Cellular Structural Biology and Multi-Scale Bioimaging

Using core stengths in electron tomography and protein bioengineering the cellular structural biology  group focuses on analysis of 3D structures of biological macromolecules in the cell, in particular using cryo-electron tomography.

Our research focuses on structure-based protein engineering to create biomolecules with novel functionalities.

We investigate the structure and function of healthy and diseased brains using a dynamical connectomics approach combining in vivo multiphoton calcium imaging in behaving mice with multi-scale electron and X-ray microscopy for dense, synaptic resolution neuronal circuit reconstruction.

In the context of research on neurodegenerative diseases, we investigate the structure and function of neurodegenerative amyloid proteins by integrative biophysical methods.