Saib A, Klaholz BP, Emiliani S, Ruff M, Zamborlini A, Benarous R
    JOURNAL OF BIOLOGICAL CHEMISTRY 293, 6172 (2018).
  • Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors. Phoo WW, Zhang Z, Wirawan M, Chew EJC, Chew ABL, Kouretova J, Steinmetzer T, Luo D
    ANTIVIRAL RESEARCH 160, 17 (2018).
  • Structures of the Peptidoglycan N-Acetylglucosamine Deacetylase Bc1974 and Its Complexes with Zinc Metalloenzyme Inhibitors. Giastas P, Andreou A, Papakyriakou A, Koutsioulis D, Balomenou S, Tzartos SJ, Bouriotis V, Eliopoulos EE
    BIOCHEMISTRY 57, 753 (2018).
  • Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures. Parnell AE, Mordhorst S, Kemper F, Giurrandino M, Prince JP, Schwarzer NJ, Hofer A, Wohlwend D, Jessen HJ, Gerhardt S, Einsle O, Oyston PCF, Andexer JN, Roach PL
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115, 3350 (2018).
  • Synthetic single domain antibodies for the conformational trapping of membrane proteins. Zimmermann I, Egloff P, Hutter CA, Arnold FM, Stohler P, Bocquet N, Hug MN, Huber S, Siegrist M, Hetemann L, Gera J, Gmur S, Spies P, Gygax D, Geertsma ER, Dawson RJ, Seeger MA
    ELIFE 7, (2018).
  • The SERK3 elongated allele defines a role for BIR ectodomains in brassinosteroid signalling Hohmann U, Nicolet J, Moretti A, Hothorn Ludwig A, Hothorn M
    NATURE PLANTS 4, 345 (2018).
    DOI: 10.1038/s41477-018-0150-9
  • The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation Nawaz M, Ferreira Juliana C, Nedyalkova L, Zhu H, Carrasco-López C, Kirmizialtin S, Rabeh Wael M
    BIOSCIENCE REPORTS 38, BSR20171666 (2018).
    DOI: 10.1042/BSR20171666
  • The functional principle of eukaryotic molybdenum insertases. Krausze J, Hercher TW, Zwerschke D, Kirk ML, Blankenfeldt W, Mendel RR, Kruse T
    BIOCHEMICAL JOURNAL 475, 1739 (2018).
  • Thermal stabilization of the deglycating enzyme Amadoriase I by rational design. Rigoldi F, Donini S, Giacomina F, Sorana F, Redaelli A, Bandiera T, Parisini E, Gautieri A
    Scientific Reports 8, 3042 (2018).
  • Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis. Reis J, Manzella N, Cagide F, Mialet-Perez J, Uriarte E, Parini A, Borges F, Binda C
    JOURNAL OF MEDICINAL CHEMISTRY 61, 4203 (2018).
  • alpha-Helix or beta-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4. Oddo A, Mortensen S, Thogersen H, De Maria L, Hennen S, McGuire JN, Kofoed J, Linderoth L, Reedtz-Runge S
    BIOCHEMISTRY 57, 4148 (2018).

2017

  • A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3. de Vink PJ, Briels JM, Schrader T, Milroy LG, Brunsveld L, Ottmann C
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56, 8998 (2017).
    DOI: 10.1002/ANIE.201701807
  • A family of archaea-like carboxylesterases preferentially expressed in the symbiotic phase of the mychorrizal fungus Tuber melanosporum. Cavazzini D, Grossi G, Levati E, Vallese F, Montanini B, Bolchi A, Zanotti G, Ottonello S
    Scientific Reports 7, 7628 (2017).
    DOI: 10.1038/S41598-017-08007-9
  • A structural model for microtubule minus-end recognition and protection by CAMSAP proteins Atherton J, Jiang K, Stangier M, Luo Y, Hua S, Houben K, van Hooff J, Joseph A, Scarabelli G, Grant B, Roberts A, Topf M, Steinmetz M, Baldus M, Moores C, Akhmanova A
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 24, 931 (2017).
    DOI: 10.1038/nsmb.3483
  • AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus. Bock T, Luxenburger E, Hoffmann J, Schutza V, Feiler C, Muller R, Blankenfeldt W
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56, 9986 (2017).
    DOI: 10.1002/ANIE.201701992
  • Allosteric cross-talk in chromatin can mediate drug-drug synergy Adhireksan Z, Palermo G, Riedel T, Ma Z, Muhammad R, Rothlisberger U, Dyson Paul J, Davey C
    NATURE COMMUNICATIONS 8, 14860 (2017).
    DOI: 10.1038/ncomms14860
  • Ariegilatite, IMA 2016-100. In CNMNC Newsletter No. 36 Galuskin EV, Krüger B, Galuskina IO, Krüger H, Vapnik Y, Wojdyla JA, Murashko M
    MINERALOGICAL MAGAZINE 81, 405 (2017).
  • Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Hugle M, Lucas X, Ostrovskyi D, Regenass P, Gerhardt S, Einsle O, Hau M, Jung M, Breit B, Gunther S, Wohlwend D
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56, 12476 (2017).
    DOI: 10.1002/ANIE.201705516
  • Biophysical analysis of Arabidopsis protein-only RNase P alone and in complex with tRNA provides a refined model of tRNA binding Pinker F, Schelcher C, Fernandez-Millan P, Gobert A, Birck C, Thureau A, Roblin P, Giegé P, Sauter C
    JOURNAL OF BIOLOGICAL CHEMISTRY 292, 13904 (2017).
    DOI: 10.1074/jbc.M117.782078
  • Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity. Lukat P, Katsuyama Y, Wenzel S, Binz T, Konig C, Blankenfeldt W, Bronstrup M, Muller R
    CHEMICAL SCIENCE 8, 7521 (2017).
    DOI: 10.1039/C7SC02622F
  • Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Morvan F, Rondeau JM, Zou C, Minetti G, Scheufler C, Scharenberg M, Jacobi C, Brebbia P, Ritter V, Toussaint G, Koelbing C, Leber X, Schilb A, Witte F, Lehmann S, Koch E, Geisse S, Glass DJ, Lach-Trifilieff E
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114, 12448 (2017).
  • Capturing Structural Heterogeneity in Chromatin Fibers Ekundayo B, Richmond Timothy J, Schalch T
    JOURNAL OF MOLECULAR BIOLOGY 429, 3031 (2017).
    DOI: 10.1016/j.jmb.2017.09.002
  • Carbohydrate-Lectin Interactions: An Unexpected Contribution to Affinity. Navarra G, Zihlmann P, Jakob RP, Stangier K, Preston RC, Rabbani S, Smiesko M, Wagner B, Maier T, Ernst B
    CHEMBIOCHEM 18, 539 (2017).
    DOI: 10.1002/CBIC.201600615
  • Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa. Acebron I, Mahasenan KV, De Benedetti S, Lee M, Artola-Recolons C, Hesek D, Wang H, Hermoso JA, Mobashery S
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 139, 6795 (2017).
    DOI: 10.1021/JACS.7B01626
  • Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1). Lienhart WD, Strandback E, Gudipati V, Koch K, Binter A, Uhl MK, Rantasa DM, Bourgeois B, Madl T, Zangger K, Gruber K, Macheroux P
    FEBS JOURNAL 284, 1233 (2017).
    DOI: 10.1111/FEBS.14051
  • Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms. Di Bonaventura I, Jin X, Visini R, Probst D, Javor S, Gan BH, Michaud G, Natalello A, Doglia SM, Kohler T, van Delden C, Stocker A, Darbre T, Reymond JL
    CHEMICAL SCIENCE 8, 6784 (2017).
    DOI: 10.1039/C7SC01314K
  • Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors. Heinzlmeir S, Lohse J, Treiber T, Kudlinzki D, Linhard V, Gande SL, Sreeramulu S, Saxena K, Liu X, Wilhelm M, Schwalbe H, Kuster B, Medard G
    CHEMMEDCHEM 12, 999 (2017).
    DOI: 10.1002/CMDC.201700217
  • Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS
    MOLECULAR CELL Oct 5;68(1), 210 (2017).
    DOI: 10.1016/j.molcel.2017.09.012
  • Conformational flexibility of an anti-IL-13 DARPin. Teplyakov A, Malia TJ, Obmolova G, Jacobs SA, ONeil KT, Gilliland GL
    PROTEIN ENGINEERING DESIGN & SELECTION 30, 31 (2017).
    DOI: 10.1093/PROTEIN/GZW059
  • Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency. Mpakali A, Giastas P, Deprez-Poulain R, Papakyriakou A, Koumantou D, Gealageas R, Tsoukalidou S, Vourloumis D, Mavridis IM, Stratikos E, Saridakis E
    ACS MEDICINAL CHEMISTRY LETTERS 8, 333 (2017).
    DOI: 10.1021/ACSMEDCHEMLETT.6B00505
  • Crystal structure and fluorescence properties of the iSpinach aptamer in complex with DFHBI. Fernandez-Millan P, Autour A, Ennifar E, Westhof E, Ryckelynck M
    RNA-A PUBLICATION OF THE RNA SOCIETY 23, 1788 (2017).
  • Crystal structure of 2C helicase from enterovirus 71 Guan H, Tian J, Qin B, Wojdyla J, Wang B, Zhao Z, Wang M, Cui S
    Science Advances 3, e1602573 (2017).
    DOI: 10.1126/sciadv.1602573
  • Crystal structure of Middle East respiratory syndrome coronavirus helicase Hao W, Wojdyla J, Zhao R, Han R, Das R, Zlatev I, Manoharan M, Wang M, Cui S
    PLOS PATHOGENS 13, e1006474 (2017).
    DOI: 10.1371/journal.ppat.1006474
  • Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C Benoit RM, Schaerer MA, Wieser MM, Li X, Frey D, Kammerer RA
    Scientific Reports 7, 43588 (2017).
    DOI: 10.1038/srep43588
  • Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1 Ou X, Guan H, Qin B, Mu Z, Wojdyla JA, Wang M, Dominguez SR, Qian Z, Cui S
    NATURE COMMUNICATIONS 8, 15216 (2017).
    DOI: 10.1038/NCOMMS15216
  • Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease. Schacherl M, Gompert M, Pardon E, Lamkemeyer T, Steyaert J, Baumann U
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA 1859, 1859 (2017).
    DOI: 10.1016/J.BBAMEM.2017.05.006
  • Curvature of designed armadillo repeat proteins allows modular peptide binding. Hansen S, Ernst P, Konig SLB, Reichen C, Ewald C, Nettels D, Mittl PRE, Schuler B, Pluckthun A
    JOURNAL OF STRUCTURAL BIOLOGY 201, 108 (2017).
    DOI: 10.1016/J.JSB.2017.08.009
  • Deconvolution of Buparlisib?s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention Bohnacker T, Prota AE, Beaufils F, Burke John E, Melone A, Inglis Alison J, Rageot D, Sele Alexander M, Cmiljanovic V, Cmiljanovic N, Bargsten K, Aher A, Akhmanova A, Díaz JFernando, Fabbro D, Zvelebil M, Williams Roger L, Steinmetz MO, Wymann Matthias P
    NATURE COMMUNICATIONS 8, 14683 (2017).
    DOI: 10.1038/ncomms14683
  • Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity. Hansen S, Stuber JC, Ernst P, Koch A, Bojar D, Batyuk A, Pluckthun A
    Scientific Reports 7, 16292 (2017).
  • Design, crystal structure and atomic force microscopy study of thioether ligated d,l-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa. He R, Di Bonaventura I, Visini R, Gan BH, Fu Y, Probst D, Luscher A, Kohler T, van Delden C, Stocker A, Hong W, Darbre T, Reymond JL
    CHEMICAL SCIENCE 8, 7464 (2017).
    DOI: 10.1039/C7SC01599B
  • Dimerization of the Plant Molybdenum Insertase Cnx1E is Required for Synthesis of the Molybdenum Cofactor. Krausze J, Probst C, Curth U, Reichelt J, Saha S, Schafflik D, Heinz DW, Mendel RR, Kruse T
    BIOCHEMICAL JOURNAL 474, 163 (2017).
    DOI: 10.1042/BCJ20160846
  • Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents. Panchaud P, Bruyere T, Blumstein AC, Bur D, Chambovey A, Ertel EA, Gude M, Hubschwerlen C, Jacob L, Kimmerlin T, Pfeifer T, Prade L, Seiler P, Ritz D, Rueedi G
    JOURNAL OF MEDICINAL CHEMISTRY 60, 3755 (2017).
    DOI: 10.1021/ACS.JMEDCHEM.6B01834
  • Discovery and characterization of an F420-dependent glucose-6-phosphate dehydrogenase (Rh-FGD1) from Rhodococcus jostii RHA1. Nguyen QT, Trinco G, Binda C, Mattevi A, Fraaije MW
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 101, 2831 (2017).
    DOI: 10.1007/S00253-016-8038-Y
  • Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library. Cuozzo JW, Centrella PA, Gikunju D, Habeshian S, Hupp CD, Keefe AD, Sigel EA, Soutter HH, Thomson HA, Zhang Y, Clark MA
    CHEMBIOCHEM 18, 864 (2017).
    DOI: 10.1002/CBIC.201600573
  • Efficient switching of mCherry fluorescence using chemical caging Cloin BMC, De Zitter E, Salas D, Gielen V, Folkers GE, Mikhaylova M, Bergeler M, Krajnik B, Harvey J, Hoogenraad CC, Van Meervelt L, Dedecker P, Kapitein LC
    Proceedings of the National Academy of Sciences 114, 7013 (2017).
    DOI: 10.1073/pnas.1617280114
  • Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin. Storm PA, Herbst DA, Maier T, Townsend CA
    CELL CHEMICAL BIOLOGY 24, 316 (2017).
    DOI: 10.1016/J.CHEMBIOL.2017.01.008
  • Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation. Afroz T, Hock EM, Ernst P, Foglieni C, Jambeau M, Gilhespy LAB, Laferriere F, Maniecka Z, Pluckthun A, Mittl P, Paganetti P, Allain FHT, Polymenidou M
    NATURE COMMUNICATIONS 8, 45 (2017).
    DOI: 10.1038/S41467-017-00062-0
  • Functional and structural characterisation of a bacterial O-methyltransferase and factors determining regioselectivity. Siegrist J, Netzer J, Mordhorst S, Karst L, Gerhardt S, Einsle O, Richter M, Andexer JN
    FEBS LETTERS 591, 312 (2017).
    DOI: 10.1002/1873-3468.12530
  • Functionalization of Ruthenium(II)(? 6 - p -cymene)(3-hydroxy-2-pyridone) Complexes with (Thio)Morpholine: Synthesis and Bioanalytical Studies Hanif M, Meier Samuel M, Adhireksan Z, Henke H, Martic S, Movassaghi S, Labib M, Kandioller W, Jamieson Stephen MF, Hejl M, Jakupec Michael A, Kraatz H, Davey Curt A, Keppler Bernhard K, Hartinger Christian G
    ChemPlusChem , (2017).
    DOI: 10.1002/cplu.201700050
  • Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport. Schenck S, Kunz L, Sahlender D, Pardon E, Geertsma ER, Savtchouk I, Suzuki T, Neldner Y, Stefanic S, Steyaert J, Volterra A, Dutzler R
    BIOCHEMISTRY 56, 3962 (2017).
    DOI: 10.1021/ACS.BIOCHEM.7B00436
  • HheG, a Halohydrin Dehalogenase with Activity on Cyclic Epoxides Koopmeiners Julia, Diederich Christina, Solarczek Jennifer, Voss Hauke, Mayer Janine, Blankenfeldt Wulf, Schallmey Anett
    ACS CATALYSIS 7, 6877-6886 (2017).
    DOI: 10.1021/acscatal.7b01854
  • Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis Hamel V, Steib E, Hamelin R, Armand F, Borgers S, Flückiger I, Busso C, Olieric N, Sorzano Carlos Oscar S, Steinmetz Michel O, Guichard P, Gönczy P
    CURRENT BIOLOGY 27, 2486 (2017).
    DOI: 10.1016/j.cub.2017.07.011
  • Identification, biochemical characterization and crystallization of the central region of human ATG16L1. Archna A, Scrima A
    Acta Crystallographica Section F Structural Biology and Crystallization Communications 73, 560 (2017).
    DOI: 10.1107/S2053230X17013280
  • Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding. Lehner F, Kudlinzki D, Richter C, Muller-Werkmeister HM, Eberl KB, Bredenbeck J, Schwalbe H, Silvers R
    CHEMBIOCHEM 18, 2340 (2017).
    DOI: 10.1002/CBIC.201700437
  • Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 Aminopeptidases family based on structure analysis Peng G, McEwen AG, Olieric V, Schmitt C, Albrecht S, Cavarelli J, Tarnus C
    PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS , (2017).
    DOI: 10.1002/prot.25301
  • Insights into biofilm dispersal regulation from the crystal structure of the PAS-GGDEF-EAL region of RbdA from Pseudomonas aeruginosa. Liu C, Liew CW, Wong YH, Tan ST, Poh WH, Manimekalai SMS, Rajan S, Xin L, Liang ZX, Gruber G, Rice SA, Lescar J
    JOURNAL OF BACTERIOLOGY 200, (2017).
    DOI: 10.1128/JB.00515-17
  • Investigations on FCAM-III (Ca 2.38 Mg 2.09 Fe 3+ 10.61 Fe 2+ 1.59 Al 9.33 O 36 ): a new homologue of the aenigmatite structure-type in the system CaO-MgO-Fe 2 O 3 -Al 2 O 3 Zöll K, Kahlenberg V, Krüger H, Tropper P
    JOURNAL OF SOLID STATE CHEMISTRY -, S0022459617303626 (2017).
    DOI: 10.1016/j.jssc.2017.09.006
  • Kinesin-4 KIF21B is a potent microtubule pausing factor van Riel W, Rai A, Bianchi S, Katrukha E, Liu Q, Heck A, Hoogenraad C, Steinmetz M, Kapitein L, Akhmanova A
    ELIFE 6, - (2017).
    DOI: 10.7554/eLife.24746
  • Levantite, IMA 2017-010. In CNMNC Newsletter No. 37 Galuskin EV, Krüger B, Galuskina IO, Krüger H, Vapnik Y, Pauluhn A, Olieric V
    MINERALOGICAL MAGAZINE 81, 740 (2017).
  • Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Rajabi N, Auth M, Troelsen KR, Pannek M, Bhatt DP, Fontenas M, Hirschey MD, Steegborn C, Madsen AS, Olsen CA
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56, 14836 (2017).
  • Microstructure dependent binding of pigment epithelium derived factor (PEDF) to type I collagen fibrils Cauble M, Yang P, Baumann U, Gebauer Jan M, Orr Bradford G, Duong Le T, Banaszak Holl Mark M
    JOURNAL OF STRUCTURAL BIOLOGY 199, 132 (2017).
    DOI: 10.1016/j.jsb.2017.06.001
  • Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Jiang K, Rezabkova L, Hua S, Liu Q, Capitani G, Maarten Altelaar AF, Heck AJR, Kammerer RA, Steinmetz MO, Akhmanova A
    NATURE CELL BIOLOGY 19, 480 (2017).
    DOI: 10.1038/NCB3511
  • Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex. Edelmann FT, Schlundt A, Heym RG, Jenner A, Niedner-Boblenz A, Syed MI, Paillart JC, Stehle R, Janowski R, Sattler M, Jansen RP, Niessing D
    NATURE STRUCTURAL AND MOLECULAR BIOLOGY 24, 152 (2017).
    DOI: 10.1038/NSMB.3351
  • Mutations in the tetramer interface of human glucose-6-phosphate dehydrogenase reveals kinetic differences between oligomeric states. Ranzani AT, Cordeiro AT
    FEBS LETTERS 591, 1278 (2017).
    DOI: 10.1002/1873-3468.12638
  • Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix Heim Joel B, Squirewell Edwin J, Neu A, Zocher G, Sominidi-Damodaran S, Wyles Saranya P, Nikolova E, Behrendt N, Saunte Ditte M, Lock-Andersen J, Gaonkar Krutika S, Yan H, Sarkaria Jann N, Krendel M, van Deursen J, Sprangers R, Stehle T, Böttcher Ralph T, Lee J, Ordog T, Meves A
    Proceedings of the National Academy of Sciences 114, 3933 (2017).
    DOI: 10.1073/pnas.1614894114
  • Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates. Heinrich T, Buchstaller HP, Cezanne B, Rohdich F, Bomke J, Friese-Hamim M, Krier M, Knochel T, Musil D, Leuthner B, Zenke F
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  • Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation Davey GE, Adhireksan Z, Ma Z, Riedel T, Sharma D, Padavattan S, Rhodes D, Ludwig A, Sandin S, Murray BS, Dyson PJ, Davey CA
    NATURE COMMUNICATIONS 8, 1575 (2017).
  • Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1 delta and Their Structural Relation to p38 alpha MAPK. Halekotte J, Witt L, Ianes C, Kruger M, Buhrmann M, Rauh D, Pichlo C, Brunstein E, Luxenburger A, Baumann U, Knippschild U, Bischof J, Peifer C
    MOLECULES 22, 522 (2017).
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  • Protein conformational flexibility modulates kinetics and thermodynamics of drug binding Amaral M, Kokh D B, Bomke J, Wegener A, Buchstaller H P, Eggenweiler H M, Matias P, Sirrenberg C, Wade R C, Frech M
    NATURE COMMUNICATIONS 8, 2276 (2017).
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  • Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin Sharma A, Sáez-Calvo G, Olieric N, de Asís Balaguer F, Barasoain I, Lamberth C, Díaz J, Steinmetz M
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18, 1336 (2017).
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  • Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators. Keune WJ, Potjewyd F, Heidebrecht T, Salgado-Polo F, Macdonald SJ, Chelvarajan L, Abdel Latif A, Soman S, Morris AJ, Watson AJ, Jamieson C, Perrakis A
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  • Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding. Ecsedi P, Kiss B, Gogl G, Radnai L, Buday L, Koprivanacz K, Liliom K, Leveles I, Vertessy B, Jeszenoi N, Hetenyi C, Schlosser G, Katona G, Nyitray L
    STRUCTURE 25, 1195 (2017).
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  • Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends. Mattarocci S, Reinert JK, Bunker RD, Fontana GA, Shi T, Klein D, Cavadini S, Faty M, Shyian M, Hafner L, Shore D, Thoma NH, Rass U
    NATURE STRUCTURAL AND MOLECULAR BIOLOGY 24, 588 (2017).
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  • Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation. Vercellino I, Rezabkova L, Olieric V, Polyhach Y, Weinert T, Kammerer RA, Jeschke G, Korkhov VM
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114, E9821 (2017).
    DOI: 10.1073/PNAS.1712621114
  • Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. Kukenshoner T, Schmit NE, Bouda E, Sha F, Pojer F, Koide A, Seeliger M, Koide S, Hantschel O
    JOURNAL OF MOLECULAR BIOLOGY 429, 1364 (2017).
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  • Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier. Aeschimann W, Staats S, Kammer S, Olieric N, Jeckelmann JM, Fotiadis D, Netscher T, Rimbach G, Cascella M, Stocker A
    Scientific Reports 7, 4970 (2017).
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  • Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family. Leonaite B, Han Z, Basquin J, Bonneau F, Libri D, Porrua O, Conti E
    EMBO JOURNAL 36, 1590 (2017).
    DOI: 10.15252/EMBJ.201696174
  • Sharyginite, IMA 2017-014. In CNMNC Newsletter No. 37 Juroszek R, Krüger H, Galuskina IO, Krüger B, Jezak L, Ternes B, Wojdyla J, Krzykawski T, Pautov LA, Galuskin EV
    MINERALOGICAL MAGAZINE 81, 741 (2017).
  • Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends. Kumar A, Manatschal C, Rai A, Grigoriev I, Degen MS, Jaussi R, Kretzschmar I, Prota AE, Volkmer R, Kammerer RA, Akhmanova A, Steinmetz MO
    STRUCTURE 25, 924 (2017).
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  • Stability and Ligand Promiscuity of Type A Carbohydrate-binding Modules Are Illustrated by the Structure of Spirochaeta thermophila StCBM64C. Pires VM, Pereira PM, Bras JL, Correia M, Cardoso V, Bule P, Alves VD, Najmudin S, Venditto I, Ferreira LM, Romao MJ, Carvalho AL, Fontes CM, Prazeres DM
    JOURNAL OF BIOLOGICAL CHEMISTRY 292, 4847 (2017).
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  • Stracherite, IMA 2016-098. In CNMNC Newsletter No. 36 Galuskin EV, Krüger B, Galuskina IO, Krüger H, Vapnik Y, Pauluhn A, Olieric V
    MINERALOGICAL MAGAZINE 81, 404 (2017).
  • Structural Basis for Copper-Oxygen Mediated C-H Bond Activation by the Formylglycine-Generating Enzyme. Meury M, Knop M, Seebeck FP
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56, 8115 (2017).
    DOI: 10.1002/ANIE.201702901
  • Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair. Betz K, Kimoto M, Diederichs K, Hirao I, Marx Andreas
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56, 12000 (2017).
    DOI: 10.1002/ANIE.201704190
  • Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a. Swarts DC, van der Oost J, Jinek M
    MOLECULAR CELL 66, 221 (2017).
    DOI: 10.1016/J.MOLCEL.2017.03.016
  • Structural Basis for the KlenTaq DNA Polymerase Catalysed Incorporation of Alkene- versus Alkyne-Modified Nucleotides. Hottin A, Betz K, Diederichs K, Marx A
    CHEMISTRY-A EUROPEAN JOURNAL 23, 2109 (2017).
    DOI: 10.1002/CHEM.201604515
  • Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage. Deshpande I, Seeber A, Shimada K, Keusch JJ, Gut H, Gasser SM
    MOLECULAR CELL 68, 431 (2017).
  • Structural Basis of Microtubule Stabilization by Discodermolide Prota Andrea E, Bargsten K, Redondo M, Smith III Amos B, Yang ChiaPing H, McDaid Hayley M, Paterson I, Horwitz Susan B, Díaz J, Steinmetz Michel O
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    DOI: 10.1002/cbic.201600696
  • Structural Basis of cis- and trans-Combretastatin Binding to Tubulin Gaspari R, Prota Andrea E, Bargsten K, Cavalli A, Steinmetz Michel O
    Chem 2, 102 (2017).
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  • Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor. Niefind K, Bischoff N, Golub AG, Bdzhola VG, Balanda AO, Prykhodko AO, Yarmoluk SM
    Pharmaceuticals 10, (2017).
    DOI: 10.3390/PH10010009
  • Structural Insights into Reovirus sigma 1 Interactions with Two Neutralizing Antibodies Dietrich Melanie H, Ogden Kristen M, Katen Sarah P, Reiss Kerstin, Sutherland Danica M, Carnahan Robert H, Goff Matthew, Cooper Tracy, Dermody Terence S, Stehle Thilo
    JOURNAL OF VIROLOGY 91, UNSP e01621 (2017).
    DOI: 10.1128/JVI.01621-16
  • Structural Insights into the Recognition of N 2 -Aryl- and C8-Aryl DNA Lesions by the Repair Protein XPA/Rad14 Ebert C, Simon N, Schneider S, Carell T
    CHEMBIOCHEM 18, 1379 (2017).
    DOI: 10.1002/cbic.201700169
  • Structural and Functional Analysis of Latex Clearing Protein (Lcp) Provides Insight into the Enzymatic Cleavage of Rubber Ilcu L, Röther W, Birke J, Brausemann A, Einsle O, Jendrossek D
    Scientific Reports 7, 6179 (2017).
    DOI: 10.1038/s41598-017-05268-2
  • Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Reckel S, Gehin C, Tardivon D, Georgeon S, Kukenshoner T, Lohr F, Koide A, Buchner L, Panjkovich A, Reynaud A, Pinho S, Gerig B, Svergun D, Pojer F, Guntert P, Dotsch V, Koide S, Gavin AC, Hantschel O
    NATURE COMMUNICATIONS 8, 2101 (2017).
  • Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family. Ehrnstorfer IA, Manatschal C, Arnold FM, Laederach J, Dutzler R
    NATURE COMMUNICATIONS 8, 14033 (2017).
    DOI: 10.1038/NCOMMS14033
  • Structural and molecular determinants affecting the interaction of retinol with human CRBP1. Menozzi I, Vallese F, Polverini E, Folli C, Berni R, Zanotti G
    JOURNAL OF STRUCTURAL BIOLOGY 197, 330 (2017).
    DOI: 10.1016/J.JSB.2016.12.012
  • Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008 Ruiz Francesc X, Crespo I, Álvarez S, Porté S, Giménez-Dejoz J, Cousido-Siah A, Mitschler A, de Lera Ángel R, Parés X, Podjarny A, Farrés J
    CHEMICO-BIOLOGICAL INTERACTIONS -, - (2017).
    DOI: 10.1016/j.cbi.2017.01.026
  • Structural basis of homo- and heterotrimerization of collagen I. Sharma U, Carrique L, Vadon-Le Goff S, Mariano N, Georges RN, Delolme F, Koivunen P, Myllyharju J, Moali C, Aghajari N, Hulmes DJ
    NATURE COMMUNICATIONS 8, 14671 (2017).
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  • Structural basis of katanin p60:p80 complex formation Rezabkova L, Jiang K, Capitani G, Prota Andrea E, Akhmanova A, Steinmetz Michel O, Kammerer Richard A
    Scientific Reports 7, 14893 (2017).
    DOI: 10.1038/s41598-017-14194-2
  • Structural insights in to the assembly and polyA signal recognition mechanism of the human CPSF complex Clerici Marcello, Faini Marco, Aebersold Ruedi, Jinek Martin
    ELIFE 6, e33111 (2017).
    DOI: 10.7554/eLife.33111
  • Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5. Barlocher K, Hutter CAJ, Swart AL, Steiner B, Welin A, Hohl M, Letourneur F, Seeger MA, Hilbi H
    NATURE COMMUNICATIONS 8, 1543 (2017).
  • Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53. Falk S, Tants JN, Basquin J, Thoms M, Hurt E, Sattler M, Conti E
    RNA-A PUBLICATION OF THE RNA SOCIETY 23, 1780 (2017).
    DOI: 10.1261/RNA.062901.117
  • Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors. Li X, Anderson M, Collin D, Muegge I, Wan J, Brennan D, Kugler S, Terenzio D, Kennedy C, Lin S, Labadia ME, Cook B, Hughes R, Farrow NA
    JOURNAL OF BIOLOGICAL CHEMISTRY 292, 11618 (2017).
    DOI: 10.1074/JBC.M117.789024
  • Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants. Noguera ME, Vazquez DS, Ferrer-Sueta G, Agudelo WA, Howard E, Rasia RM, Manta B, Cousido-Siah A, Mitschler A, Podjarny A, Santos J
    Scientific Reports 7, 42343 (2017).
    DOI: 10.1038/SREP42343
  • Structure of Phytoene Desaturase Provides Insights into Herbicide Binding and Reaction Mechanisms Involved in Carotene Desaturation Brausemann A, Gemmecker S, Koschmieder J, Ghisla S, Beyer P, Einsle O
    STRUCTURE 25, 1222 (2017).
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  • Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A. Markovic-Mueller S, Stuttfeld E, Asthana M, Weinert T, Bliven S, Goldie KN, Kisko K, Capitani G, Ballmer-Hofer K
    STRUCTURE 25, 341 (2017).
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  • Structure of the Y. pseudotuberculosis adhesin InvasinE. Sadana P, Monnich M, Unverzagt C, Scrima A
    PROTEIN SCIENCE 26, 1182 (2017).
    DOI: 10.1002/PRO.3171
  • Structure of the plant photosystem I supercomplex at 2.6 angstrom resolution. Mazor Y, Borovikova A, Caspy I, Nelson N
    NATURE PLANTS 3, 17014 (2017).
    DOI: 10.1038/NPLANTS.2017.14
  • Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode. Miller LM, Keune WJ, Castagna D, Young LC, Duffy EL, Potjewyd F, Salgado-Polo F, Engel Garcia P, Semaan D, Pritchard JM, Perrakis A, Macdonald SJ, Jamieson C, Watson AJ
    JOURNAL OF MEDICINAL CHEMISTRY 60, 722 (2017).
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  • Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure. Lanier M, Pickens J, Bigi SV, Bradshaw-Pierce EL, Chambers A, Cheruvallath ZS, Cole D, Dougan DR, Ermolieff J, Gibson T, Halkowycz P, Hirokawa A, Ivetac A, Miura J, Nunez E, Sabat M, Tyhonas J, Wang H, Wang X, Swann S
    ACS MEDICINAL CHEMISTRY LETTERS 8, 316 (2017).
    DOI: 10.1021/ACSMEDCHEMLETT.6B00481
  • Structures of designed armadillo repeat proteins binding to peptides fused to globular domains. Hansen S, Kiefer JD, Madhurantakam C, Mittl PRE, Pluckthun A
    PROTEIN SCIENCE 26, 1942 (2017).
    DOI: 10.1002/PRO.3229
  • Structures of the N-Terminal Domain of PqsA in Complex with Anthraniloyl- and 6-Fluoroanthraniloyl-AMP: Substrate Activation in Pseudomonas Quinolone Signal (PQS) Biosynthesis. Witzgall F, Ewert W, Blankenfeldt W
    CHEMBIOCHEM 18, 2045 (2017).
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  • Synthesis, Thermodynamic Properties, and Crystal Structure of RNA Oligonucleotides Containing 5-Hydroxymethylcytosine. Riml C, Lusser A, Ennifar E, Micura R
    JOURNAL OF ORGANIC CHEMISTRY 82, 7939 (2017).
    DOI: 10.1021/ACS.JOC.7B01171
  • Synthesis, synchrotron diffraction study and twinning in Na2Ca4Mg2Si4O15 ? a heteropolyhedral framework compound Kahlenberg V, Schmidmair D, Hildebrandt E, Ennemoser P, Zöll K, Krüger H
    Zeitschrift für Kristallographie - Crystalline Materials , (2017).
    DOI: 10.1515/zkri-2017-2063
  • Targeting Acidic Mammalian Chitinase is Effective in Animal Model of Asthma Mazur M, Olczak J, Olejniczak S, Koralewski R, Czestkowski W, Jedrzejczak A, Golab J, Dzwonek K, Dymek B, Sklepkiewicz Piotr L, Zagozdzon A, Noonan T, Mahboubi K, Conway B, Sheeler R, Beckett P, Hungerford William M, Podjarny Alberto D, Mitschler A, Cousido-Siah A, Fadel F, Golebiowski A
    JOURNAL OF MEDICINAL CHEMISTRY , acs.jmedchem.7b01051 (2017).
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  • The AibR-isovaleryl coenzyme A regulator and its DNA binding site - a model for the regulation of alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus. Bock T, Volz C, Hering V, Scrima A, Muller R, Blankenfeldt W
    NUCLEIC ACIDS RESEARCH 45, 2166 (2017).
    DOI: 10.1093/NAR/GKW1238
  • The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein. Fédry J, Liu Y, Péhau-Arnaudet G, Pei J, Li W, Tortorici MA, Traincard F, Meola A, Bricogne G, Grishin NV, Snell WJ, Rey FA, Krey T
    CELL 168, 904 (2017).
    DOI: 10.1016/j.cell.2017.01.024
  • The bulky and the sweet: How neutralizing antibodies and glycan receptors compete for virus binding Dietrich Melanie H, Harprecht C, Stehle T
    PROTEIN SCIENCE , (2017).
    DOI: 10.1002/pro.3319
  • The direct role of selenocysteine in [NiFeSe] hydrogenase maturation and catalysis. Marques MC, Tapia C, Gutierrez-Sanz O, Ramos AR, Keller KL, Wall JD, De Lacey AL, Matias PM, Pereira IAC
    NATURE CHEMICAL BIOLOGY 13, 544 (2017).
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  • The macro domain as fusion tag for carrier-driven crystallization Wild R, Hothorn M
    PROTEIN SCIENCE 26, 365 (2017).
    DOI: 10.1002/pro.3073
  • The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD Fu C, Sikandar A, Donner J, Zaburannyi N, Herrmann J, Reck M, Wagner-Döbler I, Koehnke J, Müller R
    NATURE COMMUNICATIONS 8, 1529 (2017).
    DOI: 10.1038/s41467-017-01671-5
  • The target landscape of clinical kinase drugs. Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tonisson N, Kramer K, Gotze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Medard G, Jeremias I, Spiekermann K, Kuster B
    SCIENCE 358, 6367 (2017).
    DOI: 10.1126/SCIENCE.AAN4368
  • Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship. Vianello P, Sartori L, Amigoni F, Cappa A, Faga G, Fattori R, Legnaghi E, Ciossani G, Mattevi A, Meroni G, Moretti L, Cecatiello V, Pasqualato S, Romussi A, Thaler F, Trifiro P, Villa M, Botrugno OA, Dessanti P, Minucci S, Vultaggio S, Zagarri E, Varasi M, Mercurio C
    JOURNAL OF MEDICINAL CHEMISTRY 60, 1693 (2017).
    DOI: 10.1021/ACS.JMEDCHEM.6B01019
  • Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin. Saez-Calvo G, Sharma A, Balaguer FA, Barasoain I, Rodriguez-Salarichs J, Olieric N, Munoz-Hernandez H, Berbis MA, Wendeborn S, Penalva MA, Matesanz R, Canales A, Prota AE, Jimenez-Barbero J, Andreu JM, Lamberth C, Steinmetz MO, Diaz JF
    CELL CHEMICAL BIOLOGY 24, 737 (2017).
    DOI: 10.1016/J.CHEMBIOL.2017.05.016
  • Two tyrosine residues, Tyr-108 and Tyr-503, are responsible for the deprotonation of phenolic substrates in vanillyl-alcohol oxidase. Ewing TA, Nguyen QT, Allan RC, Gygli G, Romero E, Binda C, Fraaije MW, Mattevi A, van Berkel WJH
    JOURNAL OF BIOLOGICAL CHEMISTRY 292, 14668 (2017).
    DOI: 10.1074/JBC.M117.778449
  • Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2 alpha and Its Paralog CK2 alpha '. Hochscherf J, Lindenblatt D, Witulski B, Birus R, Aichele D, Marminon C, Bouaziz Z, Le Borgne M, Jose J, Niefind K
    Pharmaceuticals 10, 13 (2017).
    DOI: 10.3390/ph10040098
  • Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. Field JJ, Pera B, Gallego JE, Calvo E, Rodriguez-Salarichs J, Saez-Calvo G, Zuwerra D, Jordi M, Andreu JM, Prota AE, Menchon G, Miller JH, Altmann KH, Diaz JF
    JOURNAL OF NATURAL PRODUCTS , (2017).
    DOI: 10.1021/acs.jnatprod.7b00704
  • Zoharite, IMA2017-049, in CNMNC Newsletter No. 39 Galuskina I O, Krüger B, Galuskin E V, Krüger H, Vapnik Y, Murashko M, Agakhanov A A, Pauluhn A, Olieric V
    MINERALOGICAL MAGAZINE 81, 1281 (2017).

