Publikationen

2024

  • Albertini F, Czerska K, Vazquez M, Andaca I, Bachtiary B, Besson R, et al.
    First clinical implementation of a highly efficient daily online adapted proton therapy (DAPT) workflow
    Physics in Medicine and Biology. 2024; 69(21): 205030 (17 pp.). https://doi.org/10.1088/1361-6560/ad7cbd
    DORA PSI
  • Almeida A, Togno M, Ballesteros-Zebadua P, Franco-Perez J, Geyer R, Schaefer R, et al.
    Dosimetric and biologic intercomparison between electron and proton FLASH beams
    Radiotherapy and Oncology. 2024; 190: 109953 (8 pp.). https://doi.org/10.1016/j.radonc.2023.109953
    DORA PSI
  • Amstutz F, Krcek R, Bachtiary B, Weber DC, Lomax AJ, Unkelbach J, et al.
    Treatment planning comparison for head and neck cancer between photon, proton, and combined proton-photon therapy - from a fixed beam line to an arc
    Radiotherapy and Oncology. 2024; 190: 109973 (10 pp.). https://doi.org/10.1016/j.radonc.2023.109973
    DORA PSI
  • Amstutz F, D'Almeida PG, Wu X, Albertini F, Bachtiary B, Weber DC, et al.
    Quantification of deformable image registration uncertainties for dose accumulation on head and neck cancer proton treatments
    Physica Medica. 2024; 122: 103386 (10 pp.). https://doi.org/10.1016/j.ejmp.2024.103386
    DORA PSI
  • Bobić M, Choulilitsa E, Lee H, Czerska K, Christensen JB, Mayor A, et al.
    Multi-institutional experimental validation of online adaptive proton therapy workflows
    Physics in Medicine and Biology. 2024; 69(16): 165021 (15 pp.). https://doi.org/10.1088/1361-6560/ad6527
    DORA PSI
  • Bobić M, Christensen JB, Lee H, Choulilitsa E, Czerska K, Togno M, et al.
    Optically stimulated luminescence dosimeters for simultaneous measurement of point dose and dose-weighted LET in an adaptive proton therapy workflow
    Frontiers in Oncology. 2024; 13: 1333039 (11 pp.). https://doi.org/10.3389/fonc.2023.1333039
    DORA PSI
  • Björkman D, Via R, Lomax A, De Prado M, Baroni G, Weber DC, et al.
    The effect of intra- and inter-fractional motion on target coverage and margins in proton therapy for uveal melanoma
    Physics in Medicine and Biology. 2024; 69(21): 215038 (14 pp.). https://doi.org/10.1088/1361-6560/ad8297
    DORA PSI
  • Bolsi A, De Angelis C, Vázquez M, Siewert D, Correia D, Bachmann N, et al.
    Craniospinal irradiation using pencil beam scanning: the PSI experience
    Physica Medica. 2024; 127: 104817 (13 pp.). https://doi.org/10.1016/j.ejmp.2024.104817
    DORA PSI
  • Duetschler A, Safai S, Weber DC, Lomax AJ, Zhang Y
    The impact of motion on onboard MRI-guided pencil beam scanned proton therapy treatments
    Physics in Medicine and Biology. 2024; 69(9): 095003 (13 pp.). https://doi.org/10.1088/1361-6560/ad3885
    DORA PSI
  • Jenny T, Duetschler A, Giger A, Pusterla O, Safai S, Weber DC, et al.
    Technical note: towards more realistic 4DCT(MRI) numerical lung phantoms
    Medical Physics. 2024; 51(1): 579-590. https://doi.org/10.1002/mp.16451
    DORA PSI
  • Li X, Bellotti R, Bachtiary B, Hrbacek J, Weber DC, Lomax AJ, et al.
    A unified generation-registration framework for improved MR-based CT synthesis in proton therapy
    Medical Physics. 2024; 51(11): 8302-8316. https://doi.org/10.1002/mp.17338
    DORA PSI
  • Lundberg M, Meijers A, Souris K, Deffet S, Weber DC, Lomax A, et al.
    Technical note: development of a simulation framework, enabling the investigation of locally tuned single energy proton radiography
    Biomedical Physics and Engineering Express. 2024; 10(2): 027002 (9 pp.). https://doi.org/10.1088/2057-1976/ad20a8
    DORA PSI
  • Meijers A, Daartz J, Knopf AC, van Heerden M, Bizzocchi N, Vazquez MV, et al.
    Possible association of dose rate and the development of late visual toxicity for patients with intracranial tumours treated with pencil beam scanned proton therapy
    Radiation Oncology. 2024; 19(1): 75 (9 pp.). https://doi.org/10.1186/s13014-024-02464-z
    DORA PSI
  • Missimer JH, Emert F, Lomax AJ, Weber DC
    Automatic lung segmentation of magnetic resonance images: a new approach applied to healthy volunteers undergoing enhanced Deep-Inspiration-Breath-Hold for motion-mitigated 4D proton therapy of lung tumors
    Physics and Imaging in Radiation Oncology. 2024; 29: 100531 (7 pp.). https://doi.org/10.1016/j.phro.2024.100531
    DORA PSI
  • Smolders A, Czerska K, Celicanin Z, Lomax A, Albertini F
    The influence of daily imaging and target margin reduction on secondary cancer risk in image-guided and adaptive proton therapy
    Physics in Medicine and Biology. 2024; 69(22): 225004 (14 pp.). https://doi.org/10.1088/1361-6560/ad8da3
    DORA PSI
  • Smolders A, Rivetti L, Vatterodt N, Korreman S, Lomax A, Sharma M, et al.
    DiffuseRT: predicting likely anatomical deformations of patients undergoing radiotherapy
    Physics in Medicine and Biology. 2024; 69(15): 155016 (16 pp.). https://doi.org/10.1088/1361-6560/ad61b7
    DORA PSI
  • Smolders A, Bengtsson I, Forsgren A, Lomax A, Weber DC, Fredriksson A, et al.
    Robust optimization strategies for contour uncertainties in online adaptive radiation therapy
    Physics in Medicine and Biology. 2024; 69(16): 165001 (17 pp.). https://doi.org/10.1088/1361-6560/ad6526
    DORA PSI

