Thank You SLS
Our beamline scientists look back on 22 years of brilliant science made possible by the Swiss Light Source SLS.
Bright white coloring of Pacific cleaner shrimp revelead
In a study published in Nature Photonics, researchers at the Ben-Gurion University of the Negev, Israel, explain the bright, white-colored stripes from Pacific cleaner shrimps, one of the most efficient white reflectors found in nature.
Progress of the X06DA-PXIII beamline upgrade: First light in the optics hutch
On June 7, 2023, the PXIII project team successfully shone the first light into the optics hutch at the upgraded X06DA-PXIII beamline. It is an essential first step for testing new hardware and software solutions that will be implemented at SLS2.0.
SDU: Software for high throughput automated data collection at SLS MX
The Smart Digital User (SDU) software for unattended data collection has been deployed at the macromolecular crystallography beamlines at the Swiss Light Source.
A new spin on sample delivery for membrane proteins
Proteins hover in front of the X-ray beam at a Swiss Light Source beamline. Now, spinning thin films bring on board these trickiest of proteins.
Lighting up the appealing world of hybrid perovskites
Researchers from Italy, in collaboration with the Paul Scherrer Institut, successfully used the macromolecular crystallography beamline X06DA-PXIII at the Swiss Light Source to characterize promising perovkites materials used in solar cells and other photodetector devices.
How to get chloride ions into the cell
A molecular movie shot at PSI reveals the mechanism of a light-driven chloride pump
Protein distancing
PSI researchers have developed a new method to attach proteins to the surface of virus-like particles.
Nanobodies against SARS-CoV-2
In a study published in EMBO Journal, researchers at the Max Planck Institute for Biophysical Chemistry, Göttingen, Germany, developed nanobodies that efficiently block the coronavirus SARS-CoV-2 and its variants. The high resolution structural characterization was performed at the X10SA crystallography beamline at the Swiss Light Source.
How ethane-consuming archaea pick up their favorite dish
Scientists decode the structure of the enzyme responsible for the ethane fixation by – beside others – using the SLS.
On-demand sample delivery article highlighted in "Applied Physics Letters"
An article on the on-demand sample delivery and protein crystallography using acoustic levitation has been selected in an Applied Physics Letters collection of papers on technology and application of acoustic tweezers.
Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions
In a study published in Nature Communications, researchers at the NHC Key Laboratory of Systems Biology of Pathogens in Beijing, China, in collaboration with the Paul Scherrer Institut characterize the interactions of SARS-CoV-2 orf9b and human TOM70 biochemically, and they determine the 2.2 Å crystal structure of the TOM70 cytosolic domain with a bound SARS-CoV-2 orf9b peptide.
How remdesivir works against the coronavirus
Researchers at Goethe University Frankfurt, in cooperation with the PSI have probably discovered another, previously unknown mechanism of action of the antiviral remdesivir.
Combating antimicrobial resistance
In a study addressing the global health threat of drug resistance, researchers at the Biozentrum, University of Basel, have revealed how a new antibiotic, Darobactin, binds to the external membrane of gram-negative bacteria.
Forschung zu Covid-19 am Paul Scherrer Institut
Während viele Bereiche des Lebens eingeschränkt sind, bleiben wichtige Forschungsanlagen am PSI in Betrieb.
Wait and see, and grow crystals
At PSI, researchers decipher the structure of the proteins in bacteria and viruses. This knowledge can aid, for example, in the development of drugs against infectious diseases. But before the investigation can begin, an extremely tricky problem has to be solved: the crystallisation of the molecules.
A question of binding
At PSI, researchers are screening molecule fragments to see if these bind to important proteins of the coronavirus SARS-CoV-2 and thus have the potential to disable it. They are hoping the many individual pieces of information will yield an answer as to what an effective drug might look like.
Covid-19 research: Anti-viral strategy with double effect
Frankfurt scientists identify a possible weakness of the SARS-CoV-2 virus. They carried out part of their measurements at PSI's Swiss Light Source SLS. The research results are published this week in the scientific journal Nature.
First MX results of the priority COVID-19 call
The Dikic group at the Goethe University in Frankfurt am Main, Germany has published the first results following the opening of the "PRIORITY COVID-19 Call” at SLS.
SLS MX beamtime update
Update of the SLS MX beamline operation during the COVID-19 period
A crystal-clear picture
Fast and accurate data collection for macromolecular crystallography using the JUNGFRAU detector.
First serial femtosecond crystallography (SFX) pilot user experiment at SwissFEL
On the 7th to 12th of August 2018, a collaborative group of scientists from the Paul Scherrer Institute and members of the LeadXpro and Heptares pharmaceutical companies led by Karol Nass (PSI macromolecular crystallography MX-SLS group) performed the first serial femtosecond crystallography (SFX) pilot user experiment at the SwissFEL X-ray free electron laser (XFEL).
Rhine-Knee Regiomeeting 2018
Since it was first established in 1987, the annual Regio-Meeting has been instrumental in facilitating interactions in the structural biology community in southwestern Germany, the eastern region of France and an expanding area of Switzerland. It is set as an informal event to foster young scientists to discuss their research results in an international context. The 2018 edition will take place in the heart of Switzerland in Emmetten from September 26 to 28, 2018. Registration and abstract submission deadline: September 7, 2018.
In Situ Serial Crystallography 2 Workshop at the SLS
A workshop dedicated to the presentation of the in meso in situ serial crystallography (IMISX) method (Huang et al. 2015, 2016 ActaD) for the X-ray structure determination of membrane proteins is organised at the Swiss Light Source at PSI for the second time. It will be held between November 27 and 29, 2017.
Towards understanding of human betacoronavirus HKU1 life cycle
Researchers from China and USA join forces with Swiss Light Source (SLS) macromolecular crystallography (MX) beamline scientists in a study, which aims at understanding an important step in the life cycle of the human betacoronavirus HKU1.
1000 Structures solved at X06DA-PXIII
The macromolecular crystallography beamline X06DA-PXIII has reached 1,000 structures in the Protein Data Bank (PDB) on February 22, 2017.
First protein structure solved using the JUNGFRAU detector!
JUNGFRAU is a charge-integrating, two-dimensional pixel detector developed at the Paul Scherrer Institut for use at free-electron lasers, in particular SwissFEL, and synchrotron light sources. On the 10th October, the first protein crystallography experiment using the JUNGFRAU detector, was performed at the beamline X06SA (PXI) of the Swiss Light Source by the members of the Protein Crystallography and Detectors groups at PSI.
Call for expressions of interest: Beamline partners at the SLS for PX II and PX III
We invite companies and institutions to secure access to the beamlines X10SA/PX II and X06DA/PX III through a long term contract.
Experiment in a hovering droplet
At the PSI, the exact structure of proteins is deciphered in the standard way, with X-rays. Now two PSI researchers have used a clever trick to advance this method further: Instead of pinning down the proteins, they are studying them within a levitating drop of liquid.
First EIGER X 16M in operation at the Swiss Light Source
The macromolecular crystallography beamline X06SA at the Swiss Light Source, a synchrotron operated by Paul Scherrer Institute, is the first one in the world to upgrade its detector to an EIGER X 16M.