2016

  • 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1) Huegle Martin, Lucas Xavier, Weitzel Gerhard, Ostrovskyi Dmytro, Breit Bernhard, Gerhardt Stefan, Einsle Oliver, Guenther Stefan, Wohlwend Daniel
    JOURNAL OF MEDICINAL CHEMISTRY 59, 1518-1530 (2016).
    DOI: 10.1021/acs.jmedchem.5b01267
  • A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening. Noble CG, Lim SP, Arora R, Yokokawa F, Nilar S, Seh CC, Wright SK, Benson TE, Smith PW, Shi PY
    JOURNAL OF BIOLOGICAL CHEMISTRY 291, 8541 (2016).
    DOI: 10.1074/JBC.M115.710731
  • A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme Dharadhar S, Clerici M, van Dijk Willem J, Fish A, Sixma Titia K
    JOURNAL OF STRUCTURAL BIOLOGY , (2016).
    DOI: 10.1016/j.jsb.2016.09.011
  • A novel esterase subfamily with alpha/beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to L-homoserine O-acetyl transferases Toelzer Christine, Pal Sonia, Watzlawick Hildegard, Altenbuchner Josef, Niefind Karsten
    FEBS LETTERS 590, 174-184 (2016).
    DOI: 10.1002/1873-3468.12031
  • A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria Murima Paul, Zimmermann Michael, Chopra Tarun, Pojer Florence, Fonti Giulia, Dal Peraro Matteo, Alonso Sylvie, Sauer Uwe, Pethe Kevin, McKinney John D
    NATURE COMMUNICATIONS 7, 12527 (2016).
    DOI: 10.1038/ncomms12527
  • ATP half-sites in RadA and RAD51 recombinases bind nucleotides Marsh May E, Scott Duncan E, Ehebauer Matthias T, Abell C, Blundell Tom L, Hyvönen M
    FEBS Open Bio 6, 372 (2016).
    DOI: 10.1002/2211-5463.12052
  • Accelerating the Association of the Most Stable Protein-Ligand Complex by more than Two Orders of Magnitude Giese C, Eras J, Kern A, Schärer Martin A, Capitani G, Glockshuber R
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , (2016).
    DOI: 10.1002/anie.201603652
  • Advanced Crystallographic Data Collection Protocols for Experimental Phasing Finke AD, Panepucci E, Vonrhein C, Wang M, Bricogne G, Oliéric V
    Methods in Molecular Biology 1320, 175 (2016).
    DOI: 10.1007/978-1-4939-2763-0_11
  • Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study Schiedel Matthias, Rumpf Tobias, Karaman Berin, Lehotzky Attila, Olah Judit, Gerhardt Stefan, Ovadi Judit, Sippl Wolfgang, Einsle Oliver, Jung Manfred
    JOURNAL OF MEDICINAL CHEMISTRY 59, 1599-1612 (2016).
    DOI: 10.1021/acs.jmedchem.5b01517
  • An ATP Binding Cassette Transporter Mediates the Uptake of alpha-(1,6)-Linked Dietary Oligosaccharides in Bifidobacterium and Correlates with Competitive Growth on These Substrates Ejby Morten, Fredslund Folmer, Andersen Joakim Mark, Zagar Andreja Vujicic, Henriksen Jonas Rosager, Andersen Thomas Lars, Svensson Birte, Slotboom Dirk Jan, Abou Hachem Maher
    JOURNAL OF BIOLOGICAL CHEMISTRY 291, 20220-20231 (2016).
    DOI: 10.1074/jbc.M116.746529
  • An Organometallic Compound which Exhibits a DNA Topology-Dependent One-Stranded Intercalation Mode Ma Z, Palermo G, Adhireksan Z, Murray BS, von Erlach T, Dyson PJ, Rothlisberger U, Davey CA
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55, 7441 (2016).
    DOI: 10.1002/anie.201602145
  • An enantioselective artificial Suzukiase based on the biotin-streptavidin technology Chatterjee Anamitra, Mallin Hendrik, Klehr Juliane, Vallapurackal Jaicy, Finke Aaron D, Vera Laura, Marsh May, Ward Thomas R
    CHEMICAL SCIENCE 7, 673-677 (2016).
    DOI: 10.1039/c5sc03116h
  • An essential role for the baseplate protein Gp45 in phage adsorption to Staphylococcus aureus Li X, Koç C, Kühner P, Stierhof Y, Krismer B, Enright Mark C, Penadés José R, Wolz C, Stehle T, Cambillau C, Peschel A, Xia G
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  • SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules. Job G, Brugger C, Xu T, Lowe BR, Pfister Y, Qu C, Shanker S, Banos Sanz JI, Partridge JF, Schalch T
    MOLECULAR CELL 62, 207 (2016).
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  • STRUCTURAL BIOLOGY Architecture of human mTOR complex 1 Aylett Christopher H S, Sauer Evelyn, Imseng Stefan, Boehringer Daniel, Hall Michael N, Ban Nenad, Maier Timm
    SCIENCE 351, 48-52 (2016).
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  • Sequential Inactivation of Gliotoxin by the S-Methyltransferase TmtA. Duell ER, Glaser M, Le Chapelain C, Antes I, Groll M, Huber EM
    ACS MEDICINAL CHEMISTRY LETTERS 11, 1082 (2016).
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  • Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels. Bertozzi C, Zimmermann I, Engeler S, Hilf RJ, Dutzler R
    PLOS BIOLOGY 14, 1 (2016).
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  • Small-molecule factor D inhibitors targeting the alternative complement pathway Maibaum Jurgen, Liao ShaMei, Vulpetti Anna, Ostermann Nils, Randl Stefan, Rudisser Simon, Lorthiois Edwige, Erbel Paul, Kinzel Bernd, Kolb Fabrice A, Barbieri Samuel, Wagner Julia, Durand Corinne, Fettis Kamal, Dussauge Solene, Hughes Nicola, Delgado Omar, Hommel Ulrich, Gould Ty, Mac Sweeney Aengus, Gerhartz Bernd, Cumin Frederic, Flohr Stefanie, Schubart Anna, Jaffee Bruce, Harrison Richard, Risitano Antonio Maria, Eder Jorg, Anderson Karen
    NATURE CHEMICAL BIOLOGY 12, 1105-+ (2016).
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  • Structural Basis for Bulky Adduct DNA Lesion Recognition by the Nucleotide Excision Repair Protein Rad14. Schneider S, Simon N, Ebert C
    CHEMISTRY-A EUROPEAN JOURNAL 22, 10782 (2016).
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  • Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY Gogl Gergo, Alexa Anita, Kiss Bence, Katona Gergely, Kovacs Mihaly, Bodor Andrea, Remenyi Attila, Nyitray Laszlo
    JOURNAL OF BIOLOGICAL CHEMISTRY 291, 11-27 (2016).
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  • Structural Basis of Substrate Range and Enantioselectivity of Two S-Selective Omega- Transaminases Van Oosterwijk N, Willies S, Hekelaar J, Terwisscha Van Scheltinga AC, Turner NJ, Dijkstra BW
    BIOCHEMISTRY 55, 4422 (2016).
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  • Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells Trigili C, Barasoain I, Sánchez-Murcia Pedro A, Bargsten K, Redondo-Horcajo M, Nogales A, Gardner Nicola M, Meyer A, Naylor Guy J, Gómez-Rubio E, Gago F, Steinmetz Michel O, Paterson I, Prota Andrea E, Díaz JFernando
    ACS Omega 1, 1192 (2016).
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  • Structural Insights Into Hdac6 Tubulin Deacetylation and its Selective Inhibition Miyake Y, Keusch JJ, Wang L, Saito M, Hess D, Wang X, Melancon BJ, Helquist P, Gut H, Matthias P
    CHEMBIOCHEM 12, 748 (2016).
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  • Structural Insights into Reovirus ?1 Interactions with Two Neutralizing Antibodies Dietrich Melanie H, Ogden Kristen M, Katen Sarah P, Reiss K, Sutherland Danica M, Carnahan Robert H, Goff M, Cooper T, Dermody Terence S, Stehle T
    JOURNAL OF VIROLOGY 91, e01621-16 (2016).
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  • Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9 Anders C, Bargsten K, Jinek M
    MOLECULAR CELL 61, 895 (2016).
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  • Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation Habisov Sabrina, Huber Jessica, Ichimura Yoshinobu, Akutsu Masato, Rogova Natalia, Loehr Frank, McEwan David G, Johansen Terje, Dikic Ivan, Doetsch Volker, Komatsu Masaaki, Rogov Vladimir V, Kirkin Vladimir
    JOURNAL OF BIOLOGICAL CHEMISTRY 291, 9025-9041 (2016).
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  • Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDI by Lysine Acetylation Kuhlmann Nora, Wroblowski Sarah, Knyphausen Philipp, de Boor Susanne, Brenig Julian, Zienert Anke Y, Meyer-Teschendorf Katrin, Praefcke Gerrit J K, Nolte Hendrik, Krueger Marcus, Schacherl Magdalena, Baumann Ulrich, James Leo C, Chin Jason W, Lammers Michael
    JOURNAL OF BIOLOGICAL CHEMISTRY 291, 5484-5499 (2016).
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  • Structural and biochemical insights into 7 beta-hydroxysteroid dehydrogenase stereoselectivity Savino Simone, Ferrandi Erica Elisa, Forneris Federico, Rovida Stefano, Riva Sergio, Monti Daniela, Mattevi Andrea
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 84, 859-865 (2016).
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  • Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization Kato Kazuki, Satouh Yuhkoh, Nishimasu Hiroshi, Kurabayashi Arisa, Morita Junko, Fujihara Yoshitaka, Oji Asami, Ishitani Ryuichiro, Ikawa Masahito, Nureki Osamu
    NATURE COMMUNICATIONS 7, 12198 (2016).
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  • Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations Bianchi S, van Riel Wilhelmina E, Kraatz Sebastian HW, Olieric N, Frey D, Katrukha Eugene A, Jaussi R, Missimer J, Grigoriev I, Olieric V, Benoit Roger M, Steinmetz Michel O, Akhmanova A, Kammerer Richard A
    Scientific Reports 6, 30668 (2016).
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  • Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6 Niewoehner Ole, Jinek Martin
    RNA-A PUBLICATION OF THE RNA SOCIETY 22, 318-329 (2016).
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  • Structural insight in the toppling mechanism of an energy-coupling factor transporter Swier Lotteke JYM, Guskov A, Slotboom Dirk J
    NATURE COMMUNICATIONS 7, 11072 (2016).
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  • Structural insight into DNA-assembled oligochromophores: crystallographic analysis of pyrene- and phenanthrene-modified DNA in complex with BpuJI endonuclease. Probst M, Aeschimann W, Chau TT, Langenegger SM, Stocker A, Haner R
    NUCLEIC ACIDS RESEARCH 44, 7079 (2016).
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  • Structural insights into the molecular mechanism of the m(6)A writer complex Sledz Pawel, Jinek Martin
    ELIFE 5, e18434 (2016).
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  • Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin. Hausmann J, Keune WJ, Hipgrave Ederveen AL, van Zeijl L, Joosten RP, Perrakis A
    JOURNAL OF STRUCTURAL BIOLOGY 195, 199 (2016).
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  • Structure Activity Relationship of the Peptide Binding Motif Mediating the Rad51:Brca2 Protein-Protein Interaction. Scott DE, Marsh M, Blundell TL, Abell C, Hyvonen M
    FEBS LETTERS 590, 1094 (2016).
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  • Structure and Energetic Contributions of a Designed Peptide-Binding Protein with Picomolar Affinity Hansen Simon, Tremmel Dirk, Madhurantakam Chaithanya, Reichen Christian, Mittl Peer R E, Plueckthun Andreas
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 138, 3526-3532 (2016).
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  • Structure and Function of the Unusual Tungsten Enzymes Acetylene Hydratase and Class II Benzoyl-Coenzyme A Reductase Boll M, Einsle O, Ermler U, Kroneck Peter MH, Ullmann GMatthias
    JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY 26, 119 (2016).
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  • Structure and Substrate Recognition of the Bottromycin Maturation Enzyme BotP. Mann G, Huo L, Adam S, Nardone B, Vendome J, Westwood NJ, Muller R, Koehnke J
    CHEMBIOCHEM 17, 2286 (2016).
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  • Structure and function of mammalian aldehyde oxidases Terao Mineko, Romao Maria Joao, Leimkuehler Silke, Bolis Marco, Fratelli Maddalena, Coelho Catarina, Santos-Silva Teresa, Garattini Enrico
    ARCHIVES OF TOXICOLOGY 90, 753-780 (2016).
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  • Structure of USP7 catalytic domain and three Ubl-domains reveals a connector ?-helix with regulatory role Kim Robbert Q, van Dijk Willem J, Sixma Titia K
    JOURNAL OF STRUCTURAL BIOLOGY 195, 11 (2016).
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  • Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex Kowalinski Eva, Koegel Alexander, Ebert Judith, Reichelt Peter, Stegmann Elisabeth, Habermann Bianca, Conti Elena
    MOLECULAR CELL 63, 125-134 (2016).
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  • Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53 Martinez-Zapien D, Ruiz F, Poirson J, Mitschler A, Ramirez J, Forster A, Cousido-Siah A, Masson M, Pol S, Podjarny A, Travé G, Zanier K
    NATURE , (2016).
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  • Structure of the host-recognition device of Staphylococcus aureus phage phi 11 Koc Cengiz, Xia Guoqing, Kuehner Petra, Spinelli Silvia, Roussel Alain, Cambillau Christian, Stehle Thilo
    Scientific Reports 6, 27581 (2016).
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  • Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. Martin LJ, Koegl M, Bader G, Cockcroft XL, Fedorov O, Fiegen D, Gerstberger T, Hofmann MH, Hohmann AF, Kessler D, Knapp S, Knesl P, Kornigg S, Muller S, Nar H, Rogers C, Rumpel K, Schaaf O, Steurer S, Tallant C, Vakoc CR, Zeeb M, Zoephel A, Pearson M, Boehmelt G, McConnell D
    JOURNAL OF MEDICINAL CHEMISTRY 59, 4462 (2016).
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  • Structure-Based Development of an Affinity Probe for Sirtuin 2 Schiedel M, Rumpf T, Karaman B, Lehotzky A, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55, 2252 (2016).
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  • Structure-activity relationship of the peptide binding-motif mediating the BRCA2:RAD51 protein-protein interaction Scott Duncan E, Marsh May, Blundell Tom L, Abell Chris, Hyvonen Marko
    FEBS LETTERS 590, 1094-1102 (2016).
    DOI: 10.1002/1873-3468.12139
  • Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects Reichen C, Madhurantakam C, Hansen S, Grutter MG, Pluckthun A, Mittl PRE
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 72, 168 (2016).
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  • Tackling the crystallographic structure determination of the COP9 signalosome Bunker Richard D
    ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY 72, 326-335 (2016).
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  • Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes Doodhi Harinath, Prota Andrea E, Rodriguez-Garcia Ruddi, Xiao Hui, Custar Daniel W, Bargsten Katja, Katrukha Eugene A, Hilbert Manuel, Hua Shasha, Jiang Kai, Grigoriev Ilya, Yang ChiaPing H, Cox David, Horwitz Susan Band, Kapitein Lukas C, Akhmanova Anna, Steinmetz Michel O
    CURRENT BIOLOGY 26, 1713-1721 (2016).
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  • Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid. Haruki H, Hovius R, Pedersen MG, Johnsson K
    JOURNAL OF BIOLOGICAL CHEMISTRY 291, 652 (2016).
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  • The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains Unzue Andrea, Zhao Hongtao, Lolli Graziano, Dong Jing, Zhu Jian, Zechner Melanie, Dolbois Aymeric, Caflisch Amedeo, Nevado Cristina
    JOURNAL OF MEDICINAL CHEMISTRY 59, 3087-3097 (2016).
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  • The Crystal Structure of Burkholderia cenocepacia DfsA Provides Insights into Substrate Recognition and Quorum Sensing Fatty Acid Biosynthesis Spadaro F, Scoffone Viola C, Chiarelli Laurent R, Fumagalli M, Buroni S, Riccardi G, Forneris F
    BIOCHEMISTRY 55, 3241 (2016).
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  • The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes Correia Marcia A S, Otrelo-Cardoso Ana Rita, Schwuchow Viola, Clauss Kajsa G V Sigfridsson, Haumann Michael, Romao Maria Joao, Leimkuhler Silke, Santos-Silva Teresa
    ACS CHEMICAL BIOLOGY 11, 2923-2935 (2016).
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  • The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding Kraatz S, Guichard P, Obbineni Jagan M, Olieric N, Hatzopoulos Georgios N, Hilbert M, Sen I, Missimer J, Gönczy P, Steinmetz Michel O
    STRUCTURE 24, 1358 (2016).
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  • The Structure of LiuC, a 3-Hydroxy-3-Methylglutaconyl CoA Dehydratase Involved in Isovaleryl-CoA Biosynthesis in Myxococcus xanthus, Reveals Insights into Specificity and Catalysis. Bock T, Reichelt J, Muller R, Blankenfeldt W
    CHEMBIOCHEM 17, 1658 (2016).
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  • The Structure of the Plakin Domain of Plectin Reveals an Extended Rod-like Shape. Ortega E, Manso JA, Buey RM, Carballido AM, Carabias A, Sonnenberg A, de Pereda JM
    JOURNAL OF BIOLOGICAL CHEMISTRY 291, 18643 (2016).
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  • The dynamic organization of fungal acetyl-CoA carboxylase Hunkeler Moritz, Stuttfeld Edward, Hagmann Anna, Imseng Stefan, Maier Timm
    NATURE COMMUNICATIONS 7, 11196 (2016).
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  • The flavinyl transferase ApbE of Pseudomonas stutzeri matures the NosR protein required for nitrous oxide reduction. Zhang L, Trncik C, Andrade SL, Einsle O
    Biochimica et Biophysica Acta (BBA) - Bioenergetics 1858, 95 (2016).
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  • The pH-dependent Client Release from the Collagen-specific Chaperone HSP47 Is Triggered by a Tandem Histidine Pair Oecal S, Socher E, Uthoff M, Ernst C, Zaucke F, Sticht H, Baumann U, Gebauer Jan M
    JOURNAL OF BIOLOGICAL CHEMISTRY 291, 12612 (2016).
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  • The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase Valsecchi Wanda M, Cousido-Siah A, Defelipe Lucas A, Mitschler A, Podjarny A, Santos J, Delfino José M
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  • Thermodynamic properties of leukotriene A(4) hydrolase inhibitors Wittmann Sandra K, Kalinowsky Lena, Kramer Jan S, Bloecher Rene, Knapp Stefan, Steinhilber Dieter, Pogoryelov Denys, Proschak Ewgenij, Heering Jan
    BIOORGANIC & MEDICINAL CHEMISTRY 24, 5243-5248 (2016).
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    NATURE COMMUNICATIONS 7, 13819 (2016).
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  • Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions. Zhu J, Caflisch A
    JOURNAL OF MEDICINAL CHEMISTRY 59, 5555 (2016).
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  • Unveiling the Basis of Alkaline Stability of an Evolved Versatile Peroxidase. Saez-Jimenez V, Acebes S, Garcia-Ruiz E, Romero A, Guallar V, Alcalde M, Medrano FJ, Martinez AT, Ruiz-Duenas FJ
    BIOCHEMICAL JOURNAL 473, 1917 (2016).
    DOI: 10.1042/BCJ20160248
  • X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain Fadel Firas, Zhao Yuguang, Cousido-Siah Alexandra, Ruiz Francesc X, Mitschler Andre, Podjarny Alberto
    PLOS ONE 11, e0154190 (2016).
    DOI: 10.1371/journal.pone.0154190
  • X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair Roethlisberger P, Istrate A, Lopez M J Marcaida, Visini R, Stocker A, Reymond J L, Leumann C J
    CHEMICAL COMMUNICATIONS 52, 4749-4752 (2016).
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2015