2023

  • Actis O, Mayor A, Meer D, Rechsteiner U, Bolsi A, Lomax AJ, et al.
    A bi-directional beam-line energy ramping for efficient patient treatment with scanned proton therapy
    Physics in Medicine and Biology. 2023; 68(17): 175001 (12 pp.). https://doi.org/10.1088/1361-6560/acebb2
    DORA PSI
  • Bachtiary B, Grawehr L, Grillo Ruggieri F, Held U, Weber DC
    Financial toxicity in Swiss Cancer patients treated with proton therapy: an observational cross-sectional study on self-reported outcome
    Cancers. 2023; 15(23): 5498 (15 pp.). https://doi.org/10.3390/cancers15235498
    DORA PSI
  • Challa K, Paysan D, Leiser D, Sauder N, Weber DC, Shivashankar GV
    Imaging and AI based chromatin biomarkers for diagnosis and therapy evaluation from liquid biopsies
    npj Precision Oncology. 2023; 7: 135 (13 pp.). https://doi.org/10.1038/s41698-023-00484-8
    DORA PSI
  • Duetschler A, Prendi J, Safai S, Weber DC, Lomax AJ, Zhang Y
    Limitations of phase-sorting based pencil beam scanned 4D proton dose calculations under irregular motion
    Physics in Medicine and Biology. 2023; 68(1): 015015 (17 pp.). https://doi.org/10.1088/1361-6560/aca9b6
    DORA PSI
  • Duetschler A, Huang L, Fattori G, Meier G, Bula C, Hrbacek J, et al.
    A motion model-guided 4D dose reconstruction for pencil beam scanned proton therapy
    Physics in Medicine and Biology. 2023; 68(11): 115013 (19 pp.). https://doi.org/10.1088/1361-6560/acd518
    DORA PSI
  • Duetschler A, Winterhalter C, Meier G, Safai S, Weber DC, Lomax AJ, et al.
    A fast analytical dose calculation approach for MRI-guided proton therapy
    Physics in Medicine and Biology. 2023; 68(19): 195020 (17 pp.). https://doi.org/10.1088/1361-6560/acf90d
    DORA PSI
  • Ehwald J, Togno M, Lomax AJ, Weber DC, Safai S, Winterhalter C
    Detailed Monte-Carlo characterization of a Faraday cup for proton therapy
    Medical Physics. 2023; 50(9): 5828-5841. https://doi.org/10.1002/mp.16464
    DORA PSI
  • García-Marqueta M, Vázquez M, Krcek R, Kliebsch UL, Baust K, Leiser D, et al.
    Quality of life, clinical, and patient-reported outcomes after pencil Beam Scanning Proton Therapy delivered for intracranial grade WHO 1–2 meningioma in children and adolescents
    Cancers. 2023; 15(18): 4447 (18 pp.). https://doi.org/10.3390/cancers15184447
    DORA PSI
  • Giovannelli AC, Köthe A, Safai S, Meer D, Zhang Y, Weber DC, et al.
    Exploring beamline momentum acceptance for tracking respiratory variability in lung cancer proton therapy: a simulation study
    Physics in Medicine and Biology. 2023; 68(19): 195013 (10 pp.). https://doi.org/10.1088/1361-6560/acf5c4
    DORA PSI
  • Krcek R, Leiser D, García-Marqueta M, Bolsi A, Weber DC
    Long term outcome and quality of life of intracranial meningioma patients treated with pencil beam scanning proton therapy
    Cancers. 2023; 15(12): 3099 (17 pp.). https://doi.org/10.3390/cancers15123099
    DORA PSI
  • Li X, Bellotti R, Meier G, Bachtiary B, Weber D, Lomax A, et al.
    Uncertainty-aware MR-based CT synthesis for robust proton therapy planning of brain tumour
    Radiotherapy and Oncology. 2024; 191: 110056 (9 pp.). https://doi.org/10.1016/j.radonc.2023.110056
    DORA PSI
  • Maradia V, Meer D, Dölling R, Weber DC, Lomax AJ, Psoroulas S
    Demonstration of momentum cooling to enhance the potential of cancer treatment with proton therapy
    Nature Physics. 2023; 19: 1437-1444. https://doi.org/10.1038/s41567-023-02115-2
    DORA PSI
  • Motta S, Christensen JB, Togno M, Schäfer R, Safai S, Lomax AJ, et al.
    Characterization of LiF:Mg,Ti thermoluminescence detectors in low-LET proton beams at ultra-high dose rates
    Physics in Medicine and Biology. 2023; 68(4): 045017 (13 pp.). https://doi.org/10.1088/1361-6560/acb634
    DORA PSI
  • Peteani G, Paganelli C, Giovannelli AC, Bachtiary B, Safai S, Rogers S, et al.
    Retrospective reconstruction of four-dimensional magnetic resonance from interleaved cine imaging – A comparative study with four-dimensional computed tomography in the lung
    Physics and Imaging in Radiation Oncology. 2024; 29: 100529 (7 pp.). https://doi.org/10.1016/j.phro.2023.100529
    DORA PSI
  • Pica A, Weber DC, Schweizer C, Chaouch A, Zografos L, Schalenbourg A
    Clinical outcomes in AYAs (adolescents and young adults) treated with proton therapy for uveal melanoma: a comparative matching study with elder adults
    Cancers. 2023; 15(18): 4652 (13 pp.). https://doi.org/10.3390/cancers15184652
    DORA PSI
  • Schaefer R, Psoroulas S, Weber DC
    In situ correction of recombination effects in ultra-high dose rate irradiations with protons
    Physics in Medicine and Biology. 2023; 68(10): 105013 (11 pp.). https://doi.org/10.1088/1361-6560/accf5c
    DORA PSI
  • Smolders A, Hengeveld AC, Both S, Wijsman R, Langendijk JA, Weber DC, et al.
    Inter- and intrafractional 4D dose accumulation for evaluating ΔNTCP robustness in lung cancer
    Radiotherapy and Oncology. 2023; 182: 109488 (6 pp.). https://doi.org/10.1016/j.radonc.2023.109488
    DORA PSI
  • Smolders A, Lomax A, Weber DC, Albertini F
    Patient-specific neural networks for contour propagation in online adaptive radiotherapy
    Physics in Medicine and Biology. 2023; 68(9): 095010 (12 pp.). https://doi.org/10.1088/1361-6560/accaca
    DORA PSI
  • Smolders A, Choulilitsa E, Czerska K, Bizzocchi N, Krcek R, Lomax A, et al.
    Dosimetric comparison of autocontouring techniques for online adaptive proton therapy
    Physics in Medicine and Biology. 2023; 68(17): 175006 (13 pp.). https://doi.org/10.1088/1361-6560/ace307
    DORA PSI
  • Smolders A, Lomax A, Weber DC, Albertini F
    Deep learning based uncertainty prediction of deformable image registration for contour propagation and dose accumulation in online adaptive radiotherapy
    Physics in Medicine and Biology. 2023; 68(24): 245027 (19 pp.). https://doi.org/10.1088/1361-6560/ad0282
    DORA PSI
  • Vázquez M, Bachmann N, Pica A, Bolsi A, De Angelis C, Lomax AJ, et al.
    Early outcome after craniospinal irradiation with pencil beam scanning proton therapy for children, adolescents and young adults with brain tumors
    Pediatric Blood & Cancer. 2023; 70(2): e30087 (8 pp.). https://doi.org/10.1002/pbc.30087
    DORA PSI
  • Vázquez M, Baust K, Ilundain A, Leiser D, Bachtiary B, Pica A, et al.
    Pencil beam scanning proton therapy for adolescents and young adults with head and neck sarcomas
    International Journal of Particle Therapy. 2023; 10(2): 73-84. https://doi.org/10.14338/IJPT-23-00010.1
    DORA PSI
  • Walser MA, Bachmann N, Kluckert J, Köthe A, Tully C, Leiser D, et al.
    Clinical outcome after pencil beam scanning proton therapy and dysphagia/xerostomia NTCP calculations of proton and photon radiotherapy delivered to patients with cancer of the major salivary glands
    British Journal of Radiology. 2023; 96(1148): 20220672 (9 pp.). https://doi.org/10.1259/bjr.20220672
    DORA PSI
  • Willmann J, Leiser D, Weber DC
    Oncological outcomes, long-term toxicities, quality of life and sexual health after pencil-beam scanning proton therapy in patients with low-grade glioma
    Cancers. 2023; 15(21): 5287 (16 pp.). https://doi.org/10.3390/cancers15215287
    DORA PSI
  • Wu X, Amstutz F, Weber DC, Unkelbach J, Lomax AJ, Zhang Y
    Patient-specific quality assurance for deformable IMRT/IMPT dose accumulation: proposition and validation of energy conservation based validation criterion
    Medical Physics. 2023; 50(11): 7130-7138. https://doi.org/10.1002/mp.16564
    DORA PSI
  • Zhang Y, Trnkova P, Toshito T, Heijmen B, Richter C, Aznar M, et al.
    A survey of practice patterns for real-time intrafractional motion-management in particle therapy
    Physics and Imaging in Radiation Oncology. 2023; 26: 100439 (7 pp.). https://doi.org/10.1016/j.phro.2023.100439
    DORA PSI

