Scientific Highlights

Operando radiography

Direct observation of crack formation mechanisms with operando Laser Powder Bed Fusion X-ray radiography

Operando high-speed X-ray radiography experiments reveal the cracking mechanism during 3D laser printing of a Ni superalloy.

COVID call

Priority access call for work on combating COVID-19 continues

On January 30th, 2020, the WHO declared the recent outbreak of coronavirus disease 2019 (COVID-19), a public health emergency of international concern. It declared that there is an urgent need to improve our understanding of the newly identified virus and its possible future evolution as well as to contain the spread; to develop precise diagnostics and treatment, and to improve the public health response and patient care.

The COVID priority access call continues and is still open in 2022.

amb_cu_teaser

Fingerprint of Copper in Peptides Linked to Alzheimer's Disease

In an interdisciplinary project, researchers from the Laboratory of Nanoscale Biology in BIO  and the Laboratory for Condensed Matter in PSD have revealed the reaction between the nitrogen atoms of the amyloid-beta peptide and copper/zinc ions by using soft X-ray absorption spectroscopy.

dual-photocathode laser capabilities and perspectives for exotic FEL modes

Overview of SwissFEL dual-photocathode laser capabilities and perspectives for exotic FEL modes

SwissFEL is a compact, high-brilliance, soft and hard X-ray Free Electron Laser (FEL) facility laser composed of two parallel beam lines seeded by a common linear accelerator (LINAC), and a two-bunch photo-injector. For the injector, an innovative dual-photocathode laser scheme has been developed based on state-of-the-art Ytterbium femtosecond laser systems. We just published an overview of the the SwissFEL Photo Cathode Drive Lasers (PCDL) performance, pulse shaping capabilities as well as the versatility of the systems, which allow many different modes of operation of SwissFEL [1]. The full control over the SwissFEL electron bunch properties via the unique architecture of the PCDL will enable in the future the advent of more advanced FEL modes; these modes are, but not restricted to, the generation of single or trains of sub-fs FEL pulses, multi-color FEL and finally the generation of fully coherent X-ray pulses via laser-based seeding.

Spatially resolved likelihood for glycation of collagen

Glycation of collagen: Quantifying rates

Collagen is abundant in the connective tissue of human beings, e.g. in tendons, ligament and cornea. Glycation of collagen distorts its structure, renders the extracellular matrix stiff and brittle and at the same time lowers the degradation susceptibility thereby preventing renewal. Based on models and with parameters determined from experimental data, we describe the glycation of type 1 collagen in bovine pericardium derived bio-tissues upon incubation in glucose and ribose. We hope that this contributes to a better quantitative understanding of the effects of diabetes on collagen.

Guizar-Sicairos ICO prize ceremony

Dr. Manuel Guizar-Sicairos is awarded ICO prize

Dr. Manuel Guizar-Sicairos, beamline scientist at the cSAXS beamline, is the 2019 recipient of the International Commission for Optics (ICO) Prize. The distinction was awarded in the EOSAM conference in Rome.

nanobodies

Nanobodies against SARS-CoV-2

In a study published in EMBO Journal, researchers at the Max Planck Institute for Biophysical Chemistry, Göttingen, Germany, developed nanobodies that efficiently block the coronavirus SARS-CoV-2 and its variants. The high resolution structural characterization was performed at the X10SA crystallography beamline at the Swiss Light Source.

toc fig nno

Creating novel quantum phases via the heterostructure engineering

Within this synergetic collaboration, PSI scientists have investigated the correlation between magnetic and electronic ordering in NdNiO3 by tuning its properties through proximity to a ferromagnetic manganite layer. The main outcome is that the stray magnetic field from the manganite layer causes a novel ferromagnetic-metallic (FM-M) phase in NNO. This work demonstrates the utilization of heterostructure engineering for creating novel quantum phases.

synchrotronmovies

Synchrotron movies

Prof Philip Willmott, the author of the book 'Introduction to Synchrotron Radiation: techniques and applications' (second edition, John Wiley & Sons, Chichester, 2019. ISBN: 9781119280392), makes the scripts for the simulations and animations available to the public.

SARS-CoV-2_orf9b

Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions

In a study published in Nature Communications, researchers at the NHC Key Laboratory of Systems Biology of Pathogens in Beijing, China, in collaboration with the Paul Scherrer Institut characterize the interactions of SARS-CoV-2 orf9b and human TOM70 biochemically, and they determine the 2.2 Å crystal structure of the TOM70 cytosolic domain with a bound SARS-CoV-2 orf9b peptide.

actacrysta teaser

Application of synchrotron-XRPD to protein powders

Breakthrough applications of high-resolution and high-counting statistics synchrotron X-Ray Powder Diffraction to protein powders leading to the determination of a 1.8 structural model of the pharmaceutical peptide "octreotide" - the highest resolution ever achieved for a peptide of this complexity using X-ray powder diffraction and crystallographic methods.