  • 2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 Neres Joao, Hartkoorn Ruben C, Chiarelli Laurent R, Gadupudi Ramakrishna, Pasca Maria Rosalia, Mori Giorgia, Venturelli Alberto, Savina Svetlana, Makarov Vadim, Kolly Gaelle S, Molteni Elisabetta, Binda Claudia, Dhar Neeraj, Ferrari Stefania, Brodin Priscille, Delorme Vincent, Landry Valerie, Lopes Ribeiro Ana Luisa de Jesus, Farina Davide, Saxena Puneet, Pojer Florence, Carta Antonio, Luciani Rosaria, Porta Alessio, Zanoni Giuseppe, De Rossi Edda, Costi Maria Paola, Riccardi Giovanna, Cole Stewart T
    ACS CHEMICAL BIOLOGY 10, 705-714 (2015).
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  • A Combination of Spin Diffusion Methods for the Determination of Protein-Ligand Complex Structural Ensembles Pilger Jens, Mazur Adam, Monecke Peter, Schreuder Herman, Elshorst Bettina, Bartoschek Stefan, Langer Thomas, Schiffer Alexander, Krimm Isabelle, Wegstroth Melanie, Lee Donghan, Hessler Gerhard, Wendt K Ulrich, Becker Stefan, Griesinger Christian
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54, 6511-6515 (2015).
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  • A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures. Guerra B, Bischoff N, Bdzhola VG, Yarmoluk SM, Issinger OG, Golub AG, Niefind K
    ACS CHEMICAL BIOLOGY 10, 1654 (2015).
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  • A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates Garrabou X, Beck T, Hilvert D
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54, 5609 (2015).
    DOI: 10.1002/ange.201500217
  • A Single Point Mutation Enhances Hydroxynitrile Synthesis by Halohydrin Dehalogenase. Schallmey M, Jekel P, Tang L, Majeric Elenkov M, Hoffken HW, Hauer B, Janssen DB
    ENZYME AND MICROBIAL TECHNOLOGY 70, 50 (2015).
    DOI: 10.1016/J.ENZMICTEC.2014.12.009
  • A Threonine Stabilizes the NiC and NiR Catalytic Intermediates of [NiFe]-hydrogenase Abou-Hamdan Abbas, Ceccaldi Pierre, Lebrette Hugo, Gutierrez-Sanz Oscar, Richaud Pierre, Cournac Laurent, Guigliarelli Bruno, De lacey Antonio L, Leger Christophe, Volbeda Anne, Burlat Benedicte, Dementin Sebastien
    JOURNAL OF BIOLOGICAL CHEMISTRY 290, 8550-8558 (2015).
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  • A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Dale T, Clarke PA, Esdar C, Waalboer D, Adeniji-Popoola O, Ortiz-Ruiz MJ, Mallinger A, Samant RS, Czodrowski P, Musil D, Schwarz D, Schneider K, Stubbs M, Ewan K, Fraser E, TePoele R, Court W, Box G, Valenti M, de Haven Brandon A, Gowan S, Rohdich F, Raynaud F, Schneider R, Poeschke O, Blaukat A, Workman P, Schiemann K, Eccles SA, Wienke D, Blagg J
    CHEMBIOCHEM 11, 973 (2015).
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  • A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N-6-methyladenosine demethylase FTO Toh Joel D W, Sun Lingyi, Lau Lisa Z M, Tan Jackie, Low Joanne J A, Tang Colin W Q, Cheong Eleanor J Y, Tan Melissa J H, Chen Yun, Hong Wanjin, Gao Yong-Gui, Woon Esther C Y
    CHEMICAL SCIENCE 6, 112-122 (2015).
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  • Acceleration of protein folding by four orders of magnitude through a single amino acid substitution. Roderer DJ, Scharer MA, Rubini M, Glockshuber R
    Scientific Reports 5, 11840 (2015).
    DOI: 10.1038/SREP11840
  • Active sites without restraints: high-resolution analysis of metal cofactors Burger E, Andrade S, Einsle O
    CURRENT OPINION IN STRUCTURAL BIOLOGY 35, 32 (2015).
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  • Allosteric Regulation of Focal Adhesion Kinase by Pip2 and ATP. Zhou J, Bronowska A, Le Coq J, Lietha D, Grater F
    BIOPHYSICAL JOURNAL 108, 698 (2015).
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  • An intramolecular bond at cluster of differentiation 81 ectodomain is important for hepatitis C virus entry Yang W, Zhang M, Chi X, Liu X, Qin B, Cui S
    FASEB JOURNAL , (2015).
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  • Antibiotics. Targeting Dnan for Tuberculosis Therapy Using Novel Griselimycins. Kling A, Lukat P, Almeida DV, Bauer A, Fontaine E, Sordello S, Zaburannyi N, Herrmann J, Wenzel SC, Konig C, Ammerman NC, Barrio MB, Borchers K, Bordon-Pallier F, Bronstrup M, Courtemanche G, Gerlitz M, Geslin M, Hammann P, Heinz DW, Hoffmann H, Klieber S, Kohlmann M, Kurz M, Lair C, Matter H, Nuermberger E, Tyagi S, Fraisse L, Grosset JH, Lagrange S, Muller R
    SCIENCE 348, 1106 (2015).
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  • Approved Drugs Containing Thiols as Inhibitors of Metallo-beta-lactamases: Strategy To Combat Multidrug-Resistant Bacteria Klingler FrancaM, Wichelhaus Thomas A, Frank Denia, Cuesta-Bernal Jenifer, El-Delik Jasmin, Mueller H Florian, Sjuts Hanno, Goettig Stephan, Koenigs Arno, Pos Klaas M, Pogoryelov Denys, Proschak Ewgenij
    JOURNAL OF MEDICINAL CHEMISTRY 58, 3626-3630 (2015).
    DOI: 10.1021/jm501844d
  • Approved Drugs Containing Thiols as Inhibitors of Metallo-beta-lactamases: Strategy To Combat Multidrug-Resistant Bacteria (vol 58, pg 3626, 2015) Klingler FrancaM, Wichelhaus Thomas A, Frank Denia, Cuesta-Bernal Jenifer, El-Delik Jasmin, Mueller H Florian, Sjuts Hanno, Goettig Stephan, Koenigs Arno, Pos Klaas M, Pogoryelov Denys, Proschak Ewgenij
    JOURNAL OF MEDICINAL CHEMISTRY 58, 6320-6320 (2015).
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  • Architecture of the Ubiquitylation Module of the Yeast Ccr4-Not Complex Bhaskar Varun, Basquin Jerome, Conti Elena
    STRUCTURE 23, 921-928 (2015).
    DOI: 10.1016/j.str.2015.03.011
  • Batch crystallization of rhodopsin for structural dynamics using an X-ray free-electron laser Wu W, Nogly P, Rheinberger J, M Kick L, Gati C, Nelson G, Deupi X, Standfuss J, Schertler G, Panneels V
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 71, 856 (2015).
    DOI: 10.1107/S2053230X15009966
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  • Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex Alexa A, Gogl G, Glatz G, Garai A, Zeke A, Varga J, Dudas E, Jeszen N, Bodor A, Hetenyi C, Remenyi A
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112, 2711 (2015).
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  • Structural basis for sialic acid-mediated self-recognition by complement factor H Blaum Baerbel S, Hannan Jonathan P, Herbert Andrew P, Kavanagh David, Uhrin Dusan, Stehle Thilo
    NATURE CHEMICAL BIOLOGY 11, 77-+ (2015).
    DOI: 10.1038/NCHEMBIO.1696
  • Structural basis of head to head polyketide fusion by CorB Zocher G, Vilstrup J, Heine D, Hallab A, Goralski E, Hertweck C, Stahl M, Schäberle Till F, Stehle T
    CHEMICAL SCIENCE 6, 6525 (2015).
    DOI: 10.1039/C5SC02488A
  • Structural basis of vitamin B3 transport Guskov A, Jaehme M, Slotboom D J
    FEBS JOURNAL 282, 391-391 (2015).
  • Structural characterization of metal binding to a cold-adapted frataxin Noguera M, Roman E, Rigal J, Cousido-Siah A, Mitschler A, Podjarny A, Santos J
    JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 20, 653 (2015).
    DOI: 10.1007/s00775-015-1251-9
  • Structural evidence for asymmetric ligand binding to transthyretin Cianci Michele, Folli Claudia, Zonta Francesco, Florio Paola, Berni Rodolfo, Zanotti Giuseppe
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 71, 1582-1592 (2015).
    DOI: 10.1107/S1399004715010585
  • Structural insights into the bacterial carbon-phosphorus lyase machinery. Seweryn P, Van LB, Kjeldgaard M, Russo CJ, Passmore LA, Hove-Jensen B, Jochimsen B, Brodersen DE
    NATURE 525, 68 (2015).
    DOI: 10.1038/NATURE14683
  • Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase Coelho C, Foti A, Hartmann T, Santos-Silva T, Leimkühler S, Romão M
    NATURE CHEMICAL BIOLOGY 11, 779 (2015).
    DOI: 10.1038/nchembio.1895
  • Structural insights on cholesterol endosynthesis: Binding of squalene and 2,3-oxidosqualene to supernatant protein factor. Christen M, Marcaida MJ, Lamprakis C, Aeschimann W, Vaithilingam J, Schneider P, Hilbert M, Schneider G, Cascella M, Stocker A
    JOURNAL OF STRUCTURAL BIOLOGY 190, 261 (2015).
    DOI: 10.1016/J.JSB.2015.05.001
  • Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues Koch Maximilian F, Harteis Sabrina, Blank Iris D, Pestel Galina, Tietze Lutz F, Ochsenfeld Christian, Schneider Sabine, Sieber Stephan A
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54, 13550-13554 (2015).
    DOI: 10.1002/anie.201505749
  • Structure and biochemical characterization of bacteriophage phi92 endosialidase Schwarzer David, Browning Christopher, Stummeyer Katharina, Oberbeck Astrid, Muehlenhoff Martina, Gerardy-Schahn Rita, Leiman Petr G
    VIROLOGY 477, 133-143 (2015).
    DOI: 10.1016/j.virol.2014.11.002
  • Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes Rostislavleva Ksenia, Soler Nicolas, Ohashi Yohei, Zhang Lufei, Pardon Els, Burke John E, Masson Glenn R, Johnson Chris, Steyaert Jan, Ktistakis Nicholas T, Williams Roger L
    SCIENCE 350, aac7365 (2015).
    DOI: 10.1126/science.aac7365
  • Structure and mechanism of the Rubisco-assembly chaperone Raf1. Hauser T, Bhat JY, Milicic G, Wendler P, Hartl FU, Bracher A, Hayer-Hartl M
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 22, 720 (2015).
    DOI: 10.1038/NSMB.3062
  • Structure of -carbonic anhydrase from the human pathogen Helicobacter pylori Compostella Maria Elena, Berto Paola, Vallese Francesca, Zanotti Giuseppe
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 71, 1005-1011 (2015).
    DOI: 10.1107/S2053230X15010407
  • Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis Korotkova Natalia, Piton Jeremie, Wagner Jonathan M, Boy-Roettger Stefanie, Japaridze Aleksandre, Evans Timothy J, Cole Stewart T, Pojer Florence, Korotkov Konstantin V
    JOURNAL OF STRUCTURAL BIOLOGY 191, 236-244 (2015).
    DOI: 10.1016/j.jsb.2015.06.003
  • Structure of Rab11-Fip3-Rabin8 Reveals Simultaneous Binding of Fip3 and Rabin8 Effectors to Rab11. Vetter M, Stehle R, Basquin C, Lorentzen E
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 22, 695 (2015).
    DOI: 10.1038/NSMB.3065
  • Structure of Serotype 1 Reovirus Attachment Protein sigma 1 in Complex with Junctional Adhesion Molecule A Reveals a Conserved Serotype-Independent Binding Epitope Stettner Eva, Dietrich Melanie H, Reiss Kerstin, Dermody Terence S, Stehle Thilo
    JOURNAL OF VIROLOGY 89, 6136-6140 (2015).
    DOI: 10.1128/JVI.00433-15
  • Structure of mitochondrial poly(A) RNA polymerase reveals the structural basis for dimerization, ATP selectivity and the SPAX4 disease phenotype Lapkouski M, Hällberg B Martin
    NUCLEIC ACIDS RESEARCH 43, 9065 (2015).
    DOI: 10.1093/nar/gkv861
  • Structure of the Sulfoxide Synthase EgtB from the Ergothioneine Biosynthetic Pathway Goncharenko KV, Vit A, Blankenfeldt W, Seebeck FP
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION ?, ? (2015).
    DOI: 10.1002/anie.201410045
  • Structure-Guided Design of an Anti-Dengue Antibody Directed to a Non-Immunodominant Epitope. Robinson LN, Tharakaraman K, Rowley KJ, Costa VV, Chan KR, Wong YH, Ong LC, Tan HC, Koch T, Cain D, Kirloskar R, Viswanathan K, Liew CW, Tissire H, Ramakrishnan B, Myette JR, Babcock GJ, Sasisekharan V, Alonso S, Chen J, Lescar J, Shriver Z, Ooi EE, Sasisekharan R
    CELL 162, 493 (2015).
    DOI: 10.1016/J.CELL.2015.06.057
  • Structure-based enzyme tailoring of 5-hydroxymethylfurfural oxidase. Dijkman WP, Binda C, Fraaije MW, Mattevi A
    ACS CATALYSIS 5, 1833 (2015).
    DOI: 10.1021/acscatal.5b00031
  • Synthesis, biological activity and structural study of new benzotriazole-based protein kinase CK2 inhibitors Swider R, Maslyk M, Zapico JM, Coderch C, Panchuk R, Skorokhyd N, Schnitzler A, Niefind K, de PascualTeresa B, Ramos A
    RSC ADVANCES 5, 72482 (2015).
    DOI: 10.1039/C5RA12114K
  • Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors Huber Eva M, de Bruin Gerjan, Heinemeyer Wolfgan, Soriano Guillem Paniagua, Overkleeft Herman S, Groll Michael
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137, 7835-7842 (2015).
    DOI: 10.1021/jacs.5b03688
  • TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export Stadel D, Millarte V, Tillmann Kerstin D, Huber J, Tamin-Yecheskel B, Akutsu M, Demishtein A, Ben-Zeev B, Anikster Y, Perez F, Dötsch V, Elazar Z, Rogov V, Farhan H, Behrends C
    MOLECULAR CELL 60, 89 (2015).
    DOI: 10.1016/j.molcel.2015.09.010
  • Targeting DnaN for tuberculosis therapy using novel griselimycins Kling Angela, Lukat Peer, Almeida Deepak V, Bauer Armin, Fontaine Evelyne, Sordello Sylvie, Zaburannyi Nestor, Herrmann Jennifer, Wenzel Silke C, Koenig Claudia, Ammerman Nicole C, Barrio Maria Belen, Borchers Kai, Bordon-Pallier Florence, Broenstrup Mark, Courtemanche Gilles, Gerlitz Martin, Geslin Michel, Hammann Peter, Heinz Dirk W, Hoffmann Holger, Klieber Sylvie, Kohlmann Markus, Kurz Michael, Lair Christine, Matter Hans, Nuermberger Eric, Tyagi Sandeep, Fraisse Laurent, Grosset Jacques H, Lagrange Sophie, Mueller Rolf
    SCIENCE 348, 1106-1112 (2015).
    DOI: 10.1126/science.aaa4690
  • The Crystal Structure of D-Threonine Aldolase from Alcaligenes Xylosoxidans Provides Insight Into a Metal Ion Assisted Plp-Dependent Mechanism. Uhl MK, Oberdorfer G, Steinkellner G, Riegler-Berket L, Mink D, Van Assema F, Schurmann M, Gruber K
    PLOS ONE 10, 24056 (2015).
    DOI: 10.1371/JOURNAL.PONE.0124056
  • The Crystal Structure of the Drosophila Germline Inducer Oskar Identifies Two Domains with Distinct Vasa Helicase-and RNA-Binding Activities. Jeske M, Bordi M, Glatt S, Muller S, Rybin V, Muller CW, Ephrussi A
    CELL REPORTS 12, 587 (2015).
    DOI: 10.1016/J.CELREP.2015.06.055
  • The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition Fanfrlik Jindrich, Ruiz Francesc X, Kadlcikova Aneta, Rezac Jan, Cousido-Siah Alexandra, Mitschler Andre, Haldar Susanta, Lepsik Martin, Kolar Michal H, Majer Pavel, Podjarny Alberto D, Hobza Pavel
    ACS CHEMICAL BIOLOGY 10, 1637-1642 (2015).
    DOI: 10.1021/acschembio.5b00151
  • The Fe-V Cofactor of Vanadium Nitrogenase Contains an Interstitial Carbon Atom Rees Julian A, Bjornsson R, Schlesier J, Sippel D, Einsle O, DeBeer S
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54, 13249 (2015).
    DOI: 10.1002/anie.201505930
  • The Greater Affinity of JC Polyomavirus Capsid for alpha 2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity Stroeh Luisa J, Maginnis Melissa S, Blaum Baerbel S, Nelson Christian D S, Neu Ursula, Gee Gretchen V, O'Hara Bethany A, Motamedi Nasim, DiMaio Daniel, Atwood Walter J, Stehle Thilo
    JOURNAL OF VIROLOGY 89, 6364-6375 (2015).
    DOI: 10.1128/JVI.00489-15
  • The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism. Gogl G, Schneider KD, Yeh BJ, Alam N, Nguyen Ba AN, Moses AM, Hetenyi C, Remenyi A, Weiss EL
    PLOS BIOLOGY 13, (2015).
    DOI: 10.1371/JOURNAL.PBIO.1002146
  • The Substrate-free and -bound Crystal Structures of the Duplicated Taurocyamine Kinase from the Human Parasite Schistosoma mansoni Merceron R, Awama Ayman M, Montserret R, Marcillat O, Gouet P
    JOURNAL OF BIOLOGICAL CHEMISTRY 290, 12951 (2015).
    DOI: 10.1074/jbc.M114.628909
  • The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography Fiege Brigitte, Rabbani Said, Preston Roland C, Jakob Roman P, Zihlmann Pascal, Schwardt Oliver, Jiang Xiaohua, Maier Timm, Ernst Beat
    CHEMBIOCHEM 16, 1235-1246 (2015).
    DOI: 10.1002/cbic.201402714
  • The X-ray structure of human P-cadherin EC1-EC2 in a closed conformation provides insight into the type I cadherin dimerization pathway. Dalle Vedove A, Lucarelli AP, Nardone V, Matino A, Parisini E
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 71, 371 (2015).
    DOI: 10.1107/S2053230X15003878
  • The first crystal structure of the peptidase domain of the U32 peptidase family Schacherl M, Montada Angelika AM, Brunstein E, Baumann U
    ACTA CRYSTALLOGRAPHICA SECTION D - BIOLOGICAL CRYSTALLOGRAPHY 71, 2505 (2015).
    DOI: 10.1107/S1399004715019549
  • The first step of peptide selection in antigen presentation by MHC class I molecules. Garstka MA, Fish A, Celie PH, Joosten RP, Janssen GM, Berlin I, Hoppes R, Stadnik M, Janssen L, Ovaa H, van Veelen PA, Perrakis A, Neefjes J
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112, 1505 (2015).
    DOI: 10.1073/PNAS.1416543112
  • The homopentameric chlorite dismutase from Magnetospirillum sp. Freire Diana M, Rivas Maria G, Dias Andre M, Lopes Ana T, Costa Cristina, Santos-Silva Teresa, Van Doorslaer Sabine, Gonzalez Pablo J
    JOURNAL OF INORGANIC BIOCHEMISTRY 151, 1-9 (2015).
    DOI: 10.1016/j.jinorgbio.2015.07.006
  • The octahaem MccA is a haem c-copper sulfite reductase Hermann Bianca, Kern Melanie, La Pietra Luigi, Simon Joerg, Einsle Oliver
    NATURE 520, 706-U318 (2015).
    DOI: 10.1038/nature14109
  • The structure of plant photosystem I super-complex at 2.8 angstrom resolution Mazor Yuval, Borovikova Anna, Nelson Nathan
    ELIFE 4, e07433 (2015).
    DOI: 10.7554/eLife.07433
  • Thiosulfate Dehydrogenase (TsdA) from Allochromatium vinosum: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO THIOSULFATE OXIDATION. Brito JA, Denkmann K, Pereira IA, Archer M, Dahl C
    JOURNAL OF BIOLOGICAL CHEMISTRY 290, 9222 (2015).
    DOI: 10.1074/JBC.M114.623397
  • Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of Natural Polyphenols and Their Metabolites Florio Paola, Folli Claudia, Cianci Michele, Del Rio Daniele, Zanotti Giuseppe, Berni Rodolfo
    JOURNAL OF BIOLOGICAL CHEMISTRY 290, 29769-29780 (2015).
    DOI: 10.1074/jbc.M115.690172
  • Triazole linker-based trivalent sialic acid inhibitors of adenovirus type 37 infection of human corneal epithelial cells Caraballo R, Saleeb M, Bauer J, Liaci AM, Chandra N, Storm RJ, Frängsmyr L, Qian W, Stehle T, Arnbergbde N, Elofsson M
    ORGANIC & BIOMOLECULAR CHEMISTRY 13, 9194 (2015).
    DOI: 10.1039/c5ob01025j
  • Trichodysplasia spinulosa-Associated Polyomavirus Uses a Displaced Binding Site on VP1 to Engage Sialylated Glycolipids. Ströh LJ, Gee GV, Blaum BS, Dugan AS, Feltkamp MC, Atwood WJ, Stehle T
    PLOS PATHOGENS 11, 1 (2015).
    DOI: 10.1371/journal.ppat.1005112
  • Two Putative Polysaccharide Deacetylases Are Required for Osmotic Stability and Cell Shape Maintenance in Bacillus anthracis Arnaouteli Sofia, Giastas Petros, Andreou Athina, Tzanodaskalaki Mary, Aldridge Christine, Tzartos Socrates J, Vollmer Waldemar, Eliopoulos Elias, Bouriotis Vassilis
    JOURNAL OF BIOLOGICAL CHEMISTRY 290, 13465-13478 (2015).
    DOI: 10.1074/jbc.M115.640029
  • Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics Colin P, Kintses B, Gielen F, Miton Charlotte M, Fischer G, Mohamed Mark F, Hyvönen M, Morgavi Diego P, Janssen D, Hollfelder F
    NATURE COMMUNICATIONS 6, 10008 (2015).
    DOI: 10.1038/ncomms10008
  • Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic Kottur J, Sharma A, Gore KR, Narayanan N, Samanta B, Pradeepkumar PI, Nair DT
    STRUCTURE 23, 56 (2015).
    DOI: 10.1016/J.STR.2014.10.019
  • Using Strictosidine Synthase to Prepare Novel Alkaloids Zhu Huajian, Kercmar Petra, Wu Fangrui, Rajendran Chitra, Sun Lianli, Wang Meitian, Stoeckigt Joachim
    CURRENT MEDICINAL CHEMISTRY 22, 1880-1888 (2015).
    DOI: 10.2174/0929867322666150408110919
  • X-ray crystallography and its impact on understanding bacterial cell wall remodeling processes Buettner Felix Michael, Renner-Schneck Michaela, Stehle Thilo
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY 305, 209-216 (2015).
    DOI: 10.1016/j.ijmm.2014.12.018