2022

  • Amstutz F, Fabiano S, Marc L, Weber DC, Lomax AJ, Unkelbach J, et al.
    Combined proton‐photon therapy for non‐small cell lung cancer
    Medical Physics. 2022; 49(8): 5374-5386. https://doi.org/10.1002/mp.15715
    DORA PSI
  • Bachmann N, Leiser D, Pica A, Bachtiary B, Weber DC
    Clinical outcome after pencil beam scanning proton therapy of patients with non-metastatic malignant and benign peripheral nerve sheath tumors
    Frontiers in Oncology. 2022; 12: 881665 (10 pp.). https://doi.org/10.3389/fonc.2022.881665
    DORA PSI
  • Bachtiary B, Veraguth D, Roos N, Pfiffner F, Leiser D, Pica A, et al.
    Hearing loss in cancer patients with skull base tumors undergoing pencil beam scanning proton therapy: a retrospective cohort study
    Cancers. 2022; 14(16): 3853 (11 pp.). https://doi.org/10.3390/cancers14163853
    DORA PSI
  • Bertschi S, Krieger M, Weber DC, Lomax AJ, van de Water S
    Impact of spot reduction on the effectiveness of rescanning in pencil beam scanned proton therapy for mobile tumours
    Physics in Medicine and Biology. 2022; 67(21): 215019 (13 pp.). https://doi.org/10.1088/1361-6560/ac96c5
    DORA PSI
  • Christensen JB, Togno M, Bossin L, Pakari OV, Safai S, Yukihara EG
    Improved simultaneous LET and dose measurements in proton therapy
    Scientific Reports. 2022; 12(1): 8262 (10 pp.). https://doi.org/10.1038/s41598-022-10575-4
    DORA PSI
  • Duetschler A, Bauman G, Bieri O, Cattin PC, Ehrbar S, Engin-Deniz G, et al.
    Synthetic 4DCT(MRI) lung phantom generation for 4D radiotherapy and image guidance investigations
    Medical Physics. 2022; 49(5): 2890-2903. https://doi.org/10.1002/mp.15591
    DORA PSI
  • Fattori G, Hrbacek J, Regele H, Bula C, Mayor A, Danuser S, et al.
    Commissioning and quality assurance of a novel solution for respiratory-gated PBS proton therapy based on optical tracking of surface markers
    Zeitschrift für Medizinische Physik. 2022; 3(1): 52-62. https://doi.org/10.1016/j.zemedi.2020.07.001
    DORA PSI
  • Gerken LRH, Gogos A, Starsich FHL, David H, Gerdes ME, Schiefer H, et al.
    Catalytic activity imperative for nanoparticle dose enhancement in photon and proton therapy
    Nature Communications. 2022; 13(1): 3248 (14 pp.). https://doi.org/10.1038/s41467-022-30982-5
    DORA PSI
  • Giovannelli AC, Maradia V, Meer D, Safai S, Psoroulas S, Togno M, et al.
    Beam properties within the momentum acceptance of a clinical gantry beamline for proton therapy
    Medical Physics. 2022; 49(3): 1417-1431. https://doi.org/10.1002/mp.15449
    DORA PSI
  • Hoffmann L, Mortensen H, Shamshad M, Berbee M, Bizzocchi N, Bütof R, et al.
    Treatment planning comparison in the PROTECT-trial randomising proton versus photon beam therapy in oesophageal cancer: results from eight European centres
    Radiotherapy and Oncology. 2022; 172: 32-41. https://doi.org/10.1016/j.radonc.2022.04.029
    DORA PSI
  • Kacem H, Psoroulas S, Boivin G, Folkerts M, Grilj V, Lomax T, et al.
    Comparing radiolytic production of H2O2 and development of zebrafish embryos after ultra high dose rate exposure with electron and transmission proton beams
    Radiotherapy and Oncology. 2022; 175: 197-202. https://doi.org/10.1016/j.radonc.2022.07.011
    DORA PSI
  • Köthe A, Lomax AJ, Giovannelli AC, Safai S, Bizzocchi N, Roelofs E, et al.
    The impact of organ motion and the appliance of mitigation strategies on the effectiveness of hypoxia-guided proton therapy for non-small cell lung cancer
    Radiotherapy and Oncology. 2022; 176: 208-214. https://doi.org/10.1016/j.radonc.2022.09.021
    DORA PSI
  • Krieger M, van de Water S, Folkerts MM, Mazal A, Fabiano S, Bizzocchi N, et al.
    A quantitative FLASH effectiveness model to reveal potentials and pitfalls of high dose rate proton therapy
    Medical Physics. 2022; 49(3): 2026-2038. https://doi.org/10.1002/mp.15459
    DORA PSI
  • Maradia V, Giovannelli AC, Meer D, Weber DC, Lomax AJ, Schippers JM, et al.
    Increase of the transmission and emittance acceptance through a cyclotron-based proton therapy gantry
    Medical Physics. 2022; 49(4): 2183-2192. https://doi.org/10.1002/mp.15505
    DORA PSI
  • Maradia V, van de Water S, Meer D, Weber DC, Lomax AJ, Psoroulas S
    Ultra-fast pencil beam scanning proton therapy for locally advanced non-small-cell lung cancers: field delivery within a single breath-hold
    Radiotherapy and Oncology. 2022; 174: 23-29. https://doi.org/10.1016/j.radonc.2022.06.018
    DORA PSI
  • Maradia V, Colizzi I, Meer D, Weber DC, Lomax AJ, Actis O, et al.
    Universal and dynamic ridge filter for pencil beam scanning particle therapy: a novel concept for ultra-fast treatment delivery
    Physics in Medicine and Biology. 2022; 67(22): 225005 (12 pp.). https://doi.org/10.1088/1361-6560/ac9d1f
    DORA PSI
  • McNamara K, Schiavi A, Borys D, Brzezinski K, Gajewski J, Kopeć R, et al.
    GPU accelerated Monte Carlo scoring of positron emitting isotopes produced during proton therapy for PET verification
    Physics in Medicine and Biology. 2022; 67(24): 244001 (14 pp.). https://doi.org/10.1088/1361-6560/aca515
    DORA PSI
  • Nesteruk KP, Bobić M, Sharp GC, Lalonde A, Winey BA, Nenoff L, et al.
    Low-dose computed tomography scanning protocols for online adaptive proton therapy of head-and-neck cancers
    Cancers. 2022; 14(20): 5155 (14 pp.). https://doi.org/10.3390/cancers14205155
    DORA PSI
  • Schröder C, Köthe A, De Angelis C, Basler L, Fattori G, Safai S, et al.
    NTCP modelling for high-grade temporal radionecrosis in a large cohort of patients receiving pencil beam scanning proton therapy for skull base and head and neck tumors
    International Journal of Radiation Oncology Biology Physics. 2022; 113(2): 448-455. https://doi.org/10.1016/j.ijrobp.2022.01.047
    DORA PSI
  • Togno M, Nesteruk KP, Schäfer R, Psoroulas S, Meer D, Grossmann M, et al.
    Ultra-high dose rate dosimetry for pre-clinical experiments with mm-small proton fields
    Physica Medica. 2022; 104: 101-111. https://doi.org/10.1016/j.ejmp.2022.10.019
    DORA PSI
  • Via R, Pica A, Antonioli L, Paganelli C, Fattori G, Spaccapaniccia C, et al.
    MRI and FUNDUS image fusion for improved ocular biometry in Ocular Proton Therapy
    Radiotherapy and Oncology. 2022; 174: 16-22. https://doi.org/10.1016/j.radonc.2022.06.021
    DORA PSI
  • Weber DC, Beer J, Kliebsch UL, Teske C, Baust K, Walser M, et al.
    Quality-of-life evaluations in children and adolescents with Ewing sarcoma treated with pencil-beam-scanning proton therapy
    Pediatric Blood & Cancer. 2022; 69(12): e29956 (8 pp.). https://doi.org/10.1002/pbc.29956
    DORA PSI

2021

  • Amstutz F, Nenoff L, Albertini F, Ribeiro CO, Knopf AC, Unkelbach J, et al.
