Noise appears in many areas of science, and commonly has an unwanted and disturbing nature by deteriorating signals’ quality. Therefore, various techniques have been developed over the years for separating noise from pure signals. However, noise has a key role in signal analysis of nuclear reactors as its’ appropriate assessment can be used not only for exploring the normal and dynamic behaviour of nuclear cores, but also for identifying and detecting possible anomalies of reactor systems. State of the art methods have been recently implemented within the well-established signal analysis methodology of the STARS program, at the Laboratory for Reactor Physics and Thermal-Hydraulics (LRT), for investigating nuclear reactor noise and getting a better insight on analysing reactors’ operation.