2014

  • A Complete Configurational Ensemble Approach to Expand Lsd1/Corest Druggability Robertson James C, Hurley Nate C, Kneller Julie M, Vellore Nadeem A, Mattevi Andrea, Baron Riccardo
    BIOPHYSICAL JOURNAL 106, 660A-660A (2014).
    DOI: 10.1016/j.bpj.2013.11.3655
  • A Natural-Product Switch for a Dynamic Protein Interface Scheepstra Marcel, Nieto Lidia, Hirsch Anna K H, Fuchs Sascha, Leysen Seppe, Chan Vinh Lam, Panhuis Leslie In Het, van Boeckel Constant A A, Wienk Hans, Boelens Rolf, Ottmann Christian, Milroy Lech-Gustav, Brunsveld Luc
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53, 6443-6448 (2014).
    DOI: 10.1002/anie.201403773
  • A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage Nodwell MB, Koch MF, Alte F, Schneider S, Sieber SA
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136, 4992-4999 (2014).
    DOI: 10.1021/ja411785r
  • A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization Peterhoff David, Beer Barbara, Rajendran Chitra, Kumpula Esa-Pekka, Kapetaniou Evangelia, Guldan Harald, Wierenga Rik K, Sterner Reinhard, Babinger Patrick
    MOLECULAR MICROBIOLOGY 92, 885-899 (2014).
    DOI: 10.1111/mmi.12596
  • A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs Prota Andrea E, Bargsten Katja, Fernando Diaz J, Marsh May, Cuevas Carmen, Liniger Marc, Neuhaus Christian, Andreu Jose M, Altmann Karl-Heinz, Steinmetz Michel O
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111, 13817-13821 (2014).
    DOI: 10.1073/pnas.1408124111
  • Altered Peptide Ligands Revisited: Vaccine Design through Chemically Modified HLA-A2-Restricted T Cell Epitopes Hoppes Rieuwert, Oostvoges Rimke, Luimstra Jolien J, Wals Kim, Toebes Mireille, Bies Laura, Ekkebus Reggy, Rijal Pramila, Celie Patrick H N, Huang Julie H, Emmelot Maarten E, Spaapen Robbert M, Lokhorst Henk, Schumacher Ton N M, Mutis Tuna, Rodenko Boris, Ovaa Huib
    JOURNAL OF IMMUNOLOGY 193, 4803-4813 (2014).
    DOI: 10.4049/jimmunol.1400800
  • An Antibody against the C-Terminal Domain of PCSK9 Lowers LDL Cholesterol Levels In Vivo Schiele F, Park J, Redemann N, Luippold G, Nar H
    JOURNAL OF MOLECULAR BIOLOGY 426, 843-852 (2014).
    DOI: 10.1016/j.jmb.2013.11.011
  • An artificial PPR scaffold for programmable RNA recognition Coquille Sandrine, Filipovska Aleksandra, Chia Tiongsun, Rajappa Lional, Lingford James P, Razif Muhammad F M, Thore Stephane, Rackham Oliver
    NATURE COMMUNICATIONS 5, 5729 (2014).
    DOI: 10.1038/ncomms6729
  • Analysis of Selected and Designed Chimeric D- and L-?-Helix Assemblies Kükenshöner T, Hagemann Urs B, Wohlwend D, Räuber C, Baumann T, Keller S, Einsle O, Müller Kristian M, Arndt Katja M
    BIOMACROMOLECULES 15, 3296 (2014).
    DOI: 10.1021/bm5006883
  • Apo, Zn2+-bound and Mn2+-bound structures reveal ligand-binding properties of SitA from the pathogen Staphylococcus pseudintermedius. Abate F, Malito E, Cozzi R, Lo Surdo P, Maione D, Bottomley MJ
    BIOSCIENCE REPORTS 34, e00154 (2014).
    DOI: 10.1042/BSR20140088
  • Axial helix rotation as a mechanism for signal regulation inferred from the crystallographic analysis of the E. coli serine chemoreceptor Ferris Hedda U, Zeth Kornelius, Hulko Michael, Dunin-Horkawicz Stanislaw, Lupas Andrei N
    JOURNAL OF STRUCTURAL BIOLOGY 186, 349-356 (2014).
    DOI: 10.1016/j.jsb.2014.03.015
  • Bacterial periplasmic sialic acid-binding proteins exhibit a conserved binding site Setty Thanuja Gangi, Cho Christine, Govindappa Sowmya, Apicella Michael A, Ramaswamy S
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70, 1801-1811 (2014).
    DOI: 10.1107/S139900471400830X
  • Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex Jnoff Eric, Albrecht Claudia, Barker John J, Barker Oliver, Beaumont Edward, Bromidge Steven, Brookfield Frederick, Brooks Mark, Bubert Christian, Ceska Tom, Corden Vincent, Dawson Graham, Duclos Stephanie, Fryatt Tara, Genicot Christophe, Jigorel Emilie, Kwong Jason, Maghames Rosemary, Mushi Innocent, Pike Richard, Sands Zara A, Smith Myron A, Stimson Christopher C, Courade Jean-Philippe
    CHEMMEDCHEM 9, 699-705 (2014).
    DOI: 10.1002/cmdc.201300525
  • Bioorthogonal Cleavage and Exchange of Major Histocompatibility Complex Ligands by Employing Azobenzene-Containing Peptides Choo Joanna A L, Thong Sock Yue, Yap Jiawei, van Esch Wim J E, Raida Manfred, Meijers Rob, Lescar Julien, Verhelst Steven H L, Grotenbreg Gijsbert M
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53, 13390-13394 (2014).
    DOI: 10.1002/anie.201406295
  • Carboplatin binding to histidine Tanley Simon W M, Diederichs Kay, Kroon-Batenburg Loes M J, Levy Colin, Schreurs Antoine M M, Helliwell John R
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70, 1135-1142 (2014).
    DOI: 10.1107/S2053230X14016161
  • Central role of the Na+-translocating NADH: quinone oxidoreductase (Na+-NQR) in sodium bioenergetics of Vibrio cholerae Steuber Julia, Halang Petra, Vorburger Thomas, Steffen Wojtek, Vohl Georg, Fritz Guenter
    BIOLOGICAL CHEMISTRY 395, 1389-1399 (2014).
    DOI: 10.1515/hsz-2014-0204
  • Co-Crystallization with Conformation-Specific Designed Ankyrin Repeat Proteins Explains the Conformational Flexibility of BCL-W Schilling Johannes, Schoppe Jendrik, Sauer Evelyn, Plueckthun Andreas
    JOURNAL OF MOLECULAR BIOLOGY 426, 2346-2362 (2014).
    DOI: 10.1016/j.jmb.2014.04.010
  • Connecting Photosynthetic Light Harvesting and Charge Separation at Higher Detail Einsle O
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53, 7988 (2014).
    DOI: 10.1002/anie.201405489
  • Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification Tufar Peter, Rahighi Simin, Kraas Femke I, Kirchner Donata K, Loehr Frank, Henrich Erik, Koepke Juergen, Dikic Ivan, Guentert Peter, Marahiel Mohamed A, Doetsch Volker
    CHEMISTRY & BIOLOGY 21, 552-562 (2014).
    DOI: 10.1016/j.chembiol.2014.02.014
  • Crystal Structure of an (R)-Selective omega-Transaminase from Aspergillus terreus Lyskowski Andrzej, Gruber Christian, Steinkellner Georg, Schuermann Martin, Schwab Helmut, Gruber Karl, Steiner Kerstin
    PLOS ONE 9, e87350 (2014).
    DOI: 10.1371/journal.pone.0087350
  • Crystal structure of the human COP9 signalosome Lingaraju Gondichatnahalli M, Bunker Richard D, Cavadini Simone, Hess Daniel, Hassiepen Ulrich, Renatus Martin, Fischer Eric S, Thomae Nicolas H
    NATURE 512, 161-165 (2014).
    DOI: 10.1038/nature13566
  • Crystal structure of the vitamin B-3 transporter PnuC, a full-length SWEET homolog Jaehme Michael, Guskov Albert, Slotboom Dirk Jan
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 21, 1013-1015 (2014).
    DOI: 10.1038/nsmb.2909
  • Crystal structures of designed armadillo repeat proteins: Implications of construct design and crystallization conditions on overall structure Reichen Christian, Madhurantakam Chaithanya, Plueckthun Andreas, Mittl Peer R E
    PROTEIN SCIENCE 23, 1572-1583 (2014).
    DOI: 10.1002/pro.2535
  • Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain. Zouridakis M, Giastas P, Zarkadas E, Chroni-Tzartou D, Bregestovski P, Tzartos SJ
    NATURE STRUCTURAL & MOLECULAR BIOLOGY Advanced online publ, Advanced online publ (2014).
    DOI: 10.1038/nsmb.2900
  • Crystal structures of free and antagonist-bound states of human alpha 9 nicotinic receptor extracellular domain Zouridakis Marios, Giastas Petros, Zarkadas Eleftherios, Chroni-Tzartou Dafni, Bregestovski Piotr, Tzartos Socrates J
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 21, 976-980 (2014).
    DOI: 10.1038/nsmb.2900
  • Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation Bojar Daniel, Martinez Jacobo, Santiago Julia, Rybin Vladimir, Bayliss Richard, Hothorn Michael
    PLANT JOURNAL 78, 31-43 (2014).
    DOI: 10.1111/tpj.12445
  • Crystallization and preliminary analysis of the NqrA and NqrC subunits of the Na+- translocating NADH: ubiquinone oxidoreductase from Vibrio cholerae Vohl Georg, Nedielkov Ruslan, Claussen Bjoern, Casutt Marco S, Vorburger Thomas, Diederichs Kay, Moeller Heiko M, Steuber Julia, Fritz Guenter
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70, 987-992 (2014).
    DOI: 10.1107/S2053230X14009881
  • Crystallization and preliminary crystallographic analysis of human aquaporin 1 at a resolution of 3.28 angstrom Carrillo David Ruiz, Ying Janet To Yiu, Darwis Dina, Soon Cin Huang, Cornvik Tobias, Torres Jaume, Lescar Julien
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70, 1657-1663 (2014).
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  • Structural basis for the broad specificity of a new family of amino-acid racemases Espaillat A, Carrasco-Lopez C, Bernardo-Garcia N, Pietrosemoli N, Otero LH, Alvarez L, de Pedro MA, Pazos F, Davis BM, Waldor MK, Hermoso JA, Cava F
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70, 79-90 (2014).
    DOI: 10.1107/S1399004713024838
  • Structural basis for-10 promoter element melting by environmentally induced sigma factors Campagne Sebastien, Marsh May E, Capitani Guido, Vorholt Julia A, Allain Frederic H-T
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 21, 269-276 (2014).
    DOI: 10.1038/nsmb.2777
  • Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease Anders Carolin, Niewoehner Ole, Duerst Alessia, Jinek Martin
    NATURE 513, 569 (2014).
    DOI: 10.1038/nature13579
  • Structure Analysis of the Major Capsid Proteins of Human Polyomaviruses 6 and 7 Reveals an Obstructed Sialic Acid Binding Site Stroeh Luisa J, Neu Ursula, Blaum Baerbel S, Buch Michael H C, Garcea Robert L, Stehle Thilo
    JOURNAL OF VIROLOGY 88, 10831-10839 (2014).
    DOI: 10.1128/JVI.01084-14
  • Structure and Thermodynamics of Effector Molecule Binding to the Nitrogen Signal Transduction P-II Protein GInZ from Azospirillum brasilense Truan Daphne, Bjelic Sasa, Li Xiao-Dan, Winkler Fritz K
    JOURNAL OF MOLECULAR BIOLOGY 426, 2783-2799 (2014).
    DOI: 10.1016/j.jmb.2014.05.008
  • Structure and properties of the C-terminal beta-helical domain of VgrG protein from Escherichia coli O157 Uchida Kazuya, Leiman Petr G, Arisaka Fumio, Kanamaru Shuji
    JOURNAL OF BIOCHEMISTRY 155, 173-182 (2014).
    DOI: 10.1093/jb/mvt109
  • Structure and substrate ion binding in the sodium/proton antiporter PaNhaP Woehlert David, Kuehlbrandt Werner, Yildiz Oezkan
    ELIFE 3, (2014).
    DOI: 10.7554/eLife.03579
  • Structure of Aurora B-INCENP in complex with barasertib reveals a potential transinhibitory mechanism Sessa Fabio, Villa Fabrizio
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 70, 294-298 (2014).
    DOI: 10.1107/S2053230X14002118
  • Structure of BamA, an essential factor in outer membrane protein biogenesis Albrecht Reinhard, Schuetz Monika, Oberhettinger Philipp, Faulstich Michaela, Bermejo Ivan, Rudel Thomas, Diederichs Kay, Zeth Kornelius
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70, 1779-1789 (2014).
    DOI: 10.1107/S1399004714007482
  • Structure of a Diguanylate Cyclase from Thermotoga maritima: Insights into Activation, Feedback Inhibition and Thermostability Deepthi Angeline, Liew Chong Wai, Liang Zhao-Xun, Swaminathan Kunchithapadam, Lescar Julien
    PLOS ONE 9, e110912 (2014).
    DOI: 10.1371/journal.pone.0110912
  • Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli Egloff Pascal, Hillenbrand Matthias, Klenk Christoph, Batyuk Alexander, Heine Philipp, Balada Stefanie, Schlinkmann Karola M, Scott Daniel J, Schuetz Marco, Plueckthun Andreas
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111, E655-E662 (2014).
    DOI: 10.1073/pnas.1317903111
  • Structure of the DDBI-CRBN E3 ubiquitin ligase in complex with thalidomide Fischer Eric S, Boehm Kerstin, Lydeard John R, Yang Haidi, Stadler Michael B, Cavadini Simone, Nagel Jane, Serluca Fabrizio, Acker Vincent, Lingaraju Gondichatnahalli M, Tichkule Ritesh B, Schebesta Michael, Forrester William C, Schirle Markus, Hassiepen Ulrich, Ottl Johannes, Hild Marc, Beckwith Rohan E J, Harper J Wade, Jenkins Jeremy L, Thomae Nicolas H
    NATURE 512, 49 (2014).
    DOI: 10.1038/nature13527
  • Structure of the N-Terminal Gyrase B Fragment in Complex with ADP center dot P-i Reveals Rigid-Body Motion Induced by ATP Hydrolysis Stanger Frederic V, Dehio Christoph, Schirmer Tilman
    PLOS ONE 9, e107289 (2014).
    DOI: 10.1371/journal.pone.0107289
  • Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase Steuber Julia, Vohl Georg, Casutt Marco S, Vorburger Thomas, Diederichs Kay, Fritz Guenter
    NATURE 516, 62-U379 (2014).
    DOI: 10.1038/nature14003
  • Structure of the double-stranded DNA-binding type IV secretion protein TraN from Enterococcus Goessweiner-Mohr Nikolaus, Eder Markus, Hofer Gerhard, Fercher Christian, Arends Karsten, Birner-Gruenberger Ruth, Grohmann Elisabeth, Keller Walter
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70, 2376-2389 (2014).
    DOI: 10.1107/S1399004714014187
  • Structure of the full-length yeast Arp7-Arp9 heterodimer Lobsiger Joel, Hunziker Yvonne, Richmond Timothy J
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70, 310-316 (2014).
    DOI: 10.1107/S1399004713027417
  • Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody Malito Enrico, Biancucci Marco, Faleri Agnese, Ferlenghi Ilaria, Scarselli Maria, Maruggi Giulietta, Lo Surdo Paola, Veggi Daniele, Liguori Alessia, Santini Laura, Bertoldi Isabella, Petracca Roberto, Marchi Sara, Romagnoli Giacomo, Cartocci Elena, Vercellino Irene, Savino Silvana, Spraggon Glen, Norais Nathalie, Pizza Mariagrazia, Rappuoli Rino, Masignani Vega, Bottomley Matthew James
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111, 17128-17133 (2014).
    DOI: 10.1073/pnas.1419686111
  • Structure of the oligogalacturonate-specific KdgM porin Hutter C A J, Lehner R, Wirth Ch, Condemine G, Peneff C, Schirmer T
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70, 1770-1778 (2014).
    DOI: 10.1107/S1399004714007147
  • Structure of the pseudokinase domain of BIR2, a regulator of BAK1-mediated immune signaling in Arabidopsis Blaum Baerbel S, Mazzotta Sara, Noedeke Erik R, Halter Thierry, Madlung Johannes, Kemmerling Birgit, Stehle Thilo
    JOURNAL OF STRUCTURAL BIOLOGY 186, 112-121 (2014).
    DOI: 10.1016/j.jsb.2014.02.005
  • Structure-Function Analysis of Staphylococcus aureus Amidase Reveals the Determinants of Peptidoglycan Recognition and Cleavage Buettner Felix Michael, Zoll Sebastian, Nega Mulugeta, Goetz Friedrich, Stehle Thilo
    JOURNAL OF BIOLOGICAL CHEMISTRY 289, 11083-11094 (2014).
    DOI: 10.1074/jbc.M114.557306
  • Structure-Function Elucidation of a New alpha-Conotoxin, Lo1a, from Conus longurionis Lebbe Eline K M, Peigneur Steve, Maiti Mohitosh, Devi Prabha, Ravichandran Samuthirapandian, Lescrinier Eveline, Ulens Chris, Waelkens Etienne, D'Souza Lisette, Herdewijn Piet, Tytgat Jan
    JOURNAL OF BIOLOGICAL CHEMISTRY 289, 9573-9583 (2014).
    DOI: 10.1074/jbc.M114.556175
  • Structure-based optimization of non-peptidic Cathepsin D inhibitors Graedler Ulrich, Czodrowski Paul, Tsaklakidis Christos, Klein Markus, Werkmann Daniela, Lindemann Sven, Maskos Klaus, Leuthner Birgitta
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24, 4141-4150 (2014).
    DOI: 10.1016/j.bmcl.2014.07.054
  • Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation Jinek Martin, Jiang Fuguo, Taylor David W, Sternberg Samuel H, Kaya Emine, Ma Enbo, Anders Carolin, Hauer Michael, Zhou Kaihong, Lin Steven, Kaplan Matias, Iavarone Anthony T, Charpentier Emmanuelle, Nogales Eva, Doudna Jennifer A
    SCIENCE 343, 1215-1215 (2014).
    DOI: 10.1126/science.1247997
  • Surprising Base Pairing and Structural Properties of 2 '-Trifluoromethylthio-Modified Ribonucleic Acids Kosutic Marija, Jud Lukas, Da Veiga Cyrielle, Frener Marina, Fauster Katja, Kreutz Christoph, Ennifar Eric, Micura Ronald
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136, 6656-6663 (2014).
    DOI: 10.1021/ja5005637
  • Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: A novel class of irreversible inhibitors of histone demethylase KDM1A Vianello Paola, Botrugno Oronza A, Cappa Anna, Ciossani Giuseppe, Dessanti Paola, Mai Antonello, Mattevi Andrea, Meroni Giuseppe, Minucci Saverio, Thaler Florian, Tortorici Marcello, Trifiro Paolo, Valente Sergio, Villa Manuela, Varasi Mario, Mercurio Ciro
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 86, 352-363 (2014).
    DOI: 10.1016/j.ejmech.2014.08.068
  • The Formation of Pyrroline and Tetrahydropyridine Rings in Amino Acids Catalyzed by Pyrrolysine Synthase (PylD) Quitterer Felix, Beck Philipp, Bacher Adelbert, Groll Michael
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53, 8150-8153 (2014).
    DOI: 10.1002/anie.201402595
  • The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug resistance Chong H, Yao X, Qiu Z, Sun J, Qiao Y, Zhang M, Wang M, Cui S, He Y
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 69, 2759 (2014).
    DOI: 10.1093/jac/dku183
  • The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization Prota Andrea E, Danel Franck, Bachmann Felix, Bargsten Katja, Buey Ruben M, Pohlmann Jens, Reinelt Stefan, Lane Heidi, Steinmetz Michel O
    JOURNAL OF MOLECULAR BIOLOGY 426, 1848-1860 (2014).
    DOI: 10.1016/j.jmb.2014.02.005
  • The NreA Protein Functions as a Nitrate Receptor in the Staphylococcal Nitrate Regulation System Niemann V, Koch-Singenstreu M, Neu A, Nilkens S, Gotz F, Unden G, Stehle T
    JOURNAL OF MOLECULAR BIOLOGY 426, 1539-1553 (2014).
    DOI: 10.1016/j.jmb.2013.12.026
  • The Prokaryote Ligand-Gated Ion Channel Elic Captured in a Pore Blocker-Bound Conformation by the Alzheimer's Disease Drug Memantine Ulens Chris, Spurny Radovan, Thompson Andrew J, Alqazzaz Mona, Debaveye Sarah, Lu Han, Price Kerry, Villalgordo Jose M, Tresadern Gary, Tresadern Gary, Lynch Joseph W, Lynch Joseph W, Lummis Sarah C R
    BIOPHYSICAL JOURNAL 106, 342A-342A (2014).
    DOI: 10.1016/j.bpj.2013.11.1955
  • The Protein Kinase CK2(Andante) Holoenzyme Structure Supports Proposed Models of Autoregulation and Trans-Autophosphorylation Schnitzler Alexander, Olsen Birgitte Brinkmann, Issinger Olaf-Georg, Niefind Karsten
    JOURNAL OF MOLECULAR BIOLOGY 426, 1871-1882 (2014).
    DOI: 10.1016/j.jmb.2014.02.018
  • The TRIM-NHL Protein LIN-41 Controls the Onset of Developmental Plasticity in Caenorhabditis elegans Tocchini Cristina, Keusch Jeremy J, Miller Sarah B, Finger Susanne, Gut Heinz, Stadler Michael B, Ciosk Rafal
    PLOS GENETICS 10, e1004533 (2014).
    DOI: 10.1371/journal.pgen.1004533
  • The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence Wen Yurong, Behiels Ester, Felix Jan, Elegheert Jonathan, Vergauwen Bjorn, Devreese Bart, Savvides Savvas N
    NUCLEIC ACIDS RESEARCH 42, 10134-10147 (2014).
    DOI: 10.1093/nar/gku665
  • The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA recognition motifs Arieti F, Gabus C, Tambalo M, Huet T, Round A, Thore S
    NUCLEIC ACIDS RESEARCH 42, 6742-6752 (2014).
    DOI: 10.1093/nar/gku277
  • The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron sulfur cluster biogenesis and oxidative stress defence Rybniker Jan, Pojer Florence, Marienhagen Jan, Kolly Gaelle S, Chen Jeffrey M, van Gumpel Edeltraud, Hartmann Pia, Cole Stewart T
    BIOCHEMICAL JOURNAL 459, 467-478 (2014).
    DOI: 10.1042/BJ20130732
  • The discovery of Mo(III) in FeMoco: reuniting enzyme and model chemistry Bjornsson R, Neese F, Schrock Richard R, Einsle O, DeBeer S
    JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 20, 447 (2014).
    DOI: 10.1007/s00775-014-1230-6
  • The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase Schuch Benjamin, Feigenbutz Monika, Makino Debora L, Falk Sebastian, Basquin Claire, Mitchell Phil, Conti Elena
    EMBO JOURNAL 33, 2829-2846 (2014).
    DOI: 10.15252/embj.201488757
  • The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin Schroder Tenna Juul, Christensen Soren, Lindberg Samsa, Langgard Morten, David Laurent, Maltas Philip J, Eskildsen Jorgen, Jacobsen Jan, Tagmose Lena, Simonsen Klaus Baek, Ronn Lars Christian Biilmann, de Jong Inge E M, Malik Ibrahim J, Karlsson Jens-Jakob, Bundgaard Christoffer, Egebjerg Jan, Stavenhagen Jeffrey B, Strandbygard Dorthe, Thirup Soren, Andersen Jacob Lauwring, Uppalanchi Srinivas, Pervaram Sridhar, Kasturi Shiva Prasad, Eradi Pradheep, Sakumudi Durga Rao, Watson Stephen P
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24, 177-180 (2014).
    DOI: 10.1016/j.bmcl.2013.11.046
  • The pseudo GTPase CENP-M drives human kinetochore assembly Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S, Musacchio A
    ELIFE 3, UNSP e02978 (2014).
    DOI: 10.7554/eLife.02978
  • The sweet spot: defining virus-sialic acid interactions Stencel-Baerenwald Jennifer E, Reiss Kerstin, Reiter Dirk M, Stehle Thilo, Dermody Terence S
    NATURE REVIEWS MICROBIOLOGY 12, 739-749 (2014).
    DOI: 10.1038/nrmicro3346
  • The type IV secretion protein TraK from the Enterococcus conjugative plasmid pIP501 exhibits a novel fold Goessweiner-Mohr Nikolaus, Fercher Christian, Arends Karsten, Birner-Gruenberger Ruth, Laverde-Gomez Diana, Huebner Johannes, Grohmann Elisabeth, Keller Walter
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70, 1124-1135 (2014).
    DOI: 10.1107/S1399004714001606
  • Towards a new combination therapy for tuberculosis with next generation benzothiazinones Makarov Vadim, Lechartier Benoit, Zhang Ming, Neres Joao, van der Sar Astrid M, Raadsen Susanne A, Hartkoorn Ruben C, Ryabova Olga B, Vocat Anthony, Decosterd Laurent A, Widmer Nicolas, Buclin Thierry, Bitter Wilbert, Andries Koen, Pojer Florence, Dyson Paul J, Cole Stewart T
    EMBO MOLECULAR MEDICINE 6, 372-383 (2014).
    DOI: 10.1002/emmm.201303575
  • Transport Pathway in Cu+ P-Type ATPases Andersson Magnus, Mattle Daniel, Sitsel Oleg, Nielsen Anna Marie, Lindahl Erik, White Stephen H, Nissen Poul, Gourdon Pontus
    BIOPHYSICAL JOURNAL 106, 427A-427A (2014).
    DOI: 10.1016/j.bpj.2013.11.2406
  • TrpB2 Enzymes are O-Phospho-L-serine Dependent Tryptophan Synthases Busch Florian, Rajendran Chitra, Mayans Olga, Loeffler Patrick, Merkl Rainer, Sterner Reinhard
    BIOCHEMISTRY 53, 6078-6083 (2014).
    DOI: 10.1021/bi500977y
  • Unique Crystal Structure of a Novel Surfactant Protein from the Foam Nest of the Frog Leptodactylus vastus Hissa Denise Cavalcante, Bezerra Gustavo Arruda, Birner-Gruenberger Ruth, Silva Luciano Paulino, Uson Isabel, Gruber Karl, Maciel Melo Vania Maria
    CHEMBIOCHEM 15, 393-398 (2014).
    DOI: 10.1002/cbic.201300726
  • Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members Williams Allison H, Veyrier Frederic J, Bonis Mathilde, Michaud Yann, Raynal Bertrand, Taha Muhamed-Kheir, White Stephen W, Haouz Ahmed, Boneca Ivo G
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70, 2631-2639 (2014).
    DOI: 10.1107/S1399004714016770
  • Visualizing phosphodiester-bond hydrolysis by an endonuclease. Molina R, Stella S, Redondo P, Gomez H, Marcaida MJ, Orozco M, Prieto J, Montoya G
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 22, 65 (2014).
    DOI: 10.1038/nsmb.2932
  • WXG100 Protein Superfamily Consists of Three Subfamilies and Exhibits an alpha-Helical C-Terminal Conserved Residue Pattern Poulsen Christian, Panjikar Santosh, Holton Simon J, Wilmanns Matthias, Song Young-Hwa
    PLOS ONE 9, e89313 (2014).
    DOI: 10.1371/journal.pone.0089313
  • X-ray crystal structure of an octameric RNA duplex and different divalent and trivalent metal ions Schaffer Michelle F, Schnabl Joachim, Spingler Bernhard, Peng Guanya, Olieric Vincent, Sigel Roland K O
    JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 19, S816-S816 (2014).