    An approach for estimating dosimetric uncertainties in deformable dose accumulation in pencil beam scanning proton therapy for lung cancer
    Physics in Medicine and Biology. 2021; 66(10): 105007 (12 pp.). https://doi.org/10.1088/1361-6560/abf8f5
    DORA PSI
  • Christensen JB, Togno M, Nesteruk KP, Psoroulas S, Meer D, Weber DC, et al.
    Al2O3:C optically stimulated luminescence dosimeters (OSLDs) for ultra-high dose rate proton dosimetry
    Physics in Medicine and Biology. 2021; 66(8): 085003 (11 pp.). https://doi.org/10.1088/1361-6560/abe554
    DORA PSI
  • Emert F, Missimer J, Eichenberger PA, Walser M, Gmür C, Lomax AJ, et al.
    Enhanced-deep-inspiration breath hold superior to high-frequency percussive ventilation for respiratory motion mitigation: a physiology-driven, MRI-guided assessment towards optimized lung cancer treatment with proton therapy
    Frontiers in Oncology. 2021; 11: 621350 (17 pp.). https://doi.org/10.3389/fonc.2021.621350
    DORA PSI
  • Fattori G, Lomax AJ, Weber DC, Safai S
    Technical assessment of the NDI Polaris Vega optical tracking system
    Radiation Oncology. 2021; 16(1): 87 (4 pp.). https://doi.org/10.1186/s13014-021-01804-7
    DORA PSI
  • Gut P, Krieger M, Lomax T, Weber DC, Hrbacek J
    Combining rescanning and gating for a time-efficient treatment of mobile tumors using pencil beam scanning proton therapy
    Radiotherapy and Oncology. 2021; 160: 82-89. https://doi.org/10.1016/j.radonc.2021.03.041
    DORA PSI
  • Köthe A, Bizzocchi N, Safai S, Lomax AJ, Weber DC, Fattori G
    Investigating the potential of proton therapy for hypoxia-targeted dose escalation in non-small cell lung cancer
    Radiation Oncology. 2021; 16(1): 199 (10 pp.). https://doi.org/10.1186/s13014-021-01914-2
    DORA PSI
  • Köthe A, van Luijk P, Safai S, Kountouri M, Lomax AJ, Weber DC, et al.
    Combining clinical and dosimetric features in a PBS proton therapy cohort to develop a NTCP model for radiation-induced optic neuropathy
    International Journal of Radiation Oncology Biology Physics. 2021; 110(2): 587-595. https://doi.org/10.1016/j.ijrobp.2020.12.052
    DORA PSI
  • Köthe A, Feuvret L, Weber DC, Safai S, Lomax AJ, Fattori G
    Assessment of radiation-induced optic neuropathy in a multi-institutional cohort of chordoma and chondrosarcoma patients treated with proton therapy
    Cancers. 2021; 13(21): 5327 (12 pp.). https://doi.org/10.3390/cancers13215327
    DORA PSI
  • Krieger M, Giger A, Jud C, Duetschler A, Salomir R, Bieri O, et al.
    Liver-ultrasound-guided lung tumour tracking for scanned proton therapy: a feasibility study
    Physics in Medicine and Biology. 2021; 66(3): 035011 (14 pp.). https://doi.org/10.1088/1361-6560/abcde6
    DORA PSI
  • Kroeze SGC, Mackeprang PH, De Angelis C, Pica A, Bachtiary B, Kliebsch UL, et al.
    A prospective study on health-related quality of life and patient-reported outcomes in adult brain tumor patients treated with pencil beam scanning proton therapy
    Cancers. 2021; 13(19): 4892 (13 pp.). https://doi.org/10.3390/cancers13194892
    DORA PSI
  • Maradia V, Meer D, Weber DC, Lomax AJ, Schippers JM, Psoroulas S
    A new emittance selection system to maximize beam transmission for low-energy beams in cyclotron-based proton therapy facilities with gantry
    Medical Physics. 2021; 48(12): 7613-7622. https://doi.org/10.1002/mp.15278
    DORA PSI
  • Marinkovic M, Pors LJ, van den Berg V, Peters FP, Schalenbourg A, Zografos L, et al.
    Clinical outcomes after international referral of uveal melanoma patients for proton therapy
    Cancers. 2021; 13(24): 6241 (13 pp.). https://doi.org/10.3390/cancers13246241
    DORA PSI
  • Nenoff L, Matter M, Amaya EJ, Josipovic M, Knopf A-C, Lomax AJ, et al.
    Dosimetric influence of deformable image registration uncertainties on propagated structures for online daily adaptive proton therapy of lung cancer patients
    Radiotherapy and Oncology. 2021; 159: 136-143. https://doi.org/10.1016/j.radonc.2021.03.021
    DORA PSI
  • Nenoff L, Matter M, Charmillot M, Krier S, Uher K, Weber DC, et al.
    Experimental validation of daily adaptive proton therapy
    Physics in Medicine and Biology. 2021; 66(20): 205010 (14 pp.). https://doi.org/10.1088/1361-6560/ac2b84
    DORA PSI
  • Nesteruk KP, Bolsi A, Lomax AJ, Meer D, Van De Water S, Schippers JM
    A static beam delivery device for fast scanning proton arc-therapy
    Physics in Medicine and Biology. 2021; 66(5): 055018 (15 pp.). https://doi.org/10.1088/1361-6560/abe02b
    DORA PSI
  • Nesteruk KP, Psoroulas S
    Flash irradiation with proton beams: Beam characteristics and their implications for beam diagnostics
    Applied Sciences. 2021; 11(5): 2170 (11 pp.). https://doi.org/10.3390/app11052170
    DORA PSI
  • Nesteruk KP, Togno M, Grossmann M, Lomax AJ, Weber DC, Schippers JM, et al.
    Commissioning of a clinical pencil beam scanning proton therapy unit for ultra-high dose rates (FLASH)
    Medical Physics. 2021; 48(7): 4017-4026. https://doi.org/10.1002/mp.14933
    DORA PSI
  • Nesteruk KP, Bobić M, Lalonde A, Winey BA, Lomax AJ, Paganetti H
    Ct-on-rails versus in-room cbct for online daily adaptive proton therapy of head-and-neck cancers
    Cancers. 2021; 13(23): 5991 (13 pp.). https://doi.org/10.3390/cancers13235991
    DORA PSI
  • Paganetti H, Beltran C, Both S, Dong L, Flanz J, Furutani K, et al.
    Roadmap: proton therapy physics and biology
    Physics in Medicine and Biology. 2021; 66(5): 05RM01 (61 pp.). https://doi.org/10.1088/1361-6560/abcd16
    DORA PSI
  • Spaccapaniccia C, Via R, Thominet V, Liffey A, Baroni G, Pica A, et al.
    Non-invasive recognition of eye torsion through optical imaging of the iris pattern in ocular proton therapy
    Physics in Medicine and Biology. 2021; 66(13): 135014 (13 pp.). https://doi.org/10.1088/1361-6560/ac0afb
    DORA PSI
  • Speleers B, Schoepen M, Belosi F, Vakaet V, De Neve W, Deseyne P, et al.
    Effects of deep inspiration breath hold on prone photon or proton irradiation of breast and regional lymph nodes
    Scientific Reports. 2021; 11(1): 6085 (11 pp.). https://doi.org/10.1038/s41598-021-85401-4
    DORA PSI
  • Walser M, Bojaxhiu B, Kawashiro S, Tran S, Beer J, Leiser D, et al.
    Clinical outcome of sacral chordoma patients treated with pencil beam scanning proton therapy
    Clinical Oncology. 2021; 33(12): 578-585. https://doi.org/10.1016/j.clon.2021.07.012
    DORA PSI
  • Winterhalter C, Togno M, Nesteruk KP, Emert F, Psoroulas S, Vidal M, et al.
    Faraday cup for commissioning and quality assurance for proton pencil beam scanning beams at conventional and ultra-high dose rates
    Physics in Medicine and Biology. 2021; 66(12): 124001 (10 pp.). https://doi.org/10.1088/1361-6560/abfbf2
    DORA PSI

