Scientific Highlights

Collagen is abundant in the connective tissue of human beings, e.g. in tendons, ligament and cornea. Glycation of collagen distorts its structure, renders the extracellular matrix stiff and brittle and at the same time lowers the degradation susceptibility thereby preventing renewal. Based on models and with parameters determined from experimental data, we describe the glycation of type 1 collagen in bovine pericardium derived bio-tissues upon incubation in glucose and ribose. We hope that this contributes to a better quantitative understanding of the effects of diabetes on collagen.

In a study published in EMBO Journal, researchers at the Max Planck Institute for Biophysical Chemistry, Göttingen, Germany, developed nanobodies that efficiently block the coronavirus SARS-CoV-2 and its variants. The high resolution structural characterization was performed at the X10SA crystallography beamline at the Swiss Light Source.

Breakthrough applications of high-resolution and high-counting statistics synchrotron X-Ray Powder Diffraction to protein powders leading to the determination of a 1.8 structural model of the pharmaceutical peptide "octreotide" - the highest resolution ever achieved for a peptide of this complexity using X-ray powder diffraction and crystallographic methods.

Detailed characterization of the tooth and jaw structure and development among shark ancestors by synchrotron based X-ray tomographic microscopy at TOMCAT led an international team of researchers from the Naturalis Biodiversity Center in Leiden and the University of Bristol to the discovery that while teeth evolved once, complex dentitions have been gained and lost many times in evolutionary history.

The compounds known as ‘pyrazinacenes’ are simple, stable compounds that consist of a series of connected nitrogen-containing carbon rings. They are suitable for applications in electrochemistry or synthesis, as the researchers describe in the science journal Communications Chemistry. They were first designed, synthesized and chemically characterized in solution by the Hill team and carefully investigated by Scanning Tunneling Microscopy and Surface Chemical Analysis. The compounds have been shown to reversibly release and accept electrons and arrange themselves differently depending on the oxidation state. Interestingly, the oxidation and reduction reactions of the pyrazinacenes are not only affected by a chemical impulse, but can also be stimulated by light so they can be considered photo-redox active.

High-resolution XRF imaging of the specific metal distribution within wool fibers at the PHOENIX beamline gives insights into traditional oriental dyeing procedures.

During the past decade, scientists have put high effort to achieve sub-10 nm resolution in X-ray microscopy. Recent developments in high-resolution lithography-based diffractive optics, combined with the extreme stability and precision of the PolLux and HERMES scanning X-ray microscopes, resulted now in a so far unreached resolution of seven nanometers in scanning soft X-ray microscopy. Utilizing this highly precise microscopy technique with the X-ray magnetic circular dichroism effect, dimensionality effects in an ensemble of interacting magnetic nanoparticles can be revealed.

In a joint research effort, an international team of scientists lead by Emmanuelle Jal (Sorbonne Université) performed a time-resolved experiment at the FERMI free-electron laser to disclose the dynamic behavior of two magnetic element of a compount material in only one snapshot. The X-ray Optics and Applications group developed a dedicated optical element for this experiment that is usable with two different photon energies (colors) simultaneously.

New research has demonstrated that the secrets of the tiniest active structures in integrated circuits can be revealed using a non-destructive imaging technique. The breakthrough required the efforts of an international team of scientists from JKU and Keysight Technologies (Austria), ETH/EPFL/PSI and IBM Research - Europe (Switzerland) and from UCL (UK).

In topological materials, electrons can display behaviour that is fundamentally different from that in ‘conventional’ matter, and the magnitude of many such ‘exotic’ phenomena is directly proportional to an entity known as the Chern number. New experiments establish for the first time that the theoretically predicted maximum Chern number can be reached — and controlled — in a real material.

Moon-shot missions, such as those of Horizon Europe, require exceptional solutions, and the world-leading Analytical Research Infrastructures of Europe (ARIEs) are one of the key places those solutions can be sought. The ARIE Joint Position Paper highlighting how the common, complementary approach will help address the societal challenges of the Horizon Europe Missions framework programme was presented today.