2013

  • 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors Golebiowski Adam, Beckett R Paul, Van Zandt Michael, Ji Min Koo, Whitehouse Darren, Ryder Todd R, Jagdmann Erik, Andreoli Monica, Mazur Adam, Padmanilayam Manyian, Cousido-Siah Alexandra, Mitschler Andre, Ruiz Francesc X, Podjarny Alberto, Schroeter Hagen
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23, 2027-2030 (2013).
    DOI: 10.1016/j.bmcl.2013.02.024
  • 4-Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading Lucas Xavier, Wohlwend Daniel, Huegle Martin, Schmidtkunz Karin, Gerhardt Stefan, Schuele Roland, Jung Manfred, Einsle Oliver, Guenther Stefan
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52, 14055-14059 (2013).
    DOI: 10.1002/anie.201307652
  • A Dual Anchoring Strategy for the Localization and Activation of Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology Zimbron Jeremy M, Heinisch Tillmann, Schmid Maurus, Hamels Didier, Nogueira Elisa S, Schirmer Tilman, Ward Thomas R
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 135, 5384-5388 (2013).
    DOI: 10.1021/ja309974s
  • A Structure-Guided Mutation in the Major Capsid Protein Retargets BK Polyomavirus Neu U, Allen SAA, Blaum BS, Liu Y, Frank M, Palma AS, Stroeh LJ, Feizi T, Peters T, Atwood WJ, Stehle T
    PLOS PATHOGENS 9, e1003688 (2013).
    DOI: 10.1371/journal.ppat.1003688
  • A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of G(q) and G(i) proteins Jank Thomas, Bogdanovic Xenia, Wirth Christophe, Haaf Erik, Spoerner Michael, Boehmer Kira E, Steinemann Marcus, Orth Joachim H C, Kalbitzer Hans Robert, Warscheid Bettina, Hunte Carola, Aktories Klaus
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 20, 1273-U197 (2013).
    DOI: 10.1038/nsmb.2688
  • A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli Sharma Amit, Kottur Jithesh, Narayanan Naveen, Nair Deepak T
    NUCLEIC ACIDS RESEARCH 41, 5104-5114 (2013).
    DOI: 10.1093/nar/gkt146
  • Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1H-isoindole Derivatives, Inhibitors of HIV-1 lntegrase Metifiot Mathieu, Maddali Kasthuraiah, Johnson Barry C, Hare Stephen, Smith Steven J, Zhao Xue Zhi, Marchand Christophe, Burke Terrence R Jr, Hughes Stephen H, Cherepanov Peter, Pommier Yves
    ACS CHEMICAL BIOLOGY 8, 209-217 (2013).
    DOI: 10.1021/cb300471n
  • Affinity Comparison of p3 and p8 Peptide Displaying Bacteriophages Using Surface Plasmon Resonance Knez Karel, Noppe Wim, Geukens Nick, Janssen Kris P F, Spasic Dragana, Heyligen Jeroen, Vriens Kim, Thevissen Karin, Cammue Bruno P A, Petrenko Valery, Ulens Chris, Deckmyn Hans, Lammertyn Jeroen
    ANALYTICAL CHEMISTRY 85, 10075-10082 (2013).
    DOI: 10.1021/ac402192k
  • An asymmetric SMC-kleisin bridge in prokaryotic condensin Buermann Frank, Shin Ho-Chul, Basquin Jerome, Soh Young-Min, Gimenez-Oya Victor, Kim Yeon-Gil, Oh Byung-Ha, Gruber Stephan
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 20, 371-379 (2013).
    DOI: 10.1038/nsmb.2488
  • Analysis of the Magnetic Properties of Nitrogenase FeMo Cofactor by Single-Crystal EPR Spectroscopy Spatzal Thomas, Einsle Oliver, Andrade Susana L A
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52, 10116-10119 (2013).
    DOI: 10.1002/anie.201303000
  • Autoproteolytic Activation of a Symbiosis-regulated Truffle Phospholipase A(2) Cavazzini Davide, Meschi Francesca, Corsini Romina, Bolchi Angelo, Rossi Gian Luigi, Einsle Oliver, Ottonello Simone
    JOURNAL OF BIOLOGICAL CHEMISTRY 288, 1533-1547 (2013).
    DOI: 10.1074/jbc.M112.384156
  • Better models by discarding data? Diederichs K, Karplus P A
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 69, 1215-1222 (2013).
    DOI: 10.1107/S0907444913001121
  • Beyond the Protein Matrix: Probing Cofactor Variants in a Baeyer-Villiger Oxygenation Reaction Martinoli Christian, Dudek Hanna M, Orru Roberto, Edmondson Dale E, Fraaije Marco W, Mattevi Andrea
    ACS CATALYSIS 3, 3058-3062 (2013).
    DOI: 10.1021/cs400837z
  • Bicyclic Peptide Ligands Pulled out of Cysteine-Rich Peptide Libraries Chen Shiyu, Rebollo Inmaculada Rentero, Buth Sergey A, Morales-Sanfrutos Julia, Touati Jeremy, Leiman Petr G, Heinis Christian
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 135, 6562-6569 (2013).
    DOI: 10.1021/ja400461h
  • Binding J: molecular biophysics to understand the binding of a unique protein to a unique DNA base Heidebrecht T, Fish A, Von Castelmur E, van Luenen H, Borst P, Perrakis A
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 42, S133-S133 (2013).
  • Binding of a designed anti-cancer drug to the central cavity of an RNA three-way junction Phongtongpasuk S, Paulus S, Schnabl J, Sigel RK, Spingler B, Hannon MJ, Freisinger E
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52, 11513 (2013).
  • Biochemical, Functional and Structural Characterization of a Family of Prokaryote Voltage-Gated Calcium Channels Kesters Divya, Brams Marijke, Nys Mieke, Voets Thomas, Tytgat Jan, Ulens Chris
    BIOPHYSICAL JOURNAL 104, 462A-462A (2013).
    DOI: 10.1016/j.bpj.2012.11.2556
  • Biophysical characterization and crystal structure of the Feline Immunodeficiency Virus p15 matrix protein Serriere Jennifer, Robert Xavier, Perez Magali, Gouet Patrice, Guillon Christophe
    RETROVIROLOGY 10, 64 (2013).
    DOI: 10.1186/1742-4690-10-64
  • CH-pi "T-Shape" Interaction with Histidine Explains Binding of Aromatic Galactosides to Pseudomonas aeruginosa Lectin LecA Kadam Rameshwar U, Garg Divita, Schwartz Julian, Visini Ricardo, Sattler Michael, Stocker Achim, Darbre Tamis, Reymond Jean-Louis
    ACS CHEMICAL BIOLOGY 8, 1925-1930 (2013).
    DOI: 10.1021/cb400303w
  • Catalytic Mechanism of Stereospecific Formation of cis-Configured Prenylated Pyrroloindoline Diketopiperazines by lndole Prenyltransferases Yu Xia, Zocher Georg, Xie Xiulan, Liebhold Mike, Schuetz Stefan, Stehle Thilo, Li Shu-Ming
    CHEMISTRY & BIOLOGY 20, 1492-1501 (2013).
    DOI: 10.1016/j.chembio1.2013.10.007
  • ChipX: A Novel Microfluidic Chip for Counter-Diffusion Crystallization of Biomolecules and in Situ Crystal Analysis at Room Temperature Pinker Franziska, Brun Mathieu, Morin Pierre, Deman Anne-Laure, Chateaux Jean-Francois, Olieric Vincent, Stirnimann Christian, Lorber Bernard, Terrier Nicolas, Ferrigno Rosaria, Sauter Claude
    CRYSTAL GROWTH & DESIGN 13, 3333-3340 (2013).
    DOI: 10.1021/cg301757g
  • Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase Rengachari S, Aschauer P, Schittmayer M, Mayer N, Gruber K, Breinbauer R, Birner-Gruenberger R, Dreveny I, Oberer M
    JOURNAL OF BIOLOGICAL CHEMISTRY 288, 31093 (2013).
  • Conserved Inhibitory Mechanism and Competent ATP Binding Mode for Adenylyltransferases with Fic Fold Goepfert Arnaud, Stanger Frederic V, Dehio Christoph, Schirmer Tilman
    PLOS ONE 8, e64901 (2013).
    DOI: 10.1371/journal.pone.0064901
  • Crystal Structure of 3-Hydroxybenzoate 6-Hydroxylase Uncovers Lipid-assisted Flavoprotein Strategy for Regioselective Aromatic Hydroxylation Montersino S, Orru R, Barendregt A, Westphal AH, Van Duijn E, Mattevi A, Van Berkel WJH
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    DOI: 10.1371/journal.pone.0059265
  • Structural and Biochemical Characterization of an Active Arylamine N-Acetyltransferase Possessing a Non-canonical Cys-His-Glu Catalytic Triad Kubiak Xavier, de la Sierra-Gallay Ines Li, Chaffotte Alain F, Pluvinage Benjamin, Weber Patrick, Haouz Ahmed, Dupret Jean-Marie, Rodrigues-Lima Fernando
    JOURNAL OF BIOLOGICAL CHEMISTRY 288, 22493-22505 (2013).
    DOI: 10.1074/jbc.M113.468595
  • Structural and Biophysical Characterization of the Syk Activation Switch Graedler Ulrich, Schwarz Daniel, Dresing Verena, Musil Djordje, Bomke Joerg, Frech Matthias, Greiner Hartmut, Jaekel Stefan, Rysiok Thomas, Mueller-Pompalla Dirk, Wegener Ansgar
    JOURNAL OF MOLECULAR BIOLOGY 425, 309-333 (2013).
    DOI: 10.1016/j.jmb.2012.11.007
  • Structural and functional characterisation of the methionine adenosyltransferase from Thermococcus kodakarensis Schlesier Julia, Siegrist Jutta, Gerhardt Stefan, Erb Annette, Blaesi Simone, Richter Michael, Einsle Oliver, Andexer Jennifer N
    BMC STRUCTURAL BIOLOGY 13, 22 (2013).
    DOI: 10.1186/1472-6807-13-22
  • Structural and functional characterization of two alpha-synuclein strains Bousset Luc, Pieri Laura, Ruiz-Arlandis Gemma, Gath Julia, Jensen Poul Henning, Habenstein Birgit, Madiona Karine, Olieric Vincent, Boeckmann Anja, Meier Beat H, Melki Ronald
    NATURE COMMUNICATIONS 4, 2575 (2013).
    DOI: 10.1038/ncomms3575
  • Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation Leppanen Veli-Matti, Tvorogov Denis, Kisko Kaisa, Prota Andrea E, Jeltsch Michael, Anisimov Andrey, Markovic-Mueller Sandra, Stuttfeld Edward, Goldie Kenneth N, Ballmer-Hofer Kurt, Alitalo Kari
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110, 12960-12965 (2013).
    DOI: 10.1073/pnas.1301415110
  • Structural characterization of the ribonuclease H-like type ASKHA superfamily kinase MK0840 from Methanopyrus kandleri Schacherl Magdalena, Waltersperger Sandro, Baumann Ulrich
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 69, 2440-2450 (2013).
    DOI: 10.1107/S0907444913022683
  • Structural insights into Cys-loop receptor function and ligand recognition Nys Mieke, Kesters Divya, Ulens Chris
    BIOCHEMICAL PHARMACOLOGY 86, 1042-1053 (2013).
    DOI: 10.1016/j.bcp.2013.07.001
  • Structural insights into VirB-DNA complexes reveal mechanism of transcriptional activation of virulence genes Gao Xiaopan, Zou Tingting, Mu Zhixia, Qin Bo, Yang Jian, Waltersperger Sandro, Wang Meitian, Cui Sheng, Jin Qi
    NUCLEIC ACIDS RESEARCH 41, 10529-10541 (2013).
    DOI: 10.1093/nar/gkt748
  • Structural insights into protein-only RNase P complexed with tRNA Gobert A, Pinker F, Fuchsbauer O, Gutmann B, Boutin R, Roblin P, Sauter C, Giege P
    NATURE COMMUNICATIONS 4, 1353 (2013).
    DOI: 10.1038/ncomms2358
  • Structural insights into substrate recognition in proton-dependent oligopeptide transporters Guettou Fatma, Quistgaard Esben M, Tresaugues Lionel, Moberg Per, Jegerschold Caroline, Zhu Lin, Jong Agnes Jin Oi, Nordlund Par, Low Christian
    EMBO REPORTS 14, 804-810 (2013).
    DOI: 10.1038/embor.2013.107
  • Structural insights into the oligomerization mode of the human receptor for advanced glycation end-products Yatime Laure, Andersen Gregers R
    FEBS JOURNAL 280, 6556-6568 (2013).
    DOI: 10.1111/febs.12556
  • Structure and Function of an RNA-Reading Thermostable DNA Polymerase Blatter Nina, Bergen Konrad, Nolte Oliver, Welte Wolfram, Diederichs Kay, Mayer Jutta, Wieland Markus, Marx Andreas
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52, 11935-11939 (2013).
    DOI: 10.1002/anie.201306655
  • Structure and RNA-binding properties of the Type III-A CRISPR-associated protein Csm3 Hrle A, Su A, Ebert J, Benda C, Randau L, Conti E
    RNA BIOLOGY 10, 1670 (2013).
    DOI: 10.4161/rna.26500
  • Structure and Signaling Mechanism of a Zinc-Sensory Diguanylate Cyclase Zaehringer Franziska, Lacanna Egidio, Jenal Urs, Schirmer Tilman, Boehm Alex
    STRUCTURE 21, 1149-1157 (2013).
    DOI: 10.1016/j.str.2013.04.026
  • Structure and enzymatic mechanism of a moonlighting dUTPase Leveles Ibolya, Nemeth Veronika, Szabo Judit E, Harmat Veronika, Nyiri Kinga, Bendes Abris Adam, Papp-Kadar Veronika, Zagyva Imre, Rona Gergely, Ozohanics Oliver, Vekey Karoly, Toth Judit, Vertessy Beata G
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 69, 2298-2308 (2013).
    DOI: 10.1107/S0907444913021136
  • Structure of EF-G-ribosome complex in a pretranslocation state Chen Yun, Feng Shu, Kumar Veerendra, Ero Rya, Gao Yong-Gui
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 20, 1077-+ (2013).
    DOI: 10.1038/nsmb.2645
  • Structure of Plasmodium talciparum TRAP (thrombospondin-related anonymous protein) A domain highlights distinct features in apicomplexan von Willebrand factor A homologues Pihlajamaa Tero, Kajander Tommi, Knuuti Juho, Horkka Kaisa, Sharma Amit, Permi Perttu
    BIOCHEMICAL JOURNAL 450, 469-476 (2013).
    DOI: 10.1042/BJ20121058
  • Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5 Peng Weng Chuan, de Lau Wim, Forneris Federico, Granneman Joke C M, Huch Meritxell, Clevers Hans, Gros Piet
    CELL REPORTS 3, 1885-1892 (2013).
    DOI: 10.1016/j.celrep.2013.06.009
  • Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming Maspero E, Valentini E, Mari S, Cecatiello V, Soffientini P, Pasqualato S, Polo S
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 20, 696-+ (2013).
    DOI: 10.1038/nsmb.2566
  • Structure of beta-Adrenergic Receptors Brueckner Florian, Piscitelli Chayne L, Tsai Ching-Ju, Standfuss Joerg, Deupi Xavier, Schertler Gebhard F X
    G PROTEIN COUPLED RECEPTORS: STRUCTURE 520, 117-151 (2013).
    DOI: 10.1016/B978-0-12-391861-1.00006-X
  • Structure-Based Optimization of the Terminal Tripeptide in Glycopeptide Dendrimer Inhibitors of Pseudomonas aeruginosa Biofilms Targeting LecA Kadam Rameshwar U, Bergmann Myriam, Garg Divita, Gabrieli Gabriele, Stocker Achim, Darbre Tamis, Reymond Jean-Louis
    CHEMISTRY-A EUROPEAN JOURNAL 19, 17054-17063 (2013).
    DOI: 10.1002/chem.201302587
  • Structure-Function Analysis of Arabidopsis thaliana Histidine Kinase AHK5 Bound to Its Cognate Phosphotransfer Protein AHP1 Bauer Johannes, Reiss Kerstin, Veerabagu Manikandan, Heunemann Michael, Harter Klaus, Stehle Thilo
    Molecular Plant 6, 959-970 (2013).
    DOI: 10.1093/mp/sss126
  • Structures of B-Lymphotropic Polyomavirus VP1 in Complex with Oligosaccharide Ligands Neu U, Khan ZM, Schuch B, Palma AS, Liu Y, Pawlita M, Feizi T, Stehle T
    PLOS PATHOGENS 9, e1003714 (2013).
    DOI: 10.1371/journal.ppat.1003714
  • Structures of KOD and 9 degrees N DNA Polymerases Complexed with Primer Template Duplex Bergen Konrad, Betz Karin, Welte Wolfram, Diederichs Kay, Marx Andreas
    CHEMBIOCHEM 14, 1058-1062 (2013).
    DOI: 10.1002/cbic.201300175
  • Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction Golebiowski A, Whitehouse D, Beckett RP, Zandt MV, Ji MK, Ryder TR, Jagdmann E, Andreoli M, Lee Y, Sheeler R, Conway B, Olczak J, Mazur M, Czestkowski W, Piotrowska W, Cousido-Siah A, Ruiz FX, Mitschler A, Podjarny A, Schroeter H
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23, 4837-4841 (2013).
    DOI: 10.1016/j.bmcl.2013.06.092
  • The 2.5 angstrom Structure of the Enterococcus Conjugation Protein TraM resembles VirB8 Type IV Secretion Proteins Goessweiner-Mohr Nikolaus, Grumet Lukas, Arends Karsten, Pavkov-Keller Tea, Gruber Christian C, Gruber Karl, Birner-Gruenberger Ruth, Kropec-Huebner Andrea, Huebner Johannes, Grohmann Elisabeth, Keller Walter
    JOURNAL OF BIOLOGICAL CHEMISTRY 288, 2018-2028 (2013).
    DOI: 10.1074/jbc.M112.428847
  • The Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegans Gazda Linn, Pokrzywa Wojciech, Hellerschmied Doris, Loewe Thomas, Forne Ignasi, Mueller-Planitz Felix, Hoppe Thorsten, Clausen Tim
    CELL 152, 183-195 (2013).
    DOI: 10.1016/j.cell.2012.12.025
  • The Structure of Glycerol Trinitrate Reductase NerA from Agrobacterium radiobacter Reveals the Molecular Reason for Nitro- and Ene-Reductase Activity in OYE Homologues Oberdorfer Gustav, Binter Alexandra, Wallner Silvia, Durchschein Katharina, Hall Melanie, Faber Kurt, Macheroux Peter, Gruber Karl
    CHEMBIOCHEM 14, 836-845 (2013).
    DOI: 10.1002/cbic.201300136
  • The Tricky Task of Nitrate/Nitrite Antiport Andrade Susana L A, Einsle Oliver
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52, 10422-10424 (2013).
    DOI: 10.1002/anie.201305421
  • The structural basis of autotransporter translocation by TamA Gruss Fabian, Zaehringer Franziska, Jakob Roman P, Burmann Bjoern M, Hiller Sebastian, Maier Timm
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 20, 1318-U247 (2013).
    DOI: 10.1038/nsmb.2689
  • The structure of the KtrAB potassium transporter Vieira-Pires Ricardo S, Szollosi Andras, Morais-Cabral Joao H
    NATURE 496, 323-+ (2013).
    DOI: 10.1038/nature12055
  • Thermodynamic origins of protein folding, allostery, and capsid formation in the human hepatitis B virus core protein Alexander Crispin G, Juergens Maike C, Shepherd Dale A, Freund Stefan M V, Ashcroft Alison E, Ferguson Neil
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110, E2782-E2791 (2013).
    DOI: 10.1073/pnas.1308846110
  • Thermodynamic properties distinguish human mitochondrial aspartyl-tRNA synthetase from bacterial homolog with same 3D architecture Neuenfeldt A, Lorber B, Ennifar E, Gaudry A, Sauter C, Sissler M, Florentz C
    NUCLEIC ACIDS RESEARCH 41, 2698-2708 (2013).
    DOI: 10.1093/nar/gks1322
  • Unexpected non-Hoogsteen-based mutagenicity mechanism of FaPy-DNA lesions. Gehrke TH, Lischke U, Gasteiger KL, Schneider S, Arnold S, Mueller HC, Stephenson DS, Zipse H, Carell T
    NATURE CHEMICAL BIOLOGY advanced online , 1 (2013).
    DOI: 10.1038/nchembio .1254
  • Using a Fragment-Based Approach To Target Protein-Protein Interactions Scott Duncan E, Ehebauer Matthias T, Pukala Tara, Marsh May, Blundell Tom L, Venkitaraman Ashok R, Abell Chris, Hyvoenen Marko
    CHEMBIOCHEM 14, 332-342 (2013).
    DOI: 10.1002/cbic.201200521
  • Vinylogous chain branching catalysed by a dedicated polyketide synthase module Bretschneider Tom, Heim Joel B, Heine Daniel, Winkler Robert, Busch Benjamin, Kusebauch Bjoern, Stehle Thilo, Zocher Georg, Hertweck Christian
    NATURE 502, 124-+ (2013).
    DOI: 10.1038/nature12588
  • alpha-Hydroxy-beta-keto acid rearrangement-decarboxylation: impact on thiamine diphosphate-dependent enzymatic transformations Beigi Maryam, Loschonsky Sabrina, Lehwald Patrizia, Brecht Volker, Andrade Susana L A, Leeper Finian J, Hummel Werner, Mueller Michael
    ORGANIC & BIOMOLECULAR CHEMISTRY 11, 252-256 (2013).
    DOI: 10.1039/c2ob26981c