2020

  • Basler L, Poel R, Schröder C, Bolsi A, Lomax A, Tanadini-Lang S, et al.
    Dosimetric analysis of local failures in skull-base chordoma and chondrosarcoma following pencil beam scanning proton therapy
    Radiation Oncology. 2020; 15(1): 266 (10 pp.). https://doi.org/10.1186/s13014-020-01711-3
    DORA PSI
  • Beer J, Kountouri M, Kole AJ, Murray FR, Leiser D, Kliebsch U, et al.
    Outcomes, prognostic factors and salvage treatment for recurrent chordoma after pencil beam scanning proton therapy at the Paul Scherrer Institute
    Clinical Oncology. 2020; 32(8): 537-544. https://doi.org/10.1016/j.clon.2020.03.002
    DORA PSI
  • Bolsi A, Placidi L, Pica A, Ahlhelm FJ, Walser M, Lomax AJ, et al.
    Pencil beam scanning proton therapy for the treatment of craniopharyngioma complicated with radiation-induced cerebral vasculopathies: a dosimetric and linear energy transfer (LET) evaluation
    Radiotherapy and Oncology. 2020; 149: 197-204. https://doi.org/10.1016/j.radonc.2020.04.052
    DORA PSI
  • Colvill E, Krieger M, Bosshard P, Steinacher P, Rohrer Schnidrig BA, Parkel T, et al.
    Anthropomorphic phantom for deformable lung and liver CT and MR imaging for radiotherapy
    Physics in Medicine and Biology. 2020; 65(7): 07NT02 (10 pp.). https://doi.org/10.1088/1361-6560/ab7508
    DORA PSI
  • Dominietto M, Pica A, Safai S, Lomax AJ, Weber DC, Capobianco E
    Role of complex networks for integrating medical images and radiomic features of intracranial ependymoma patients in response to proton radiotherapy
    Frontiers in Medicine. 2020; 6: 333 (13 pp.). https://doi.org/10.3389/fmed.2019.00333
    DORA PSI
  • Fattori G, Zhang Y, Meer D, Weber DC, Lomax AJ, Safai S
    The potential of Gantry beamline large momentum acceptance for real time tumour tracking in pencil beam scanning proton therapy
    Scientific Reports. 2020; 10(1): 15325 (13 pp.). https://doi.org/10.1038/s41598-020-71821-1
    DORA PSI
  • Fattori G, Hrbacek J, Regele H, Bula C, Mayor A, Danuser S, et al.
    Commissioning and quality assurance of a novel solution for respiratory-gated PBS proton therapy based on optical tracking of surface markers
    Zeitschrift für Medizinische Physik. 2022; 3(1): 52-62. https://doi.org/10.1016/j.zemedi.2020.07.001
    DORA PSI
  • Giger A, Krieger M, Jud C, Duetschler A, Salomir R, Bieri O, et al.
    Liver-ultrasound based motion modelling to estimate 4D dose distributions for lung tumours in scanned proton therapy
    Physics in Medicine and Biology. 2020; 65(23): 235050 (12 pp.). https://doi.org/10.1088/1361-6560/abaa26
    DORA PSI
  • Grau C, Durante M, Georg D, Langendijk JA, Weber DC
    Particle therapy in Europe
    Molecular Oncology. 2020; 14(7): 1492-1499. https://doi.org/10.1002/1878-0261.12677
    DORA PSI
  • Hottinger A-L, Bojaxhiu B, Ahlhelm F, Walser M, Bachtiary B, Zepter S, et al.
    Prognostic impact of the "Sekhar grading system for cranial chordomas" in patients treated with pencil beam scanning proton therapy: an institutional analysis
    Radiation Oncology. 2020; 15(1): 96 (8 pp.). https://doi.org/10.1186/s13014-020-01547-x
    DORA PSI
  • Krieger M, Giger A, Salomir R, Bieri O, Celicanin Z, Cattin PC, et al.
    Impact of internal target volume definition for pencil beam scanned proton treatment planning in the presence of respiratory motion variability for lung cancer: a proof of concept
    Radiotherapy and Oncology. 2020; 145: 154-161. https://doi.org/10.1016/j.radonc.2019.12.001
    DORA PSI
  • Lim PS, Pica A, Hrbacek J, Bachtiary B, Walser M, Lomax AJ, et al.
    Pencil beam scanning proton therapy for paediatric neuroblastoma with motion mitigation strategy for moving target volumes
    Clinical Oncology. 2020; 32(7): 467-476. https://doi.org/10.1016/j.clon.2020.02.002
    DORA PSI
  • Lim PS, Tran S, Kroeze SGC, Pica A, Hrbacek J, Bachtiary B, et al.
    Outcomes of adolescents and young adults treated for brain and skull base tumors with pencil beam scanning proton therapy
    Pediatric Blood & Cancer. 2020; 67(12): e28664 (10 pp.). https://doi.org/10.1002/pbc.28664
    DORA PSI
  • Matter M, Nenoff L, Marc L, Weber DC, Lomax AJ, Albertini F
    Update on yesterday's dose – use of delivery log-files for daily adaptive proton therapy (DAPT)
    Physics in Medicine and Biology. 2020; 65(19): 195011 (14 pp.). https://doi.org/10.1088/1361-6560/ab9f5e
    DORA PSI
  • Mishra KK, Afshar A, Thariat J, Shih HA, Scholey JE, Daftari IK, et al.
    Practice considerations for proton beam radiation therapy of uveal melanoma during the coronavirus disease pandemic: particle therapy co-operative group ocular experience
    Advances in Radiation Oncology. 2020; 5(4): 682-686. https://doi.org/10.1016/j.adro.2020.04.010
    DORA PSI
  • Murray FR, Snider JW, Schneider RA, Walser M, Bolsi A, Pica A, et al.
    Prognostic factors for spinal chordomas and chondrosarcomas treated with postoperative pencil-beam scanning proton therapy: a large, single-institution experience
    Journal of Neurosurgery: Spine. 2020; 32(6): 921-930. https://doi.org/10.3171/2019.11.SPINE1927
    DORA PSI
  • Nenoff L, Ribeiro CO, Matter M, Hafner L, Josipovic M, Langendijk JA, et al.
    Deformable image registration uncertainty for inter-fractional dose accumulation of lung cancer proton therapy
    Radiotherapy and Oncology. 2020; 147: 178-185. https://doi.org/10.1016/j.radonc.2020.04.046
    DORA PSI
  • Nenoff L, Matter M, Jarhall AG, Winterhalter C, Gorgisyan J, Josipovic M, et al.
    Daily adaptive proton therapy: is it appropriate to use analytical dose calculations for plan adaption?
    International Journal of Radiation Oncology Biology Physics. 2020; 107(4): 747-755. https://doi.org/10.1016/j.ijrobp.2020.03.036
    DORA PSI
  • Oponowicz E, Owen HL, Psoroulas S, Meer D
    Geometry optimisation of graphite energy degrader for proton therapy
    Physica Medica. 2020; 76: 227-235. https://doi.org/10.1016/j.ejmp.2020.06.023
    DORA PSI
  • Pandya D, Podofillini L, Emert F, Lomax AJ, Dang VN, Sansavini G
    Quantification of a human reliability analysis method for radiotherapy applications based on expert judgment aggregation
    Reliability Engineering and System Safety. 2020; 194: 106489 (22 pp.). https://doi.org/10.1016/j.ress.2019.05.001
    DORA PSI
  • Pelak MJ, Walser M, Bachtiary B, Hrbacek J, Lomax AJ, Kliebsch UL, et al.
    Clinical outcomes of head and neck adenoid cystic carcinoma patients treated with pencil beam-scanning proton therapy
    Oral Oncology. 2020; 107: 104752 (6 pp.). https://doi.org/10.1016/j.oraloncology.2020.104752
    DORA PSI
  • Pica A, Weber DC, Vallat L, Bergin C, Hrbacek J, Schweizer C, et al.
    Good long-term visual outcomes of parapapillary choroidal melanoma patients treated with proton therapy: a comparative study
    International Ophthalmology. 2020; 41(2): 441-452. https://doi.org/10.1007/s10792-020-01594-z
    DORA PSI
  • Poel R, Belosi F, Albertini F, Walser M, Gisep A, Lomax AJ, et al.
    Assessing the advantages of CFR-PEEK over titanium spinal stabilization implants in proton therapy - a phantom study
    Physics in Medicine and Biology. 2020; 65(24): 245031 (13 pp.). https://doi.org/10.1088/1361-6560/ab8ba0
    DORA PSI
  • Psoroulas S, Meer D, Oponowicz E, Owen H
    Mean excitation energy determination for Monte Carlo simulations of boron carbide as degrader material for proton therapy
    Physica Medica. 2020; 80: 111-118. https://doi.org/10.1016/j.ejmp.2020.09.017
    DORA PSI
  • Rosas S, Belosi FM, Bizzocchi N, Böhlen T, Zepter S, Morach P, et al.
    Benchmarking a commercial proton therapy solution: the Paul Scherrer Institut experience
    British Journal of Radiology. 2020; 93(1107): 20190920 (6 pp.). https://doi.org/10.1259/bjr.20190920
    DORA PSI
  • Tran S, Lim PS, Bojaxhiu B, Teske C, Baust K, Zepter S, et al.
    Clinical outcomes and quality of life in children and adolescents with primary brain tumors treated with pencil beam scanning proton therapy
    Pediatric Blood & Cancer. 2020; 67(12): e28465 (12 pp.). https://doi.org/10.1002/pbc.28465
    DORA PSI
  • Van De Water S, Belosi MF, Albertini F, Winterhalter C, Weber DC, Lomax AJ
    Shortening delivery times for intensity-modulated proton therapy by reducing the number of proton spots: An experimental verification
    Physics in Medicine and Biology. 2020; 65(9): 095008 (14 pp.). https://doi.org/10.1088/1361-6560/ab7e7c
    DORA PSI
  • Via R, Hennings F, Fattori G, Pica A, Lomax A, Weber DC, et al.
    Technical note: benchmarking automated eye tracking and human detection for motion monitoring in ocular proton therapy
    Medical Physics. 2020; 47(5): 2237-2241. https://doi.org/10.1002/mp.14087
    DORA PSI
  • Via R, Hennings F, Pica A, Fattori G, Beer J, Peroni M, et al.
    Potential and pitfalls of 1.5T MRI imaging for target volume definition in ocular proton therapy
    Radiotherapy and Oncology. 2021; 154: 53-59. https://doi.org/10.1016/j.radonc.2020.08.023
    DORA PSI
  • Weber DC, Langendijk JA, Grau C, Thariat J
    Proton therapy and the European Particle Therapy Network: the past, present and future
    Cancer/Radiothérapie. 2020; 24(6-7): 687-690. https://doi.org/10.1016/j.canrad.2020.05.002
    DORA PSI
  • Weber DC, Bizzocchi N, Bolsi A, Jenkinson MD
    Proton therapy for intracranial meningioma for the treatment of primary/recurrent disease including re-irradiation
    Frontiers in Oncology. 2020; 10: 558845 (13 pp.). https://doi.org/10.3389/fonc.2020.558845
    DORA PSI
  • Winterhalter C, Aitkenhead A, Oxley D, Richardson J, Weber DC, MacKay RI, et al.
    Pitfalls in the beam modelling process of Monte Carlo calculations for proton pencil beam scanning
    British Journal of Radiology. 2020; 93(1107): 20190919 (11 pp.). https://doi.org/10.1259/bjr.20190919
    DORA PSI

