The Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences within Switzerland. We perform cutting-edge research in the fields of future technologies, energy and climate, health innovation and fundamentals of nature. By performing fundamental and applied research, we work on sustainable solutions for major challenges facing society, science and economy. PSI is committed to the training of future generations. Therefore, about one quarter of our staff are post-docs, post-graduates or apprentices. Altogether, PSI employs 2300 people.

The team is highly interdisciplinary, combining X-ray techniques (such as SAXS, spectroscopy, and imaging through the Swiss Light Source and other synchrotron facilities), cryo-EM, and single nanopore methods to investigate the dynamics, nanoclusters, and aggregation of neurodegeneration-related proteins both in vitro and in C. elegans. While traditionally focused on experimental in vitro characterization, we have expanded to include in vitro and in vivo correlation studies. This now incorporates C. elegans and mammalian cells as models, utilizing RNAi to explore the potential of molecular glue for amyloid protein degradation. Training in the team represents the emerging paradigm of mechanistic biophysics, integrating in vitro and in vivo approaches, large-scale facilities, and unique nanopore techniques.


Our group is situated within the Center for Life Sciences at PSI, providing access to state-of-the-art facilities in high-performance computing, cryo-EM, single-nanopore sensing, mass spectrometry, and a variety of other biophysical instruments. 

 For the Nanodiffraction group we are looking for a

Postdoctoral Fellow

Apply online now

Your tasks

This role focuses on creating the next generation of molecular glues through in vitro biophysical techniques using C. elegans or cell models to investigate their potential for protein degradation. While experience with C. elegans and mammalian cell models in neurodegeneration research is highly desirable, training in X-ray techniques, cryo-EM, and other biophysical methods will be provided. The project is integral to collaborations with various institutions and companies, combining in vitro screening and characterization with C. elegans and mammalian cell models within our lab.

Your profile

  • A Ph.D. in Biochemistry, Biophysics, Cell Biology, or a related field 
  • Experience in expressing and purifying amyloid proteins, including biochemical and biophysical characterization 
  • Strong analytical and critical thinking skills for addressing complex scientific challenges
  • Excellent organizational skills and attention to detail
  • A passion for scientific research with a proactive approach to new challenges
  • Ability to work independently and collaboratively as part of a team
  • Actively contributes to a supportive and engaging lab environment by participating in meetings and events
  • Preferably experienced with C. elegans and mammalian cell models for neurodegeneration studies
  • Preferably experienced with X-ray, cryo-EM, or fluorescence methods for neurodegeneration studies
  • Strong communication skills
  • Dedicated and motivated postdoctoral fellow who contributes to our cutting-edge research on the development of novel molecular glues

We offer

Our institution is based on an interdisciplinary, innovative and dynamic collaboration. You will profit from a systematic training on the job, in addition to personal development possibilities and our pronounced vocational training culture. If you wish to optimally combine work and family life or other personal interests, we are able to support you with our modern employment conditions and the on-site infrastructure.

Your employment contract is limited to 2 years.

For further information, please contact Dr. Jinghui Luo, phone +41 56 310 47 64.


Please submit your application online by 31. March 2025 (including list of publications and addresses of referees) for the position as a Postdoctoral Fellow (index no. 2411-02).


Paul Scherrer Institute, Human Resources Management, Mariusz Prus, 5232 Villigen PSI, Switzerland