2012

  • A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing Evnouchidou Irini, Birtley James, Seregin Sergey, Papakyriakou Athanasios, Zervoudi Efthalia, Samiotaki Martina, Panayotou George, Giastas Petros, Petrakis Olivia, Georgiadis Dimitris, Amalfitano Andrea, Saridakis Emmanuel, Mavridis Irene M, Stratikos Efstratios
    JOURNAL OF IMMUNOLOGY 189, 2383-2392 (2012).
    DOI: 10.4049/jimmunol.1200918
  • A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes Tiels Petra, Baranova Ekaterina, Piens Kathleen, De Visscher Charlotte, Pynaert Gwenda, Nerinckx Wim, Stout Jan, Fudalej Franck, Hulpiau Paco, Tannler Simon, Geysens Steven, Van Hecke Annelies, Valevska Albena, Vervecken Wouter, Remaut Han, Callewaert Nico
    NATURE BIOTECHNOLOGY 30, 1225-+ (2012).
    DOI: 10.1038/nbt.2427
  • A bimodular mechanism of calcium control in eukaryotes Tidow Henning, Poulsen Lisbeth R, Andreeva Antonina, Knudsen Michael, Hein Kim L, Wiuf Carsten, Palmgren Michael G, Nissen Poul
    NATURE 491, 468-+ (2012).
    DOI: 10.1038/nature11539
  • A common polymorphism in ER aminopeptidase 2 induces a specificity switch that leads to altered processing of antigenic peptides Evnouchidou I, Birtley J, Seregin S, Papakyriakou A, Zervoudi E, Samiotaki M, Panayotou G, Giastas P, Petrakis O, Georgiadis D, Amalfitano A, Saridakis E, Mavridis IM, Stratikos E
    JOURNAL OF PEPTIDE SCIENCE 18, S42-S42 (2012).
  • A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis Bretschneider Tom, Zocher Georg, Unger Michelle, Scherlach Kirstin, Stehle Thilo, Hertweck Christian
    NATURE CHEMICAL BIOLOGY 8, 154-161 (2012).
    DOI: 10.1038/nchembio.746
  • A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency Chodorge M, Zueger S, Stirnimann C, Briand C, Jermutus L, Gruetter M G, Minter R R
    CELL DEATH AND DIFFERENTIATION 19, 1187-1195 (2012).
    DOI: 10.1038/cdd.2011.208
  • A sugar isomerization reaction established on various (beta alpha)(8)-barrel scaffolds is based on substrate-assisted catalysis Reisinger Bernd, Bocola Marco, List Felix, Claren Joerg, Rajendran Chitra, Sterner Reinhard
    PROTEIN ENGINEERING DESIGN & SELECTION 25, 751-760 (2012).
    DOI: 10.1093/protein/gzs080
  • Acyl Coenzyme A Thioesterase Them5/Acot15 Is Involved in Cardiolipin Remodeling and Fatty Liver Development Zhuravleva Elena, Gut Heinz, Hynx Debby, Marcellin David, Bleck Christopher K E, Genoud Christel, Cron Peter, Keusch Jeremy J, Dummler Bettina, Esposti Mauro Degli, Hemmings Brian A
    MOLECULAR AND CELLULAR BIOLOGY 32, 2685-2697 (2012).
    DOI: 10.1128/MCB.00312-12
  • Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins Engel P, Goepfert A, Stanger FV, Harms A, Schmidt A, Schirmer T, Dehio C
    NATURE 482, 107-U138 (2012).
    DOI: 10.1038/nature10729
  • Allosteric Modulators Targeting Multiple Binding Sites in Bacterial Homolog of GABAA Receptor Spurny Radovan, Billen Bert, Brams Marijke, Howard Rebecca, Harris Adron R, Ulens Chris
    BIOPHYSICAL JOURNAL 102, 111A-112A (2012).
    DOI: 10.1016/j.bpj.2011.11.628
  • Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1 Elegheert Jonathan, Bracke Nathalie, Pouliot Philippe, Gutsche Irina, Shkumatov Alexander V, Tarbouriech Nicolas, Verstraete Kenneth, Bekaert Anais, Burmeister Wim P, Svergun Dmitri I, Lambrecht Bart N, Vergauwen Bjorn, Savvides Sawas N
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 19, 938-947 (2012).
    DOI: 10.1038/nsmb.2367
  • Atomic resolution structure of human alpha-tubulin acetyltransferase bound to acetyl-CoA Taschner Michael, Vetter Melanie, Lorentzen Esben
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109, 19649-19654 (2012).
    DOI: 10.1073/pnas.1209343109
  • Atomic structure of the vimentin central alpha-helical domain and its implications for intermediate filament assembly Chernyatina Anastasia A, Nicolet Stefan, Aebi Ueli, Herrmann Harald, Strelkov Sergei V
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109, 13620-13625 (2012).
    DOI: 10.1073/pnas.1206836109
  • Autoproteolytic and Catalytic Mechanisms for the beta-Aminopeptidase BapA-A Member of the Ntn Hydrolase Family Merz Tobias, Heck Tobias, Geueke Birgit, Mittl Peer R E, Briand Christophe, Seebach Dieter, Kohler Hans-Peter E, Gruetter Markus G
    STRUCTURE 20, 1850-1860 (2012).
    DOI: 10.1016/j.str.2012.07.017
  • Bicyclic Peptide Inhibitor Reveals Large Contact Interface with a Protease Target Angelini Alessandro, Cendron Laura, Chen Shiyu, Touati Jeremy, Winter Greg, Zanotti Giuseppe, Heinis Christian
    ACS CHEMICAL BIOLOGY 7, 817-821 (2012).
    DOI: 10.1021/cb200478t
  • Broad Antiviral Activity and Crystal Structure of HIV-1 Fusion Inhibitor Sifuvirtide Yao Xue, Chong Huihui, Zhang Chao, Waltersperger Sandro, Wang Meitian, Cui Sheng, He Yuxian
    JOURNAL OF BIOLOGICAL CHEMISTRY 287, 6788-6796 (2012).
    DOI: 10.1074/jbc.M111.317883
  • Crystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 Reveals That Sugar Chain Interacting with WSXWS Motif Is Integral Part of IL-21R Hamming OJ, Kang LS, Svensson A, Karlsen JL, Rahbek-Nielsen H, Paludan SR, Hjorth SA, Bondensgaard K, Hartmann R
    JOURNAL OF BIOLOGICAL CHEMISTRY 287, 9454 (2012).
    DOI: 10.1074/jbc.M111.311084
  • Crystal Structure of Perakine Reductase, Founding Member of a Novel Aldo-Keto Reductase (AKR) Subfamily That Undergoes Unique Conformational Changes during NADPH Binding Sun Lianli, Chen Yixin, Rajendran Chitra, Mueller Uwe, Panjikar Santosh, Wang Meitian, Mindnich Rebekka, Rosenthal Cindy, Penning Trevor M, Stoeckigt Joachim
    JOURNAL OF BIOLOGICAL CHEMISTRY 287, 11213-11221 (2012).
    DOI: 10.1074/jbc.M111.335521
  • Crystal Structure of Pseudomonas aeruginosa Tsi2 Reveals a Stably Folded Superhelical Antitoxin Zou Tingting, Yao Xue, Qin Bo, Zhang Meng, Cai Lifeng, Shang Weifeng, Svergun Dmitri I, Wang Meitian, Cui Sheng, Jin Qi
    JOURNAL OF MOLECULAR BIOLOGY 417, 351-361 (2012).
    DOI: 10.1016/j.jmb.2012.01.040
  • Crystal Structure of Sol I 2, a Major Allergen from Fire Ant Venom Borer AS, Wassmann P, Schmidt M, Hoffman DR, Zhou JJ, Wright C, Schirmer T, Markovic-Housley Z
    JOURNAL OF MOLECULAR BIOLOGY 415, 635 (2012).
  • Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis Liew Chong Wai, Nilsson Martina, Chen Ming Wei, Sun Huihua, Cornvik Tobias, Liang Zhao-Xun, Lescar Julien
    JOURNAL OF BIOLOGICAL CHEMISTRY 287, 23203-23215 (2012).
    DOI: 10.1074/jbc.M112.362210
  • Crystal Structures of Archaemetzincin Reveal a Moldable Substrate-Binding Site Graef Christine, Schacherl Magdalena, Waltersperger Sandro, Baumann Ulrich
    PLOS ONE 7, e43863 (2012).
    DOI: 10.1371/journal.pone.0043863
  • Crystal Structures of BapA Complexes with beta-Lactam-Derived Inhibitors Illustrate Substrate Specificity and Enantioselectivity of beta-Aminopeptidases Heck Tobias, Merz Tobias, Reimer Artur, Seebach Dieter, Rentsch Daniel, Briand Christophe, Gruetter Markus G, Kohler Hans-Peter E, Geueke Birgit
    CHEMBIOCHEM 13, 2137-2145 (2012).
    DOI: 10.1002/cbic.201200393
  • Crystal structure and location of gp131 in the bacteriophage phiKZ virion Sycheva Lada V, Shneider Mikhail M, Sykilinda Nina N, Ivanova Maria A, Miroshnikov Konstantin A, Leiman Petr G
    VIROLOGY 434, 257-264 (2012).
    DOI: 10.1016/j.virol.2012.09.001
  • Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc Voigt Franka, Reuter Michael, Kasaruho Anisa, Schulz Eike C, Pillai Ramesh S, Barabas Orsolya
    RNA-A PUBLICATION OF THE RNA SOCIETY 18, 2128-2134 (2012).
    DOI: 10.1261/rna.034967.112
  • Crystal structures of the tRNA:m(2)G6 methyltransferase Trm14/TrmN from two domains of life Fislage Marcus, Roovers Martine, Tuszynska Irina, Bujnicki Janusz M, Droogmans Louis, Versees Wim
    NUCLEIC ACIDS RESEARCH 40, 5149-5161 (2012).
    DOI: 10.1093/nar/gks163
  • Crystallization and first data collection of the putative transfer protein TraN from the Gram-positive conjugative plasmid pIP501 Goessweiner-Mohr Nikolaus, Fercher Christian, Abajy Mohammad Yaser, Grohmann Elisabeth, Keller Walter
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 68, 1402-1405 (2012).
    DOI: 10.1107/S174430911204184X
  • Crystallization of domains involved in self-assembly of the S-layer protein SbsC Dordic Andela, Egelseer Eva M, Tesarz Manfred, Sleytr Uwe B, Keller Walter, Pavkov-Keller Tea
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 68, 1511-1514 (2012).
    DOI: 10.1107/S1744309112042650
  • Current trends in epigenetic drug discovery Stolfa Diana A, Einsle Oliver, Sippl Wolfgang, Jung Manfred
    FUTURE MEDICINAL CHEMISTRY 4, 2029-2037 (2012).
    DOI: 10.4155/FMC.12.144
  • Discovery of Critical Residues for Viral Entry and Inhibition through Structural Insight of HIV-1 Fusion Inhibitor CP621-652 Chong Huihui, Yao Xue, Qiu Zonglin, Qin Bo, Han Ruiyun, Waltersperger Sandro, Wang Meitian, Cui Sheng, He Yuxian
    JOURNAL OF BIOLOGICAL CHEMISTRY 287, 20281-20289 (2012).
    DOI: 10.1074/jbc.M112.354126
  • Discovery of Novel N -Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis Flipo M, Willand N, Lecat-Guillet N, Hounsou C, Desroses M, Leroux F, Lens Z, Villeret V, Wohlkönig A, Wintjens R, Christophe T, Kyoung Jeon H, Locht C, Brodin P, Baulard A, Déprez B
    JOURNAL OF MEDICINAL CHEMISTRY 55, 6391 (2012).
    DOI: 10.1021/jm300377g
  • Discovery of a Novel Chemotype of Tyrosine Kinase Inhibitors by Fragment-Based Docking and Molecular Dynamics Zhao Hongtao, Dong Jing, Lafleur Karine, Nevado Cristina, Caflisch Amedeo
    ACS MEDICINAL CHEMISTRY LETTERS 3, 834-838 (2012).
    DOI: 10.1021/ml3001984
  • EBEC 2012: Combining the multiple facets of bioenergetics Preface Friedrich Thorsten, Einsle Oliver, Graeber Peter
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1817, 1709-1710 (2012).
    DOI: 10.1016/j.bbabio.2012.07.003
  • Engineered glucose isomerase from Streptomyces sp. SK is resistant to Ca^(2+) inhibition and Co^(2+) independent. Hlima HB, Aghajari N, Ali MB, Haser R, Bejar S
    JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 39(4), 537 (2012).
  • Enzyme or Electrode? Einsle Oliver
    STRUCTURE 20, 1132-1134 (2012).
    DOI: 10.1016/j.str.2012.06.005
  • Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors Flipo M, Desroses M, Lecat-Guillet N, Villemagne B, Blondiaux N, Leroux F, Piveteau C, Mathys V, Flament MP, Siepmann J, Villeret V, Wohlkoenig A, Wintjens R, Soror SH, Christophe T, Jeon HK, Locht C, Brodin P, Deprez B, Baulard AR, Willand N
    JOURNAL OF MEDICINAL CHEMISTRY 55, 68-83 (2012).
    DOI: 10.1021/jm200825u
  • Experimental and Computational Active Site Mapping as a Starting Point to Fragment-Based Lead Discovery Behnen Juergen, Koester Helene, Neudert Gerd, Craan Tobias, Heine Andreas, Klebe Gerhard
    CHEMMEDCHEM 7, 248-261 (2012).
    DOI: 10.1002/cmdc.201100490
  • Exploration of Pipecolate Sulfonamides as Binders of the FK506-Binding Proteins 51 and 52 Gopalakrishnan R, Kozany C, Wang YS, Schneider S, Hoogeland B, Bracher A, Hausch F
    JOURNAL OF MEDICINAL CHEMISTRY 55, 4123-4131 (2012).
    DOI: 10.1021/jm201747c
  • Exploring the Molecular Linkage of Protein Stability Traits for Enzyme Optimization by Iterative Truncation and Evolution Speck Janina, Hecky Jochen, Tam Heng-Keat, Arndt Katja M, Einsle Oliver, Mueller Kristian M
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  • Structure of the haptoglobin-haemoglobin complex Andersen Christian Brix Folsted, Torvund-Jensen Morten, Nielsen Marianne Jensby, Pinto de Oliveira Cristiano Luis, Hersleth Hans-Petter, Andersen Niels Hojmark, Pedersen Jan Skov, Andersen Gregers Rom, Moestrup Soren Kragh
    NATURE 489, 456-U150 (2012).
    DOI: 10.1038/nature11369
  • Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis Spahr Henrik, Habermann Bianca, Gustafsson Claes M, Larsson Nils-Goeran, Hallberg B Martin
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109, 15253-15258 (2012).
    DOI: 10.1073/pnas.1210688109
  • Structure-Based Engineering Increased the Catalytic Turnover Rate of a Novel Phenazine Prenyltransferase Zocher Georg, Saleh Orwah, Heim Joel B, Herbst Dominik A, Heide Lutz, Stehle Thilo
    PLOS ONE 7, e48427 (2012).
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  • Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties Cummings Maxwell D, Lin Tse-I, Hu Lili, Tahri Abdellah, McGowan David, Amssoms Katie, Last Stefaan, Devogelaere Benoit, Rouan Marie-Claude, Vijgen Leen, Berke Jan Martin, Dehertogh Pascale, Fransen Els, Cleiren Erna, van der Helm Liesbet, Fanning Gregory, Van Emelen Kristof, Nyanguile Origene, Simmen Kenny, Raboisson Pierre, Vendeville Sandrine
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 51, 4637-4640 (2012).
    DOI: 10.1002/anie.201200110
  • Structure-based optimization of designed Armadillo-repeat proteins Madhurantakam Chaithanya, Varadamsetty Gautham, Gruetter Markus G, Plueckthun Andreas, Mittl Peer R E
    PROTEIN SCIENCE 21, 1015-1028 (2012).
    DOI: 10.1002/pro.2085
  • Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity Surivet Jean-Philippe, Lange Roland, Hubschwerlen Christian, Keck Wolfgang, Specklin Jean-Luc, Ritz Daniel, Bur Daniel, Locher Hans, Seiler Peter, Strasser Daniel Stefan, Prade Lars, Kohl Christopher, Schmitt Christine, Chapoux Gaelle, Ilhan Eser, Ekambaram Nadia, Athanasiou Alcibiade, Knezevic Andreja, Sabato Daniela, Chambovey Alain, Gaertner Mika, Enderlin Michel, Boehme Maria, Sippel Virginie, Wyss Pierre
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22, 6705-6711 (2012).
    DOI: 10.1016/j.bmcl.2012.08.094
  • Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection Neu U, Hengel H, Blaum BS, Schowalter RM, Macejak D, Gilbert M, Wakarchuk WW, Imamura A, Ando H, Kiso M, Arnberg N, Garcea RL, Peters T, Buck CB, Stehle T
    PLOS PATHOGENS 8, e1002738 (2012).
    DOI: 10.1371/journal.ppat.1002738
  • Structures of the major capsid protein (VP1) from closely related Human Polyomavirus-9 (HPyV-9) and African Green Monkey Polyomavirus (AGMPyV) provide insights into host range and tropism Khan Zaigham, Neu Ursula, Feizi Ten, Ehlers Bernhard, Stehle Thilo
    PROTEIN SCIENCE 21, 117-118 (2012).
  • Targeting cancer with small-molecular-weight kinase inhibitors Fabbro D, Cowan-Jacob SW, Moebitz H, Martiny-Baron G
    Methods in Molecular Biology 795, 1 (2012).
  • The GM2 Glycan Serves as a Functional Coreceptor for Serotype 1 Reovirus Reiss Kerstin, Stencel Jennifer E, Liu Yan, Blaum Baerbel S, Reiter Dirk M, Feizi Ten, Dermody Terence S, Stehle Thilo
    PLOS PATHOGENS 8, e1003078 (2012).
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  • The Last Piece in the Vitamin B-1 Biosynthesis Puzzle structual and functional insight into yeast 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synthase Coquille Sandrine, Roux Celine, Fitzpatrick Teresa B, Thore Stephane
    JOURNAL OF BIOLOGICAL CHEMISTRY 287, 42333-42343 (2012).
    DOI: 10.1074/jbc.M112.397240
  • The M-T Hook Structure Is Critical for Design of HIV-1 Fusion Inhibitors Chong Huihui, Yao Xue, Sun Jianping, Qiu Zonglin, Zhang Meng, Waltersperger Sandro, Wang Meitian, Cui Sheng, He Yuxian
    JOURNAL OF BIOLOGICAL CHEMISTRY 287, 34558-34568 (2012).
    DOI: 10.1074/jbc.M112.390393
  • The Molecular Mechanism of Thermostable alpha-Galactosidases AgaA and AgaB Explained by X-ray Crystallography and Mutational Studies Merceron Romain, Foucault Marine, Haser Richard, Mattes Ralf, Watzlawick Hildegard, Gouet Patrice
    JOURNAL OF BIOLOGICAL CHEMISTRY 287, (2012).
    DOI: 10.1074/jbc.M112.394114
  • The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction Furet Pascal, Chene Patrick, De Pover Alain, Valat Therese Stachyra, Lisztwan Joanna Hergovich, Kallen Joerg, Masuya Keiichi
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22, 3498-3502 (2012).
    DOI: 10.1016/j.bmcl.2012.03.083
  • The epithelial adhesin 1 (Epa1p) from the human-pathogenic yeast Candida glabrata: structural and functional study of the carbohydrate-binding domain Ielasi Francesco S, Decanniere Klaas, Willaert Ronnie G
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 68, 210-217 (2012).
    DOI: 10.1107/S0907444911054898
  • The formate channel FocA exports the products of mixed-acid fermentation Lue Wei, Du Juan, Schwarzer Nikola J, Gerbig-Smentek Elke, Einsle Oliver, Andrade Susana L A
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109, 13254-13259 (2012).
    DOI: 10.1073/pnas.1204201109
  • The impact of structural biology on alkaloid biosynthesis research Panjikar Santosh, Stoeckigt Joachim, O'Connor Sarah, Warzecha Heribert
    NATURAL PRODUCT REPORTS 29, 1176-1200 (2012).
    DOI: 10.1039/c2np20057k
  • The mechanics behind DNA sequence-dependent properties of the nucleosome Chua Eugene Y D, Vasudevan Dileep, Davey Gabriela E, Wu Bin, Davey Curt A
    NUCLEIC ACIDS RESEARCH 40, 6338-6352 (2012).
    DOI: 10.1093/nar/gks261
  • The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor Thompson Andrew J, Algazzaz Mona, Ulens Chris, Lummis Sarah C R
    NEUROPHARMACOLOGY 63, 761-767 (2012).
    DOI: 10.1016/j.neuropharm.2012.05.027
  • The structure of Ca2+-loaded S100A2 at 1.3-angstrom resolution Koch M, Fritz G
    FEBS JOURNAL 279, 1799 (2012).
    DOI: 10.1111/j.1742-4658.2012.08556.x
  • The structure of monoacylglycerol lipase from Bacillus sp H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes Rengachari Srinivasan, Bezerra Gustavo A, Riegler-Berket Lina, Gruber Christian C, Sturm Christian, Taschler Ulrike, Boeszoermenyi Andras, Dreveny Ingrid, Zimmermann Robert, Gruber Karl, Oberer Monika
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1821, 1012-1021 (2012).
    DOI: 10.1016/j.bbalip.2012.04.006
  • The structure of the NADH:ubiquinone oxidoreductase from Vibrio cholerae Vohl G, Casutt M, Vorburger T, Muras V, Steffen W, Steuber J, Fritz G
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1817, S62-S62 (2012).
    DOI: 10.1016/j.bbabio.2012.06.176
  • Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization Brozzo MS, Bjelic S, Kisko K, Schleier T, Leppanen VM, Alitalo K, Winkler FK, Ballmer-Hofer K
    BLOOD 119, 1781 (2012).
    DOI: 10.1182/blood-2011-11-390922
  • Towards a new tuberculosis drug: pyridomycin - nature's isoniazid Hartkoorn Ruben C, Sala Claudia, Neres Joao, Pojer Florence, Magnet Sophie, Mukherjee Raju, Uplekar Swapna, Boy-Roettger Stefanie, Altmann Karl-Heinz, Cole Stewart T
    EMBO MOLECULAR MEDICINE 4, 1032-1042 (2012).
    DOI: 10.1002/emmm.201201689
  • Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop Eicher Thomas, Cha Hi-jea, Seeger Markus A, Brandstaetter Lorenz, El-Delik Jasmin, Bohnert Juergen A, Kern Winfried V, Verrey Francois, Gruetter Markus G, Diederichs Kay, Pos Klaas M
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109, 5687-5692 (2012).
    DOI: 10.1073/pnas.1114944109
  • Water Makes the Difference: Rearrangement of Water Solvation Layer Triggers Non-additivity of Functional Group Contributions in Protein-Ligand Binding Biela A, Betz M, Heine A, Klebe G
    CHEMMEDCHEM 7, 1423 (2012).
    DOI: 10.1002/cmdc.201200206
  • [(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX Can D, Spingler B, Schmutz P, Mendes F, Raposinho P, Fernandes C, Carta F, Innocenti A, Santos I, Supuran CT, Alberto R
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 51, 3354 (2012).
    DOI: 10.1002/anie.201107333