2016-2019

  • Precise beam delivery for proton therapy with dynamic energy modulation Actis O, Mayor A, Meer D, et al.
    J Phys (2018).
    DOI: 10.1088/1742-6596/1067/9/092002
  • A comprehensive and efficient daily quality assurance for PBS proton therapy Actis O, Meer D, König S, et al.
    Phys Med Biol (2017).
    DOI: 10.1088/1361-6560/aa5131
  • Online daily adaptive proton therapy Albertini F, Matter M, Nenoff L, et al.
    Br J Radiol (2019).
    DOI: 10.1259/bjr.20190594
  • Pencil beam scanning proton therapy for pediatric intracranial ependymoma Ares C, Albertini F, Frei-Welte M, et al.
    J Neurooncol (2016).
    DOI: 10.1007/s11060-016-2090-4
  • Clinical and Radiologic Outcomes in Adults and Children Treated with Pencil-Beam Scanning Proton Therapy for Low-Grade Glioma Badiyan S, Ulmer S, Ahlhelm FJ, et al.
    Int J Particle Ther (2017).
    DOI: 10.14338/IJPT-16-00031.1
  • Treatment log files as a tool to identify treatment plan sensitivity to inaccuracies in scanned proton beam delivery Belosi MF, van der Meer R, Garcia de Acilu Laa P, et al.
    Radiother Oncol (2017).
    DOI: 10.1016/j.radonc.2017.09.037
  • Advanced treatment planning using direct 4D optimisation for pencil-beam scanned particle therapy Bernatowicz K, Zhang Y, Perrin RL, et al.
    Phys Med Biol (2017).
    DOI: 10.1088/1361-6560/aa7ab8
  • Four-Dimensional Dose Reconstruction for Scanned Proton Therapy Using Liver 4DCT-MRI Bernatowicz K, Peroni M, Perrin R, et al.
    Int J Rad Onc Biol Phys (2016).
    DOI: 10.1016/j.ijrobp.2016.02.050
  • Radiation Necrosis and White Matter Lesions in Pediatric Patients With Brain Tumors Treated With Pencil Beam Scanning Proton Therapy Bojaxhiu B, Ahlhelm F, Walser M, et al.
    Int J Rad Onc Biol Phys (2018).
    DOI: 10.1016/j.ijrobp.2017.11.037
  • Dynamic beam current control for improved dose accuracy in PBS proton therapy Bula C, Belosi MF, Eichin M, et al.
    Phys Med Biol Phys (2019).
    DOI: 10.1088/1361-6560/ab3317
  • Whole-ventricular irradiation for intracranial germ cell tumors: Dosimetric comparison of pencil beam scanned protons, intensity-modulated radiotherapy and volumetric-modulated arc therapy Correia D, Terribilini D, Zepter S, et al.
    Clin Transl Radiat Oncol (2019).
    DOI: 10.1016/j.ctro.2019.01.002
  • Proton Irradiation with Hyperthermia in Unresectable Soft Tissue Sarcoma Datta NR, Schneider R, Puric E, et al.
    Int J Particle Ther (2016).
    DOI: 10.14338/IJPT-16-00016.1
  • 4Comparing the effectiveness and efficiency of various gating approaches for PBS proton therapy of pancreatic cancer using 4D-MRI datasets Dolde K, Naumann P, David C, et al.
    Phys Med Biol (2019).
    DOI: 10.1088/1361-6560/ab1175
  • 4DMRI-based investigation on the interplay effect for pencil beam scanning proton therapy of pancreatic cancer patients Dolde K, Zhang Y, Chaudhri N, et al.
    Radiat Oncol (2019).
    DOI: 10.1186/s13014-019-1231-2
  • 4D dose calculation for pencil beam scanning proton therapy of pancreatic cancer using repeated 4DMRI datasets Dolde K, Naumann P, David C, et al.
    Phys Med Biol (2018).
    DOI: 10.1088/1361-6560/aad43f
  • Robustness of the Voluntary Breath-Hold Approach for the Treatment of Peripheral Lung Tumors Using Hypofractionated Pencil Beam Scanning Proton Therapy Dueck J, Knopf A, Lomax A, et al.
    Int J Rad Onc Biol Phys (2016).
    DOI: 10.1016/j.ijrobp.2015.11.015
  • The Simulated Effect of the Breath-Hold Reproducibility Treating Locally-Advanced Lung Cancer with Pencil Beam Scanned Proton Therapy Dueck J, Perrin R, Persson GF, et al.
    Med Phys (2016).
    DOI: 10.1118/1.4956259
  • Respiratory motion-management in stereotactic body radiation therapy for lung cancer - A dosimetric comparison in an anthropomorphic lung phantom (LuCa) Ehrbar S, Perrin R, Peroni M, et al.
    Radiother Oncol (2016).
    DOI: 10.1016/j.radonc.2016.10.011
  • The dependence of interplay effects on the field scan direction in PBS proton therapy Fattori G, Klimpki G, Hrbacek J, et al.
    Phys Med Biol (2019).
    DOI: 10.1088/1361-6560/ab1150
  • Monitoring of breathing motion in image-guided PBS proton therapy: comparative analysis of optical and elecromagnetic technologies Fattori G, Safai S, Carmona PF, et al.
    Radiat Oncol (2017).
    DOI: 10.1186/s13014-017-0797-9
  • Preliminary Experimental Comparison of Spot- and Continuous Line Scanning with Or Without Rescanning for Gated Proton Therapy Fattori G, Klimpki G, Safai S, et al.
    Med Phys (2016).
    DOI: 10.1118/1.4958201
  • Dose–response curves for MRI-detected radiation-induced temporal lobe reactions in patients after proton and carbon ion therapy: Does the same RBE-weighted dose lead to the same biological effect? Gillmann C, Lomax AJ, Weber DC, et al.
    Radiother Oncol (2018).
    DOI: 10.1016/j.radonc.2018.01.018
  • The role of a microDiamond detector in the dosimetry of proton pencil beams Gomà C, Marinelli M, Safai S, et al.
    Z Med Phys (2016).
    DOI: 10.1016/j.zemedi.2015.08.003
  • The dosimetric effect of residual breath-hold motion in pencil beam scanned proton therapy - An experimental study Gorgisyan J, Lomax AJ, Rosenschold PMA, et al.
    Radiother Oncol (2019).
    DOI: 10.1016/j.radonc.2019.01.033
  • Impact of beam angle choice on pencil beam scanning breath-hold proton therapy for lung lesions Gorgisyan J, Perrin R, Lomax AJ, et al.
    Acta Oncol (2017).
    DOI: 10.1080/0284186X.2017.1287950
  • Feasibility of Pencil Beam Scanned Intensity Modulated Proton Therapy in Breath-hold for Locally Advanced Non-Small Cell Lung Cancer Gorgisyan J, Munck Af Rosenschold P, Perrin R, et al.
    Int J Rad Onc Biol Phys (2017).
    DOI: 10.1016/j.ijrobp.2017.08.023
  • Patient positioning verification for proton therapy using proton range probes: experimental validation in phantom geometries Hammi A, Koenig S, Weber DC, et al.
    Phys Med Biol (2018).
    DOI: 10.1088/1361-6560/aadf79
  • Positioning of head and neck patients for proton therapy using proton range probes: a proof of concept study Hammi A, Placidi L, Weber DC, et al.
    Phys Med Biol (2017).
    DOI: 10.1088/1361-6560/aa9cff
  • Validation Study of Proton Radiography Against CT Data for Quantitative Imaging of Anatomical Changes in Head and Neck Patients Hammi A, Weber D, Lomax A
    Med Phys (2016).
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  • Automated Treatment Planning System for Uveal Melanomas Treated With Proton Therapy: A Proof-of-Concept Analysis Hennings F, Lomax AJ, Pica A, et al.
    Int J Rad Onc Biol Phys (2018).
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  • A beam monitoring and validation system for continuous line scanning in proton therapy Klimpki G, Psoroulas S, Bula C, et al.
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  • Radiation-induced optic neuropathy after pencil beam scanning proton therapy for skull-base and head and neck tumours Kountouri M, Pica A, Walser M, et al.
    Br J Radiol (2019).
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  • Experimental validation of a deforming grid 4D dose calculation for PBS proton therapy Krieger M, Klimpki G, Fattori GF, et al.
    Phys Med Biol (2018).
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  • Tumour control and Quality of Life in children with Rhabdomyosarcoma treated with pencil beam scanning Proton Therapy Leiser D, Calaminus G, Malyapa R, et al.
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  • What will the medical physics of proton therapy look like 10 yr from now? A personal view Lomax A
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  • A robust optimisation approach accounting for the effect of fractionation on setup uncertainties Lowe M, Aitkenhead A, Albertini F, et al.
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  • Incorporating the effect of fractionation in the evaluation of proton plan robustness to setup errors Lowe M, Albertini F, Aitkenhead A, et al.
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  • Evaluation of Robustness to Setup and Range Uncertainties for Head and Neck Patients Treated With Pencil Beam Scanning Proton Therapy Malyapa R, Lowe M, Bolsi A, et al.
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  • Intensity modulated proton therapy plan generation in under ten seconds Matter M, Nenoff L, Meier G, et al.
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  • Contour scanning for penumbra improvement in pencil beam scanned proton therapy Meier G, Leiser D, Besson R, et al.
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  • Distant Subconjunctival Recurrences following Proton Therapy for a Choroidal Melanoma with Extrascleral Extension Mouvet V, Moulin A, Pica A, et al.
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  • Long-Term Clinical Outcomes of Pencil Beam Scanning Proton Therapy for Benign and Non-benign Intracranial Meningiomas Murray FR, Snider JW, Bolsi A, et al.