2011

  • A Blue Corrinoid from Partial Degradation of Vitamin B-12 in Aqueous Bicarbonate: Spectra, Structure, and Interaction with Proteins of B-12 Transport Fedosov SN, Ruetz M, Gruber K, Fedosova NU, Krautler B
    BIOCHEMISTRY 50, 8090 (2011).
    DOI: 10.1021/bi200724s
  • A Crystal Structure of the Catalytic Core Domain of an Avian Sarcoma and Leukemia Virus Integrase Suggests an Alternate Dimeric Assembly Ballandras A, Moreau K, Robert X, Confort MP, Merceron R, Haser R, Ronfort C, Gouet P
    PLOS ONE 6, e23032 (2011).
    DOI: 10.1371/journal.pone.0023032
  • A Potent Trivalent Sialic Acid Inhibitor of Adenovirus Type 37 Infection of Human Corneal Cells Spjut S, Qian WX, Bauer J, Storm R, Frangsmyr L, Stehle T, Arnberg N, Elofsson M
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50, 6519 (2011).
    DOI: 10.1002/anie.201101559
  • A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core Wu B, Ong MS, Groessl M, Adhireksan Z, Hartinger CG, Dyson PJ, Davey CA
    CHEMISTRY-A EUROPEAN JOURNAL 17, 3562 (2011).
    DOI: 10.1002/chem.201100298
  • A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and d-Tubocurarine by Different Cys-Loop Receptors Brams Marijke, Pandya Anshul, Kuzmin Dmitry, van Elk Rene, Krijnen Liz, Yakel Jerrel L, Tsetlin Victor, Smit August B, Ulens Chris
    PLOS BIOLOGY 9, e1001034 (2011).
    DOI: 10.1371/journal.pbio.1001034
  • Allosteric Regulation of Protein Kinase PKC zeta by the N-Terminal C1 Domain and Small Compounds to the PIF-Pocket Lopez-Garcia LA, Schulze JO, Frohner W, Zhang H, Suss E, Weber N, Navratil J, Amon S, Hindie V, Zeuzem S, Jorgensen TJD, Alzari PM, Neimanis S, Engel M, Biondi RM
    CHEMISTRY & BIOLOGY 18, 1463 (2011).
    DOI: 10.1016/j.chembiol.2011.08.010
  • Antibodies against Extracellular Domains of alpha4 and alpha7 Subunits Alter the Levels of Nicotinic Receptors in the Mouse Brain and Affect Memory: Possible Relevance to Alzheimer's Pathology Lykhmus O, Koval L, Skok M, Zouridakis M, Zisimopoulou P, Tzartos S, Tsetlin V, Granon S, Changeux JP, Komisarenko S, Cloez-Tayarani I
    JOURNAL OF ALZHEIMERS DISEASE 24, 693-704 (2011).
    DOI: 10.3233/JAD-2011-101842
  • Archaeal RNA polymerase: the influence of the protruding stalk in crystal packing and preliminary biophysical analysis of the Rpo13 subunit Wojtas M, Peralta B, Ondiviela M, Mogni M, Bell SD, Abrescia NGA
    BIOCHEMICAL SOCIETY TRANSACTIONS 39, 25-30 (2011).
    DOI: 10.1042/BST0390025
  • Artificial Transfer Hydrogenases for the Enantioselective Reduction of Cyclic Imines Durrenberger M, Heinisch T, Wilson YM, Rossel T, Nogueira E, Knorr L, Mutschler A, Kersten K, Zimbron MJ, Pierron J, Schirmer T, Ward TR
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50, 3026 (2011).
    DOI: 10.1002/anie.201007820
  • Atypical DNA recognition mechanism used by the EspR virulence regulator of Mycobacterium tuberculosis Blasco B, Stenta M, Alonso-Sarduy L, Dietler G, Dal Peraro M, Cole ST, Pojer F
    MOLECULAR MICROBIOLOGY 82, 251 (2011).
    DOI: 10.1111/j.1365-2958.2011.07813.x
  • Automatic loop centring with a high-precision goniometer head at the SLS macromolecular crystallography beamlines Pauluhn A, Pradervand C, Rossetti D, Salathe M, Schulze-Briese C
    JOURNAL OF SYNCHROTRON RADIATION 18, 595 (2011).
    DOI: 10.1107/S0909049511011848
  • Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop Strohmeier J, Hertel I, Diederichsen U, Rudolph MG, Klostermeier D
    BIOLOGICAL CHEMISTRY 392, 357 (2011).
    DOI: 10.1515/BC.2011.034
  • Clostridial glucosylating toxins: Inositol hexakisphosphate-dependent processing of Clostridium sordellii lethal toxin and Clostridium novyi alpha-toxin Guttenberg G, Papatheodorou P, Genisyuerek S, Lu W, Einsle O, Aktories K
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 383, 84 (2011).
  • Combining in-situ proteolysis and microseed matrix screening to promote crystallization of PrPc-nanobody complexes Abskharon RNN, Soror SH, Pardon E, El Hassan H, Legname G, Steyaert J, Wohlkonig A
    PROTEIN ENGINEERING DESIGN & SELECTION 24, 737 (2011).
    DOI: 10.1093/protein/gzr017
  • Crystal Structure of Human Enterovirus 71 3C Protease Cui S, Wang J, Fan TT, Qin B, Guo L, Lei XB, Wang JW, Wang MT, Jin Q
    JOURNAL OF MOLECULAR BIOLOGY 408, 449 (2011).
    DOI: 10.1016/j.jmb.2011.03.007
  • Crystal Structure of Reovirus Attachment Protein sigma 1 in Complex with Sialylated Oligosaccharides Reiter DM, Frierson JM, Halvorson EE, Kobayashi T, Dermody TS, Stehle T
    PLOS PATHOGENS 7, e1002166 (2011).
    DOI: 10.1371/journal.ppat.1002166
  • Crystal Structure of a BCL-W Domain-Swapped Dimer: Implications for the Function of BCL-2 Family Proteins Lee EF, Dewson G, Smith BJ, Evangelista M, Pettikiriarachchi A, Dogovski C, Perugini MA, Colman PM, Fairlie WD
    STRUCTURE 19, 1467 (2011).
    DOI: 10.1016/j.str.2011.07.015
  • Crystal Structures and Repair Studies Reveal the Identity and the Base-Pairing Properties of the UV-Induced Spore Photoproduct DNA Lesion Heil K, Kneuttinger AC, Schneider S, Lischke U, Carell T
    CHEMISTRY-A EUROPEAN JOURNAL 17, 9651 (2011).
    DOI: 10.1002/chem.201100177
  • Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues Wang J, Fan TT, Yao X, Wu ZQ, Guo L, Lei XB, Wang JW, Wang MT, Jin Q, Cui S
    JOURNAL OF VIROLOGY 85, 10021 (2011).
    DOI: 10.1128/JVI.05107-11
  • Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation Kuettel S, Greenwald J, Kostrewa D, Ahmed S, Scapozza L, Perozzo R
    PLOS NEGLECTED TROPICAL DISEASES 5, e1164 (2011).
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  • Crystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding Protein Brams Marijke, Gay Elaine A, Saez Jose Colon, Guskov Albert, van Elk Rene, van der Schors Roel C, Peigneur Steve, Tytgat Jan, Strelkov Sergei V, Smit August B, Yakel Jerrel L, Ulens Chris
    JOURNAL OF BIOLOGICAL CHEMISTRY 286, 4420-4428 (2011).
    DOI: 10.1074/jbc.M110.188730
  • Crystal Structures of the Armadillo Repeat Domain of Adenomatous Polyposis Coli and Its Complex with the Tyrosine-Rich Domain of Sam68 Morishita EC, Murayama K, Kato-Murayama M, Ishizuka-Katsura Y, Tomabechi Y, Hayashi T, Terada T, Handa N, Shirouzu M, Akiyama T, Yokoyama S
    STRUCTURE 19, 1496 (2011).
    DOI: 10.1016/j.str.2011.07.013
  • Crystal structure of a copper-transporting PIB-type ATPase Gourdon P, Liu XY, Skjorringe T, Morth JP, Moller LB, Pedersen BP, Nissen P
    NATURE 475, 59 (2011).
    DOI: 10.1038/nature10191
  • Crystal structure of the EphA4 protein tyrosine kinase domain in the apo- and dasatinib-bound state Farenc C, Celie PHN, Tensen CP, de Esch IJP, Siegal G
    FEBS LETTERS 585, 3593 (2011).
    DOI: 10.1016/j.febslet.2011.10.028
  • Crystal structure of the GlnZ-DraG complex reveals a different form of P-II-target interaction Rajendran C, Gerhardt ECM, Bjelic S, Gasperina A, Scarduelli M, Pedrosa FO, Chubatsu LS, Merrick M, Souza EM, Winkler FK, Huergo LF, Li XD
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108, 18972 (2011).
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  • Crystallization and preliminary X-ray analysis of a cold-active endo-beta-1,4-D-xylanase from glycoside hydrolase family 8 Schoepe J, Pollet A, Verjans P, Delcour JA, Strelkov SV, Courtin CM
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 67, 150 (2011).
    DOI: 10.1107/S1744309110048451
  • Crystallization and preliminary X-ray diffraction analysis of kanamycin-binding beta-lactamase in complex with its ligand Van de Water K, Soror SH, Wohlkonig A, van Nuland NAJ, Volkov AN
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 67, 703 (2011).
    DOI: 10.1107/S1744309111013832
  • Delineation of the Pasteurellaceae-specific GbpA-family of glutathione-binding proteins Vergauwen B, Van der Meeren R, Dansercoer A, Savvides SN
    BMC BIOLOGY 12, 59 (2011).
  • Drug Resistance: A Periplasmic Menage a Trois Oswald Christine, Pos Klaas M
    CHEMISTRY & BIOLOGY 18, 405-407 (2011).
    DOI: 10.1016/j.chembiol.2011.04.004
  • Elucidation of the alpha-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition Grawert MA, Gallastegui N, Stein M, Schmidt B, Kloetzel PM, Huber R, Groll M
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50, 542 (2011).
    DOI: 10.1002/anie.201005488
  • Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor Spatzal T, Aksoyoglu M, Zhang LM, Andrade SLA, Schleicher E, Weber S, Rees DC, Einsle O
    SCIENCE 334, 940 (2011).
    DOI: 10.1126/science.1214025
  • Exploiting Protein Engineering and Crystal Polymorphism for Successful X-ray Structure Determination Bonnefond L, Schellenberger P, Basquin J, Demangeat G, Ritzenthaler C, Chenevert R, Balg C, Frugier M, Rudinger-Thirion J, Giege R, Lorber B, Sauter C
    CRYSTAL GROWTH & DESIGN 11, 4334 (2011).
    DOI: 10.1021/cg101468p
  • Expression, crystallization and preliminary X-ray data analysis of NT-Als9-2, a fungal adhesin from Candida albicans Salgado PS, Yan R, Rowan F, Cota E
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 67, 467 (2011).
    DOI: 10.1107/S1744309111003460
  • Fic domain-catalyzed adenylylation: Insight provided by the structural analysis of the type IV secretion system effector BepA Palanivelu DV, Goepfert A, Meury M, Guye P, Dehio C, Schirmer T
    PROTEIN SCIENCE 20, 492-499 (2011).
    DOI: 10.1002/pro.581
  • From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1 Sledz P, Stubbs CJ, Lang S, Yang YQ, McKenzie GJ, Venkitaraman AR, Hyvonen M, Abell C
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50, 4003 (2011).
    DOI: 10.1002/anie.201008019
  • Functional Plasticity and Allosteric Regulation of alpha-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism Wagner T, Bellinzoni M, Wehenkel A, O'hare HM, Alzari PM
    CHEMISTRY & BIOLOGY 18, 1011-1020 (2011).
    DOI: 10.1016/j.chembiol.2011.06.004
  • Functional analyses of mutants of the central core domain of an Avian Sarcoma/Leukemia Virus integrase Charmetant J, Moreau K, Gallay K, Ballandras A, Gouet P, Ronfort C
    VIROLOGY 421, 42 (2011).
    DOI: 10.1016/j.virol.2011.09.008
  • Geobacter sulfurreducens Cytochrome c Peroxidases: Electrochemical Classification of Catalytic Mechanisms Ellis KE, Seidel J, Einsle O, Elliott SJ
    BIOCHEMISTRY 50, 4513 (2011).
    DOI: 10.1021/bi200399h
  • High-Resolution X-Ray Structure of the Trimeric Scar/WAVE-Complex Precursor Brk1 Linkner J, Witte G, Stradal T, Curth U, Faix J
    PLOS ONE 6, e21327 (2011).
    DOI: 10.1371/journal.pone.0021327
  • Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor Monnard FW, Heinisch T, Nogueira ES, Schirmer T, Ward TR
    CHEMICAL COMMUNICATIONS 47, 8238-8240 (2011).
    DOI: 10.1039/c1cc10345h
  • Importance of a Hydrophobic Pocket for Peptide Binding in Lactococcal OppA Berntsson RPA, Thunnissen AMWH, Poolman B, Slotboom DJ
    JOURNAL OF BACTERIOLOGY 193, 4254 (2011).
    DOI: 10.1128/JB.00447-11
  • In Vitro Folding and Assembly of the Escherichia coli ATP-binding Cassette Transporter, BtuCD Di Bartolo ND, Hvorup RN, Locher KP, Booth PJ
    JOURNAL OF BIOLOGICAL CHEMISTRY 286, 18807 (2011).
    DOI: 10.1074/jbc.M110.176891
  • In silico identification and crystal structure validation of caspase-3 inhibitors without a P1 aspartic acid moiety Ganesan R, Jelakovic S, Mittl PRE, Caflisch A, Grutter MG
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 67, 842 (2011).
    DOI: 10.1107/S1744309111018604
  • Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes Verstraete K, Remmerie B, Elegheert J, Lintermans B, Haegeman G, Vanhoenacker P, Van Craenenbroeck K, Savvides SN
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 67, 325 (2011).
    DOI: 10.1107/S1744309111003319
  • Inositol Hexakisphosphate-dependent Processing of Clostridium sordellii Lethal Toxin and Clostridium novyi alpha-Toxin Guttenberg G, Papatheodorou P, Genisyuerek S, Lu W, Jank T, Einsle O, Aktories K
    JOURNAL OF BIOLOGICAL CHEMISTRY 286, 14779 (2011).
    DOI: 10.1074/jbc.M110.200691
  • Investigation of the Electron Transport Chain to and the Catalytic Activity of the Diheme Cytochrome c Peroxidase CcpA of Shewanella oneidensis Schutz B, Seidel J, Sturm G, Einsle O, Gescher J
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY 77, 6172 (2011).
    DOI: 10.1128/AEM.00606-11
  • Key factors for successful generation of protein-fragment structures: requirement on protein, crystals, and technology Bottcher J, Jestel A, Kiefersauer R, Krapp S, Nagel S, Steinbacher S, Steuber H
    FRAGMENT-BASED DRUG DESIGN: TOOLS, PRACTICAL APPROACHES, AND EXAMPLES 493, 61 (2011).
    DOI: 10.1016/B978-0-12-381274-2.00003-0
  • Lights and Shadows on Monoamine Oxidase Inhibition in Neuroprotective Pharmacological Therapies Binda C, Milczek EM, Bonivento D, Wang J, Mattevi A, Edmondson DE
    CURRENT TOPICS IN MEDICINAL CHEMISTRY 11, 2788-2796 (2011).
    DOI: 10.2174/156802611798184355
  • Mechanism of Disruption of the Amt-GlnK Complex by P-II-Mediated Sensing of 2-Oxoglutarate Maier S, Schleberger P, Lu W, Wacker T, Pfluger T, Litz C, Andrade SLA
    PLOS ONE 6, e26327 (2011).
    DOI: 10.1371/journal.pone.0026327
  • Molecular Basis of Bacterial Defense against Host Lysozymes: X-ray Structures of Periplasmic Lysozyme Inhibitors PliI and PliC Leysen S, Van Herreweghe JM, Callewaert L, Heirbaut M, Buntinx P, Michiels CW, Strelkov SV
    JOURNAL OF MOLECULAR BIOLOGY 405, 1233 (2011).
    DOI: 10.1016/j.jmb.2010.12.007
  • Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase LSD1-CoREST Complex Baron R, Binda C, Tortorici M, McCammon JA, Mattevi A
    STRUCTURE 19, 212 (2011).
    DOI: 10.1016/j.str.2011.01.001
  • Novel approach to controlled protein crystallization through ligandation of yttrium cations Zhang FJ, Zocher G, Sauter A, Stehle T, Schreiber F
    JOURNAL OF APPLIED CRYSTALLOGRAPHY 44, 755 (2011).
    DOI: 10.1107/S0021889811017997
  • Nucleosome structural studies Tan S, Davey CA
    CURRENT OPINION IN STRUCTURAL BIOLOGY 21, 128 (2011).
    DOI: 10.1016/j.sbi.2010.11.006
  • Odd-Numbered Oxacalix[n]arenes (n=5, 7): Synthesis and Solid-State Structures Van Rossom W, Robeyns K, Ovaere M, Van Meervelt L, Dehaen W, Maes W
    ORGANIC LETTERS 13, 126 (2011).
    DOI: 10.1021/ol1026969
  • OsO4 center dot Streptavidin: A Tunable Hybrid Catalyst for the Enantioselective cis-Dihydroxylation of Olefins Kohler V, Mao JC, Heinisch T, Pordea A, Sardo A, Wilson YM, Knorr L, Creus M, Prost JC, Schirmer T, Ward TR
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50, 10863-10866 (2011).
    DOI: 10.1002/anie.201103632
  • Phosphoenolpyruvate: Sugar Phosphotransferase System from the Hyperthermophilic Thermoanaerobacter tengcongensis Navdaeva V, Zurbriggen A, Waltersperger S, Schneider P, Oberholzer AE, Bahler P, Bachler C, Grieder A, Baumann U, Erni B
    BIOCHEMISTRY 50, 1184 (2011).
    DOI: 10.1021/bi101721f
  • Physiological function and catalytic versatility of bacterial multihaem cytochromes c involved in nitrogen and sulfur cycling Simon J, Kern M, Hermann B, Einsle O, Butt JN
    BIOCHEMICAL SOCIETY TRANSACTIONS 39, 1864 (2011).
    DOI: 10.1042/BST20110713
  • Probing the reactivity of different forms of azurin by flavin photoreduction Alagaratnam S, Meeuwenoord NJ, Navarro JA, Hervas M, De la Rosa MA, Hoffmann M, Einsle O, Ubbink M, Canters GW
    FEBS JOURNAL 278, 1506 (2011).
    DOI: 10.1111/j.1742-4658.2011.08067.x
  • Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only. Vadon-Le Goff S, Kronenberg D, Bourhis JM, Bijakowski C, Raynal N, Ruggiero F, Farndale RW, Stoecker W, Hulmes DJ, Moali C
    JOURNAL OF BIOLOGICAL CHEMISTRY 286(45), 38932 (2011).
  • Quaternary Structure of the Oxaloacetate Decarboxylase Membrane Complex and Mechanistic Relationships to Pyruvate Carboxylases Balsera M, Buey RM, Li XD
    JOURNAL OF BIOLOGICAL CHEMISTRY 286, 9457 (2011).
    DOI: 10.1074/jbc.M110.197442
  • Radiation damage reveals promising interaction position Koch C, Heine A, Klebe G
    JOURNAL OF SYNCHROTRON RADIATION 18, 782 (2011).
    DOI: 10.1107/S0909049511027920
  • Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair Kaul C, Muller M, Wagner M, Schneider S, Carell T
    NATURE CHEMISTRY 3, 794 (2011).
    DOI: 10.1038/NCHEM.1117
  • SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase van der Vaart B, Manatschal C, Grigoriev I, Olieric V, Gouveia SM, Bjelic S, Demmers J, Vorobjev I, Hoogenraad CC, Steinmetz MO, Akhmanova A
    JOURNAL OF CELL BIOLOGY 193, 1083 (2011).
    DOI: 10.1083/jcb.201012179
  • SLS Crystallization Platform at Beamline X06DA-A Fully Automated Pipeline Enabling in Situ X-ray Diffraction Screening Bingel-Erlenmeyer R, Olieric V, Grimshaw JPA, Gabadinho J, Wang X, Ebner SG, Isenegger A, Schneider R, Schneider J, Glettig W, Pradervand C, Panepucci EH, Tomizaki T, Wang M, Schulze-Briese C
    CRYSTAL GROWTH & DESIGN 11, 916 (2011).
    DOI: 10.1021/cg101375j
  • Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase Lim SP, Sonntag LS, Noble C, Nilar SH, Ng RH, Zou G, Monaghan P, Chung KY, Dong HP, Liu BP, Bodenreider C, Lee G, Ding M, Chan WL, Wang G, Jian YL, Chao AT, Lescar J, Yin Z, Vedananda TR, Keller TH, Shi PY
    JOURNAL OF BIOLOGICAL CHEMISTRY 286, 6233 (2011).
    DOI: 10.1074/jbc.M110.179184
  • Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation Wu B, Davey GE, Nazarov AA, Dyson PJ, Davey CA
    NUCLEIC ACIDS RESEARCH 39, 8200 (2011).
    DOI: 10.1093/nar/gkr491
  • Stabilization of C4a-Hydroperoxyflavin in a Two-component Flavin-dependent Monooxygenase Is Achieved through Interactions at Flavin N5 and C4a Atoms Thotsaporn K, Chenprakhon P, Sucharitakul J, Mattevi A, Chaiyen P
    JOURNAL OF BIOLOGICAL CHEMISTRY 286, 28170-28180 (2011).
    DOI: 10.1074/jbc.M111.241836
  • Strategies for the crystallization of viruses: Using phase diagrams and gels to produce 3D crystals of Grapevine fanleaf virus Schellenberger P, Demangeat G, Lemaire O, Ritzenthaler C, Bergdoll M, Olieric V, Sauter C, Lorber B
    JOURNAL OF STRUCTURAL BIOLOGY 174, 344 (2011).
    DOI: 10.1016/j.jsb.2011.02.007
  • Structural Basis of the 9-Fold Symmetry of Centrioles Kitagawa D, Vakonakis I, Olieric N, Hilbert M, Keller D, Olieric V, Bortfeld M, Erat MC, Fluckiger I, Gonczy P, Steinmetz MO
    CELL 144, 364 (2011).
    DOI: 10.1016/j.cell.2011.01.008
  • Structural Insights into Viral Determinants of Nematode Mediated Grapevine fanleaf virus Transmission Schellenberger P, Sauter C, Lorber B, Bron P, Trapani S, Bergdoll M, Marmonier A, Schmitt-Keichinger C, Lemaire O, Demangeat G, Ritzenthaler C
    PLOS PATHOGENS 7, e1002034 (2011).
    DOI: 10.1371/journal.ppat.1002034
  • Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands Carette X, Blondiaux N, Willery E, Hoos S, Lecat-Guillet N, Lens Z, Wohlkonig A, Wintjens R, Soror SH, Frenois F, Dirie B, Villeret V, England P, Lippens G, Deprez B, Locht C, Willand N, Baulard AR
    NUCLEIC ACIDS RESEARCH 40, 3018 (2011).
    DOI: 10.1093/nar/gkr1113
  • Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering Kisko K, Brozzo MS, Missimer J, Schleier T, Menzel A, Leppanen VM, Alitalo K, Walzthoeni T, Aebersold R, Ballmer-Hofer K
    FASEB JOURNAL 25, 2980 (2011).
    DOI: 10.1096/fj.11-185397
  • Structural and Phylogenetic Analyses of the GP42 Transglutaminase from Phytophthora sojae Reveal an Evolutionary Relationship between Oomycetes and Marine Vibrio Bacteria Reiss K, Kirchner E, Gijzen M, Zocher G, Loffelhardt B, Nurnberger T, Stehle T, Brunner F
    JOURNAL OF BIOLOGICAL CHEMISTRY 286, 42585 (2011).
    DOI: 10.1074/jbc.M111.290544
  • Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans Salgado PS, Yan R, Taylor JD, Burchell L, Jones R, Hoyer LL, Matthews SJ, Simpson PJ, Cota E
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108, 15775 (2011).
    DOI: 10.1073/pnas.1103496108
  • Structural determinants of vascular endothelial growth factor-D receptor binding and specificity Leppanen VM, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, Toivanen P, Yla-Herttuala S, Ballmer-Hofer K, Alitalo K
    BLOOD 117, 1507 (2011).
    DOI: 10.1182/blood-2010-08-301549
  • Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex Verstraete K, Vandriessche G, Januar M, Elegheert J, Shkumatov AV, Desfosses A, Van Craenenbroeck K, Svergun DI, Gutsche I, Vergauwen B, Savvides SN
    BLOOD 118, 60 (2011).
    DOI: 10.1182/blood-2011-01-329532
  • Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis Dias MVB, Snee WC, Bromfield KM, Payne RJ, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL
    BIOCHEMICAL JOURNAL 436, 729 (2011).
    DOI: 10.1042/BJ20110002
  • Structure and function of formate-dependent cytochrome c nitrite reductase, NRFA Einsle O
    METHODS IN ENZYMOLOGY, VOL 46: RESEARCH ON NITRIFICATION AND RELATED PROCESSES, PT B 496, 399 (2011).
    DOI: 10.1016/B978-0-12-386489-5.00016-6
  • Structure of human mitochondrial RNA polymerase Ringel R, Sologub M, Morozov YI, Litonin D, Cramer P, Temiakov D
    NATURE 478, 269 (2011).
    DOI: 10.1038/nature10435
  • Structure-Based Design of Short Peptide Ligands Binding onto the E. coli Processivity Ring Wolff P, Olieric V, Briand JP, Chaoin O, Dejaegere A, Dumas P, Ennifar E, Guichard G, Wagner J, Burnouf DY
    JOURNAL OF MEDICINAL CHEMISTRY 54, 4627 (2011).
    DOI: 10.1021/jm200311m
  • Structures of the Major Capsid Proteins of the Human Karolinska Institutet and Washington University Polyomaviruses Neu U, Wang JB, Macejak D, Garcea RL, Stehle T
    JOURNAL OF VIROLOGY 85, 7384 (2011).
    DOI: 10.1128/JVI.00382-11
  • Structuring Detergents for Extracting and Stabilizing Functional Membrane Proteins Matar-Merheb R, Rhimi M, Leydier A, Huche F, Galian C, Desuzinges-Mandon E, Ficheux D, Flot D, Aghajari N, Kahn R, Di Pietro A, Jault JM, Coleman AW, Falson P
    PLOS ONE 6, e18036 (2011).
    DOI: 10.1371/journal.pone.0018036
  • Supramolecular stabilization of acid tolerant L-arabinose isomerase from Lactobacillus sakei Jebors S, Tauran Y, Aghajari N, Boudebbouze S, Maguin E, Haser R, Coleman AW, Rhimi M
    CHEMICAL COMMUNICATIONS 47, 12307 (2011).
    DOI: 10.1039/c1cc14930j
  • Synthesis, Crystal Structure, and in Vitro Biological Evaluation of C-6 Pyrimidine Derivatives: New Lead Structures for Monitoring Gene Expression in Vivo Martic M, Pernot L, Westermaier Y, Perozzo R, Kraljevic TG, Kristafor S, Raic-Malic S, Scapozza L, Ametamey S
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 30, 293 (2011).
    DOI: 10.1080/15257770.2011.581258
  • Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions Hardegger LA, Kuhn B, Spinnler B, Anselm L, Ecabert R, Stihle M, Gsell B, Thoma R, Diez J, Benz J, Plancher JM, Hartmann G, Banner DW, Haap W, Diederich F
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50, 314 (2011).
    DOI: 10.1002/anie.201006781
  • Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K, Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ, Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, Schwede T
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 79, 6 (2011).
    DOI: 10.1002/prot.23196
  • The 'gating' residues Ile199 and Tyr326 in human monoamine oxidase B function in substrate and inhibitor recognition Milczek EM, Binda C, Rovida S, Mattevi A, Edmondson DE
    FEBS JOURNAL 278, 4860-4869 (2011).
    DOI: 10.1111/j.1742-4658.2011.08386.x
  • The Conformational Flexibility of the Helicase-like Domain from Thermotoga maritima Reverse Gyrase Is Restricted by the Topoisomerase Domain Duany YD, Klostermeier D, Rudolph MG
    BIOCHEMISTRY 50, 5816 (2011).
    DOI: 10.1021/bi200236a
  • The Crystal Structure of the CeNA:RNA Hybrid ce(GCGTAGCG):r(CGCUACGC) Ovaere M, Herdewijn P, Van Meervelt L
    CHEMISTRY-A EUROPEAN JOURNAL 17, 7823 (2011).
    DOI: 10.1002/chem.201003594
  • The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis Nilsson EC, Storm RJ, Bauer J, Johansson SMC, Lookene A, Angstrom J, Hedenstrom M, Eriksson TL, Frangsmyr L, Rinaldi S, Willison HJ, Domellof FP, Stehle T, Arnberg N
    NATURE MEDICINE 17, 105 (2011).
    DOI: 10.1038/nm.2267
  • The Structure of E. coil IgG-Binding Protein D Suggests a General Model for Bending and Binding in Trimeric Autotransporter Adhesins Leo JC, Lyskowski A, Hattula K, Hartmann MD, Schwarz H, Butcher SJ, Linke D, Lupas AN, Goldman A
    STRUCTURE 19, 1021 (2011).
    DOI: 10.1016/j.str.2011.03.021
  • The acid-tolerant L-arabinose isomerase from the mesophilic Shewanella sp ANA-3 is highly active at low temperatures Rhimi M, Bajic G, Ilhammami R, Boudebbouze S, Maguin E, Haser R, Aghajari N
    MICROBIAL CELL FACTORIES 10, 96 (2011).
    DOI: 10.1186/1475-2859-10-96
  • The crystal structures of human S100B in the zinc- and calcium-loaded state at three pH values reveal zinc ligand swapping Ostendorp T, Diez J, Heizmann CW, Fritz G
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1813, 1083 (2011).
    DOI: 10.1016/j.bbamcr.2010.10.006
  • The latch modulates nucleotide and DNA binding to the helicase-like domain of Thermotoga maritima reverse gyrase and is required for positive DNA supercoiling Ganguly A, Duany YD, Rudolph MG, Klostermeier D
    NUCLEIC ACIDS RESEARCH 39, 1789 (2011).
    DOI: 10.1093/nar/gkq1048
  • The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity Clerc J, Li N, Krahn D, Groll M, Bachmann AS, Florea BI, Overkleeft HS, Kaiser M
    CHEMICAL COMMUNICATIONS 47, 385 (2011).
    DOI: 10.1039/c0cc02238a
  • The structural basis of modularity in ECF-type ABC transporters Erkens GB, Berntsson RPA, Fulyani F, Majsnerowska M, Vujicic-Zagar A, ter Beek J, Poolman B, Slotboom DJ
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 18, 755 (2011).
    DOI: 10.1038/nsmb.2073
  • Three-Dimensional Structure of alpha-Crystallin Domain Dimers of Human Small Heat Shock Proteins HSPB1 and HSPB6 Baranova EV, Weeks SD, Beelen S, Bukach OV, Gusev NB, Strelkov SV
    JOURNAL OF MOLECULAR BIOLOGY 411, 110 (2011).
    DOI: 10.1016/j.jmb.2011.05.024
  • Virtual screening for the discovery of authentic inhibitors against cytosolic 5 '-nucleotidase II: therapeutic use and benefit in cancer treatment Marton Z, Rhimi M, Lallemand P, Jordheim LP, Dumontet C, Aghajari N, Lionne C, Peyrottes S, Chaloin L
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 40, 41 (2011).
  • Viruses and sialic acids: rules of engagement Neu Ursula, Bauer Johannes, Stehle Thilo
    CURRENT OPINION IN STRUCTURAL BIOLOGY 21, 610-618 (2011).
    DOI: 10.1016/j.sbi.2011.08.009
  • X-Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase Muckelbauer J, Sack JS, Ahmed N, Burke J, Chang CYY, Gao M, Tino J, Xie DL, Tebben AJ
    CHEMICAL BIOLOGY & DRUG DESIGN 78, 739 (2011).
    DOI: 10.1111/j.1747-0285.2011.01230.x