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  • Daily adaptive proton therapy - the key to innovative planning approaches for paranasal cancer treatments Nenoff L, Matter M, Hedlund Lindmar J, et al.
    Acta Oncol (2019).
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  • Large energy acceptance gantry for proton therapy utilizing superconducting technology Nesteruk KP, Calzolaio C, Meer D, et al.
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  • Personalized Anatomic Eye Model From T1-Weighted Volume Interpolated Gradient Echo Magnetic Resonance Imaging of Patients With Uveal Melanoma Nguyen HG, Sznitman R, Maeder P, et al.
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  • An anthropomorphic breating phantom for testing new motion mitigation techniques for pencil beam scanning proton therapy Perrin RL, Zakova M, Peroni M, et al.
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  • Range resolution and reproducibility of a dedicated phantom for proton PBS daily quality assurance Placidi L, Togno M, Weber DC, et al.
    Z Med Phys (2018).
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  • Effect of Anatomic Changes on Pencil Beam Scanned Proton Dose Distributions for Cranial and Extracranial Tumors Placidi L, Bolsi A, Lomax AJ, et al.
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  • A predictive algorithm for spot position corrections after fast energy switching in proton pencil beam scanning Psoroulas S, Bula C, Actis O, et al.
    Med Phys (2018).
    DOI: /10.1002/mp.13217
  • Assessment of dosimetric errors induced by deformable image registration methods in 4D pencil beam scanned proton treatment planning for liver tumours Ribeiro CO, Knopf A, Langendijk JA, et al.
    Radiother Oncol (2018).
    DOI: /10.1016/j.radonc.2018.03.001
  • Assessing the Quality of Proton PBS Treatment delivery using machine log files: comprehensive Analysis of clinical Treatments delivered at PSI Gantry 2 Scandurra D, Albertini F, van der Meer R, et al.
    Phys Med Biol (2016).
    DOI: 10.1088/0031-9155/61/3/1171
  • Liquid fiducial marker applicability in proton therapy of locally advanced lung cancer Scherman Rydhög J, Perrin R, Rolck RI, et al.
    Radiother Oncol (2017).
    DOI: 10.1016/j.radonc.2016.12.027
  • Can Technological Improvements Reduce the Cost of Proton Radiation Therapy? Schippers JM, Lomax A, Garonna A, et al.
    Semin Radiat Oncol (2018).
    DOI: 10.1016/j.semradonc.2017.11.007
  • Neutrons in active proton therapy: Parameterization of dose and dose equivalent Schneider U, Haelg RA, Lomax T
    Z Med Phys (2017).
    DOI: 10.1016/j.zemedi.2016.07.001
  • Long-Term Outcomes and Prognostic Factors After Pencil-Beam Scanning Proton Radiation Therapy for Spinal Chordomas: A Large, Single-Institution Cohort Snider JW, Schneider RA, Poelma-Tap D et al.
    Int J Rad Onc Biol Phys (2018).
    DOI: 10.1016/j.ijrobp.2018.01.060
  • Comparison of supine or prone crawl photon or proton breast and regional lymph node radiation therapy including the internal mammary chain Speleers BA, Belosi FM, De Gersem WR, et al.
    Sci Rep (2019).
    DOI: 10.1038/s41598-019-41283-1
  • Long-Term Clinical Safety of High-Dose Proton Radiation Therapy Delivered With Pencil Beam Scanning Technique for Extracranial Chordomas and Chondrosarcomas in Adult Patients: Clinical Evidence of Spinal Cord Tolerance Stieb S, Snider JW, Placidi L, et al.
    Int J Rad Onc Biol Phys (2017).
    DOI: 10.1016/j.ijrobp.2017.08.037
  • Early results and volumetric analysis after spot-scanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas Tran S, Puric E, Walser M, et al.
    BR J Radiol (2019).
    DOI: 10.1259/bjr.20180883
  • Factors influencing the performance of patient specific quality assurance for pencil beam scanning IMPT fields Trnková P, Bolsi A, Albertini F, et al.
    Med Phys (2016).
    DOI: 10.1118/1.4964449
  • Towards FLASH proton therapy: the impact of treatment planning and machine characteristics on achievable dose rates van de Water S, Safai S, Schippers JM, et al.
    Acta Oncol (2019).
    DOI: 10.1080/0284186X.2019.1627416
  • Anatomical robust optimization to account for nasal cavity filling Variation during intensity-modulated proton therapy: a comparison with conventional and adaptive planning strategies van de Water S, Albertini F, Weber DC, et al.
    Phys Med Biol (2017).
    DOI: 10.1088/1361-6560/aa9c1c
  • Noninvasive eye localization in ocular proton therapy through optical eye tracking: A proof of concept Via R, Hennings F, Fattori G, et al.
    Med Phys (2018).
    DOI: 10.1002/mp.12841
  • Proton therapy for brain tumours in the area of evidence-based medicine Weber DC, Lim PS, Tran S, et al.
    Br J Radiol (2019).
    DOI: 10.1259/bjr.20190237
  • Bringing Europe together in building clinical evidence for proton therapy – the EPTN–ESTRO–EORTC endeavor Weber DC, Grau C, Lim PS, et al.
    Acta Oncol (2019).
    DOI: 10.1080/0284186X.2019.1624820
  • Long term outcome of skull-base chondrosarcoma patients treated with high-dose proton therapy with or without conventional radiation therapy Weber DC, Murray FR, Combescure C, et al.
    Radiother Oncol (2018).
    DOI: 10.1016/j.radonc.2018.06.040
  • Proton therapy for pediatric malignancies: Fact, figures and costs. A joint consensus statement from the pediatric subcommittee of PTCOG, PROS and EPTN Weber DC, Habrand JL, Hoppe BS, et al.
    Radiother Oncol (2018).
    DOI: 10.1016/j.radonc.2018.05.020
  • Adjuvant postoperative high-dose radiotherapy for atypical and malignant meningioma: A phase-II parallel non-randomized and observation study (EORTC 22042-26042) Weber DC, Ares C, Villa S, et al.
    Radiother Oncol (2018).
    DOI: 10.1016/j.radonc.2018.06.018
  • Pencil beam scanned protons for the treatment of patients with Ewing sarcoma Weber DC, Murray FR, Correia D, et al.
    Pediatr Blood Cancer (2017).
    DOI: 10.1002/pbc.26688
  • Profile of European proton and carbon ion therapy centers assessed by the EORTC facility questionnaire Weber DC, Murray FR, Correia D, et al.
    Radiother Oncol (2017).
    DOI: 10.1016/j.radonc.2017.07.012
  • Long-term outcomes and prognostic factors of skull-base chondrosarcoma patients treated with pencil-beam scanning proton therapy at the Paul Scherrer Institute Weber DC, Badiyan S, Malyapa R, et al.
    Neuro-Oncol (2016).
    DOI: 10.1093/neuonc/nov154
  • Long term outcomes of patients with skull-base low-grade chondrosarcoma and chordoma patients treated with pencil beam scanning proton therapy Weber DC, Malyapa R, Albertini F, et al.
    Radiother Oncol (2016).
    DOI: 10.1016/j.radonc.2016.05.011
  • Rhabdoid Tumour of the Orbit in a Child Wilms V, Jaeger M, Schlamann M, et al.
    Klin Monbl Augenheilkd (2019).
    DOI: 10.1055/a-0838-5604
  • Evaluation of the ray-casting analytical algorithm for pencil beam scanning proton therapy Winterhalter C, Zepter S, Shim S, et al.
    Phys Med Biol (2019).
    DOI: 10.1088/1361-6560/aafe58
  • Comment on 'Collimated proton pencil-beam scanning for superficial targets: impact of the order of range shifter and aperture' Winterhalter C, Lomax AJ, Oxley D, et al.
    Phys Med Biol (2018).
    DOI: 10.1088/1361-6560/aae0e1
  • Validating a Monte Carlo approach to absolute dose quality assurance for proton pencil beam scanning Winterhalter C, Fura E, Tian Y, et al.
    Phys Med Biol (2018).
    DOI: 10.1088/1361-6560/aad3ae
  • Contour scanning, multi-leaf collimation and the combination thereof for proton pencil beam scanning Winterhalter C, Meier G, Oxley D, et al.
    Phys Med Biol (2018).
    DOI: 10.1088/1361-6560/aaf2e8
  • Log file based Monte Carlo calculations for proton pencil beam scanning therapy Winterhalter C, Meier G, Oxley D, et al.
    Phys Med Biol (2018).
    DOI: 10.1088/1361-6560/aaf82d
  • A study of lateral fall-off (penumbra) optimisation for pencil beam scanning (PBS) Proton therapy Winterhalter C, Lomax AJ, Oxley D, et al.
    Phys Med Biol (2018).
    DOI: 10.1088/1361-6560/aaa2ad
  • Dosimetric uncertainties as a result of temporal resolution in 4D dose calculations for PBS proton therapy Zhang Y, Huth I, Weber DC, et al.
    Phys Med Biol (2019).
    DOI: 10.1088/1361-6560/ab1d6f
  • A statistical comparison of motion mitigation performances and robustness of various pencil beam scanned proton systems for liver tumour treatments Zhang Y, Huth I, Weber DC, et al.
    Radiother Oncol (2018).
    DOI: 10.1016/j.radonc.2018.01.019
  • Surface as a motion surrogate for gated re-scanned pencil beam proton therapy Zhang Y, Huth I, Wegner M, et al.
    Phys Med Biol (2017).
    DOI: 10.1088/1361-6560/aa66c5
  • An evaluation of rescanning technique for liver tumor treatments using a commercial PBS proton therapy system Zhang Y, Huth I, Wegner M, et al.
    Radiother-Oncol (2016).
    DOI: 10.1016/j.radonc.2016.09.011

2011-2015

  • Experimental verification of IMPT treatment plans in an anthropomorphic phantom in the presence of delivery uncertainties Albertini F, Casiraghi M, Lorentini S, Rombi B, Lomax AJ.
    Phys Med Biol (2011).
    DOI: 10.1088/0031-9155/56/14/012
  • Is it necessary to plan with safety margins for actively scanned proton therapy? Albertini F, Hug EB, Lomax AJ.
    Phys Med Biol (2011).
    DOI: 10.1088/0031-9155/56/14/011
  • Quantifying the impact of respiratory-gated 4D CT acquisition on thoracic image quality: A digital phantom study Bernatowicz K, Keall P, Mishra P, et al.
    Med Phys (2015).
    DOI: 10.1118/1.4903936
  • Advantages and limitations of the "worst case scenario" approach in IMPT treatment planning Casiraghi M, Albertini F, Lomax AJ
    Phys Med Biol (2013).
    DOI: 10.1088/0031-9155/58/5/1323
  • Could hyperthermia with proton therapy mimic carbon ion therapy? Exploring a thermo-radiobiological rationale Datta NR, Puric E, Schneider R, et al.
    Int J Hyperthermia (2014).
    DOI: 10.3109/02656736.2014.963703
  • The effect of surgical titanium rods on proton therapy delivered for cervical bone tumors: experimental validation using an anthropomorphic phantom Dietlicher I, Casiraghi M, Ares C, et al.
    Phys Med Biol (2014).
    DOI: 10.1088/0031-9155/59/23/7181
  • Pediatric anesthesia for proton radiotherapy : medicine remote from the medical centre Frei-Welte M, Weiss M, Neuhaus D, et al.
    Anaesthesist (2012).
    DOI: 10.1007/s00101-012-2085-2
  • Experimental validation of beam quality correction factors for proton beams Goma C, Hofstetter-Boillat B, Safai S, Vörös S
    Phys Med Biol (2015).
    DOI: 10.1088/0031-9155/60/8/3207
  • Benchmarking of a treatment planning system for spot scanning proton therapy: Comparison and analysis of robustness to setup errors of photon IMRT and proton SFUD treatment plans of base of skull meningioma Harding R, Trnková P, Weston SJ, et al.
    Med Phys (2014).
    DOI: 10.1118/1.4897571
  • In the context of radiosurgery: Pros and cons of rescanning as a solution for treating moving targets with scanned particle beams Knopf AC, Lomax AJ
    Physica Medica (2014).
    DOI: 10.1016/j.ejmp.2014.03.010
  • Dose-painting intensity-modulated Proton therapy for intermediate- and high-risk meningioma Madani I, Lomax AJ, Albertini F, et al.
    Radiat Oncol (2015).
    DOI: 10.1186/s13014-015-0384-x
  • Defining robustness protocols: a method to include and evaluate robustness in clinical plans McGowan SE, Albertini F, Thomas SJ, Lomax AJ
    Phys Med Biol (2015).
    DOI: 10.1088/0031-9155/60/7/2671
  • Independent dose calculations for commissioning, quality assurance and dose reconstruction of PBS proton therapy Meier G, Besson R, Nanz A, et al.
    Phys Med Biol (2015).
    DOI: 10.1088/0031-9155/60/7/2819
  • Temporal lobe toxicity analysis after proton radiation therapy for skull base tumors Pehlivan B, Ares C, Lomax AJ, et al.
    Int J Rad Onc Biol Phys (2012).
    DOI: 10.1016/j.ijrobp.2011.10.042
  • Proton therapy for uveal melanoma in 43 juvenile patients: long-term results Petrovic A, Bergin C, Schalenbourg A, et al.
    Ophthalmology (2014).
    DOI: 10.1016/j.ophtha.2013.10.032
  • Spot-scanning proton radiation therapy for pediatric chordoma and chondrosarcoma: clinical outcome of 26 patients treated at Paul Scherrer Institute Rombi B, Ares C, Hug EB, et al.
    Int J Rad Onc Biol Phys (2013).
    DOI: 10.1016/j.ijrobp.2013.02.026
  • First experimental results of motion mitigation by continuous line scanning of protons Schatti A, Meer D, Lomax AJ
    Phys Med Biol (2014).
    DOI: 10.1088/0031-9155/59/19/5707
  • The effectiveness of combined gating and re-scanning for treating mobile targets with proton spot scanning. An experimental and simulation-based investigation Schatti A, Zakova M, Meer D, et al.
    Phys Med Biol (2014).
    DOI: 10.1088/0031-9155/59/14/3813
  • Experimental verification of motion mitigation of discrete proton spot scanning by re-scanning Schatti A, Zakova M, Meer D, et al.
    Phys Med Biol (2013).
    DOI: 10.1088/0031-9155/58/23/8555
  • Small bowel toxicity after high dose spot scanning-based proton beam therapy for paraspinal/retroperitoneal neoplasms Schneider R, Vitolo V, Albertini F, et al.
    Strahlenther Onkol (2013).
    DOI: 10.1007/s00066-013-0432-0
  • Spot-scanning based proton therapy for extracranial chordoma Staab A, Rutz HP, Ares C, et al.
    Int J Rad Onc Biol Phys (2011).
    DOI: 10.1016/j.ijrobp.2011.02.018
  • Dose to the developing dentition during therapeutic Irradiation: organ at risk determination and clinical implications Thompson RF, Schneider RA, Albertini F, et al.
    Int J Rad Onc Biol Phys (2013).
    DOI: 10.1016/j.ijrobp.2012.11.041
  • Tumor control and QoL outcome of very young children with atypical teratoid/rhabdoid Tumor treated with focal only chemo-radiation therapy using pencil beam scanning proton therapy Weber DC, Ares C, Malyapa R, et al.
    J Neurooncol (2015).
    DOI: 10.1007/s11060-014-1648-2
  • Pencil Beam Scanning Proton Therapy for Pediatric Parameningeal Rhabdomyosarcomas: Clinical Outcome of Patients Treated at the Paul Scherrer Institute Weber DC, Ares C, Albertini F, et al.
    Pediatr Blood Cancer (2015).
    DOI: 10.1002/pbc.25864
  • Long-term outcome of patients with spinal myxopapillary ependymoma: treatment results from the MD Anderson Cancer Center and institutions from the Rare Cancer Network Weber DC, Wang Y, Miller R, et al.
    Neuro Oncol (2015).
    DOI: 10.1093/neuonc/nou293
  • IMRT credentialing for prospective trials using institutional virtual phantoms: results of a joint European Organization for the Research and Treatment of Cancer and Radiological Physics Center project Weber DC, Vallet V, Molineu A, et al.
    Radiat Oncol (2014).
    DOI: 10.1186/1748-717X-9-123
  • Outcome impact and cost-effectiveness of quality assurance for radiotherapy planned for the EORTC 22071-24071 prospective study for head and neck cancer Weber DC, Hurkmans CW, Melidis C, et al.
    Radiother Oncol (2014).
    DOI: 10.1016/j.radonc.2014.04.015
  • Spot scanning-based proton therapy for intracranial meningioma: long-term results from the Paul Scherrer Institute Weber DC, Schneider R, Goitein G, et al.
    Int J Rad Onc Biol Phys (2012).
    DOI: 10.1016/j.ijrobp.2011.08.027
  • Improving 4D plan quality for PBS-based liver tumour treatments by combining online image guided beam gating with rescanning Zhang Y, Knopf AC, Weber DC, et al.
    Phys Med Biol (2015).
    DOI: 10.1088/0031-9155/60/20/8141
  • Online image guided tumour tracking with scanned proton beams: a comprehensive simulation study Zhang Y, Knopf A, Tanner C, et al.
    Phys Med Biol (2014).
    DOI: 10.1088/0031-9155/59/24/7793
  • Respiratory liver motion estimation and its effect on scanned proton beam therapy Zhang Y, Boye D, Tanner C, et al.
    Phys Med Biol (2012).
    DOI: 10.1088/0031-9155/57/7/1779

2006-2010

  • The influence of the optimization starting conditions on the robustness of intensity-modulated proton therapy plans Albertini F, Hug EB, Lomax AJ.
    Phys Med Biol (2010).
    DOI: 10.1088/0031-9155/55/10/005
  • Sensitivity of intensity modulated proton therapy plans to changes in patient weight Albertini F, Bolsi A, Lomax AJ, et al.
    Radiother Oncol (2008).
    DOI: 10.1016/j.radonc.2007.11.032
  • Postoperative Proton Radiotherapy for Localized and Locoregional Breast Cancer: Potential for Clinically Relevant Improvements? Ares C, Khan S, MacArtain AM, et al.
    Int J Rad Onc Biol Phys (2010).
    DOI: 10.1016/j.ijrobp.2009.02.062
  • Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report Ares C, Hug EB, Lomax AJ, et al.
    Int J Rad Onc Biol Phys (2009).
    DOI: 10.1016/j.ijrobp.2008.12.055
  • Experiences at the Paul Scherrer Institute with a remote patient positioning procedure for high-throughput proton radiation therapy Bolsi A, Lomax AJ, Pedroni E, et al.
    Int J Rad Onc Biol Phys (2008).
    DOI: 10.1016/j.ijrobp.2008.02.079
  • More than 10 years experience of beam monitoring with the Gantry 1 spot scanning proton therapy facility at PSI Lin S, Boehringer T, Coray A, et al.
    Med Phys (2009).
    DOI: 10.1118/1.3244034
  • Postoperative spot-scanning proton radiation therapy for chordoma and chondrosarcoma in children and adolescents: initial experience at Paul Scherrer Institute Rutz HP, Weber DC, Goitein G, et al.
    Int J Rad Onc Biol Phys (2008).
    DOI: 10.1016/j.ijrobp.2007.09.014
  • Spot-scanning proton therapy for rhabdomyosarcomas of early childhood. First experiences at PSI Timmermann B, Schuck A, Niggli F, et al.
    Strahlenther Onkol (2006).
    DOI: 10.1007/s00066-006-1592-y
  • Spot-scanning proton therapy for malignant soft tissue tumors in childhood: First experiences at the Paul Scherrer Institute Timmermann B, Schuck A, Niggli F, et al.
    Int J Rad Onc Biol Phys (2007).
    DOI: 10.1016/j.ijrobp.2006.08.053
  • Spot scanning proton therapy in the curative treatment of adult patients with sarcoma: the Paul Scherrer Institute experience Weber DC, Rutz HP, Bolsi A, et al.
    Int J Rad Onc Biol Phys (2007).
    DOI: 10.1016/j.ijrobp.2007.04.034

2001-2005

  • Eye retention after proton beam radiotherapy for uveal melanoma Egger E, Zografos L, Schalenbourg A, et al.
    Int J Rad Oncol Biol Phys (2003).
    DOI: 10.1016/S0360-3016(02)04200-1
  • Maximizing local tumor control and survival after proton beam radiotherapy of uveal melanoma Egger E, Schalenbourg A, Zografos L, et al.
    Int J Rad Oncol Biol Phys (2001).
    DOI: 10.1016/S0360-3016(01)01560-7
  • Potential role of intensity-modulated photons and Protons in the Treatment of the breast and regional nodes Lomax AJ, Cella L, Weber D, et al.
    Int J Rad Oncol Biol Phys (2003).
    DOI: 10.1016/S0360-3016(02)04210-4
  • Results of spot-scanning proton radiation therapy for chordoma and chondrosarcoma of skull base: The Paul Scherrer Institut experience Weber DC, Rutz HP, Pedroni ES, et al.
    Int J Rad Oncol Biol Phys (2005).
    DOI: 10.1016/j.ijrobp.2005.02.023
  • Spot-scanning proton radiation therapy for recurrent, residual or untreated intracranial meningiomas Weber DC, Lomax AJ, Rutz HP, et al.
    Radiother Oncol (2004).
    DOI: 10.1016/j.radonc.2004.02.011

Patientenbüro
Paul Scherrer Institut PSI
Zentrum für Protonentherapie
5232 Villigen PSI West, Schweiz
Eingang PSI West

Tel: +41 56 310 35 21
Tel: +41 56 310 35 24
protonentherapie@psi.ch

Leiter und Chefarzt
Prof. Dr. med. Damien Charles Weber

 

Primo medico

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