2010

  • 20S Proteasome Inhibition: Designing Noncovalent Linear Peptide Mimics of the Natural Product TMC-95A Groll M, Gallastegui N, Marechal X, Le Ravalec V, Basse N, Richy N, Genin E, Huber R, Moroder L, Vidal J, Reboud-Ravaux M
    CHEMMEDCHEM 5, 1701 (2010).
    DOI: 10.1002/cmdc.201000293
  • A Facile Chemoenzymatic Approach : One-Step Syntheses of Monoterpenoid Indole Alkaloids Zou HB, Zhu HJ, Zhang L, Yang L, Yu Y, Stoeckigt J
    CHEMISTRY, AN ASIAN JOURNAL 5, 2400 (2010).
  • Allosteric IGF-1R Inhibitors Heinrich T, Gradler U, Bottcher H, Blaukat A, Shutes A
    ACS MEDICINAL CHEMISTRY LETTERS 1, 199 (2010).
    DOI: 10.1021/ml100044h
  • Atomic structure of vimentin coil 2 Nicolet S, Herrmann H, Aebi U, Strelkov SV
    JOURNAL OF STRUCTURAL BIOLOGY 170, 369 (2010).
    DOI: 10.1016/j.jsb.2010.02.012
  • Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2 Binda C, Valente S, Romanenghi M, Pilotto S, Cirilli R, Karytinos A, Ciossani G, Botrugno OA, Forneris F, Tardugno M, Edmondson DE, Minucci S, Mattevi A, Mai A
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132, 6827 (2010).
    DOI: 10.1021/ja101557k
  • Biosynthesis of Isoprenoids: Crystal Structure of the [4Fe-4S] Cluster Protein IspG Lee M, Grawert T, Quitterer F, Rohdich F, Eppinger J, Eisenreich W, Bacher A, Groll M
    JOURNAL OF MOLECULAR BIOLOGY 404, 600 (2010).
    DOI: 10.1016/j.jmb.2010.09.050
  • Caenorhabditis elegans N-glycan Core beta-galactoside Confers Sensitivity towards Nematotoxic Fungal Galectin CGL2 Butschi A, Titz A, Walti MA, Olieric V, Paschinger K, Nobauer K, Guo XQ, Seeberger PH, Wilson IBH, Aebi M, Hengartner MO, Kunzler M
    PLOS PATHOGENS 6, e1000717 (2010).
    DOI: 10.1371/journal.ppat.1000717
  • Chemical discrimination between dC and (5Me)dC via their hydroxylamine adducts Munzel M, Lercher L, Muller M, Carell T
    NUCLEIC ACIDS RESEARCH 38, e192 (2010).
    DOI: 10.1093/nar/gkq724
  • Chemo-Genetic Optimization of DNA Recognition by Metallodrugs using a Presenter-Protein Strategy Zimbron JM, Sardo A, Heinisch T, Wohlschlager T, Gradinaru J, Massa C, Schirmer T, Creus M, Ward TR
    CHEMISTRY-A EUROPEAN JOURNAL 16, 12883 (2010).
    DOI: 10.1002/chem.201001573
  • Construction and expression of a dual vector for chemo-enzymatic synthesis of plant indole alkaloids in Escherichia coli Stoeckigt J, Hammes B, Ruppert M
    NATURAL PRODUCT REPORTS 24, 759 (2010).
  • Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action Freisz S, Bec G, Radi M, Wolff P, Crespan E, Angeli L, Dumas P, Maga G, Botta M, Ennifar E
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 49, 1805 (2010).
    DOI: 10.1002/anie.200905651
  • Crystal Structure of Prostate Secretory Protein P5P94 Shows an Edge-to-Edge Association of two Monomers to Form a Homodimer Kumar A, Jagtap DD, Mahale SD, Kumar M
    JOURNAL OF MOLECULAR BIOLOGY 397, 947 (2010).
    DOI: 10.1016/j.jmb.2010.02.035
  • Crystal Structure of a Cisplatin-1,3-GTG Cross-Link Inside DNA Polymerase Reissner T, Schneider S, Schorr S, Carell T
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 49, 3077 (2010).
  • Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5 '-Capped Octameric RNA Yap LJ, Luo DH, Chung KY, Lim SP, Bodenreider C, Noble C, Shi PY, Lescar J
    PLOS ONE 5, e12836 (2010).
    DOI: 10.1371/journal.pone.0012836
  • Crystal Structures of Nucleosome Core Particles Containing the '601' Strong Positioning Sequence Vasudevan D, Chua EYD, Davey CA
    JOURNAL OF MOLECULAR BIOLOGY 403, 1 (2010).
    DOI: 10.1016/j.jmb.2010.08.039
  • Crystallization and X-ray diffraction studies of cellobiose phosphorylase from Cellulomonas uda Van Hoorebeke A, Stout J, Kyndt J, De Groeve M, Dix I, Desmet T, Soetaert W, Van Beeumen J, Savvides SN
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 66, 346 (2010).
    DOI: 10.1107/S1744309110002642
  • Crystallization and X-ray diffraction studies of inverting trehalose phosphorylase from Thermoanaerobacter sp. Van Hoorebeke A, Stout J, Van der Meeren R, Kyndt J, Van Beeumen J, Savvides SN
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 66, 442 (2010).
    DOI: 10.1107/S1744309110005749
  • Crystallization and calcium/sulfur SAD phasing of the human EF-hand protein S100A2 Koch M, Diez J, Wagner A, Fritz G
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 66, 1032 (2010).
    DOI: 10.1107/S1744309110030691
  • Crystallization and preliminary X-ray study of the d-altritol oligonucleotide GTGTACAC Ovaere M, Van Aerschot A, Abramov M, Herdewijn P, Van Meervelt L
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 66, 460 (2010).
    DOI: 10.1107/S1744309110007050
  • DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization into (6-4) Lesions Glas AF, Kaya E, Schneider S, Heil K, Fazio D, Maul MJ, Carell T
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132, 3254 (2010).
    DOI: 10.1021/ja910917f
  • DNA stretching in the nucleosome facilitates alkylation by an intercalating antitumour agent Davey GE, Wu B, Dong YC, Surana U, Davey CA
    NUCLEIC ACIDS RESEARCH 38, 2081 (2010).
    DOI: 10.1093/nar/gkp1174
  • Efficient bioconversion of lactose in milk and whey: immobilization and biochemical characterization of a beta-galactosidase from the dairy Streptococcus thermophilus LMD9 strain Rhimi M, Boisson A, Dejob M, Boudebouze S, Maguin E, Haser R, Aghajari N
    RESEARCH IN MICROBIOLOGY 161, 515 (2010).
    DOI: 10.1016/j.resmic.2010.04.011
  • Enhancement of the thermostability and the catalytic efficiency of Bacillus pumilus CBS protease by site-directed mutagenesis Jaouadi B, Aghajari N, Haser R, Bejar S
    BIOCHIMIE 92, 360 (2010).
    DOI: 10.1016/j.biochi.2010.01.008
  • Enzymatic and Chemo-Enzymatic Approaches Towards Natural and Non-Natural Alkaloids : Indoles, Isoquinolines, and Others Stoeckigt J, Chen Z, Ruppert M
    Topics Current Chemistry 1, 67 (2010).
  • Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8 Tidow H, Hein KL, Baekgaard L, Palmgren MG, Nissen P
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 66, 361 (2010).
    DOI: 10.1107/S1744309110003805
  • Flexibility between the Protease and Helicase Domains of the Dengue Virus NS3 Protein Conferred by the Linker Region and Its Functional Implications Luo DH, Wei N, Doan DN, Paradkar PN, Chong YW, Davidson AD, Kotaka M, Lescar J, Vasudevan SG
    JOURNAL OF BIOLOGICAL CHEMISTRY 285, 18817 (2010).
    DOI: 10.1074/jbc.M109.090936
  • Fragment-based discovery and optimization of BACE1 inhibitors Madden J, Dod JR, Godemann R, Kraemer J, Smith M, Biniszkiewicz M, Hallett DJ, Barker J, Dyekjaer JD, Hesterkamp T
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20, 5329 (2010).
    DOI: 10.1016/j.bmcl.2010.06.089
  • From Touchdown to Transcription: The Reovirus Cell Entry Pathway Danthi P, Guglielmi KM, Kirchner E, Mainou B, Stehle T, Dermody TS
    CELL ENTRY BY NON-ENVELOPED VIRUSES 343, 91 (2010).
    DOI: 10.1007/82_2010_32
  • Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA Vergauwen B, Elegheert J, Dansercoer A, Devreese B, Savvides SN
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107, 13270 (2010).
    DOI: 10.1073/pnas.1005198107
  • Human DNA polymerase mutations allowing efficient abasic site bypass Gieseking S, Bergen K, Di Pasquale F, Diederichs K, Welte W, Marx A
    JOURNAL OF BIOLOGICAL CHEMISTRY Epub, Epub (2010).
  • Implications for Collagen Binding from the Crystallographic Structure of Fibronectin (6)FnI(1-2)FnII(7)FnI Erat MC, Schwarz-Linek U, Pickford AR, Farndale RW, Campbell ID, Vakonakis I
    JOURNAL OF BIOLOGICAL CHEMISTRY 285, 33764 (2010).
    DOI: 10.1074/jbc.M110.139394
  • Improved expression of His(6) - tagged strictosidine synthase cDNA for chemo-enzymatic alkaloid diversification Yang L, B Zou H, J Zhu H, Ruppert M, X Gong J, Stoeckigt J
    Chemistry & Biodiversity 7, 860 (2010).
  • Induced-fit upon Ligand Binding Revealed by Crystal Structures of the Hot-dog Fold Thioesterase in Dynemicin Biosynthesis Liew CW, Sharff A, Kotaka M, Kong R, Sun HH, Qureshi I, Bricogne G, Liang ZX, Lescar J
    JOURNAL OF MOLECULAR BIOLOGY 404, 291 (2010).
    DOI: 10.1016/j.jmb.2010.09.041
  • Insights into Peroxisome Function from the Structure of PEX3 in Complex with a Soluble Fragment of PEX19 Schmidt F, Treiber N, Zocher G, Bjelic S, Steinmetz MO, Kalbacher H, Stehle T, Dodt G
    JOURNAL OF BIOLOGICAL CHEMISTRY 285, 25410 (2010).
    DOI: 10.1074/jbc.M110.138503
  • Insights into the mechanism of drug resistance: X-ray structure analysis of G48V/C95F tethered HIV-1 protease dimer/saquinavir complex Prashar V, Bihani SC, Das A, Rao DR, Hosur MV
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 396, 1018 (2010).
    DOI: 10.1016/j.bbrc.2010.05.049
  • Interactions of Monoamine Oxidases with the Antiepileptic Drug Zonisamide: Specificity of Inhibition and Structure of the Human Monoamine Oxidase B Complex. Binda C, Aldeco M, Mattevi A, Edmondson DE
    JOURNAL OF MEDICINAL CHEMISTRY in press, in press (2010).
  • Investigations into Protein Crystallization in the Presence of a Strong Magnetic Field Surade S, Ochi T, Nietlispach D, Chirgadze D, Moreno A
    CRYSTAL GROWTH & DESIGN 10, 691 (2010).
    DOI: 10.1021/cg901109e
  • Molecular Basis of RNA Polymerase III Transcription Repression by Maf1 Vannini A, Ringel R, Kusser AG, Berninghausen O, Kassavetis GA, Cramer P
    CELL 143, 59 (2010).
    DOI: 10.1016/j.cell.2010.09.002
  • Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance Hare S, Vos AM, Clayton RF, Thuring JW, Cummings MD, Cherepanov P
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107, 20057 (2010).
    DOI: 10.1073/pnas.1010246107
  • NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1 Guttler T, Madl T, Neumann P, Deichsel D, Corsini L, Monecke T, Ficner R, Sattler M, Gorlich D
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 17, 1367 (2010).
    DOI: 10.1038/nsmb.1931
  • NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35 Alag R, Qureshi IA, Bharatham N, Shin J, Lescar J, Yoon HS
    PROTEIN SCIENCE 19, 1577 (2010).
    DOI: 10.1002/pro.438
  • Natural and amyloid self-assembly of S100 proteins: structural basis of functional diversity Fritz G, Botelho HM, Morozova-Roche LA, Gomes CM
    FEBS JOURNAL 277, 4578 (2010).
    DOI: 10.1111/j.1742-4658.2010.07887.x
  • Optimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery against Mycobacterium tuberculosis Pantothenate Synthetase Sledz P, Silvestre HL, Hung AW, Ciulli A, Blundell TL, Abell C
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132, 4544 (2010).
    DOI: 10.1021/ja100595u
  • Perturbations in nucleosome structure from heavy metal association Mohideen K, Muhammad R, Davey CA
    NUCLEIC ACIDS RESEARCH 38, 6301 (2010).
    DOI: 10.1093/nar/gkq420
  • Potentiation of Ligand Binding through Cooperative Effects in Monoamine Oxidase B Bonivento D, Milczek EM, McDonald GR, Binda C, Holt A, Edmondson DE, Mattevi A
    JOURNAL OF BIOLOGICAL CHEMISTRY 285, 36849 (2010).
    DOI: 10.1074/jbc.M110.169482
  • Replication through an abasic DNA lesion: structural basis for adenine selectivity Obeid S, Blatter N, Kranaster R, Schnur A, Diederichs K, Welte W, Marx A
    EMBO JOURNAL 29, 1738 (2010).
    DOI: 10.1038/emboj.2010.64
  • Shared Active Site Architecture between the Large Subunit of Eukaryotic Primase and DNA Photolyase Sauguet L, Klinge S, Perera RL, Maman JD, Pellegrini L
    PLOS ONE 5, e10083 (2010).
    DOI: 10.1371/journal.pone.0010083
  • Structural Basis for Ligand Recognition and Activation of RAGE Koch M, Chitayat S, Dattilo BM, Schiefner A, Diez J, Chazin WJ, Fritz G
    STRUCTURE 18, 1342 (2010).
    DOI: 10.1016/j.str.2010.05.017
  • Structural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlK Dias MVB, Huang FL, Chirgadze DY, Tosin M, Spiteller D, Dry EFV, Leadlay PF, Spencer JB, Blundell TL
    JOURNAL OF BIOLOGICAL CHEMISTRY 285, 22495 (2010).
    DOI: 10.1074/jbc.M110.107177
  • Structural Basis of Multivalent Binding to Wheat Germ Agglutinin Schwefel D, Maierhofer C, Beck JG, Seeberger S, Diederichs K, Moller HM, Welte W, Wittmann V
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132, 8704 (2010).
    DOI: 10.1021/ja101646k
  • Structural Insight into the Sequence Dependence of Nucleosome Positioning Wu B, Mohideen K, Vasudevan D, Davey CA
    STRUCTURE 18, 528 (2010).
    DOI: 10.1016/j.str.2010.01.015
  • Structural and Kinetic Analysis of Bacillus subtilis N-Acetylglucosaminidase Reveals a Unique Asp-His Dyad Mechanism Litzinger S, Fischer S, Polzer P, Diederichs K, Welte W, Mayer C
    JOURNAL OF BIOLOGICAL CHEMISTRY 285, 35675 (2010).
    DOI: 10.1074/jbc.M110.131037
  • Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase Obeid S, Baccaro A, Welte W, Diederichs K, Marx A
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107, 21327 (2010).
  • Structural determinants of growth factor binding and specificity by VEGF receptor 2 Leppanen VM, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, Lankinen H, Goldman A, Ballmer-Hofer K, Alitalo K
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107, 2425 (2010).
    DOI: 10.1073/pnas.0914318107
  • Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenase ADH-'A' from Rhodococcus ruber DSM 44541 Karabec M, Lyskowski A, Tauber KC, Steinkellner G, Kroutil W, Grogan G, Gruber K
    CHEMICAL COMMUNICATIONS 46, 6314 (2010).
    DOI: 10.1039/c0cc00929f
  • Structure and Function of CinD (YtjD) of Lactococcus lactis, a Copper-Induced Nitroreductase Involved in Defense against Oxidative Stress Mermod M, Mourlane F, Waltersperger S, Oberholzer AE, Baumann U, Solioz M
    JOURNAL OF BACTERIOLOGY 192, 4172 (2010).
    DOI: 10.1128/JB.00372-10
  • Structure and Function of Polarity-Inducing Kinase Family Mark Par-1 within the Branch of Ampk/Snf1 Related Kinases Marx A, Nugoor C, Panneerselvam S, Mandelkow E
    FASEB JOURNAL , 1 (2010).
  • Structure of a soluble subcomplex of NADH:ubiquinone oxidoreductase from Aquifex aeolicus Labatzke R, Kohlstadt M, Jakob L, Friedrich T, Einsle O
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1797, 18 (2010).
    DOI: 10.1016/j.bbabio.2010.04.072
  • Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins Treiber N, Treiber T, Zocher G, Grosschedl R
    GENES & DEVELOPMENT 24, 2270 (2010).
    DOI: 10.1101/gad.1976610
  • Structure of the Extracellular Portion of CD46 Provides Insights into Its Interactions with Complement Proteins and Pathogens Persson BD, Schmitz NB, Santiago C, Zocher G, Larvie M, Scheu U, Casasnovas JM, Stehle T
    PLOS PATHOGENS 6, e1001122 (2010).
    DOI: 10.1371/journal.ppat.1001122
  • Structure of the measles virus hemagglutinin bound to the CD46 receptor Santiago C, Celma ML, Stehle T, Casasnovas JM
    NATURE STRUCTURAL & MOLECULAR BIOLOGY 17, 124 (2010).
    DOI: 10.1038/nsmb.1726
  • Structure-Function Analysis of an Enzymatic Prenyl Transfer Reaction Identifies a Reaction Chamber with Modifiable Specificity Jost M, Zocher G, Tarcz S, Matuschek M, Xie XL, Li SM, Stehle T
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132, 17849 (2010).
    DOI: 10.1021/ja106817c
  • Structure-Function Analysis of the Human JC Polyomavirus Establishes the LSTc Pentasaccharide as a Functional Receptor Motif Neu U, Maginnis MS, Palma AS, Stroh LJ, Nelson CDS, Feizi T, Atwood WJ, Stehle T
    CELL HOST & MICROBE 8, 309 (2010).
    DOI: 10.1016/j.chom.2010.09.004
  • Structures of DNA Polymerases Caught Processing Size-Augmented Nucleotide Probes Betz K, Streckenbach F, Schnur A, Exner T, Welte W, Diederichs K, Marx A
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 49, 5181 (2010).
    DOI: 10.1002/anie.200905724
  • Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats Ginn JD, Bosanac T, Chen R, Cywin C, Hickey E, Kashem M, Kerr S, Kugler S, Li XA, Prokopowicz A, Schlyer S, Smith JD, Turner MR, Wu F, Young ERR
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20, 5153 (2010).
    DOI: 10.1016/j.bmcl.2010.07.014
  • Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 3, aryl substituted pyrrolidines Bosanac T, Hickey ER, Ginn J, Kashem M, Kerr S, Kugler S, Li X, Olague A, Schlyer S, Young ERR
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20, 3746 (2010).
    DOI: 10.1016/j.bmcl.2010.04.069
  • Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin Behrendt CT, Kunfermann A, Illarionova V, Matheeussen A, Graewert T, Groll M, Rohdich F, Bacher A, Eisenreich W, Fischer M, Maes L, Kurz T
    CHEMMEDCHEM 5, 1673 (2010).
  • Synthesis of S-Adenosyl-L-homocysteine Capture Compounds for Selective Photoinduced Isolation of Methyltransferases Dalhoff C, Huben M, Lenz T, Poot P, Nordhoff E, Koster H, Weinhold E
    CHEMBIOCHEM 11, 256 (2010).
    DOI: 10.1002/cbic.200900349
  • The Canonical Helix of Urea Oligomers at Atomic Resolution: Insights Into Folding-Induced Axial Organization Fischer L, Claudon P, Pendem N, Miclet E, Didierjean C, Ennifar E, Guichard G
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 49, 1067 (2010).
    DOI: 10.1002/anie.200905592
  • The Crystal Structure of Non-Modified and Bipyridine-Modified PNA Duplexes Yeh JI, Pohl E, Truan D, He W, Sheldrick GM, Du SC, Achim C
    CHEMISTRY-A EUROPEAN JOURNAL 16, 11867 (2010).
    DOI: 10.1002/chem.201000392
  • The Crystal Structure of a Constitutively Active Mutant RON Kinase Suggests an Intramolecular Autophosphorylation Hypothesis Wang J, Steinbacher S, Augustin M, Schreiner P, Epstein D, Mulvihill MJ, Crew AP
    BIOCHEMISTRY 49, 7972 (2010).
    DOI: 10.1021/bi100409w
  • The Crystal Structure of the [NiFe] Hydrogenase from the Photosynthetic Bacterium Allochromatium vinosum: Characterization of the Oxidized Enzyme (Ni-A State) Ogata H, Kellers P, Lubitz W
    JOURNAL OF MOLECULAR BIOLOGY 402, 428 (2010).
    DOI: 10.1016/j.jmb.2010.07.041
  • The Extended Conformation of the 2.9-angstrom Crystal Structure of the Three-PASTA Domain of a Ser/Thr Kinase from the Human Pathogen Staphylococcus aureus Paracuellos P, Ballandras A, Robert X, Kahn R, Herve M, Mengin-Lecreulx D, Cozzone AJ, Duclos B, Gouet P
    JOURNAL OF MOLECULAR BIOLOGY 404, 847 (2010).
    DOI: 10.1016/j.jmb.2010.10.012
  • The acid tolerant L-arabinose isomerase from the food grade Lactobacillus sakei 23K is an attractive D-tagatose producer Rhimi M, Ilhammami R, Bajic G, Boudebbouze S, Maguin E, Haser R, Aghajari N
    BIORESOURCE TECHNOLOGY 101, 9171 (2010).
    DOI: 10.1016/j.biortech.2010.07.036
  • The use of novel organic gels and hydrogels in protein crystallization Pietras Z, Lin HT, Surade S, Luisi B, Slattery O, Pos KM, Moreno A
    JOURNAL OF APPLIED CRYSTALLOGRAPHY 43, 58 (2010).
    DOI: 10.1107/S0021889809051917
  • Towards structural studies of the old yellow enzyme homologue SYE4 from Shewanella oneidensis and its complexes at atomic resolution Elegheert J, van den Hemel D, Dix I, Stout J, Van Beeumen J, Brige A, Savvides SN
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 66, 85 (2010).
    DOI: 10.1107/S1744309109050386
  • Trends for diverse production strategies of plant medicinal alkaloids Yang L, Stoeckigt J
    NATURAL PRODUCT REPORTS 27, 1469 (2010).
  • Two Stacked Heme Molecules in the Binding Pocket of the Periplasmic Heme-Binding Protein HmuT from Yersinia pestis Mattle Daniel, Zeltina Antra, Woo Jae-Sung, Goetz Birke A, Locher Kaspar P
    JOURNAL OF MOLECULAR BIOLOGY 404, 220-231 (2010).
    DOI: 10.1016/j.jmb.2010.09.005
  • UV and X-ray structural studies of a 101-residue long Tat protein from a HIV-1 primary isolate and of its mutated, detoxified, vaccine candidate Foucault M, Mayol K, Receveur-Brechot V, Bussat MC, Klinguer-Hamour C, Verrier B, Beck A, Haser R, Gouet P, Guillon C
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 78, 1441 (2010).
    DOI: 10.1002/prot.22661
  • Using Soft X-Rays for a Detailed Picture of Divalent Metal Binding in the Nucleosome Wu B, Davey CA
    JOURNAL OF MOLECULAR BIOLOGY 398, 633 (2010).
    DOI: 10.1016/j.jmb.2010.03.038

2009

  • 3D-Structure of dipeptidyl-peptidase III (DPP III) Gruber K, Arruda GB, Baral PK, Deller S, Macheroux P, Jajcanin-Jozic N, Abramic M
    NEUROPEPTIDES 43, 444 (2009).
  • A fast selenium derivatization strategy for crystallization and phasing of RNA structures Olieric V, Rieder U, Lang K, Serganov A, Schulze-Briese C, Micura R, Dumas P, Ennifar E
    RNA-A PUBLICATION OF THE RNA SOCIETY 15, 707 (2009).
    DOI: 10.1261/rna.1499309
  • A single intersubunit salt bridge affects oligomerization and catalytic activity in a bacterial quinone reductase Binter A, Staunig N, Jelesarov I, Lohner K, Palfey BA, Deller S, Gruber K, Macheroux P
    FEBS JOURNAL 276, 5263 (2009).
    DOI: 10.1111/j.1742-4658.2009.07222.x
  • An Arginine Switch in the Species B Adenovirus Knob Determines High-Affinity Engagement of Cellular Receptor CD46 Persson BD, Muller S, Reiter DM, Schmitt BBT, Marttila M, Sumowski CV, Schweizer S, Scheu U, Ochsenfeld C, Arnberg N, Stehle T
    JOURNAL OF VIROLOGY 83, 673 (2009).
    DOI: 10.1128/JVI.01967-08
  • Application of Fragment Growing and Fragment Linking to the Discovery of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Hung AW, Silvestre HL, Wen SJ, Ciulli A, Blundell TL, Abell C
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 48, 8452 (2009).
    DOI: 10.1002/anie.200903821
  • Berberine bridge enzyme catalyzes the six electron oxidation of (S)-reticuline to dehydroscoulerine Winkler A, Puhl M, Weber H, Kutchan TM, Gruber K, Macheroux P
    PHYTOCHEMISTRY 70, 1092 (2009).
    DOI: 10.1016/j.phytochem.2009.06.005
  • Binding of S100 proteins to RAGE: An update Leclerc E, Fritz G, Vetter SW, Heizmann CW
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1793, 993 (2009).
    DOI: 10.1016/j.bbamcr.2008.11.016
  • CcpA from Geobacter sulfurreducens Is a Basic Di-Heme Cytochrome c Peroxidase Hoffmann M, Seidel J, Einsle O
    JOURNAL OF MOLECULAR BIOLOGY 393, 951 (2009).
    DOI: 10.1016/j.jmb.2009.09.001
  • Chimeric Glycosyltransferases for the Generation of Hybrid Glycopeptides Truman AW, Dias MVB, Wu S, Blundell TL, Huang FL, Spencer JB
    CHEMISTRY & BIOLOGY 16, 676 (2009).
    DOI: 10.1016/j.chembiol.2009.04.013
  • Complete Ion-Coordination Structure in the Rotor Ring of Na+-Dependent F-ATP Synthases Meier T, Krah A, Bond PJ, Pogoryelov D, Diederichs K, Faraldo-Gomez JD
    JOURNAL OF MOLECULAR BIOLOGY 391, 498 (2009).
    DOI: 10.1016/j.jmb.2009.05.082
  • Crystal Structure of Enzyme I of the Phosphoenolpyruvate Sugar Phosphotransferase System in the Dephosphorylated State Oberholzer AE, Schneider P, Siebold C, Baumann U, Erni B
    JOURNAL OF BIOLOGICAL CHEMISTRY 284, 33169 (2009).
    DOI: 10.1074/jbc.M109.057612
  • Crystal Structure of a Major Outer Membrane Protein from Thermus thermophilus HB27 Brosig A, Nesper J, Boos W, Welte W, Diederichs K
    JOURNAL OF MOLECULAR BIOLOGY 385, 1445 (2009).
    DOI: 10.1016/j.jmb.2008.12.003
  • Crystal Structure of the T(6-4)C Lesion in Complex with a (6-4) DNA Photolyase and Repair of UV-Induced (6-4) and Dewar Photolesions Glas AF, Schneider S, Maul MJ, Hennecke U, Carell T
    CHEMISTRY-A EUROPEAN JOURNAL 15, 10387 (2009).
    DOI: 10.1002/chem.200901004
  • Crystal growth of proteins, nucleics acids, and viruses in gels Lorber B, Sauter C, Theobald-Dietrich A, Moreno A, Schellenberger P, Robert MC, Capelle B, Sanglier S, Potier N, Giege R
    PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY 101, 13 (2009).
  • Crystallization and preliminary X-ray diffraction analysis of human seminal plasma protein PSP94 Kumar M, Jagtap DD, Mahale SD, Prashar V, Kumar A, Das A, Bihani SC, Ferrer JL, Hosur MV, Ramanadham M
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 65, 389 (2009).
    DOI: 10.1107/S1744309109008549
  • Discovery of Chiral Cyclopropyl Dihydro-Alkylthio-Benzyl-Oxopyrimidine (S-DABO) Derivatives as Potent HIV-1 Reverse Transcriptase Inhibitors with High Activity Against Clinically Relevant Mutants Radi M, Maga G, Alongi M, Angeli L, Samuele A, Zanoli S, Bellucci L, Tafi A, Casaluce G, Giorgi G, Armand-Ugon M, Gonzalez E, Este JA, Baltzinger M, Bec G, Dumas P, Ennifar E, Botta M
    JOURNAL OF MEDICINAL CHEMISTRY 52, 840 (2009).
    DOI: 10.1021/jm801330n
  • Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays Godemann R, Madden J, Kramer J, Smith MA, Fritz U, Hesterkamp T, Barker J, Hoeppner S, Hallett D, Cesura A, Ebneth A, Kemp J
    BIOCHEMISTRY 48, 10743 (2009).
  • Generation and characterization of a novel, permanently active S100P mutant Austermann J, Nazmi AR, Heil A, Fritz G, Kolinski M, Filipek S, Gerke V
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1793, 1078 (2009).
    DOI: 10.1016/j.bbamcr.2008.11.012
  • Insights into the function of S100B from structural and spectroscopic studies Fritz G
    AMINO ACIDS 37, 76 (2009).
  • Isolation, crystallization and preliminary X-ray analysis of the transamidosome, a ribonucleoprotein involved in asparagine formation Bailly M, Blaise M, Lorber B, Thirup S, Kern D
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 65, 577 (2009).
    DOI: 10.1107/S1744309109015000
  • Metal ions modulate the folding and stability of the tumor suppressor protein S100A2 Botelho HM, Koch M, Fritz G, Gomes CM
    FEBS JOURNAL 276, 1776 (2009).
    DOI: 10.1111/j.1742-4658.2009.06912.x
  • NanC Crystal Structure, a Model for Outer-Membrane Channels of the Acidic Sugar-Specific KdgM Porin Family Wirth C, Condemine G, Boiteux C, Berneche S, Schirmer T, Peneff CM
    JOURNAL OF MOLECULAR BIOLOGY 394, 718 (2009).
    DOI: 10.1016/j.jmb.2009.09.054
  • Post-processing intensity measurements at favourable dose values Diederichs K, Junk M
    JOURNAL OF APPLIED CRYSTALLOGRAPHY 42, 48 (2009).
    DOI: 10.1107/S0021889808036716
  • Role of the General Base Glu-268 in Nitroglycerin Bioactivation and Superoxide Formation by Aldehyde Dehydrogenase-2 Wenzl MV, Beretta M, Gorren ACF, Zeller A, Baral PK, Gruber K, Russwurm M, Koesling D, Schmidt K, Mayer B
    JOURNAL OF BIOLOGICAL CHEMISTRY 284, 19878 (2009).
    DOI: 10.1074/jbc.M109.005652
  • Structural Basis and Enzymatic Mechanism of the Biosynthesis of C9- from C10-Monoterpenoid Indole Alkaloids Yang L, Hill M, Wang M, Panjikar S, Stoeckigt J
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 48, 5211 (2009).
  • Structural Comparison of Crystal and Solution States of the 138 kDa Complex of Methylamine Dehydrogenase and Amicyanin from Paracoccus versutus (vol 47, pg 6560, 2008) Cavalieri C, Biermann N, Vlasie MD, Einsle O, Merli A, Ferrari D, Rossi GL, Ubbink M
    BIOCHEMISTRY 48, 4008 (2009).
    DOI: 10.1021/bi9004667
  • Structural and Mechanistic Studies Reveal the Functional Role of Bicovalent Flavinylation in Berberine Bridge Enzyme Winkler A, Motz K, Riedl S, Puhl M, Macheroux P, Gruber K
    JOURNAL OF BIOLOGICAL CHEMISTRY 284, 19993 (2009).
    DOI: 10.1074/jbc.M109.015727
  • Structural comparison of two CSPG-binding DBL domains from the VAR2CSA protein important in malaria during pregnancy Khunrae P, M D Philip J, R Bull D, K Higgins M
    JOURNAL OF MOLECULAR BIOLOGY 393, 202 (2009).
  • Structure of the major carrot allergen Dau c 1 Markovic-Housley Z, Basle A, Padavattan S, Maderegger B, Schirmer T, Hoffmann-Sommergruber K
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 65, 1206 (2009).
    DOI: 10.1107/S0907444909034854
  • Substrate Binding in the FAD-Dependent Hydroxynitrile Lyase from Almond Provides Insight into the Mechanism of Cyanohydrin Formation and Explains the Absence of Dehydrogenation Activity Dreveny I, Andryushkova AS, Glieder A, Gruber K, Kratky C
    BIOCHEMISTRY 48, 3370 (2009).
    DOI: 10.1021/bi802162s
  • The Thermus thermophilus DEAD box helicase Hera contains a modified RNA recognition motif domain loosely connected to the helicase core Rudolph MG, Klostermeier D
    RNA-A PUBLICATION OF THE RNA SOCIETY 15, 1993 (2009).
    DOI: 10.1261/rna.1820009
  • Towards the structure of the C-terminal part of the S-layer protein SbsC Kroutil M, Pavkov T, Birner-Gruenberger R, Tesarz M, Sleytr UB, Egelseer EM, Keller W
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 65, 1042 (2009).
    DOI: 10.1107/S1744309109035386
  • Transcriptome and Functional Analysis of the Eukaryotic-Type Serine/Threonine Kinase PknB in Staphylococcus aureus Donat S, Streker K, Schirmeister T, Rakette S, Stehle T, Liebeke M, Lalk M, Ohlsen K
    JOURNAL OF BACTERIOLOGY 191, 4056 (2009).
    DOI: 10.1128/JB.00117-09
  • Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin Leiman Petr G, Basler Marek, Ramagopal Udupi A, Bonanno Jeffrey B, Sauder J Michael, Pukatzki Stefan, Burley Stephen K, Almo Steven C, Mekalanos John J
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106, 4154-4159 (2009).
    DOI: 10.1073/pnas.0813360106

2008

  • A concerted mechanism for berberine bridge enzyme Winkler A, Lyskowski A, Riedl S, Puhl M, Kutchan TM, Macheroux P, Gruber K
    NATURE CHEMICAL BIOLOGY 4, 739 (2008).
    DOI: 10.1038/nchembio.123
  • A crystalline B-12 dimer from beta-cyano-neocobyrate Murtaza S, Butler P, Kratky C, Gruber K, Krautler B
    CHEMISTRY-A EUROPEAN JOURNAL 14, 7521 (2008).
    DOI: 10.1002/chem.200800809
  • Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases Beretta M, Gruber K, Kollau A, Russwurm M, Koesling D, Goessler W, Keung WM, Schmidt K, Mayer B
    JOURNAL OF BIOLOGICAL CHEMISTRY 283, 17873 (2008).
    DOI: 10.1074/jbc.M801182200
  • Characterization of a Carbonyl-Conjugated Polyene Precursor in 10-Membered Enediyne Biosynthesis Kong R, Goh LP, Liew CW, Ho QS, Murugan E, Li B, Tang K, Liang ZX
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130, 8142 (2008).
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